Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance

Neuroscience

Volumn 164, Issue 2, 2009, Pages 702-710

  Doyle, T ^a   Bryant, L ^a   Batinic Haberle, I ^b   Little, J ^a   Cuzzocrea, S ^c,d   Masini, E ^e   Spasojevic, I ^b   Salvemini, D ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MESSINA   (Italy)

^d IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^e UNIVERSITY OF FLORENCE   (Italy)

Author keywords

mitochondrial superoxide dismutase; morphine; nitroxidative stress; peroxynitrite; peroxynitrite decomposition catalysts; superoxide

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DNA; MANGANESE 5,10,15,20 TETRAKIS(N ETHYLPYRIDINIUM 2 YL)PORPHYRIN; MANGANESE 5,10,15,20 TETRAKIS(N HEXYLPYRIDINIUM 2 YL)PORPHYRIN; MANGANESE SUPEROXIDE DISMUTASE; MORPHINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXYNITRITE; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BLOOD BRAIN BARRIER; BRAIN HOMOGENATE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFICACY; DRUG PENETRATION; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INACTIVATION; MALE; MITOCHONDRION; MORPHINE TOLERANCE; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PAIN THRESHOLD; PRIORITY JOURNAL; SPINAL CORD;

ANALGESICS; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; DNA DAMAGE; DRUG TOLERANCE; MALE; MANGANESE COMPOUNDS; MICE; MICE, INBRED STRAINS; MITOCHONDRIA; MORPHINE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEROXYNITROUS ACID; POLY(ADP-RIBOSE) POLYMERASES; SUPEROXIDE DISMUTASE;

EID: 70349734371     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.07.019     Document Type: Article

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