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Volumn 85, Issue 4, 2012, Pages 447-468

Cytokine control of inflammation and repair in the pathology of multiple sclerosis

Author keywords

Cytokines; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Neuroinflammation

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 1BETA; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 23P19; INTERLEUKIN 33; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

EID: 84871597188     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (59)

References (250)
  • 1
    • 0020053716 scopus 로고
    • Autoimmune effector cells. II. Transfer of experimental allergic encephalomyelitis with a subset of T lymphocytes
    • Holda JH, Swanborg RH. Autoimmune effector cells. II. Transfer of experimental allergic encephalomyelitis with a subset of T lymphocytes. Eur J Immunol. 1982;12(5):453-5.
    • (1982) Eur J Immunol. , vol.12 , Issue.5 , pp. 453-455
    • Holda, J.H.1    Swanborg, R.H.2
  • 2
    • 0016814666 scopus 로고
    • Experimental autoimmune demyelinating diseases: Experimental allergic encephalomyelitis and experimental allergic neuritis
    • Lisak RP, Behan PO. Experimental autoimmune demyelinating diseases: experimental allergic encephalomyelitis and experimental allergic neuritis. Biomedicine. 1975;22(2):81-7.
    • (1975) Biomedicine. , vol.22 , Issue.2 , pp. 81-87
    • Lisak, R.P.1    Behan, P.O.2
  • 3
    • 0016123431 scopus 로고
    • Use of water-soluble adjuvant fraction from "Mycobacterium smegmatis" with encephalitogenic basic protein to induce autoimmune experimental allergic encephalomyelitis in guinea pigs (author's transl)
    • Lebar R, Voisin GA. [Use of water-soluble adjuvant fraction from "Mycobacterium smegmatis" with encephalitogenic basic protein to induce autoimmune experimental allergic encephalomyelitis in guinea pigs (author's transl)]. Ann Immunol (Paris). 1974;125(6):911-6.
    • (1974) Ann Immunol (Paris). , vol.125 , Issue.6 , pp. 911-916
    • Lebar, R.1    Voisin, G.A.2
  • 4
    • 0023700004 scopus 로고
    • Reflections on the pathogenesis of optic (retrobulbar) neuritis in multiple sclerosis
    • Schwyzer RU, Henzi H. Reflections on the pathogenesis of optic (retrobulbar) neuritis in multiple sclerosis. Med Hypotheses. 1988;27(3):167-79.
    • (1988) Med Hypotheses. , vol.27 , Issue.3 , pp. 167-179
    • Schwyzer, R.U.1    Henzi, H.2
  • 5
    • 0033615464 scopus 로고    scopus 로고
    • The pathophysiology of multiple sclerosis: The mechanisms underlying the production of symptoms and the natural history of the disease
    • Smith KJ, McDonald WI. The pathophysiology of multiple sclerosis: the mechanisms underlying the production of symptoms and the natural history of the disease. Philos Trans R Soc Lond B Biol Sci. 1999;354(1390):1649-73.
    • (1999) Philos Trans R Soc Lond B Biol Sci. , vol.354 , Issue.1390 , pp. 1649-1673
    • Smith, K.J.1    McDonald, W.I.2
  • 6
    • 84859540194 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Miller E. Multiple sclerosis. Adv Exp Med Biol. 2012;724:222-38.
    • (2012) Adv Exp Med Biol. , vol.724 , pp. 222-238
    • Miller, E.1
  • 7
    • 0019973150 scopus 로고
    • Immunohistochemical identification of Tlymphocytes in the central nervous system of patients with multiple sclerosis and subacute sclerosing panencephalitis
    • Kreth HW, Dunker R, Rodt H, Meyermann R. Immunohistochemical identification of Tlymphocytes in the central nervous system of patients with multiple sclerosis and subacute sclerosing panencephalitis. J Neuroimmunol. 1982;2(2):177-83.
    • (1982) J Neuroimmunol. , vol.2 , Issue.2 , pp. 177-183
    • Kreth, H.W.1    Dunker, R.2    Rodt, H.3    Meyermann, R.4
  • 8
    • 0022459287 scopus 로고
    • Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions
    • Hauser SL, Bhan AK, Gilles F, Kemp M, Kerr C, Weiner HL. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann Neurol. 1986;19(6):578-87.
    • (1986) Ann Neurol. , vol.19 , Issue.6 , pp. 578-587
    • Hauser, S.L.1    Bhan, A.K.2    Gilles, F.3    Kemp, M.4    Kerr, C.5    Weiner, H.L.6
  • 9
    • 0030008758 scopus 로고    scopus 로고
    • Inflammation in EAE: Role of chemokine/cytokine expression by resident and infiltrating cells
    • Eng LF, Ghirnikar RS, Lee YL. Inflammation in EAE: role of chemokine/cytokine expression by resident and infiltrating cells. Neurochem Res. 1996;21(4):511-25.
    • (1996) Neurochem Res. , vol.21 , Issue.4 , pp. 511-525
    • Eng, L.F.1    Ghirnikar, R.S.2    Lee, Y.L.3
  • 10
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • Ferber IA, Brocke S, Taylor-Edwards C, Ridgway W, Dinisco C, Steinman L, et al. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol. 1996;156(1):5-7.
    • (1996) J Immunol. , vol.156 , Issue.1 , pp. 5-7
    • Ferber, I.A.1    Brocke, S.2    Taylor-Edwards, C.3    Ridgway, W.4    Dinisco, C.5    Steinman, L.6
  • 11
    • 0019465748 scopus 로고
    • Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: Requirement for Lyt 1+ 2-T lymphocytes
    • Pettinelli CB, McFarlin DE. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2-T lymphocytes. J Immunol. 1981;127(4):1420-3.
    • (1981) J Immunol. , vol.127 , Issue.4 , pp. 1420-1423
    • Pettinelli, C.B.1    McFarlin, D.E.2
  • 12
    • 0022391542 scopus 로고
    • Relapsing experimental allergic encephalomyelitis. An autoimmune model of multiple sclerosis
    • Lublin FD. Relapsing experimental allergic encephalomyelitis. An autoimmune model of multiple sclerosis. Springer Semin Immunopathol. 1985;8(3):197-208.
    • (1985) Springer Semin Immunopathol. , vol.8 , Issue.3 , pp. 197-208
    • Lublin, F.D.1
  • 13
    • 0029000750 scopus 로고
    • Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
    • McRae BL, Vanderlugt CL, Dal Canto MC, Miller SD. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J Exp Med. 1995;182(1):75-85.
    • (1995) J Exp Med. , vol.182 , Issue.1 , pp. 75-85
    • McRae, B.L.1    Vanderlugt, C.L.2    Dal Canto, M.C.3    Miller, S.D.4
  • 14
    • 2442700643 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in autoimmune encephalomyelitis as a model for central nervous system inflammatory disease regulation
    • Dogan RN, Karpus WJ. Chemokines and chemokine receptors in autoimmune encephalomyelitis as a model for central nervous system inflammatory disease regulation. Front Biosci. 2004;9:1500-5.
    • (2004) Front Biosci. , vol.9 , pp. 1500-1505
    • Dogan, R.N.1    Karpus, W.J.2
  • 15
    • 14744298180 scopus 로고    scopus 로고
    • Engagement of human monocyte-derived dendritic cells into interleukin (IL)-12 producers by IL-1beta + interferon (IFN)-gamma
    • Nakahara T, Urabe K, Fukagawa S, Uchi H, Inaba K, Furue M, et al. Engagement of human monocyte-derived dendritic cells into interleukin (IL)-12 producers by IL-1beta + interferon (IFN)-gamma. Clin Exp Immunol. 2005;139(3):476-82.
    • (2005) Clin Exp Immunol. , vol.139 , Issue.3 , pp. 476-482
    • Nakahara, T.1    Urabe, K.2    Fukagawa, S.3    Uchi, H.4    Inaba, K.5    Furue, M.6
  • 16
    • 81755184012 scopus 로고    scopus 로고
    • Cytokines and effector T cell subsets causing autoimmune CNS disease
    • Petermann F, Korn T. Cytokines and effector T cell subsets causing autoimmune CNS disease. FEBS Lett. 2011;585(23):3747-57.
    • (2011) FEBS Lett. , vol.585 , Issue.23 , pp. 3747-3757
    • Petermann, F.1    Korn, T.2
  • 17
    • 0037327907 scopus 로고    scopus 로고
    • Astrocytes are the major intracerebral source of macrophage inflammatory protein-3alpha/CCL20 in relapsing experimental autoimmune encephalomyelitis and in vitro
    • Ambrosini E, Columba-Cabezas S, Serafini B, Muscella A, Aloisi F. Astrocytes are the major intracerebral source of macrophage inflammatory protein-3alpha/CCL20 in relapsing experimental autoimmune encephalomyelitis and in vitro. Glia. 2003;41(3):290-300.
    • (2003) Glia. , vol.41 , Issue.3 , pp. 290-300
    • Ambrosini, E.1    Columba-Cabezas, S.2    Serafini, B.3    Muscella, A.4    Aloisi, F.5
  • 18
    • 0028004282 scopus 로고
    • Experimental allergic encephalomyelitis. T cell trafficking to the central nervous system in a resistant Thy-1 congenic mouse strain
    • Skundric DS, Huston K, Shaw M, Tse HY, Raine CS. Experimental allergic encephalomyelitis. T cell trafficking to the central nervous system in a resistant Thy-1 congenic mouse strain. Lab Invest. 1994;71(5):671-9.
    • (1994) Lab Invest. , vol.71 , Issue.5 , pp. 671-679
    • Skundric, D.S.1    Huston, K.2    Shaw, M.3    Tse, H.Y.4    Raine, C.S.5
  • 19
    • 77949973725 scopus 로고    scopus 로고
    • Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis
    • Kang Z, Altuntas CZ, Gulen MF, Liu C, Giltiay N, Qin H, et al. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity. 2010;32(3):414-25.
    • (2010) Immunity. , vol.32 , Issue.3 , pp. 414-425
    • Kang, Z.1    Altuntas, C.Z.2    Gulen, M.F.3    Liu, C.4    Giltiay, N.5    Qin, H.6
  • 20
    • 46949104323 scopus 로고    scopus 로고
    • IL-12-and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    • Kroenke MA, Carlson TJ, Andjelkovic AV, Segal BM. IL-12-and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med. 2008;205(7):1535-41.
    • (2008) J Exp Med. , vol.205 , Issue.7 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 21
    • 77951636292 scopus 로고    scopus 로고
    • Cellular mechanisms of IL-17-induced blood-brain barrier disruption
    • Huppert J, Closhen D, Croxford A, White R, Kulig P, Pietrowski E, et al. Cellular mechanisms of IL-17-induced blood-brain barrier disruption. Faseb J. 2010;24(4):1023-34.
    • (2010) Faseb J. , vol.24 , Issue.4 , pp. 1023-1034
    • Huppert, J.1    Closhen, D.2    Croxford, A.3    White, R.4    Kulig, P.5    Pietrowski, E.6
  • 22
    • 0030987073 scopus 로고    scopus 로고
    • The effect of interferon beta-1b on cytokine-induced adhesion molecule expression
    • Jiang H, Williams GJ, Dhib-Jalbut S. The effect of interferon beta-1b on cytokine-induced adhesion molecule expression. Neurochem Int. 1997;30(4-5):449-53.
    • (1997) Neurochem Int. , vol.30 , Issue.4-5 , pp. 449-453
    • Jiang, H.1    Williams, G.J.2    Dhib-Jalbut, S.3
  • 23
    • 57649244985 scopus 로고    scopus 로고
    • Neuroinflammation activates Mdr1b efflux transport through NFkappaB: Promoter analysis in BBB endothelia
    • Yu C, Argyropoulos G, Zhang Y, Kastin AJ, Hsuchou H, Pan W. Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia. Cell Physiol Biochem. 2008;22(5-6):745-56.
    • (2008) Cell Physiol Biochem. , vol.22 , Issue.5-6 , pp. 745-756
    • Yu, C.1    Argyropoulos, G.2    Zhang, Y.3    Kastin, A.J.4    Hsuchou, H.5    Pan, W.6
  • 24
    • 0029908222 scopus 로고    scopus 로고
    • Differential permeability of the BBB in acute EAE: Enhanced transport of TNT-alpha
    • Pan W, Banks WA, Kennedy MK, Gutierrez EG, Kastin AJ. Differential permeability of the BBB in acute EAE: enhanced transport of TNT-alpha. Am J Physiol. 1996;271(4 Pt 1):E636-42.
    • (1996) Am J Physiol. , vol.271 , Issue.4 PART 1
    • Pan, W.1    Banks, W.A.2    Kennedy, M.K.3    Gutierrez, E.G.4    Kastin, A.J.5
  • 25
    • 33847223756 scopus 로고    scopus 로고
    • Interferongamma-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis
    • Balabanov R, Strand K, Goswami R, McMahon E, Begolka W, Miller SD, et al. Interferongamma-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis. J Neurosci. 2007;27(8):2013-24.
    • (2007) J Neurosci. , vol.27 , Issue.8 , pp. 2013-2024
    • Balabanov, R.1    Strand, K.2    Goswami, R.3    McMahon, E.4    Begolka, W.5    Miller, S.D.6
  • 26
    • 18744407600 scopus 로고    scopus 로고
    • Effect of tumor necrosis factor-alpha on developing optic nerve oligodendrocytes in culture
    • Pang Y, Cai Z, Rhodes PG. Effect of tumor necrosis factor-alpha on developing optic nerve oligodendrocytes in culture. J Neurosci Res. 2005;80(2):226-34.
    • (2005) J Neurosci Res. , vol.80 , Issue.2 , pp. 226-234
    • Pang, Y.1    Cai, Z.2    Rhodes, P.G.3
  • 27
    • 0036353262 scopus 로고    scopus 로고
    • Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells
    • Vela JM, Molina-Holgado E, Arevalo-Martin A, Almazan G, Guaza C. Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells. Mol Cell Neurosci. 2002;20(3):489-502.
    • (2002) Mol Cell Neurosci. , vol.20 , Issue.3 , pp. 489-502
    • Vela, J.M.1    Molina-Holgado, E.2    Arevalo-Martin, A.3    Almazan, G.4    Guaza, C.5
  • 28
    • 0041864076 scopus 로고    scopus 로고
    • Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli
    • Meeuwsen S, Persoon-Deen C, Bsibsi M, Ravid R, Noort JM. Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli. Glia. 2003;43(3):243-53.
    • (2003) Glia. , vol.43 , Issue.3 , pp. 243-253
    • Meeuwsen, S.1    Persoon-Deen, C.2    Bsibsi, M.3    Ravid, R.4    Noort, J.M.5
  • 30
    • 0026037661 scopus 로고
    • Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGF beta
    • Merrill JE, Zimmerman RP. Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGF beta. Glia. 1991;4(3):327-31.
    • (1991) Glia. , vol.4 , Issue.3 , pp. 327-331
    • Merrill, J.E.1    Zimmerman, R.P.2
  • 31
    • 0025813019 scopus 로고
    • Effects of interleukin-1 and tumor necrosis factor-alpha on astrocytes, microglia, oligodendrocytes, and glial precursors in vitro
    • Merrill JE. Effects of interleukin-1 and tumor necrosis factor-alpha on astrocytes, microglia, oligodendrocytes, and glial precursors in vitro. Dev Neurosci. 1991;13(3):130-7.
    • (1991) Dev Neurosci. , vol.13 , Issue.3 , pp. 130-137
    • Merrill, J.E.1
  • 32
    • 0030739650 scopus 로고    scopus 로고
    • Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
    • Lafaille JJ, Keere FV, Hsu AL, Baron JL, Haas W, Raine CS, et al. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J Exp Med. 1997;186(2):307-12.
    • (1997) J Exp Med. , vol.186 , Issue.2 , pp. 307-312
    • Lafaille, J.J.1    Keere, F.V.2    Hsu, A.L.3    Baron, J.L.4    Haas, W.5    Raine, C.S.6
  • 33
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986;136(7):2348-57.
    • (1986) J Immunol. , vol.136 , Issue.7 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 34
    • 0030039962 scopus 로고    scopus 로고
    • Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms
    • Waldburger KE, Hastings RC, Schaub RG, Goldman SJ, Leonard JP. Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms. Am J Pathol. 1996;148(2):375-82.
    • (1996) Am J Pathol. , vol.148 , Issue.2 , pp. 375-382
    • Waldburger, K.E.1    Hastings, R.C.2    Schaub, R.G.3    Goldman, S.J.4    Leonard, J.P.5
  • 35
    • 0035421324 scopus 로고    scopus 로고
    • Role of MOGstimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE)
    • Yura M, Takahashi I, Serada M, Koshio T, Nakagami K, Yuki Y, et al. Role of MOGstimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE). J Autoimmun. 2001;17(1):17-25.
    • (2001) J Autoimmun. , vol.17 , Issue.1 , pp. 17-25
    • Yura, M.1    Takahashi, I.2    Serada, M.3    Koshio, T.4    Nakagami, K.5    Yuki, Y.6
  • 36
    • 43949163341 scopus 로고
    • Interleukin-12 and its role in the generation of TH1 cells
    • Trinchieri G. Interleukin-12 and its role in the generation of TH1 cells. Immunol Today. 1993;14(7):335-8.
    • (1993) Immunol Today. , vol.14 , Issue.7 , pp. 335-338
    • Trinchieri, G.1
  • 37
    • 0028943484 scopus 로고
    • Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
    • Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE, Jr., et al. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med. 1995;181(5):1755-62.
    • (1995) J Exp Med. , vol.181 , Issue.5 , pp. 1755-1762
    • Jacobson, N.G.1    Szabo, S.J.2    Weber-Nordt, R.M.3    Zhong, Z.4    Schreiber, R.D.5    Darnell Jr., J.E.6
  • 39
    • 78649752513 scopus 로고    scopus 로고
    • Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
    • Domingues HS, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G. Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS One. 2010;5(11):e15531.
    • (2010) PLoS One. , vol.5 , Issue.11
    • Domingues, H.S.1    Mues, M.2    Lassmann, H.3    Wekerle, H.4    Krishnamoorthy, G.5
  • 40
    • 0027324876 scopus 로고
    • IFN-gamma-mediated antimicrobial response. Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplasma growth
    • Thomas SM, Garrity LF, Brandt CR, Schobert CS, Feng GS, Taylor MW, et al. IFN-gamma-mediated antimicrobial response. Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplasma growth. J Immunol. 1993;150(12):5529-34.
    • (1993) J Immunol. , vol.150 , Issue.12 , pp. 5529-5534
    • Thomas, S.M.1    Garrity, L.F.2    Brandt, C.R.3    Schobert, C.S.4    Feng, G.S.5    Taylor, M.W.6
  • 41
    • 0023875737 scopus 로고
    • IFNgamma-activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophila
    • Nash TW, Libby DM, Horwitz MA. IFNgamma-activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophila. J Immunol. 1988;140(11):3978-81.
    • (1988) J Immunol. , vol.140 , Issue.11 , pp. 3978-3981
    • Nash, T.W.1    Libby, D.M.2    Horwitz, M.A.3
  • 42
    • 8444226727 scopus 로고    scopus 로고
    • Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes
    • Lovett-Racke AE, Rocchini AE, Choy J, Northrop SC, Hussain RZ, Ratts RB, et al. Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity. 2004;21(5):719-31.
    • (2004) Immunity. , vol.21 , Issue.5 , pp. 719-731
    • Lovett-Racke, A.E.1    Rocchini, A.E.2    Choy, J.3    Northrop, S.C.4    Hussain, R.Z.5    Ratts, R.B.6
  • 43
    • 0034789247 scopus 로고    scopus 로고
    • Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
    • Chitnis T, Najafian N, Benou C, Salama AD, Grusby MJ, Sayegh MH, et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001;108(5):739-47.
    • (2001) J Clin Invest. , vol.108 , Issue.5 , pp. 739-747
    • Chitnis, T.1    Najafian, N.2    Benou, C.3    Salama, A.D.4    Grusby, M.J.5    Sayegh, M.H.6
  • 45
    • 0034541139 scopus 로고    scopus 로고
    • IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites
    • Wu C, Wang X, Gadina M, O'Shea JJ, Presky DH, Magram J. IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J Immunol. 2000;165(11):6221-8.
    • (2000) J Immunol. , vol.165 , Issue.11 , pp. 6221-6228
    • Wu, C.1    Wang, X.2    Gadina, M.3    O'Shea, J.J.4    Presky, D.H.5    Magram, J.6
  • 46
    • 0037125988 scopus 로고    scopus 로고
    • STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation
    • Morinobu A, Gadina M, Strober W, Visconti R, Fornace A, Montagna C, et al. STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc Natl Acad Sci USA. 2002;99(19):12281-6.
    • (2002) Proc Natl Acad Sci USA. , vol.99 , Issue.19 , pp. 12281-12286
    • Morinobu, A.1    Gadina, M.2    Strober, W.3    Visconti, R.4    Fornace, A.5    Montagna, C.6
  • 47
    • 0033551119 scopus 로고    scopus 로고
    • Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus
    • Yamamoto K, Shibata F, Miura O, Kamiyama R, Hirosawa S, Miyasaka N. Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus. Biochem Biophys Res Commun. 1999;257(2):400-4.
    • (1999) Biochem Biophys Res Commun. , vol.257 , Issue.2 , pp. 400-404
    • Yamamoto, K.1    Shibata, F.2    Miura, O.3    Kamiyama, R.4    Hirosawa, S.5    Miyasaka, N.6
  • 48
    • 1042280965 scopus 로고    scopus 로고
    • A mechanism underlying STAT4-mediated up-regulation of IFN-gamma induction inTCR-triggered T cells
    • Park WR, Nakahira M, Sugimoto N, Bian Y, Yashiro-Ohtani Y, Zhou XY, et al. A mechanism underlying STAT4-mediated up-regulation of IFN-gamma induction inTCR-triggered T cells. Int Immunol. 2004;16(2):295-302.
    • (2004) Int Immunol. , vol.16 , Issue.2 , pp. 295-302
    • Park, W.R.1    Nakahira, M.2    Sugimoto, N.3    Bian, Y.4    Yashiro-Ohtani, Y.5    Zhou, X.Y.6
  • 49
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003;421(6924):744-8.
    • (2003) Nature. , vol.421 , Issue.6924 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6
  • 50
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran B, Zhang GX, Yu S, Li J, Chen XH, Ventura ES, et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol. 2002;169(12):7104-10.
    • (2002) J Immunol. , vol.169 , Issue.12 , pp. 7104-7110
    • Gran, B.1    Zhang, G.X.2    Yu, S.3    Li, J.4    Chen, X.H.5    Ventura, E.S.6
  • 51
    • 0028892869 scopus 로고
    • Cloning and characterization of a mouse IL-12 receptor-beta component
    • Chua AO, Wilkinson VL, Presky DH, Gubler U. Cloning and characterization of a mouse IL-12 receptor-beta component. J Immunol. 1995;155(9):4286-94.
    • (1995) J Immunol. , vol.155 , Issue.9 , pp. 4286-4294
    • Chua, A.O.1    Wilkinson, V.L.2    Presky, D.H.3    Gubler, U.4
  • 52
    • 0019460753 scopus 로고
    • Production of immune interferon by murine T-cell clones from long-term cultures
    • Marcucci F, Waller M, Kirchner H, Krammer P. Production of immune interferon by murine T-cell clones from long-term cultures. Nature. 1981;291(5810):79-81.
    • (1981) Nature. , vol.291 , Issue.5810 , pp. 79-81
    • Marcucci, F.1    Waller, M.2    Kirchner, H.3    Krammer, P.4
  • 53
    • 0021240685 scopus 로고
    • Requirement for IFN gamma in potentiation of interferon's antiviral and anticellular activities: Identity of mouse and human systems
    • Fleischmann WR, Jr., Schwarz LA, Fleischmann CM. Requirement for IFN gamma in potentiation of interferon's antiviral and anticellular activities: identity of mouse and human systems. J Interferon Res. 1984;4(2):265-74.
    • (1984) J Interferon Res. , vol.4 , Issue.2 , pp. 265-274
    • Fleischmann Jr., W.R.1    Schwarz, L.A.2    Fleischmann, C.M.3
  • 54
    • 0025741052 scopus 로고
    • Early gamma interferon production by natural killer cells is important in defense against murine listeriosis
    • Dunn PL, North RJ. Early gamma interferon production by natural killer cells is important in defense against murine listeriosis. Infect Immun. 1991;59(9):2892-900.
    • (1991) Infect Immun. , vol.59 , Issue.9 , pp. 2892-2900
    • Dunn, P.L.1    North, R.J.2
  • 55
    • 70349852932 scopus 로고    scopus 로고
    • Natural killer T cells expressing IFN-gamma and IL-4 in lesional skin of atopic eczema
    • Simon D, Kozlowski E, Simon H. Natural killer T cells expressing IFN-gamma and IL-4 in lesional skin of atopic eczema. Allergy. 2009;64(11):1681-4.
    • (2009) Allergy. , vol.64 , Issue.11 , pp. 1681-1684
    • Simon, D.1    Kozlowski, E.2    Simon, H.3
  • 56
    • 84866995862 scopus 로고    scopus 로고
    • Predominance of heterosubtypic IFN-gamma-onlysecreting effector memory T cells in pandemic H1N1 naive adults
    • Sridhar S, Begom S, Bermingham A, Ziegler T, Roberts KL, Barclay WS, et al. Predominance of heterosubtypic IFN-gamma-onlysecreting effector memory T cells in pandemic H1N1 naive adults. Eur J Immunol. 2012;42:2913-24.
    • (2012) Eur J Immunol. , vol.42 , pp. 2913-2924
    • Sridhar, S.1    Begom, S.2    Bermingham, A.3    Ziegler, T.4    Roberts, K.L.5    Barclay, W.S.6
  • 57
    • 33645986483 scopus 로고    scopus 로고
    • Mycobacteria induce IFN-gamma production in human dendritic cells via triggering of TLR2
    • Fricke I, Mitchell D, Mittelstadt J, Lehan N, Heine H, Goldmann T, et al. Mycobacteria induce IFN-gamma production in human dendritic cells via triggering of TLR2. J Immunol. 2006;176(9):5173-82.
    • (2006) J Immunol. , vol.176 , Issue.9 , pp. 5173-5182
    • Fricke, I.1    Mitchell, D.2    Mittelstadt, J.3    Lehan, N.4    Heine, H.5    Goldmann, T.6
  • 58
    • 0029067876 scopus 로고
    • Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor
    • Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zauodny PJ, et al. Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor. Nature. 1995;376(6537):230-5.
    • (1995) Nature. , vol.376 , Issue.6537 , pp. 230-235
    • Walter, M.R.1    Windsor, W.T.2    Nagabhushan, T.L.3    Lundell, D.J.4    Lunn, C.A.5    Zauodny, P.J.6
  • 60
    • 0028175454 scopus 로고
    • Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system
    • Greenlund AC, Farrar MA, Viviano BL, Schreiber RD. Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system. EMBO J. 1994;13(7):1591-600.
    • (1994) EMBO J. , vol.13 , Issue.7 , pp. 1591-1600
    • Greenlund, A.C.1    Farrar, M.A.2    Viviano, B.L.3    Schreiber, R.D.4
  • 61
    • 0028175969 scopus 로고
    • Interferongamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor
    • Igarashi K, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpur AG, et al. Interferongamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. J Biol Chem. 1994;269(20):14333-6.
    • (1994) J Biol Chem. , vol.269 , Issue.20 , pp. 14333-14336
    • Igarashi, K.1    Garotta, G.2    Ozmen, L.3    Ziemiecki, A.4    Wilks, A.F.5    Harpur, A.G.6
  • 62
    • 0026770248 scopus 로고
    • Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
    • Schindler C, Shuai K, Prezioso VR, Darnell JE, Jr. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992;257(5071):809-13.
    • (1992) Science. , vol.257 , Issue.5071 , pp. 809-813
    • Schindler, C.1    Shuai, K.2    Prezioso, V.R.3    Darnell Jr., J.E.4
  • 63
    • 0030670639 scopus 로고    scopus 로고
    • Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1
    • Sekimoto T, Imamoto N, Nakajima K, Hirano T, Yoneda Y. Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1. EMBO J. 1997;16(23):7067-77.
    • (1997) EMBO J. , vol.16 , Issue.23 , pp. 7067-7077
    • Sekimoto, T.1    Imamoto, N.2    Nakajima, K.3    Hirano, T.4    Yoneda, Y.5
  • 64
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE, Jr., Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994;264(5164):1415-21.
    • (1994) Science. , vol.264 , Issue.5164 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 65
    • 0031436585 scopus 로고    scopus 로고
    • Jaks, Stats and the immune system
    • Decker T, Meinke A. Jaks, Stats and the immune system. Immunobiology. 1997;198(1-3):99-111.
    • (1997) Immunobiology. , vol.198 , Issue.1-3 , pp. 99-111
    • Decker, T.1    Meinke, A.2
  • 66
    • 0027742729 scopus 로고
    • Interferon-induced nuclear signalling by Jak protein tyrosine kinases
    • Silvennoinen O, Ihle JN, Schlessinger J, Levy DE. Interferon-induced nuclear signalling by Jak protein tyrosine kinases. Nature. 1993;366(6455):583-5.
    • (1993) Nature. , vol.366 , Issue.6455 , pp. 583-585
    • Silvennoinen, O.1    Ihle, J.N.2    Schlessinger, J.3    Levy, D.E.4
  • 67
    • 0026033453 scopus 로고
    • Regulation of MHC class II antigen expression. Opposing effects of tumor necrosis factor-alpha on IFNgamma-induced HLA-DR and Ia expression depends on the maturation and differentiation stage of the cell
    • Watanabe Y, Jacob CO. Regulation of MHC class II antigen expression. Opposing effects of tumor necrosis factor-alpha on IFNgamma-induced HLA-DR and Ia expression depends on the maturation and differentiation stage of the cell. J Immunol. 1991;146(3):899-905.
    • (1991) J Immunol. , vol.146 , Issue.3 , pp. 899-905
    • Watanabe, Y.1    Jacob, C.O.2
  • 68
    • 0026012869 scopus 로고
    • IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway
    • Celada A, Maki RA. IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway. J Immunol. 1991;146(1):114-20.
    • (1991) J Immunol. , vol.146 , Issue.1 , pp. 114-120
    • Celada, A.1    Maki, R.A.2
  • 69
    • 0031570123 scopus 로고    scopus 로고
    • Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts
    • Pechhold K, Patterson NB, Craighead N, Lee KP, June CH, Harlan DM. Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts. J Immunol. 1997;158(10):4921-9.
    • (1997) J Immunol. , vol.158 , Issue.10 , pp. 4921-4929
    • Pechhold, K.1    Patterson, N.B.2    Craighead, N.3    Lee, K.P.4    June, C.H.5    Harlan, D.M.6
  • 70
    • 0032080658 scopus 로고    scopus 로고
    • Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes
    • Tan L, Gordon KB, Mueller JP, Matis LA, Miller SD. Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes. J Immunol. 1998;160(9):4271-9.
    • (1998) J Immunol. , vol.160 , Issue.9 , pp. 4271-4279
    • Tan, L.1    Gordon, K.B.2    Mueller, J.P.3    Matis, L.A.4    Miller, S.D.5
  • 71
    • 77956981608 scopus 로고
    • Selective enrichment of Th1 CD45RBlow CD4+ T cells in autoimmune infiltrates in experimental allergic encephalomyelitis
    • Renno T, Zeine R, Girard JM, Gillani S, Dodelet V, Owens T. Selective enrichment of Th1 CD45RBlow CD4+ T cells in autoimmune infiltrates in experimental allergic encephalomyelitis. Int Immunol. 1994;6(3):347-54.
    • (1994) Int Immunol. , vol.6 , Issue.3 , pp. 347-354
    • Renno, T.1    Zeine, R.2    Girard, J.M.3    Gillani, S.4    Dodelet, V.5    Owens, T.6
  • 72
    • 0028949152 scopus 로고
    • B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
    • Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 1995;80(5):707-18.
    • (1995) Cell. , vol.80 , Issue.5 , pp. 707-718
    • Kuchroo, V.K.1    Das, M.P.2    Brown, J.A.3    Ranger, A.M.4    Zamvil, S.S.5    Sobel, R.A.6
  • 73
    • 0026707402 scopus 로고
    • Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
    • Kennedy MK, Torrance DS, Picha KS, Mohler KM. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J Immunol. 1992;149(7):2496-505.
    • (1992) J Immunol. , vol.149 , Issue.7 , pp. 2496-2505
    • Kennedy, M.K.1    Torrance, D.S.2    Picha, K.S.3    Mohler, K.M.4
  • 74
    • 0032532022 scopus 로고    scopus 로고
    • Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis
    • Begolka WS, Vanderlugt CL, Rahbe SM, Miller SD. Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis. J Immunol. 1998;161(8):4437-46.
    • (1998) J Immunol. , vol.161 , Issue.8 , pp. 4437-4446
    • Begolka, W.S.1    Vanderlugt, C.L.2    Rahbe, S.M.3    Miller, S.D.4
  • 75
    • 0029829385 scopus 로고    scopus 로고
    • Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: Enhancement by monoclonal antibodies against interferon-gamma
    • Heremans H, Dillen C, Groenen M, Martens E, Billiau A. Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interferon-gamma. Eur J Immunol. 1996;26(10):2393-8.
    • (1996) Eur J Immunol. , vol.26 , Issue.10 , pp. 2393-2398
    • Heremans, H.1    Dillen, C.2    Groenen, M.3    Martens, E.4    Billiau, A.5
  • 76
    • 0027889130 scopus 로고
    • Monoclonal antigamma interferon antibodies enhance experimental allergic encephalomyelitis
    • Lublin FD, Knobler RL, Kalman B, Goldhaber M, Marini J, Perrault M, et al. Monoclonal antigamma interferon antibodies enhance experimental allergic encephalomyelitis. Autoimmunity. 1993;16(4):267-74.
    • (1993) Autoimmunity. , vol.16 , Issue.4 , pp. 267-274
    • Lublin, F.D.1    Knobler, R.L.2    Kalman, B.3    Goldhaber, M.4    Marini, J.5    Perrault, M.6
  • 77
    • 0025293228 scopus 로고
    • Suppression of experimental allergic en-cephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats
    • Voorthuis JA, Uitdehaag BM, De Groot CJ, Goede PH, van der Meide PH, Dijkstra CD. Suppression of experimental allergic en-cephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats. Clin Exp Immunol. 1990;81(2):183-8.
    • (1990) Clin Exp Immunol. , vol.81 , Issue.2 , pp. 183-188
    • Voorthuis, J.A.1    Uitdehaag, B.M.2    de Groot, C.J.3    Goede, P.H.4    van der Meide, P.H.5    Dijkstra, C.D.6
  • 78
    • 0024405827 scopus 로고
    • The biology of cachectin/TNF-a primary mediator of the host response
    • Beutler B, Cerami A. The biology of cachectin/TNF-a primary mediator of the host response. Annu Rev Immunol. 1989;7:625-55.
    • (1989) Annu Rev Immunol. , vol.7 , pp. 625-655
    • Beutler, B.1    Cerami, A.2
  • 79
    • 55949104665 scopus 로고    scopus 로고
    • TNF signaling inhibition in the CNS: Implications for normal brain function and neurodegenerative disease
    • McCoy MK, Tansey MG. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation. 2008;5:45.
    • (2008) J Neuroinflammation. , vol.5 , pp. 45
    • McCoy, M.K.1    Tansey, M.G.2
  • 80
    • 0028866022 scopus 로고
    • The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
    • Grell M, Douni E, Wajant H, Lohden M, Clauss M, Maxeiner B, et al. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell. 1995;83(5):793-802.
    • (1995) Cell. , vol.83 , Issue.5 , pp. 793-802
    • Grell, M.1    Douni, E.2    Wajant, H.3    Lohden, M.4    Clauss, M.5    Maxeiner, B.6
  • 81
    • 0031882913 scopus 로고    scopus 로고
    • The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
    • Grell M, Wajant H, Zimmermann G, Scheurich P. The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc Natl Acad Sci USA. 1998;95(2):570-5.
    • (1998) Proc Natl Acad Sci USA. , vol.95 , Issue.2 , pp. 570-575
    • Grell, M.1    Wajant, H.2    Zimmermann, G.3    Scheurich, P.4
  • 82
    • 0030999560 scopus 로고    scopus 로고
    • Early events in TNF signaling: A story of associations and dissociations
    • Darnay BG, Aggarwal BB. Early events in TNF signaling: a story of associations and dissociations. J Leukoc Biol. 1997;61(5):559-66.
    • (1997) J Leukoc Biol. , vol.61 , Issue.5 , pp. 559-566
    • Darnay, B.G.1    Aggarwal, B.B.2
  • 83
    • 30044446136 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation
    • Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol. 2006;69(1):195-206.
    • (2006) Mol Pharmacol. , vol.69 , Issue.1 , pp. 195-206
    • Aggarwal, S.1    Ichikawa, H.2    Takada, Y.3    Sandur, S.K.4    Shishodia, S.5    Aggarwal, B.B.6
  • 84
    • 0024366885 scopus 로고
    • Tumor necrosis factor identified in multiple sclerosis brain
    • Hofman FM, Hinton DR, Johnson K, Merrill JE. Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med. 1989;170(2):607-12.
    • (1989) J Exp Med. , vol.170 , Issue.2 , pp. 607-612
    • Hofman, F.M.1    Hinton, D.R.2    Johnson, K.3    Merrill, J.E.4
  • 85
    • 0025773147 scopus 로고
    • Association between tumor necrosis factor-alpha and disease progression in patients with multiple sclerosis
    • Sharief MK, Hentges R. Association between tumor necrosis factor-alpha and disease progression in patients with multiple sclerosis. N Engl J Med. 1991;325(7):467-72.
    • (1991) N Engl J Med. , vol.325 , Issue.7 , pp. 467-472
    • Sharief, M.K.1    Hentges, R.2
  • 86
    • 0025000863 scopus 로고
    • An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis
    • Ruddle NH, Bergman CM, McGrath KM, Lingenheld EG, Grunnet ML, Padula SJ, et al. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J Exp Med. 1990;172(4):1193-200.
    • (1990) J Exp Med. , vol.172 , Issue.4 , pp. 1193-1200
    • Ruddle, N.H.1    Bergman, C.M.2    McGrath, K.M.3    Lingenheld, E.G.4    Grunnet, M.L.5    Padula, S.J.6
  • 87
    • 0026094706 scopus 로고
    • Anti-tumor necrosis factor therapy abrogates autoimmune demyelination
    • Selmaj K, Raine CS, Cross AH. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann Neurol. 1991;30(5):694-700.
    • (1991) Ann Neurol. , vol.30 , Issue.5 , pp. 694-700
    • Selmaj, K.1    Raine, C.S.2    Cross, A.H.3
  • 88
    • 0035479122 scopus 로고    scopus 로고
    • Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness
    • Kassiotis G, Kranidioti K, Kollias G. Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness. J Neuroimmunol. 2001;119(2):239-47.
    • (2001) J Neuroimmunol. , vol.119 , Issue.2 , pp. 239-247
    • Kassiotis, G.1    Kranidioti, K.2    Kollias, G.3
  • 89
    • 0034633542 scopus 로고    scopus 로고
    • Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis
    • Suvannavejh GC, Lee HO, Padilla J, Dal Canto MC, Barrett TA, Miller SD. Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis. Cell Immunol. 2000;205(1):24-33.
    • (2000) Cell Immunol. , vol.205 , Issue.1 , pp. 24-33
    • Suvannavejh, G.C.1    Lee, H.O.2    Padilla, J.3    Dal Canto, M.C.4    Barrett, T.A.5    Miller, S.D.6
  • 90
    • 1842407250 scopus 로고    scopus 로고
    • Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system
    • Korner H, Lemckert FA, Chaudhri G, Etteldorf S, Sedgwick JD. Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system. Eur J Immunol. 1997;27(8):1973-81.
    • (1997) Eur J Immunol. , vol.27 , Issue.8 , pp. 1973-1981
    • Korner, H.1    Lemckert, F.A.2    Chaudhri, G.3    Etteldorf, S.4    Sedgwick, J.D.5
  • 91
    • 79955646245 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha (TNF-alpha), anti-TNFalpha and demyelination revisited: An ongoing story
    • Caminero A, Comabella M, Montalban X. Tumor necrosis factor alpha (TNF-alpha), anti-TNFalpha and demyelination revisited: an ongoing story. J Neuroimmunol. 2011;234(1-2):1-6.
    • (2011) J Neuroimmunol. , vol.234 , Issue.1-2 , pp. 1-6
    • Caminero, A.1    Comabella, M.2    Montalban, X.3
  • 92
    • 0029751983 scopus 로고    scopus 로고
    • Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2
    • van Oosten BW, Barkhof F, Truyen L, Boringa JB, Bertelsmann FW, von Blomberg BM, et al. Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2. Neurology. 1996;47(6):1531-4.
    • (1996) Neurology. , vol.47 , Issue.6 , pp. 1531-1534
    • van Oosten, B.W.1    Barkhof, F.2    Truyen, L.3    Boringa, J.B.4    Bertelsmann, F.W.5    von Blomberg, B.M.6
  • 93
    • 0033546665 scopus 로고    scopus 로고
    • The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group
    • TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study
    • TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. Neurology. 1999;53(3):457-65.
    • (1999) Neurology. , vol.53 , Issue.3 , pp. 457-465
  • 94
    • 0035674613 scopus 로고    scopus 로고
    • Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides
    • Mohan N, Edwards ET, Cupps TR, Oliverio PJ, Sandberg G, Crayton H, et al. Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides. Arthritis Rheum. 2001;44(12):2862-9.
    • (2001) Arthritis Rheum. , vol.44 , Issue.12 , pp. 2862-2869
    • Mohan, N.1    Edwards, E.T.2    Cupps, T.R.3    Oliverio, P.J.4    Sandberg, G.5    Crayton, H.6
  • 95
    • 0035960624 scopus 로고    scopus 로고
    • Onset of multiple sclerosis associated with anti-TNF therapy
    • Sicotte NL, Voskuhl RR. Onset of multiple sclerosis associated with anti-TNF therapy. Neurology. 2001;57(10):1885-8.
    • (2001) Neurology. , vol.57 , Issue.10 , pp. 1885-1888
    • Sicotte, N.L.1    Voskuhl, R.R.2
  • 96
    • 15344349687 scopus 로고    scopus 로고
    • Association of anti-tumor necrosis factor therapy with the development of multiple sclerosis
    • Enayati PJ, Papadakis KA. Association of anti-tumor necrosis factor therapy with the development of multiple sclerosis. J Clin Gastroenterol. 2005;39(4):303-6.
    • (2005) J Clin Gastroenterol. , vol.39 , Issue.4 , pp. 303-306
    • Enayati, P.J.1    Papadakis, K.A.2
  • 97
    • 24144479466 scopus 로고    scopus 로고
    • Increased risk for demyelinating diseases in patients with inflammatory bowel disease
    • Gupta G, Gelfand JM, Lewis JD. Increased risk for demyelinating diseases in patients with inflammatory bowel disease. Gastroenterology. 2005;129(3):819-26.
    • (2005) Gastroenterology. , vol.129 , Issue.3 , pp. 819-826
    • Gupta, G.1    Gelfand, J.M.2    Lewis, J.D.3
  • 98
    • 33749188761 scopus 로고    scopus 로고
    • New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients
    • Tanno M, Nakamura I, Kobayashi S, Kurihara K, Ito K. New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients. Clin Rheumatol. 2006;25(6):929-33.
    • (2006) Clin Rheumatol. , vol.25 , Issue.6 , pp. 929-933
    • Tanno, M.1    Nakamura, I.2    Kobayashi, S.3    Kurihara, K.4    Ito, K.5
  • 99
    • 64149089616 scopus 로고    scopus 로고
    • Cerebral MRI lesions and anti-tumor necrosis factor-alpha therapy
    • Winkelmann A, Patejdl R, Wagner S, Benecke R, Zettl UK. Cerebral MRI lesions and anti-tumor necrosis factor-alpha therapy. J Neurol. 2008;255(Suppl 6):109-14.
    • (2008) J Neurol. , vol.255 , Issue.SUPPL. 6 , pp. 109-114
    • Winkelmann, A.1    Patejdl, R.2    Wagner, S.3    Benecke, R.4    Zettl, U.K.5
  • 100
    • 1042267236 scopus 로고    scopus 로고
    • Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    • Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA, et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum. 2004;50(2):650-9.
    • (2004) Arthritis Rheum. , vol.50 , Issue.2 , pp. 650-659
    • Lubberts, E.1    Koenders, M.I.2    Oppers-Walgreen, B.3    van den Bersselaar, L.4    Coenen-de Roo, C.J.5    Joosten, L.A.6
  • 101
    • 0036192064 scopus 로고    scopus 로고
    • Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction
    • Lubberts E, Joosten LA, van de Loo FA, Schwarzenberger P, Kolls J, van den Berg WB. Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction. Inflamm Res. 2002;51(2):102-4.
    • (2002) Inflamm Res. , vol.51 , Issue.2 , pp. 102-104
    • Lubberts, E.1    Joosten, L.A.2    van de Loo, F.A.3    Schwarzenberger, P.4    Kolls, J.5    van den Berg, W.B.6
  • 103
    • 67649197343 scopus 로고    scopus 로고
    • Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus
    • Doreau A, Belot A, Bastid J, Riche B, Trescol-Biemont MC, Ranchin B, et al. Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat Immunol. 2009;10(7):778-85.
    • (2009) Nat Immunol. , vol.10 , Issue.7 , pp. 778-785
    • Doreau, A.1    Belot, A.2    Bastid, J.3    Riche, B.4    Trescol-Biemont, M.C.5    Ranchin, B.6
  • 105
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol. 2007;8(9):942-9.
    • (2007) Nat Immunol. , vol.8 , Issue.9 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 106
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton C, Brereton C, Keogh B, Mills KH, Lavelle EC. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med. 2006;203(7):1685-91.
    • (2006) J Exp Med. , vol.203 , Issue.7 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.4    Lavelle, E.C.5
  • 107
    • 34250192169 scopus 로고    scopus 로고
    • Retinoidrelated orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity
    • Huang Z, Xie H, Wang R, Sun Z. Retinoidrelated orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity. Expert Opin Ther Targets. 2007;11(6):737-43.
    • (2007) Expert Opin Ther Targets. , vol.11 , Issue.6 , pp. 737-743
    • Huang, Z.1    Xie, H.2    Wang, R.3    Sun, Z.4
  • 108
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006;126(6):1121-33.
    • (2006) Cell. , vol.126 , Issue.6 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 109
    • 36849036211 scopus 로고    scopus 로고
    • IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
    • Wei L, Laurence A, Elias KM, O'Shea JJ. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 2007;282(48):34605-10.
    • (2007) J Biol Chem. , vol.282 , Issue.48 , pp. 34605-34610
    • Wei, L.1    Laurence, A.2    Elias, K.M.3    O'Shea, J.J.4
  • 110
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin
    • Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-J Biol Chem. 2003;278(3):1910-4.
    • (2003) J Biol Chem. , vol.278 , Issue.3 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 111
    • 65249175159 scopus 로고    scopus 로고
    • C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
    • Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol. 2009;10(5):514-23.
    • (2009) Nat Immunol. , vol.10 , Issue.5 , pp. 514-523
    • Reboldi, A.1    Coisne, C.2    Baumjohann, D.3    Benvenuto, F.4    Bottinelli, D.5    Lira, S.6
  • 112
    • 84862695017 scopus 로고    scopus 로고
    • Th17 cells: Biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies
    • Maddur MS, Miossec P, Kaveri SV, Bayry J. Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. Am J Pathol. 2012;181(1):8-18.
    • (2012) Am J Pathol. , vol.181 , Issue.1 , pp. 8-18
    • Maddur, M.S.1    Miossec, P.2    Kaveri, S.V.3    Bayry, J.4
  • 113
    • 67249090787 scopus 로고    scopus 로고
    • T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta
    • Durelli L, Conti L, Clerico M, Boselli D, Contessa G, Ripellino P, et al. T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta. Ann Neurol. 2009;65(5):499-509.
    • (2009) Ann Neurol. , vol.65 , Issue.5 , pp. 499-509
    • Durelli, L.1    Conti, L.2    Clerico, M.3    Boselli, D.4    Contessa, G.5    Ripellino, P.6
  • 114
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13(5):715-25.
    • (2000) Immunity. , vol.13 , Issue.5 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6
  • 115
    • 0036604306 scopus 로고    scopus 로고
    • A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
    • Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002;168(11):5699-708.
    • (2002) J Immunol. , vol.168 , Issue.11 , pp. 5699-5708
    • Parham, C.1    Chirica, M.2    Timans, J.3    Vaisberg, E.4    Travis, M.5    Cheung, J.6
  • 116
    • 33645959483 scopus 로고    scopus 로고
    • STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
    • Cho ML, Kang JW, Moon YM, Nam HJ, Jhun JY, Heo SB, et al. STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J Immunol. 2006;176(9):5652-61.
    • (2006) J Immunol. , vol.176 , Issue.9 , pp. 5652-5661
    • Cho, M.L.1    Kang, J.W.2    Moon, Y.M.3    Nam, H.J.4    Jhun, J.Y.5    Heo, S.B.6
  • 117
    • 37749021324 scopus 로고    scopus 로고
    • Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity
    • Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, et al. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol. 2007;179(7):4313-7.
    • (2007) J Immunol. , vol.179 , Issue.7 , pp. 4313-4317
    • Harris, T.J.1    Grosso, J.F.2    Yen, H.R.3    Xin, H.4    Kortylewski, M.5    Albesiano, E.6
  • 118
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol. 2007;8(12):1390-7.
    • (2007) Nat Immunol. , vol.8 , Issue.12 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3    Tato, C.M.4    Blumenschein, W.5    McClanahan, T.6
  • 119
    • 69249134656 scopus 로고    scopus 로고
    • IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo
    • Gyulveszi G, Haak S, Becher B. IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo. Eur J Immunol. 2009;39(7):1864-9.
    • (2009) Eur J Immunol. , vol.39 , Issue.7 , pp. 1864-1869
    • Gyulveszi, G.1    Haak, S.2    Becher, B.3
  • 122
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • Gaffen SL. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 2009;9(8):556-67.
    • (2009) Nat Rev Immunol. , vol.9 , Issue.8 , pp. 556-567
    • Gaffen, S.L.1
  • 123
    • 33745297345 scopus 로고    scopus 로고
    • Cutting edge: Interleukin 17 signals through a heteromeric receptor complex
    • Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, et al. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol. 2006;177(1):36-9.
    • (2006) J Immunol. , vol.177 , Issue.1 , pp. 36-39
    • Toy, D.1    Kugler, D.2    Wolfson, M.3    Vanden Bos, T.4    Gurgel, J.5    Derry, J.6
  • 124
    • 53149138236 scopus 로고    scopus 로고
    • The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex
    • Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, et al. The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. J Immunol. 2008;181(4):2799-805.
    • (2008) J Immunol. , vol.181 , Issue.4 , pp. 2799-2805
    • Wright, J.F.1    Bennett, F.2    Li, B.3    Brooks, J.4    Luxenberg, D.P.5    Whitters, M.J.6
  • 125
    • 62749094302 scopus 로고    scopus 로고
    • IL-17F: Regulation, signaling and function in inflammation
    • Chang SH, Dong C. IL-17F: regulation, signaling and function in inflammation. Cytokine. 2009;46(1):7-11.
    • (2009) Cytokine. , vol.46 , Issue.1 , pp. 7-11
    • Chang, S.H.1    Dong, C.2
  • 126
    • 34247873196 scopus 로고    scopus 로고
    • The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease
    • Qian Y, Liu C, Hartupee J, Altuntas CZ, Gulen MF, Jane-Wit D, et al. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol. 2007;8(3):247-56.
    • (2007) Nat Immunol. , vol.8 , Issue.3 , pp. 247-256
    • Qian, Y.1    Liu, C.2    Hartupee, J.3    Altuntas, C.Z.4    Gulen, M.F.5    Jane-Wit, D.6
  • 127
    • 33846022750 scopus 로고    scopus 로고
    • Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor
    • Chang SH, Park H, Dong C. Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem. 2006;281(47):35603-7.
    • (2006) J Biol Chem. , vol.281 , Issue.47 , pp. 35603-35607
    • Chang, S.H.1    Park, H.2    Dong, C.3
  • 129
    • 75949102667 scopus 로고    scopus 로고
    • Interleukin-17 and its target genes: Mechanisms of interleukin-17 function in disease
    • Onishi RM, Gaffen SL. Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology. 2010;129(3):311-21.
    • (2010) Immunology. , vol.129 , Issue.3 , pp. 311-321
    • Onishi, R.M.1    Gaffen, S.L.2
  • 130
    • 35748973565 scopus 로고    scopus 로고
    • IL-17 enhances chemokine gene expression through mRNA stabilization
    • Hartupee J, Liu C, Novotny M, Li X, Hamilton T. IL-17 enhances chemokine gene expression through mRNA stabilization. J Immunol. 2007;179(6):4135-41.
    • (2007) J Immunol. , vol.179 , Issue.6 , pp. 4135-4141
    • Hartupee, J.1    Liu, C.2    Novotny, M.3    Li, X.4    Hamilton, T.5
  • 131
    • 78049433417 scopus 로고    scopus 로고
    • Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis
    • Kasten KR, Prakash PS, Unsinger J, Goetzman HS, England LG, Cave CM, et al. Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infect Immun. 2010;78(11):4714-22.
    • (2010) Infect Immun. , vol.78 , Issue.11 , pp. 4714-4722
    • Kasten, K.R.1    Prakash, P.S.2    Unsinger, J.3    Goetzman, H.S.4    England, L.G.5    Cave, C.M.6
  • 132
    • 74949108768 scopus 로고    scopus 로고
    • IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    • Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, et al. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest. 2010;120(1):331-42.
    • (2010) J Clin Invest. , vol.120 , Issue.1 , pp. 331-342
    • Li, L.1    Huang, L.2    Vergis, A.L.3    Ye, H.4    Bajwa, A.5    Narayan, V.6    et al7
  • 135
    • 79953656440 scopus 로고    scopus 로고
    • Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-gamma/IL-17 balance in T cell-mediated skin inflammation
    • Vanbervliet B, Akdis M, Vocanson M, Rozieres A, Benetiere J, Rouzaire P, et al. Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-gamma/IL-17 balance in T cell-mediated skin inflammation. J Allergy Clin Immunol. 2011;127(4):943-53 e1-10.
    • (2011) J Allergy Clin Immunol. , vol.127 , Issue.4
    • Vanbervliet, B.1    Akdis, M.2    Vocanson, M.3    Rozieres, A.4    Benetiere, J.5    Rouzaire, P.6
  • 136
    • 0034669270 scopus 로고    scopus 로고
    • IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells
    • Witowski J, Pawlaczyk K, Breborowicz A, Scheuren A, Kuzlan-Pawlaczyk M, Wisniewska J, et al. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells. J Immunol. 2000;165(10):5814-21.
    • (2000) J Immunol. , vol.165 , Issue.10 , pp. 5814-5821
    • Witowski, J.1    Pawlaczyk, K.2    Breborowicz, A.3    Scheuren, A.4    Kuzlan-Pawlaczyk, M.5    Wisniewska, J.6
  • 137
    • 0033557728 scopus 로고    scopus 로고
    • Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways
    • Laan M, Cui ZH, Hoshino H, Lotvall J, Sjostrand M, Gruenert DC, et al. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 1999;162(4):2347-52.
    • (1999) J Immunol. , vol.162 , Issue.4 , pp. 2347-2352
    • Laan, M.1    Cui, Z.H.2    Hoshino, H.3    Lotvall, J.4    Sjostrand, M.5    Gruenert, D.C.6
  • 138
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med. 2002;8(5):500-8.
    • (2002) Nat Med. , vol.8 , Issue.5 , pp. 500-508
    • Lock, C.1    Hermans, G.2    Pedotti, R.3    Brendolan, A.4    Schadt, E.5    Garren, H.6
  • 139
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • Matusevicius D, Kivisakk P, He B, Kostulas N, Ozenci V, Fredrikson S, et al. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler. 1999;5(2):101-4.
    • (1999) Mult Scler. , vol.5 , Issue.2 , pp. 101-104
    • Matusevicius, D.1    Kivisakk, P.2    He, B.3    Kostulas, N.4    Ozenci, V.5    Fredrikson, S.6
  • 140
    • 51249090471 scopus 로고    scopus 로고
    • T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis
    • Hedegaard CJ, Krakauer M, Bendtzen K, Lund H, Sellebjerg F, Nielsen CH. T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. Immunology. 2008;125(2):161-9.
    • (2008) Immunology. , vol.125 , Issue.2 , pp. 161-169
    • Hedegaard, C.J.1    Krakauer, M.2    Bendtzen, K.3    Lund, H.4    Sellebjerg, F.5    Nielsen, C.H.6
  • 141
    • 33745321276 scopus 로고    scopus 로고
    • IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    • Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol. 2006;177(1):566-73.
    • (2006) J Immunol. , vol.177 , Issue.1 , pp. 566-573
    • Komiyama, Y.1    Nakae, S.2    Matsuki, T.3    Nambu, A.4    Ishigame, H.5    Kakuta, S.6
  • 142
    • 61749093508 scopus 로고    scopus 로고
    • IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
    • Haak S, Croxford AL, Kreymborg K, Heppner FL, Pouly S, Becher B, et al. IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest. 2009;119(1):61-9.
    • (2009) J Clin Invest. , vol.119 , Issue.1 , pp. 61-69
    • Haak, S.1    Croxford, A.L.2    Kreymborg, K.3    Heppner, F.L.4    Pouly, S.5    Becher, B.6
  • 143
    • 30944452780 scopus 로고    scopus 로고
    • Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
    • Hofstetter HH, Ibrahim SM, Koczan D, Kruse N, Weishaupt A, Toyka KV, et al. Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell Immunol. 2005;237(2):123-30.
    • (2005) Cell Immunol. , vol.237 , Issue.2 , pp. 123-130
    • Hofstetter, H.H.1    Ibrahim, S.M.2    Koczan, D.3    Kruse, N.4    Weishaupt, A.5    Toyka, K.V.6
  • 144
    • 0035476518 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor: A new putative therapeutic target in multiple sclerosis
    • McQualter JL, Darwiche R, Ewing C, Onuki M, Kay TW, Hamilton JA, et al. Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis. J Exp Med. 2001;194(7):873-82.
    • (2001) J Exp Med. , vol.194 , Issue.7 , pp. 873-882
    • McQualter, J.L.1    Darwiche, R.2    Ewing, C.3    Onuki, M.4    Kay, T.W.5    Hamilton, J.A.6
  • 145
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of T(H)17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GMCSF
    • El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F, et al. The encephalitogenicity of T(H)17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GMCSF. Nat Immunol. 2011;12(6):568-75.
    • (2011) Nat Immunol. , vol.12 , Issue.6 , pp. 568-575
    • El-Behi, M.1    Ciric, B.2    Dai, H.3    Yan, Y.4    Cullimore, M.5    Safavi, F.6
  • 146
    • 79956116032 scopus 로고    scopus 로고
    • RORgammat drives production of the cytokine GMCSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • Codarri L, Gyulveszi G, Tosevski V, Hesske L, Fontana A, Magnenat L, et al. RORgammat drives production of the cytokine GMCSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol. 2011;12(6):560-7.
    • (2011) Nat Immunol. , vol.12 , Issue.6 , pp. 560-567
    • Codarri, L.1    Gyulveszi, G.2    Tosevski, V.3    Hesske, L.4    Fontana, A.5    Magnenat, L.6
  • 147
    • 0025073748 scopus 로고
    • GMCSF: Receptor structure and transmembrane signaling
    • discussion, 75
    • DiPersio JF, Golde DW, Gasson JD. GMCSF: receptor structure and transmembrane signaling. Int J Cell Cloning. 1990;8(Suppl 1):63-74; discussion, 75.
    • (1990) Int J Cell Cloning. , vol.8 , Issue.SUPPL. 1 , pp. 63-74
    • DiPersio, J.F.1    Golde, D.W.2    Gasson, J.D.3
  • 149
    • 0023152915 scopus 로고
    • Internalisation and recycling of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor on a murine myelomonocytic leukemia
    • Walker F, Burgess AW. Internalisation and recycling of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor on a murine myelomonocytic leukemia. J Cell Physiol. 1987;130(2):255-61.
    • (1987) J Cell Physiol. , vol.130 , Issue.2 , pp. 255-261
    • Walker, F.1    Burgess, A.W.2
  • 150
    • 0033151937 scopus 로고    scopus 로고
    • Signal transduction pathways induced by GM-CSF in microglia: Significance in the control of proliferation
    • Liva SM, Kahn MA, Dopp JM, de Vellis J. Signal transduction pathways induced by GM-CSF in microglia: significance in the control of proliferation. Glia. 1999;26(4):344-52.
    • (1999) Glia. , vol.26 , Issue.4 , pp. 344-352
    • Liva, S.M.1    Kahn, M.A.2    Dopp, J.M.3    de Vellis, J.4
  • 151
    • 65149093082 scopus 로고    scopus 로고
    • Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
    • King IL, Dickendesher TL, Segal BM. Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease. Blood. 2009;113(14):3190-7.
    • (2009) Blood. , vol.113 , Issue.14 , pp. 3190-3197
    • King, I.L.1    Dickendesher, T.L.2    Segal, B.M.3
  • 152
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 2007;448(7152):480-3.
    • (2007) Nature. , vol.448 , Issue.7152 , pp. 480-483
    • Nurieva, R.1    Yang, X.O.2    Martinez, G.3    Zhang, Y.4    Panopoulos, A.D.5    Ma, L.6
  • 153
    • 68649088121 scopus 로고    scopus 로고
    • Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
    • Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity. 2009;31(2):331-41.
    • (2009) Immunity. , vol.31 , Issue.2 , pp. 331-341
    • Sutton, C.E.1    Lalor, S.J.2    Sweeney, C.M.3    Brereton, C.F.4    Lavelle, E.C.5    Mills, K.H.6
  • 154
    • 78650673588 scopus 로고    scopus 로고
    • IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation
    • Beyeen AD, Adzemovic MZ, Ockinger J, Stridh P, Becanovic K, Laaksonen H, et al. IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation. J Immunol. 2010;185(11):6883-90.
    • (2010) J Immunol. , vol.185 , Issue.11 , pp. 6883-6890
    • Beyeen, A.D.1    Adzemovic, M.Z.2    Ockinger, J.3    Stridh, P.4    Becanovic, K.5    Laaksonen, H.6
  • 155
    • 40049103352 scopus 로고    scopus 로고
    • IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis
    • Kreymborg K, Etzensperger R, Dumoutier L, Haak S, Rebollo A, Buch T, et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol. 2007;179(12):8098-104.
    • (2007) J Immunol. , vol.179 , Issue.12 , pp. 8098-8104
    • Kreymborg, K.1    Etzensperger, R.2    Dumoutier, L.3    Haak, S.4    Rebollo, A.5    Buch, T.6
  • 156
    • 46749156754 scopus 로고    scopus 로고
    • Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
    • Coquet JM, Chakravarti S, Smyth MJ, Godfrey DI. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J Immunol. 2008;180(11):7097-101.
    • (2008) J Immunol. , vol.180 , Issue.11 , pp. 7097-7101
    • Coquet, J.M.1    Chakravarti, S.2    Smyth, M.J.3    Godfrey, D.I.4
  • 157
    • 46749133961 scopus 로고    scopus 로고
    • IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo
    • Sonderegger I, Kisielow J, Meier R, King C, Kopf M. IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. Eur J Immunol. 2008;38(7):1833-8.
    • (2008) Eur J Immunol. , vol.38 , Issue.7 , pp. 1833-1838
    • Sonderegger, I.1    Kisielow, J.2    Meier, R.3    King, C.4    Kopf, M.5
  • 159
    • 84859503124 scopus 로고    scopus 로고
    • GABAergic signaling and connectivity on Purkinje cells are impaired in experimental autoimmune encephalomyelitis
    • Mandolesi G, Grasselli G, Musella A, Gentile A, Musumeci G, Sepman H, et al. GABAergic signaling and connectivity on Purkinje cells are impaired in experimental autoimmune encephalomyelitis. Neurobiol Dis. 2012;46(2):414-24.
    • (2012) Neurobiol Dis. , vol.46 , Issue.2 , pp. 414-424
    • Mandolesi, G.1    Grasselli, G.2    Musella, A.3    Gentile, A.4    Musumeci, G.5    Sepman, H.6
  • 160
    • 84864002777 scopus 로고    scopus 로고
    • IL-33 attenuates EAE by suppressing IL-17 and IFN-gamma production and inducing alternatively activated macrophages
    • Jiang HR, Milovanovic M, Allan D, Niedbala W, Besnard AG, Fukada SY, et al. IL-33 attenuates EAE by suppressing IL-17 and IFN-gamma production and inducing alternatively activated macrophages. Eur J Immunol. 2012;42(7):1804-14.
    • (2012) Eur J Immunol. , vol.42 , Issue.7 , pp. 1804-1814
    • Jiang, H.R.1    Milovanovic, M.2    Allan, D.3    Niedbala, W.4    Besnard, A.G.5    Fukada, S.Y.6
  • 161
    • 84860838601 scopus 로고    scopus 로고
    • IL-33 blockade suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice
    • Li M, Li Y, Liu X, Gao X, Wang Y. IL-33 blockade suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice. J Neuroimmunol. 2012;247(1-2):25-31.
    • (2012) J Neuroimmunol. , vol.247 , Issue.1-2 , pp. 25-31
    • Li, M.1    Li, Y.2    Liu, X.3    Gao, X.4    Wang, Y.5
  • 162
    • 77953458011 scopus 로고    scopus 로고
    • Review of interferon beta-1b in the treatment of early and relapsing multiple sclerosis
    • Paolicelli D, Direnzo V, Trojano M. Review of interferon beta-1b in the treatment of early and relapsing multiple sclerosis. Biologics. 2009;3:369-76.
    • (2009) Biologics. , vol.3 , pp. 369-376
    • Paolicelli, D.1    Direnzo, V.2    Trojano, M.3
  • 163
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group
    • Paty DW, Li DK. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group. Neurology. 1993;43(4):662-7.
    • (1993) Neurology. , vol.43 , Issue.4 , pp. 662-667
    • Paty, D.W.1    Li, D.K.2
  • 164
    • 84867893880 scopus 로고    scopus 로고
    • Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system
    • Prinz M, Knobeloch KP. Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system. Front Immunol. 2012;3:67.
    • (2012) Front Immunol. , vol.3 , pp. 67
    • Prinz, M.1    Knobeloch, K.P.2
  • 165
    • 0034710346 scopus 로고    scopus 로고
    • Extended observations on MS patients treated with IM interferon-beta1a (Avonex): Implications for modern MS trials and therapeutics
    • Jacobs L, Rudick R, Simon J. Extended observations on MS patients treated with IM interferon-beta1a (Avonex): implications for modern MS trials and therapeutics. J Neuroimmunol. 2000;107(2):167-73.
    • (2000) J Neuroimmunol. , vol.107 , Issue.2 , pp. 167-173
    • Jacobs, L.1    Rudick, R.2    Simon, J.3
  • 166
    • 36849035929 scopus 로고    scopus 로고
    • Full results of the Evidence of Interferon Dose-Response-European North American Comparative Efficacy (EVIDENCE) study: A multicenter, randomized, assessor-blinded comparison of low-dose weekly versus high-dose, high-frequency interferon beta-1a for relapsing multiple sclerosis
    • Schwid SR, Panitch HS. Full results of the Evidence of Interferon Dose-Response-European North American Comparative Efficacy (EVIDENCE) study: a multicenter, randomized, assessor-blinded comparison of low-dose weekly versus high-dose, high-frequency interferon beta-1a for relapsing multiple sclerosis. Clin Ther. 2007;29(9):2031-48.
    • (2007) Clin Ther. , vol.29 , Issue.9 , pp. 2031-2048
    • Schwid, S.R.1    Panitch, H.S.2
  • 168
    • 79960219135 scopus 로고    scopus 로고
    • IL-27 mediates the response to IFN-beta therapy in multiple sclerosis patients by inhibiting Th17 cells
    • Sweeney CM, Lonergan R, Basdeo SA, Kinsella K, Dungan LS, Higgins SC, et al. IL-27 mediates the response to IFN-beta therapy in multiple sclerosis patients by inhibiting Th17 cells. Brain Behav Immun. 2011;25(6):1170-81.
    • (2011) Brain Behav Immun. , vol.25 , Issue.6 , pp. 1170-1181
    • Sweeney, C.M.1    Lonergan, R.2    Basdeo, S.A.3    Kinsella, K.4    Dungan, L.S.5    Higgins, S.C.6
  • 169
    • 77955423259 scopus 로고    scopus 로고
    • New lessons about old molecules: How type I interferons shape Th1/Th17-mediated autoimmunity in the CNS
    • Prinz M, Kalinke U. New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS. Trends Mol Med. 2010;16(8):379-86.
    • (2010) Trends Mol Med. , vol.16 , Issue.8 , pp. 379-386
    • Prinz, M.1    Kalinke, U.2
  • 170
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6(11):1123-32.
    • (2005) Nat Immunol. , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6
  • 171
    • 84862308491 scopus 로고    scopus 로고
    • Effect of short-term interferon-beta treatment on cytokines in multiple sclerosis: Significant modulation of IL-17 and IL-23
    • Kurtuncu M, Tuzun E, Turkoglu R, Petek-Balci B, Icoz S, Pehlivan M, et al. Effect of short-term interferon-beta treatment on cytokines in multiple sclerosis: Significant modulation of IL-17 and IL-23. Cytokine. 2012;59(2):400-2.
    • (2012) Cytokine. , vol.59 , Issue.2 , pp. 400-402
    • Kurtuncu, M.1    Tuzun, E.2    Turkoglu, R.3    Petek-Balci, B.4    Icoz, S.5    Pehlivan, M.6
  • 172
    • 77950534540 scopus 로고    scopus 로고
    • T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis
    • Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, et al. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med. 2010;16(4):406-12.
    • (2010) Nat Med. , vol.16 , Issue.4 , pp. 406-412
    • Axtell, R.C.1    de Jong, B.A.2    Boniface, K.3    van der Voort, L.F.4    Bhat, R.5    de Sarno, P.6
  • 173
    • 84866250538 scopus 로고    scopus 로고
    • Type I Interferons: Beneficial in Th1 and Detrimental in Th17 Autoimmunity
    • Jan 10. Epub ahead of print
    • Axtell RC, Raman C, Steinman L. Type I Interferons: Beneficial in Th1 and Detrimental in Th17 Autoimmunity. Clin Rev Allergy Immunol. 2012 Jan 10. Epub ahead of print.
    • (2012) Clin Rev Allergy Immunol
    • Axtell, R.C.1    Raman, C.2    Steinman, L.3
  • 174
    • 0037407587 scopus 로고    scopus 로고
    • IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis
    • Teige I, Treschow A, Teige A, Mattsson R, Navikas V, Leanderson T, et al. IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis. J Immunol. 2003;170(9):4776-84.
    • (2003) J Immunol. , vol.170 , Issue.9 , pp. 4776-4784
    • Teige, I.1    Treschow, A.2    Teige, A.3    Mattsson, R.4    Navikas, V.5    Leanderson, T.6
  • 175
    • 43049177588 scopus 로고    scopus 로고
    • Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    • Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, et al. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity. 2008;28(5):675-86.
    • (2008) Immunity. , vol.28 , Issue.5 , pp. 675-686
    • Prinz, M.1    Schmidt, H.2    Mildner, A.3    Knobeloch, K.P.4    Hanisch, U.K.5    Raasch, J.6
  • 177
    • 0028957419 scopus 로고
    • Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs
    • Platzer C, Meisel C, Vogt K, Platzer M, Volk HD. Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs. Int Immunol. 1995;7(4):517-23.
    • (1995) Int Immunol. , vol.7 , Issue.4 , pp. 517-523
    • Platzer, C.1    Meisel, C.2    Vogt, K.3    Platzer, M.4    Volk, H.D.5
  • 178
    • 0032858430 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells
    • Platzer C, Fritsch E, Elsner T, Lehmann MH, Volk HD, Prosch S. Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells. Eur J Immunol. 1999;29(10):3098-104.
    • (1999) Eur J Immunol. , vol.29 , Issue.10 , pp. 3098-3104
    • Platzer, C.1    Fritsch, E.2    Elsner, T.3    Lehmann, M.H.4    Volk, H.D.5    Prosch, S.6
  • 179
    • 0342615036 scopus 로고    scopus 로고
    • Catecholamines trigger IL-10 release in acute systemic stress reaction by direct stimulation of its promoter/enhancer activity in monocytic cells
    • Platzer C, Docke W, Volk H, Prosch S. Catecholamines trigger IL-10 release in acute systemic stress reaction by direct stimulation of its promoter/enhancer activity in monocytic cells. J Neuroimmunol. 2000;105(1):31-8.
    • (2000) J Neuroimmunol. , vol.105 , Issue.1 , pp. 31-38
    • Platzer, C.1    Docke, W.2    Volk, H.3    Prosch, S.4
  • 180
    • 0038283161 scopus 로고    scopus 로고
    • Interleukin-10 therapy-review of a new approach
    • Asadullah K, Sterry W, Volk HD. Interleukin-10 therapy-review of a new approach. Pharmacol Rev. 2003;55(2):241-69.
    • (2003) Pharmacol Rev. , vol.55 , Issue.2 , pp. 241-269
    • Asadullah, K.1    Sterry, W.2    Volk, H.D.3
  • 181
    • 0033104946 scopus 로고    scopus 로고
    • Interleukin-10 inhibits expression of both interferon alpha-and interferon gamma-induced genes by suppressing tyrosine phosphorylation of STAT1
    • Ito S, Ansari P, Sakatsume M, Dickensheets H, Vazquez N, Donnelly RP, et al. Interleukin-10 inhibits expression of both interferon alpha-and interferon gamma-induced genes by suppressing tyrosine phosphorylation of STAT1. Blood. 1999;93(5):1456-63.
    • (1999) Blood. , vol.93 , Issue.5 , pp. 1456-1463
    • Ito, S.1    Ansari, P.2    Sakatsume, M.3    Dickensheets, H.4    Vazquez, N.5    Donnelly, R.P.6
  • 182
    • 0027959417 scopus 로고
    • Interleukin 10 pretreatment protects target cells from tumorand allo-specific cytotoxic T cells and downregulates HLA class I expression
    • Matsuda M, Salazar F, Petersson M, Masucci G, Hansson J, Pisa P, et al. Interleukin 10 pretreatment protects target cells from tumorand allo-specific cytotoxic T cells and downregulates HLA class I expression. J Exp Med. 1994;180(6):2371-6.
    • (1994) J Exp Med. , vol.180 , Issue.6 , pp. 2371-2376
    • Matsuda, M.1    Salazar, F.2    Petersson, M.3    Masucci, G.4    Hansson, J.5    Pisa, P.6
  • 184
    • 0028299069 scopus 로고
    • Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes
    • Willems F, Marchant A, Delville JP, Gerard C, Delvaux A, Velu T, et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol. 1994;24(4):1007-9.
    • (1994) Eur J Immunol. , vol.24 , Issue.4 , pp. 1007-1009
    • Willems, F.1    Marchant, A.2    Delville, J.P.3    Gerard, C.4    Delvaux, A.5    Velu, T.6
  • 185
    • 0026094306 scopus 로고
    • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med. 1991;174(5):1209-20.
    • (1991) J Exp Med. , vol.174 , Issue.5 , pp. 1209-1220
    • de Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    de Vries, J.E.5
  • 186
    • 0030058433 scopus 로고    scopus 로고
    • Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells
    • Groux H, Bigler M, de Vries JE, Roncarolo MG. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med. 1996;184(1):19-29.
    • (1996) J Exp Med. , vol.184 , Issue.1 , pp. 19-29
    • Groux, H.1    Bigler, M.2    de Vries, J.E.3    Roncarolo, M.G.4
  • 187
    • 0032055224 scopus 로고    scopus 로고
    • Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells
    • Groux H, Bigler M, de Vries JE, Roncarolo MG. Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells. J Immunol. 1998;160(7):3188-93.
    • (1998) J Immunol. , vol.160 , Issue.7 , pp. 3188-3193
    • Groux, H.1    Bigler, M.2    de Vries, J.E.3    Roncarolo, M.G.4
  • 188
    • 0028084441 scopus 로고
    • Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein
    • Levy Y, Brouet JC. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein. J Clin Invest. 1994;93(1):424-8.
    • (1994) J Clin Invest. , vol.93 , Issue.1 , pp. 424-428
    • Levy, Y.1    Brouet, J.C.2
  • 189
    • 0029103042 scopus 로고
    • Long-term cultured CD40-activated B lymphocytes differentiate into plasma cells in response to IL-10 but not IL-4
    • Rousset F, Peyrol S, Garcia E, Vezzio N, Andujar M, Grimaud JA, et al. Long-term cultured CD40-activated B lymphocytes differentiate into plasma cells in response to IL-10 but not IL-4. Int Immunol. 1995;7(8):1243-53.
    • (1995) Int Immunol. , vol.7 , Issue.8 , pp. 1243-1253
    • Rousset, F.1    Peyrol, S.2    Garcia, E.3    Vezzio, N.4    Andujar, M.5    Grimaud, J.A.6
  • 190
    • 0028245010 scopus 로고
    • Interleukin-10 prevents experimental allergic encephalomyelitis in rats
    • Rott O, Fleischer B, Cash E. Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur J Immunol. 1994;24(6):1434-40.
    • (1994) Eur J Immunol. , vol.24 , Issue.6 , pp. 1434-1440
    • Rott, O.1    Fleischer, B.2    Cash, E.3
  • 191
    • 0035869309 scopus 로고    scopus 로고
    • Different therapeutic outcomes in experimental allergic encephalomyelitis dependent upon the mode of delivery of IL-10: A comparison of the effects of protein, adenoviral or retroviral IL-10 delivery into the central nervous system
    • Croxford JL, Feldmann M, Chernajovsky Y, Baker D. Different therapeutic outcomes in experimental allergic encephalomyelitis dependent upon the mode of delivery of IL-10: a comparison of the effects of protein, adenoviral or retroviral IL-10 delivery into the central nervous system. J Immunol. 2001;166(6):4124-30.
    • (2001) J Immunol. , vol.166 , Issue.6 , pp. 4124-4130
    • Croxford, J.L.1    Feldmann, M.2    Chernajovsky, Y.3    Baker, D.4
  • 192
    • 0035159581 scopus 로고    scopus 로고
    • Central nervous system expression of IL-10 inhibits autoimmune encephalomyelitis
    • Cua DJ, Hutchins B, LaFace DM, Stohlman SA, Coffman RL. Central nervous system expression of IL-10 inhibits autoimmune encephalomyelitis. J Immunol. 2001;166(1):602-8.
    • (2001) J Immunol. , vol.166 , Issue.1 , pp. 602-608
    • Cua, D.J.1    Hutchins, B.2    LaFace, D.M.3    Stohlman, S.A.4    Coffman, R.L.5
  • 193
    • 0030950036 scopus 로고    scopus 로고
    • Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules
    • Yue FY, Dummer R, Geertsen R, Hofbauer G, Laine E, Manolio S, et al. Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules. Int J Cancer. 1997;71(4):630-7.
    • (1997) Int J Cancer. , vol.71 , Issue.4 , pp. 630-637
    • Yue, F.Y.1    Dummer, R.2    Geertsen, R.3    Hofbauer, G.4    Laine, E.5    Manolio, S.6
  • 194
    • 0029121415 scopus 로고
    • IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response
    • Kim J, Modlin RL, Moy RL, Dubinett SM, McHugh T, Nickoloff BJ, et al. IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response. J Immunol. 1995;155(4):2240-7.
    • (1995) J Immunol. , vol.155 , Issue.4 , pp. 2240-2247
    • Kim, J.1    Modlin, R.L.2    Moy, R.L.3    Dubinett, S.M.4    McHugh, T.5    Nickoloff, B.J.6
  • 195
    • 0036155784 scopus 로고    scopus 로고
    • Phosphoserine-dependent regulation of protein-protein interactions in the Smad pathway
    • Wrana JL. Phosphoserine-dependent regulation of protein-protein interactions in the Smad pathway. Structure. 2002;10(1):5-7.
    • (2002) Structure. , vol.10 , Issue.1 , pp. 5-7
    • Wrana, J.L.1
  • 196
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGFbeta-Smad signalling
    • ten Dijke P, Hill CS. New insights into TGFbeta-Smad signalling. Trends Biochem Sci. 2004;29(5):265-73.
    • (2004) Trends Biochem Sci. , vol.29 , Issue.5 , pp. 265-273
    • ten Dijke, P.1    Hill, C.S.2
  • 198
    • 33745818935 scopus 로고    scopus 로고
    • TGFbeta1, a "Jack of all trades:" the link with pro-inflammatory IL-17-producing T cells
    • Veldhoen M, Stockinger B. TGFbeta1, a "Jack of all trades:" the link with pro-inflammatory IL-17-producing T cells. Trends Immunol. 2006;27(8):358-61.
    • (2006) Trends Immunol. , vol.27 , Issue.8 , pp. 358-361
    • Veldhoen, M.1    Stockinger, B.2
  • 199
    • 0025850691 scopus 로고
    • Protection against experimental autoimmune encephalomyelitis requires both CD4+ T suppressor cells and myelin basic protein-primed B cells
    • Karpus WJ, Swanborg RH. Protection against experimental autoimmune encephalomyelitis requires both CD4+ T suppressor cells and myelin basic protein-primed B cells. J Neuroimmunol. 1991;33(2):173-7.
    • (1991) J Neuroimmunol. , vol.33 , Issue.2 , pp. 173-177
    • Karpus, W.J.1    Swanborg, R.H.2
  • 200
    • 34248592104 scopus 로고    scopus 로고
    • T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1-and Th17-cell differentiation
    • Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1-and Th17-cell differentiation. Immunity. 2007;26(5):579-91.
    • (2007) Immunity. , vol.26 , Issue.5 , pp. 579-591
    • Li, M.O.1    Wan, Y.Y.2    Flavell, R.A.3
  • 201
    • 51649112340 scopus 로고    scopus 로고
    • T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
    • Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, et al. T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature. 2008;455(7210):246-50.
    • (2008) Nature. , vol.455 , Issue.7210 , pp. 246-250
    • Pesu, M.1    Watford, W.T.2    Wei, L.3    Xu, L.4    Fuss, I.5    Strober, W.6
  • 202
    • 79952771167 scopus 로고    scopus 로고
    • Autocrine transforming growth factor-beta1 promotes in vivo Th17 cell differentiation
    • Gutcher I, Donkor MK, Ma Q, Rudensky AY, Flavell RA, Li MO. Autocrine transforming growth factor-beta1 promotes in vivo Th17 cell differentiation. Immunity. 2011;34(3):396-408.
    • (2011) Immunity. , vol.34 , Issue.3 , pp. 396-408
    • Gutcher, I.1    Donkor, M.K.2    Ma, Q.3    Rudensky, A.Y.4    Flavell, R.A.5    Li, M.O.6
  • 203
    • 18644381773 scopus 로고    scopus 로고
    • TGFbeta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: Differential involvement of Stat4 and T-bet
    • Lin JT, Martin SL, Xia L, Gorham JD. TGFbeta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet. J Immunol. 2005;174(10):5950-8.
    • (2005) J Immunol. , vol.174 , Issue.10 , pp. 5950-5958
    • Lin, J.T.1    Martin, S.L.2    Xia, L.3    Gorham, J.D.4
  • 204
    • 78650173611 scopus 로고    scopus 로고
    • Disruption of central nervous system barriers in multiple sclerosis
    • Alvarez JI, Cayrol R, Prat A. Disruption of central nervous system barriers in multiple sclerosis. Biochim Biophys Acta. 2011;1812(2):252-64.
    • (2011) Biochim Biophys Acta. , vol.1812 , Issue.2 , pp. 252-264
    • Alvarez, J.I.1    Cayrol, R.2    Prat, A.3
  • 205
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 2005;308(5726):1314-8.
    • (2005) Science. , vol.308 , Issue.5726 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 206
    • 4644232615 scopus 로고    scopus 로고
    • Microglia initiate central nervous system innate and adaptive im-mune responses through multiple TLRs
    • Olson JK, Miller SD. Microglia initiate central nervous system innate and adaptive im-mune responses through multiple TLRs. J Immunol. 2004;173(6):3916-24.
    • (2004) J Immunol. , vol.173 , Issue.6 , pp. 3916-3924
    • Olson, J.K.1    Miller, S.D.2
  • 207
    • 80355143546 scopus 로고    scopus 로고
    • Microglial cell origin and phenotypes in health and disease
    • Saijo K, Glass CK. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol. 2011;11(11):775-87.
    • (2011) Nat Rev Immunol. , vol.11 , Issue.11 , pp. 775-787
    • Saijo, K.1    Glass, C.K.2
  • 208
    • 0032524997 scopus 로고    scopus 로고
    • Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation
    • Aloisi F, Ria F, Penna G, Adorini L. Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation. J Immunol. 1998;160(10):4671-80.
    • (1998) J Immunol. , vol.160 , Issue.10 , pp. 4671-4680
    • Aloisi, F.1    Ria, F.2    Penna, G.3    Adorini, L.4
  • 209
    • 0034807351 scopus 로고    scopus 로고
    • Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus
    • Olson JK, Girvin AM, Miller SD. Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus. J Virol. 2001;75(20):9780-9.
    • (2001) J Virol. , vol.75 , Issue.20 , pp. 9780-9789
    • Olson, J.K.1    Girvin, A.M.2    Miller, S.D.3
  • 210
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • Aloisi F. Immune function of microglia. Glia. 2001;36(2):165-79.
    • (2001) Glia. , vol.36 , Issue.2 , pp. 165-179
    • Aloisi, F.1
  • 211
    • 0032752573 scopus 로고    scopus 로고
    • Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice
    • Katz-Levy Y, Neville KL, Girvin AM, Vanderlugt CL, Pope JG, Tan LJ, et al. Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice. J Clin Invest. 1999;104(5):599-610.
    • (1999) J Clin Invest. , vol.104 , Issue.5 , pp. 599-610
    • Katz-Levy, Y.1    Neville, K.L.2    Girvin, A.M.3    Vanderlugt, C.L.4    Pope, J.G.5    Tan, L.J.6
  • 212
    • 0036709090 scopus 로고    scopus 로고
    • Characterization of microglial responses to Staphylococcus aureus: Effects on cytokine, costimulatory molecule, and Toll-like receptor expression
    • Kielian T, Mayes P, Kielian M. Characterization of microglial responses to Staphylococcus aureus: effects on cytokine, costimulatory molecule, and Toll-like receptor expression. J Neuroimmunol. 2002;130(1-2):86-99.
    • (2002) J Neuroimmunol. , vol.130 , Issue.1-2 , pp. 86-99
    • Kielian, T.1    Mayes, P.2    Kielian, M.3
  • 213
    • 77955661661 scopus 로고    scopus 로고
    • Protective effects of microglia in multiple sclerosis
    • Napoli I, Neumann H. Protective effects of microglia in multiple sclerosis. Exp Neurol. 2010;225(1):24-8.
    • (2010) Exp Neurol. , vol.225 , Issue.1 , pp. 24-28
    • Napoli, I.1    Neumann, H.2
  • 214
    • 0035705454 scopus 로고    scopus 로고
    • TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination
    • Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK, Ting JP. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci. 2001;4(11):1116-22.
    • (2001) Nat Neurosci. , vol.4 , Issue.11 , pp. 1116-1122
    • Arnett, H.A.1    Mason, J.2    Marino, M.3    Suzuki, K.4    Matsushima, G.K.5    Ting, J.P.6
  • 215
    • 30044434850 scopus 로고    scopus 로고
    • Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells
    • Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, et al. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci. 2006;31(1):149-60.
    • (2006) Mol Cell Neurosci. , vol.31 , Issue.1 , pp. 149-160
    • Butovsky, O.1    Ziv, Y.2    Schwartz, A.3    Landa, G.4    Talpalar, A.E.5    Pluchino, S.6
  • 216
    • 0032937860 scopus 로고    scopus 로고
    • The role of microglia and macrophages in the pathophysiology of the CNS
    • Stoll G, Jander S. The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol. 1999;58(3):233-47.
    • (1999) Prog Neurobiol. , vol.58 , Issue.3 , pp. 233-247
    • Stoll, G.1    Jander, S.2
  • 217
    • 0026582993 scopus 로고
    • TNF-alpha suppresses CR3-mediated myelin removal by macrophages
    • Bruck W, Bruck Y, Friede RL. TNF-alpha suppresses CR3-mediated myelin removal by macrophages. J Neuroimmunol. 1992;38(1-2):9-17.
    • (1992) J Neuroimmunol. , vol.38 , Issue.1-2 , pp. 9-17
    • Bruck, W.1    Bruck, Y.2    Friede, R.L.3
  • 218
    • 0028339366 scopus 로고
    • Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis
    • Bauer J, Sminia T, Wouterlood FG, Dijkstra CD. Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis. J Neurosci Res. 1994;38(4):365-75.
    • (1994) J Neurosci Res. , vol.38 , Issue.4 , pp. 365-375
    • Bauer, J.1    Sminia, T.2    Wouterlood, F.G.3    Dijkstra, C.D.4
  • 219
    • 40349089504 scopus 로고    scopus 로고
    • The biology of CNS remyelination: The key to therapeutic advances
    • Franklin RJ, Kotter MR. The biology of CNS remyelination: the key to therapeutic advances. J Neurol. 2008;255(Suppl 1):19-25.
    • (2008) J Neurol. , vol.255 , Issue.SUPPL. 1 , pp. 19-25
    • Franklin, R.J.1    Kotter, M.R.2
  • 220
    • 56949092726 scopus 로고    scopus 로고
    • The astrocyte odyssey
    • Wang DD, Bordey A. The astrocyte odyssey. Prog Neurobiol. 2008;86(4):342-67.
    • (2008) Prog Neurobiol. , vol.86 , Issue.4 , pp. 342-367
    • Wang, D.D.1    Bordey, A.2
  • 222
    • 51349134916 scopus 로고    scopus 로고
    • Astrocytes in multiple sclerosis: A product of their environment
    • Nair A, Frederick TJ, Miller SD. Astrocytes in multiple sclerosis: a product of their environment. Cell Mol Life Sci. 2008;65(17):2702-20.
    • (2008) Cell Mol Life Sci. , vol.65 , Issue.17 , pp. 2702-2720
    • Nair, A.1    Frederick, T.J.2    Miller, S.D.3
  • 224
    • 0034676994 scopus 로고    scopus 로고
    • Astrocytes in chronic active multiple sclerosis plaques express MHC class II molecules
    • Zeinstra E, Wilczak N, Streefland C, De Keyser J. Astrocytes in chronic active multiple sclerosis plaques express MHC class II molecules. Neuroreport. 2000;11(1):89-91.
    • (2000) Neuroreport. , vol.11 , Issue.1 , pp. 89-91
    • Zeinstra, E.1    Wilczak, N.2    Streefland, C.3    de Keyser, J.4
  • 225
    • 0033942134 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and interleukin-1 alpha inhibit through different pathways interferon-gamma-induced antigen presentation, processing and MHC class II surface expression on astrocytes, but not on microglia
    • Gresser O, Hein A, Riese S, Regnier-Vigouroux A. Tumor necrosis factor alpha and interleukin-1 alpha inhibit through different pathways interferon-gamma-induced antigen presentation, processing and MHC class II surface expression on astrocytes, but not on microglia. Cell Tissue Res. 2000;300(3):373-82.
    • (2000) Cell Tissue Res. , vol.300 , Issue.3 , pp. 373-382
    • Gresser, O.1    Hein, A.2    Riese, S.3    Regnier-Vigouroux, A.4
  • 226
    • 0032775459 scopus 로고    scopus 로고
    • Differential expression of B7 co-stimulatory molecules by astrocytes correlates with T cell activation and cytokine production
    • Soos JM, Ashley TA, Morrow J, Patarroyo JC, Szente BE, Zamvil SS. Differential expression of B7 co-stimulatory molecules by astrocytes correlates with T cell activation and cytokine production. Int Immunol. 1999;11(7):1169-79.
    • (1999) Int Immunol. , vol.11 , Issue.7 , pp. 1169-1179
    • Soos, J.M.1    Ashley, T.A.2    Morrow, J.3    Patarroyo, J.C.4    Szente, B.E.5    Zamvil, S.S.6
  • 228
    • 84863463743 scopus 로고    scopus 로고
    • CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes
    • Yan Y, Ding X, Li K, Ciric B, Wu S, Xu H, et al. CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes. Mol Ther. 2012;20(7):1338-48.
    • (2012) Mol Ther. , vol.20 , Issue.7 , pp. 1338-1348
    • Yan, Y.1    Ding, X.2    Li, K.3    Ciric, B.4    Wu, S.5    Xu, H.6
  • 229
    • 71749103005 scopus 로고    scopus 로고
    • Astrocytes in the damaged brain: Molecular and cellular insights into their reactive response and healing potential
    • Buffo A, Rolando C, Ceruti S. Astrocytes in the damaged brain: Molecular and cellular insights into their reactive response and healing potential. Biochem Pharmacol. 2010;79(2):77-89.
    • (2010) Biochem Pharmacol. , vol.79 , Issue.2 , pp. 77-89
    • Buffo, A.1    Rolando, C.2    Ceruti, S.3
  • 230
    • 0032797304 scopus 로고    scopus 로고
    • Antigen presentation function of brain-derived dendriform cells depends on astrocyte help
    • Fischer HG, Bielinsky AK. Antigen presentation function of brain-derived dendriform cells depends on astrocyte help. Int Immunol. 1999;11(8):1265-74.
    • (1999) Int Immunol. , vol.11 , Issue.8 , pp. 1265-1274
    • Fischer, H.G.1    Bielinsky, A.K.2
  • 231
    • 0031858899 scopus 로고    scopus 로고
    • Astrocytic factors deactivate antigen presenting cells that invade the central nervous system
    • Hailer NP, Heppner FL, Haas D, Nitsch R. Astrocytic factors deactivate antigen presenting cells that invade the central nervous system. Brain Pathol. 1998;8(3):459-74.
    • (1998) Brain Pathol. , vol.8 , Issue.3 , pp. 459-474
    • Hailer, N.P.1    Heppner, F.L.2    Haas, D.3    Nitsch, R.4
  • 232
    • 0034651767 scopus 로고    scopus 로고
    • Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colonystimulating factor and interaction with Th1 cells
    • Aloisi F, De Simone R, Columba-Cabezas S, Penna G, Adorini L. Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colonystimulating factor and interaction with Th1 cells. J Immunol. 2000;164(4):1705-12.
    • (2000) J Immunol. , vol.164 , Issue.4 , pp. 1705-1712
    • Aloisi, F.1    de Simone, R.2    Columba-Cabezas, S.3    Penna, G.4    Adorini, L.5
  • 233
    • 0033999887 scopus 로고    scopus 로고
    • Regulation of Tcell responses by CNS antigen-presenting cells: Different roles for microglia and astrocytes
    • Aloisi F, Ria F, Adorini L. Regulation of Tcell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. Immunol Today. 2000;21(3):141-7.
    • (2000) Immunol Today. , vol.21 , Issue.3 , pp. 141-147
    • Aloisi, F.1    Ria, F.2    Adorini, L.3
  • 234
    • 0345104338 scopus 로고    scopus 로고
    • Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression
    • Marz P, Heese K, Dimitriades-Schmutz B, Rose-John S, Otten U. Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression. Glia. 1999;26(3):191-200.
    • (1999) Glia. , vol.26 , Issue.3 , pp. 191-200
    • Marz, P.1    Heese, K.2    Dimitriades-Schmutz, B.3    Rose-John, S.4    Otten, U.5
  • 235
    • 0034634740 scopus 로고    scopus 로고
    • Interleukin-6 expression in human multiple sclerosis lesions
    • Schonrock LM, Gawlowski G, Bruck W. Interleukin-6 expression in human multiple sclerosis lesions. Neurosci Lett. 2000;294(1):45-8.
    • (2000) Neurosci Lett. , vol.294 , Issue.1 , pp. 45-48
    • Schonrock, L.M.1    Gawlowski, G.2    Bruck, W.3
  • 236
    • 0035212170 scopus 로고    scopus 로고
    • Interleukin-6 enhances expression of adenosine A(1) receptor mRNA and signaling in cultured rat cortical astrocytes and brain slices
    • Biber K, Lubrich B, Fiebich BL, Boddeke HW, van Calker D. Interleukin-6 enhances expression of adenosine A(1) receptor mRNA and signaling in cultured rat cortical astrocytes and brain slices. Neuropsychopharmacology. 2001;24(1):86-96.
    • (2001) Neuropsychopharmacology. , vol.24 , Issue.1 , pp. 86-96
    • Biber, K.1    Lubrich, B.2    Fiebich, B.L.3    Boddeke, H.W.4    van Calker, D.5
  • 237
    • 0034810795 scopus 로고    scopus 로고
    • Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion
    • Herx LM, Yong VW. Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion. J Neuropathol Exp Neurol. 2001;60(10):961-71.
    • (2001) J Neuropathol Exp Neurol. , vol.60 , Issue.10 , pp. 961-971
    • Herx, L.M.1    Yong, V.W.2
  • 238
    • 0034663946 scopus 로고    scopus 로고
    • Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor
    • Herx LM, Rivest S, Yong VW. Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor. J Immunol. 2000;165(4):2232-9.
    • (2000) J Immunol. , vol.165 , Issue.4 , pp. 2232-2239
    • Herx, L.M.1    Rivest, S.2    Yong, V.W.3
  • 239
    • 0036848529 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor (CNTF) enhances myelin formation: A novel role for CNTF and CNTF-related molecules
    • Stankoff B, Aigrot MS, Noel F, Wattilliaux A, Zalc B, Lubetzki C. Ciliary neurotrophic factor (CNTF) enhances myelin formation: a novel role for CNTF and CNTF-related molecules. J Neurosci. 2002;22(21):9221-7.
    • (2002) J Neurosci. , vol.22 , Issue.21 , pp. 9221-9227
    • Stankoff, B.1    Aigrot, M.S.2    Noel, F.3    Wattilliaux, A.4    Zalc, B.5    Lubetzki, C.6
  • 240
    • 33847332489 scopus 로고    scopus 로고
    • CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo
    • Talbott JF, Cao Q, Bertram J, Nkansah M, Benton RL, Lavik E, et al. CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Exp Neurol. 2007;204(1):485-9.
    • (2007) Exp Neurol. , vol.204 , Issue.1 , pp. 485-489
    • Talbott, J.F.1    Cao, Q.2    Bertram, J.3    Nkansah, M.4    Benton, R.L.5    Lavik, E.6
  • 242
    • 0030135421 scopus 로고    scopus 로고
    • Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development
    • Corbin JG, Kelly D, Rath EM, Baerwald KD, Suzuki K, Popko B. Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development. Mol Cell Neurosci. 1996;7(5):354-70.
    • (1996) Mol Cell Neurosci. , vol.7 , Issue.5 , pp. 354-370
    • Corbin, J.G.1    Kelly, D.2    Rath, E.M.3    Baerwald, K.D.4    Suzuki, K.5    Popko, B.6
  • 243
    • 22344435167 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma
    • Lin W, Harding HP, Ron D, Popko B. Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. J Cell Biol. 2005;169(4):603-12.
    • (2005) J Cell Biol. , vol.169 , Issue.4 , pp. 603-612
    • Lin, W.1    Harding, H.P.2    Ron, D.3    Popko, B.4
  • 244
    • 33646232737 scopus 로고    scopus 로고
    • Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress
    • Lin W, Kemper A, Dupree JL, Harding HP, Ron D, Popko B. Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress. Brain. 2006;129(Pt 5):1306-18.
    • (2006) Brain. , vol.129 , Issue.PART 5 , pp. 1306-1318
    • Lin, W.1    Kemper, A.2    Dupree, J.L.3    Harding, H.P.4    Ron, D.5    Popko, B.6
  • 245
    • 33846811702 scopus 로고    scopus 로고
    • The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage
    • Lin W, Bailey SL, Ho H, Harding HP, Ron D, Miller SD, et al. The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. J Clin Invest. 2007;117(2):448-56.
    • (2007) J Clin Invest. , vol.117 , Issue.2 , pp. 448-456
    • Lin, W.1    Bailey, S.L.2    Ho, H.3    Harding, H.P.4    Ron, D.5    Miller, S.D.6
  • 246
    • 79959707104 scopus 로고    scopus 로고
    • Reactive astrocytes inhibit the survival and differentiation of oligodendrocyte precursor cells by secreted TNF-alpha
    • Su Z, Yuan Y, Chen J, Zhu Y, Qiu Y, Zhu F, et al. Reactive astrocytes inhibit the survival and differentiation of oligodendrocyte precursor cells by secreted TNF-alpha. J Neurotrauma. 2011;28(6):1089-100.
    • (2011) J Neurotrauma. , vol.28 , Issue.6 , pp. 1089-1100
    • Su, Z.1    Yuan, Y.2    Chen, J.3    Zhu, Y.4    Qiu, Y.5    Zhu, F.6
  • 247
    • 27144460509 scopus 로고    scopus 로고
    • Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis
    • Hovelmeyer N, Hao Z, Kranidioti K, Kassiotis G, Buch T, Frommer F, et al. Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol. 2005;175(9):5875-84.
    • (2005) J Immunol. , vol.175 , Issue.9 , pp. 5875-5884
    • Hovelmeyer, N.1    Hao, Z.2    Kranidioti, K.3    Kassiotis, G.4    Buch, T.5    Frommer, F.6
  • 248
    • 1542407681 scopus 로고    scopus 로고
    • Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices
    • Pizzi M, Sarnico I, Boroni F, Benarese M, Dreano M, Garotta G, et al. Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices. Mol Cell Neurosci. 2004;25(2):301-11.
    • (2004) Mol Cell Neurosci. , vol.25 , Issue.2 , pp. 301-311
    • Pizzi, M.1    Sarnico, I.2    Boroni, F.3    Benarese, M.4    Dreano, M.5    Garotta, G.6
  • 249
    • 0036942881 scopus 로고    scopus 로고
    • Soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro differentiation of purified rat oligodendroglial lineage cells
    • Valerio A, Ferrario M, Dreano M, Garotta G, Spano P, Pizzi M. Soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro differentiation of purified rat oligodendroglial lineage cells. Mol Cell Neurosci. 2002;21(4):602-15.
    • (2002) Mol Cell Neurosci. , vol.21 , Issue.4 , pp. 602-615
    • Valerio, A.1    Ferrario, M.2    Dreano, M.3    Garotta, G.4    Spano, P.5    Pizzi, M.6
  • 250
    • 0038120893 scopus 로고    scopus 로고
    • Immune-modifying agents do not impair the survival, migration or proliferation of oligodendrocyte progenitors (CG-4) in vitro
    • Halfpenny CA, Scolding NJ. Immune-modifying agents do not impair the survival, migration or proliferation of oligodendrocyte progenitors (CG-4) in vitro. J Neuroimmunol. 2003;139(1-2):9-16.
    • (2003) J Neuroimmunol. , vol.139 , Issue.1-2 , pp. 9-16
    • Halfpenny, C.A.1    Scolding, N.J.2


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