IL-12 receptor β2 (IL-12Rβ2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites

Journal of Immunology

Volumn 165, Issue 11, 2000, Pages 6221-6228

  Wu, C Y ^a   Wang, X ^a   Gadina, M ^a   O'Shea, J J ^a   Presky, D H ^a   Magram, J ^a  

^a OSI PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; INTERLEUKIN 12 RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL PROLIFERATION; CELLULAR IMMUNITY; CYTOKINE RELEASE; CYTOLYSIS; DISULFIDE BOND; GENE TARGETING; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SPLEEN CELL;

EID: 0034541139     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.11.6221     Document Type: Article

References (39)

1. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
2. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
3. Expression cloning of a human IL-12 receptor component: A new member of the cytokine receptor superfamily with strong homology to gp130
4. Cloning and characterization of a mouse 1L-12 receptor-β component
5. A functional interleukin-12 receptor complex is composed of two β-type cytokine receptor subunits
6. Functional characterization of mouse IL-12 receptors
7. Characterization of IL-12 receptor β1 chain (IL-12Rβ1)-deficient mice
8. Role of asialo-GMI-positive lymphoid cells in mediating the toxic effects of recombinant IL-2 in mice
9. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo
10. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses
11. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
12. Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins
13. Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice
14. Derivation of embryonic stem cell lines
15. Simplified mammalian DNA isolation procedure
16. IL-12 receptor, I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts
17. Cloning and expression of murine IL-12
18. IL-12: Monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts
19. Analysis of radioligand binding experiments: A collection of computer programs for the IBM PC
20. The attractions of proteins for small molecules and ions
21. Activation of STAT4 by IL-12 and IFN-α: Evidence for involvement of ligand-induced tyrosine and serine phosphorylation
22. Expression and methylation of imprinted genes during in vitro differentiation of mouse parthenogenetic and androgenetic embryonic stem cells
23. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes
24. + T cells through IL-12 produced by Lister-induced macrophages
25. + T cells to enhance priming for interferon-γ production and diminishes interleukin 4 inhibition of such priming
26. + T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β
27. Biological function and distribution of human interleukin-12 receptor β-chain
28. Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
29. Severe mycobacterial and salmonella infections in interleukin-12 receptor-deficient patients
30. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
31. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1(Th1) and Th2 cells
32. Selective expression of an interleukin-12 receptor component by human T helper 1 cells
33. Antibodies to the IL-12 receptorβ2 chain mark human Th1 but not Th2 cells in vitro and in vivo
34. The biology of Stat4 and Stat6
35. Tyrosine phosphorylation and activation of STAT5, STAT3, and janus kinases by interleukins 2 and 15
36. Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene transcription in T lymphocytes
37. Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex
38. Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits