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Volumn 1812, Issue 2, 2011, Pages 252-264

Disruption of central nervous system barriers in multiple sclerosis

Author keywords

Adherens junctions; ALCAM; Astrocyte; Basal lamina; Basement membrane; BBB; BCB; CAMs; Chemokine; Choroid plexus; EAE; ECM; Endothelial cells; Ependyma; ICAM 1; MS; Neuroinflammation; P selectin; Pericyte; Tight junctions; Transmigration; VCAM 1; VLA 4

Indexed keywords

CELL ADHESION MOLECULE; INTEGRIN; NATALIZUMAB; SELECTIN;

EID: 78650173611     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2010.06.017     Document Type: Review
Times cited : (262)

References (219)
  • 1
    • 0036319335 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions and blood-brain barrier permeability
    • Abbott N.J. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 2002, 200:629.
    • (2002) J. Anat. , vol.200 , pp. 629
    • Abbott, N.J.1
  • 2
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott N.J., Ronnback L., Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 2006, 7:41.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 41
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 3
    • 0033105628 scopus 로고    scopus 로고
    • Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway
    • Adamson P., Etienne S., Couraud P.O., Calder V., Greenwood J. Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway. J. Immunol. 1999, 162:2964.
    • (1999) J. Immunol. , vol.162 , pp. 2964
    • Adamson, P.1    Etienne, S.2    Couraud, P.O.3    Calder, V.4    Greenwood, J.5
  • 4
    • 33645869560 scopus 로고    scopus 로고
    • Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
    • Agrawal S., Anderson P., Durbeej M., van Rooijen N., Ivars F., Opdenakker G., Sorokin L.M. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J. Exp. Med. 2006, 203:1007.
    • (2006) J. Exp. Med. , vol.203 , pp. 1007
    • Agrawal, S.1    Anderson, P.2    Durbeej, M.3    van Rooijen, N.4    Ivars, F.5    Opdenakker, G.6    Sorokin, L.M.7
  • 5
    • 34248643192 scopus 로고    scopus 로고
    • Immunopathogenesis of multiple sclerosis
    • Agrawal S.M., Yong V.W. Immunopathogenesis of multiple sclerosis. Int. Rev. Neurobiol. 2007, 79:99.
    • (2007) Int. Rev. Neurobiol. , vol.79 , pp. 99
    • Agrawal, S.M.1    Yong, V.W.2
  • 6
    • 33746580847 scopus 로고    scopus 로고
    • Elevated serum soluble vascular adhesion protein-1 (VAP-1) in patients with active relapsing remitting multiple sclerosis
    • Airas L., Mikkola J., Vainio J.M., Elovaara I., Smith D.J. Elevated serum soluble vascular adhesion protein-1 (VAP-1) in patients with active relapsing remitting multiple sclerosis. J. Neuroimmunol. 2006, 177:132.
    • (2006) J. Neuroimmunol. , vol.177 , pp. 132
    • Airas, L.1    Mikkola, J.2    Vainio, J.M.3    Elovaara, I.4    Smith, D.J.5
  • 7
    • 78650178703 scopus 로고    scopus 로고
    • Astrocyte-secreted sonic hedgehog supports CNS anti-inflammatory activity and promotes optimal human blood brain barrier functioning
    • Alvarez J.I., Dodelet-Devillers A., Ifergan I., Bernard M., van Horssen J., Charron F., Prat A. Astrocyte-secreted sonic hedgehog supports CNS anti-inflammatory activity and promotes optimal human blood brain barrier functioning. Clin. Immunol. 2009, 131:S34.
    • (2009) Clin. Immunol. , vol.131
    • Alvarez, J.I.1    Dodelet-Devillers, A.2    Ifergan, I.3    Bernard, M.4    van Horssen, J.5    Charron, F.6    Prat, A.7
  • 8
    • 34347271663 scopus 로고    scopus 로고
    • Differential changes in junctional complex proteins suggest the ependymal lining as the main source of leukocyte infiltration into ventricles in murine neurocysticercosis
    • Alvarez J.I., Teale J.M. Differential changes in junctional complex proteins suggest the ependymal lining as the main source of leukocyte infiltration into ventricles in murine neurocysticercosis. J. Neuroimmunol. 2007, 187:102.
    • (2007) J. Neuroimmunol. , vol.187 , pp. 102
    • Alvarez, J.I.1    Teale, J.M.2
  • 9
    • 34548515468 scopus 로고    scopus 로고
    • Evidence for differential changes of junctional complex proteins in murine neurocysticercosis dependent upon CNS vasculature
    • Alvarez J.I., Teale J.M. Evidence for differential changes of junctional complex proteins in murine neurocysticercosis dependent upon CNS vasculature. Brain Res. 2007, 1169:98.
    • (2007) Brain Res. , vol.1169 , pp. 98
    • Alvarez, J.I.1    Teale, J.M.2
  • 11
    • 0033551811 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors
    • Antonetti D.A., Barber A.J., Hollinger L.A., Wolpert E.B., Gardner T.W. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J. Biol. Chem. 1999, 274:23463.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23463
    • Antonetti, D.A.1    Barber, A.J.2    Hollinger, L.A.3    Wolpert, E.B.4    Gardner, T.W.5
  • 12
    • 0036323373 scopus 로고    scopus 로고
    • Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin
    • Antonetti D.A., Wolpert E.B., DeMaio L., Harhaj N.S., Scaduto R.C. Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin. J. Neurochem. 2002, 80:667.
    • (2002) J. Neurochem. , vol.80 , pp. 667
    • Antonetti, D.A.1    Wolpert, E.B.2    DeMaio, L.3    Harhaj, N.S.4    Scaduto, R.C.5
  • 14
    • 0035478029 scopus 로고    scopus 로고
    • Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia
    • Asahi M., Wang X., Mori T., Sumii T., Jung J.C., Moskowitz M.A., Fini M.E., Lo E.H. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J. Neurosci. 2001, 21:7724.
    • (2001) J. Neurosci. , vol.21 , pp. 7724
    • Asahi, M.1    Wang, X.2    Mori, T.3    Sumii, T.4    Jung, J.C.5    Moskowitz, M.A.6    Fini, M.E.7    Lo, E.H.8
  • 15
    • 0035895050 scopus 로고    scopus 로고
    • Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members
    • Aurrand-Lions M., Johnson-Leger C., Wong C., Du P.L., Imhof B.A. Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members. Blood 2001, 98:3699.
    • (2001) Blood , vol.98 , pp. 3699
    • Aurrand-Lions, M.1    Johnson-Leger, C.2    Wong, C.3    Du, P.L.4    Imhof, B.A.5
  • 16
    • 0032077870 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells
    • Badovinac V., Mostarica-Stojkovic M., Dinarello C.A., Stosic-Grujicic S. Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells. J. Neuroimmunol. 1998, 85:87.
    • (1998) J. Neuroimmunol. , vol.85 , pp. 87
    • Badovinac, V.1    Mostarica-Stojkovic, M.2    Dinarello, C.A.3    Stosic-Grujicic, S.4
  • 17
    • 0032530520 scopus 로고    scopus 로고
    • Role of the CNS microvascular pericyte in the blood-brain barrier
    • Balabanov R., Dore-Duffy P. Role of the CNS microvascular pericyte in the blood-brain barrier. J. Neurosci. Res. 1998, 53:637.
    • (1998) J. Neurosci. Res. , vol.53 , pp. 637
    • Balabanov, R.1    Dore-Duffy, P.2
  • 18
    • 0030250260 scopus 로고    scopus 로고
    • CNS microvascular pericytes express macrophage-like function, cell surface integrin alpha M, and macrophage marker ED-2
    • Balabanov R., Washington R., Wagnerova J., Dore-Duffy P. CNS microvascular pericytes express macrophage-like function, cell surface integrin alpha M, and macrophage marker ED-2. Microvasc. Res. 1996, 52:127.
    • (1996) Microvasc. Res. , vol.52 , pp. 127
    • Balabanov, R.1    Washington, R.2    Wagnerova, J.3    Dore-Duffy, P.4
  • 19
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier: an overview: structure, regulation, and clinical implications
    • Ballabh P., Braun A., Nedergaard M. The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol. Dis. 2004, 16:1.
    • (2004) Neurobiol. Dis. , vol.16 , pp. 1
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 20
  • 24
    • 77957726951 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement
    • Bauer A.T., Burgers H.F., Rabie T., Marti H.H. Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement. J. Cereb. Blood Flow Metab. 2009.
    • (2009) J. Cereb. Blood Flow Metab.
    • Bauer, A.T.1    Burgers, H.F.2    Rabie, T.3    Marti, H.H.4
  • 25
    • 3042590902 scopus 로고    scopus 로고
    • Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis
    • Bazzoni G., Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol. Rev. 2004, 84:869.
    • (2004) Physiol. Rev. , vol.84 , pp. 869
    • Bazzoni, G.1    Dejana, E.2
  • 26
    • 0642345898 scopus 로고    scopus 로고
    • Axonal degeneration and progressive neurologic disability in multiple sclerosis
    • Bjartmar C., Trapp B.D. Axonal degeneration and progressive neurologic disability in multiple sclerosis. Neurotox. Res. 2003, 5:157.
    • (2003) Neurotox. Res. , vol.5 , pp. 157
    • Bjartmar, C.1    Trapp, B.D.2
  • 28
    • 0032543607 scopus 로고    scopus 로고
    • Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo
    • Bolton S.J., Anthony D.C., Perry V.H. Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo. Neuroscience 1998, 86:1245.
    • (1998) Neuroscience , vol.86 , pp. 1245
    • Bolton, S.J.1    Anthony, D.C.2    Perry, V.H.3
  • 29
    • 0032744877 scopus 로고    scopus 로고
    • CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease
    • Brennan F.R., O'Neill J.K., Allen S.J., Butter C., Nuki G., Baker D. CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease. Immunology 1999, 98:427.
    • (1999) Immunology , vol.98 , pp. 427
    • Brennan, F.R.1    O'Neill, J.K.2    Allen, S.J.3    Butter, C.4    Nuki, G.5    Baker, D.6
  • 30
  • 32
    • 20444481707 scopus 로고    scopus 로고
    • Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process
    • Bruewer M., Utech M., Ivanov A.I., Hopkins A.M., Parkos C.A., Nusrat A. Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J. 2005, 19:923.
    • (2005) FASEB J. , vol.19 , pp. 923
    • Bruewer, M.1    Utech, M.2    Ivanov, A.I.3    Hopkins, A.M.4    Parkos, C.A.5    Nusrat, A.6
  • 33
    • 48249092633 scopus 로고    scopus 로고
    • All vertebrates started out with a glial blood-brain barrier 4-500 million years ago
    • Bundgaard M., Abbott N.J. All vertebrates started out with a glial blood-brain barrier 4-500 million years ago. Glia 2008, 56:699.
    • (2008) Glia , vol.56 , pp. 699
    • Bundgaard, M.1    Abbott, N.J.2
  • 34
    • 0035795039 scopus 로고    scopus 로고
    • T lymphocytes conditioned with Interferon beta induce membrane and soluble VCAM on human brain endothelial cells
    • Calabresi P.A., Prat A., Biernacki K., Rollins J., Antel J.P. T lymphocytes conditioned with Interferon beta induce membrane and soluble VCAM on human brain endothelial cells. J. Neuroimmunol. 2001, 115:161.
    • (2001) J. Neuroimmunol. , vol.115 , pp. 161
    • Calabresi, P.A.1    Prat, A.2    Biernacki, K.3    Rollins, J.4    Antel, J.P.5
  • 35
    • 37549061456 scopus 로고    scopus 로고
    • A genomic comparison of in vivo and in vitro brain microvascular endothelial cells
    • Calabria A.R., Shusta E.V. A genomic comparison of in vivo and in vitro brain microvascular endothelial cells. J. Cereb. Blood Flow Metab. 2008, 28:135.
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 135
    • Calabria, A.R.1    Shusta, E.V.2
  • 36
    • 0024999613 scopus 로고
    • Upregulation and coexpression of adhesion molecules correlate with relapsing autoimmune demyelination in the central nervous system
    • Cannella B., Cross A.H., Raine C.S. Upregulation and coexpression of adhesion molecules correlate with relapsing autoimmune demyelination in the central nervous system. J. Exp. Med. 1990, 172:1521.
    • (1990) J. Exp. Med. , vol.172 , pp. 1521
    • Cannella, B.1    Cross, A.H.2    Raine, C.S.3
  • 37
    • 0028941871 scopus 로고
    • The adhesion molecule and cytokine profile of multiple sclerosis lesions
    • Cannella B., Raine C.S. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann. Neurol. 1995, 37:424.
    • (1995) Ann. Neurol. , vol.37 , pp. 424
    • Cannella, B.1    Raine, C.S.2
  • 38
    • 50849085193 scopus 로고    scopus 로고
    • Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation
    • Cardona A.E., Li M., Liu L., Savarin C., Ransohoff R.M. Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation. J. Leukoc. Biol. 2008.
    • (2008) J. Leukoc. Biol.
    • Cardona, A.E.1    Li, M.2    Liu, L.3    Savarin, C.4    Ransohoff, R.M.5
  • 39
    • 7244248569 scopus 로고    scopus 로고
    • A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them
    • Carman C.V., Springer T.A. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J. Cell Biol. 2004, 167:377.
    • (2004) J. Cell Biol. , vol.167 , pp. 377
    • Carman, C.V.1    Springer, T.A.2
  • 40
    • 0036341221 scopus 로고    scopus 로고
    • Role of genetic background in P selectin-dependent immune surveillance of the central nervous system
    • Carrithers M.D., Visintin I., Viret C., Janeway C.S. Role of genetic background in P selectin-dependent immune surveillance of the central nervous system. J. Neuroimmunol. 2002, 129:51.
    • (2002) J. Neuroimmunol. , vol.129 , pp. 51
    • Carrithers, M.D.1    Visintin, I.2    Viret, C.3    Janeway, C.S.4
  • 42
    • 32144454172 scopus 로고    scopus 로고
    • The many roles of chemokines and chemokine receptors in inflammation
    • Charo I.F., Ransohoff R.M. The many roles of chemokines and chemokine receptors in inflammation. N Engl J. Med. 2006, 354:610.
    • (2006) N Engl J. Med. , vol.354 , pp. 610
    • Charo, I.F.1    Ransohoff, R.M.2
  • 45
    • 0033754531 scopus 로고    scopus 로고
    • The molecular organization of endothelial junctions and their functional role in vascular morphogenesis and permeability
    • Dejana E., Lampugnani M.G., Martinez-Estrada O., Bazzoni G. The molecular organization of endothelial junctions and their functional role in vascular morphogenesis and permeability. Int. J. Dev. Biol. 2000, 44:743.
    • (2000) Int. J. Dev. Biol. , vol.44 , pp. 743
    • Dejana, E.1    Lampugnani, M.G.2    Martinez-Estrada, O.3    Bazzoni, G.4
  • 46
    • 48049094159 scopus 로고    scopus 로고
    • The role of adherens junctions and VE-cadherin in the control of vascular permeability
    • Dejana E., Orsenigo F., Lampugnani M.G. The role of adherens junctions and VE-cadherin in the control of vascular permeability. J. Cell Sci. 2008, 121:2115.
    • (2008) J. Cell Sci. , vol.121 , pp. 2115
    • Dejana, E.1    Orsenigo, F.2    Lampugnani, M.G.3
  • 48
    • 0034652002 scopus 로고    scopus 로고
    • CD47 engagement inhibits cytokine production and maturation of human dendritic cells
    • Demeure C.E., Tanaka H., Mateo V., Rubio M., Delespesse G., Sarfati M. CD47 engagement inhibits cytokine production and maturation of human dendritic cells. J. Immunol. 2000, 164:2193.
    • (2000) J. Immunol. , vol.164 , pp. 2193
    • Demeure, C.E.1    Tanaka, H.2    Mateo, V.3    Rubio, M.4    Delespesse, G.5    Sarfati, M.6
  • 50
    • 20044387390 scopus 로고    scopus 로고
    • Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production
    • Dohgu S., Takata F., Yamauchi A., Nakagawa S., Egawa T., Naito M., Tsuruo T., Sawada Y., Niwa M., Kataoka Y. Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res. 2005, 1038:208.
    • (2005) Brain Res. , vol.1038 , pp. 208
    • Dohgu, S.1    Takata, F.2    Yamauchi, A.3    Nakagawa, S.4    Egawa, T.5    Naito, M.6    Tsuruo, T.7    Sawada, Y.8    Niwa, M.9    Kataoka, Y.10
  • 51
    • 0028963171 scopus 로고
    • Circulating, soluble adhesion proteins in cerebrospinal fluid and serum of patients with multiple sclerosis: correlation with clinical activity
    • Dore-Duffy P., Newman W., Balabanov R., Lisak R.P., Mainolfi E., Rothlein R., Peterson M. Circulating, soluble adhesion proteins in cerebrospinal fluid and serum of patients with multiple sclerosis: correlation with clinical activity. Ann. Neurol. 1995, 37:55.
    • (1995) Ann. Neurol. , vol.37 , pp. 55
    • Dore-Duffy, P.1    Newman, W.2    Balabanov, R.3    Lisak, R.P.4    Mainolfi, E.5    Rothlein, R.6    Peterson, M.7
  • 52
    • 0027241616 scopus 로고
    • Expression of endothelial cell activation antigens in microvessels from patients with multiple sclerosis
    • Dore-Duffy P., Washington R., Dragovic L. Expression of endothelial cell activation antigens in microvessels from patients with multiple sclerosis. Adv. Exp. Med. Biol. 1993, 331:243.
    • (1993) Adv. Exp. Med. Biol. , vol.331 , pp. 243
    • Dore-Duffy, P.1    Washington, R.2    Dragovic, L.3
  • 53
    • 40049095589 scopus 로고    scopus 로고
    • E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice
    • Doring A., Wild M., Vestweber D., Deutsch U., Engelhardt B. E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice. J. Immunol. 2007, 179:8470.
    • (2007) J. Immunol. , vol.179 , pp. 8470
    • Doring, A.1    Wild, M.2    Vestweber, D.3    Deutsch, U.4    Engelhardt, B.5
  • 54
    • 0029991148 scopus 로고    scopus 로고
    • Serum and cerebrospinal fluid levels of soluble adhesion molecules in multiple sclerosis: predominant intrathecal release of vascular cell adhesion molecule-1
    • Droogan A.G., McMillan S.A., Douglas J.P., Hawkins S.A. Serum and cerebrospinal fluid levels of soluble adhesion molecules in multiple sclerosis: predominant intrathecal release of vascular cell adhesion molecule-1. J. Neuroimmunol. 1996, 64:185.
    • (1996) J. Neuroimmunol. , vol.64 , pp. 185
    • Droogan, A.G.1    McMillan, S.A.2    Douglas, J.P.3    Hawkins, S.A.4
  • 55
    • 34249781999 scopus 로고    scopus 로고
    • Pathogenesis of axonal and neuronal damage in multiple sclerosis
    • Dutta R., Trapp B.D. Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology 2007, 68:S22-S31.
    • (2007) Neurology , vol.68
    • Dutta, R.1    Trapp, B.D.2
  • 56
    • 33749002256 scopus 로고    scopus 로고
    • Regulation of immune cell entry into the central nervous system
    • Engelhardt B. Regulation of immune cell entry into the central nervous system. Results Probl. Cell Differ. 2006, 43:259.
    • (2006) Results Probl. Cell Differ. , vol.43 , pp. 259
    • Engelhardt, B.1
  • 57
    • 70350741505 scopus 로고    scopus 로고
    • PSGL-1-the hidden player in T cell trafficking into the brain in multiple sclerosis?
    • Engelhardt B. PSGL-1-the hidden player in T cell trafficking into the brain in multiple sclerosis?. J. Leukoc. Biol. 2009, 86:1023.
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 1023
    • Engelhardt, B.1
  • 58
    • 37149030961 scopus 로고    scopus 로고
    • Natalizumab: targeting alpha4-integrins in multiple sclerosis
    • Engelhardt B., Kappos L. Natalizumab: targeting alpha4-integrins in multiple sclerosis. Neurodegener. Dis. 2008, 5:16.
    • (2008) Neurodegener. Dis. , vol.5 , pp. 16
    • Engelhardt, B.1    Kappos, L.2
  • 59
    • 23244449103 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice
    • Engelhardt B., Kempe B., Merfeld-Clauss S., Laschinger M., Furie B., Wild M.K., Vestweber D. P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice. J. Immunol. 2005, 175:1267.
    • (2005) J. Immunol. , vol.175 , pp. 1267
    • Engelhardt, B.1    Kempe, B.2    Merfeld-Clauss, S.3    Laschinger, M.4    Furie, B.5    Wild, M.K.6    Vestweber, D.7
  • 60
    • 23744475685 scopus 로고    scopus 로고
    • The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms
    • Engelhardt B., Ransohoff R.M. The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol. 2005, 26:485.
    • (2005) Trends Immunol. , vol.26 , pp. 485
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 61
    • 73449115641 scopus 로고    scopus 로고
    • The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction
    • Engelhardt B., Sorokin L. The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction. Semin. Immunopathol. 2009, 31:497.
    • (2009) Semin. Immunopathol. , vol.31 , pp. 497
    • Engelhardt, B.1    Sorokin, L.2
  • 62
    • 0035153262 scopus 로고    scopus 로고
    • Involvement of the choroid plexus in central nervous system inflammation
    • Engelhardt B., Wolburg-Buchholz K., Wolburg H. Involvement of the choroid plexus in central nervous system inflammation. Microsc. Res. Tech. 2001, 52:112.
    • (2001) Microsc. Res. Tech. , vol.52 , pp. 112
    • Engelhardt, B.1    Wolburg-Buchholz, K.2    Wolburg, H.3
  • 63
    • 21444450963 scopus 로고    scopus 로고
    • H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway
    • Fischer S., Wiesnet M., Renz D., Schaper W. H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway. Eur. J. Cell Biol. 2005, 84:687.
    • (2005) Eur. J. Cell Biol. , vol.84 , pp. 687
    • Fischer, S.1    Wiesnet, M.2    Renz, D.3    Schaper, W.4
  • 64
    • 70149122373 scopus 로고    scopus 로고
    • Pathogenic CD8(+) T cells in multiple sclerosis
    • Friese M.A., Fugger L. Pathogenic CD8(+) T cells in multiple sclerosis. Ann. Neurol. 2009, 66:132.
    • (2009) Ann. Neurol. , vol.66 , pp. 132
    • Friese, M.A.1    Fugger, L.2
  • 66
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis-the plaque and its pathogenesis
    • Frohman E.M., Racke M.K., Raine C.S. Multiple sclerosis-the plaque and its pathogenesis. N Engl J. Med. 2006, 354:942.
    • (2006) N Engl J. Med. , vol.354 , pp. 942
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 68
    • 33750529948 scopus 로고    scopus 로고
    • VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
    • Gavard J., Gutkind J.S. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat. Cell Biol. 2006, 8:1223.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 1223
    • Gavard, J.1    Gutkind, J.S.2
  • 69
    • 0033927061 scopus 로고    scopus 로고
    • N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken
    • Gerhardt H., Wolburg H., Redies C. N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken. Dev. Dyn. 2000, 218:472.
    • (2000) Dev. Dyn. , vol.218 , pp. 472
    • Gerhardt, H.1    Wolburg, H.2    Redies, C.3
  • 70
    • 0025213321 scopus 로고
    • Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis
    • Gijbels K., Van Damme J., Proost P., Put W., Carton H., Billiau A. Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 1990, 20:233.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 233
    • Gijbels, K.1    Van Damme, J.2    Proost, P.3    Put, W.4    Carton, H.5    Billiau, A.6
  • 72
    • 0028242968 scopus 로고
    • Expression of P-selectin on endothelial cells is upregulated by LPS and TNF-alpha in vivo
    • Gotsch U., Jager U., Dominis M., Vestweber D. Expression of P-selectin on endothelial cells is upregulated by LPS and TNF-alpha in vivo. Cell Adhes. Commun. 1994, 2:7.
    • (1994) Cell Adhes. Commun. , vol.2 , pp. 7
    • Gotsch, U.1    Jager, U.2    Dominis, M.3    Vestweber, D.4
  • 73
  • 74
    • 0034703180 scopus 로고    scopus 로고
    • Distinct roles for matrix metalloproteinase-2 and alpha4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis
    • Graesser D., Mahooti S., Madri J.A. Distinct roles for matrix metalloproteinase-2 and alpha4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2000, 109:121.
    • (2000) J. Neuroimmunol. , vol.109 , pp. 121
    • Graesser, D.1    Mahooti, S.2    Madri, J.A.3
  • 75
    • 0036627483 scopus 로고    scopus 로고
    • Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier
    • Greenwood J., Etienne-Manneville S., Adamson P., Couraud P.O. Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier. Vascul. Pharmacol 2002, 38:315.
    • (2002) Vascul. Pharmacol , vol.38 , pp. 315
    • Greenwood, J.1    Etienne-Manneville, S.2    Adamson, P.3    Couraud, P.O.4
  • 76
    • 0028791506 scopus 로고
    • Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off
    • Greenwood J., Wang Y., Calder V.L. Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off. Immunology 1995, 86:408.
    • (1995) Immunology , vol.86 , pp. 408
    • Greenwood, J.1    Wang, Y.2    Calder, V.L.3
  • 77
    • 33746637520 scopus 로고    scopus 로고
    • Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA
    • Guillemot L., Citi S. Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA. Mol. Biol. Cell 2006, 17:3569.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 3569
    • Guillemot, L.1    Citi, S.2
  • 79
    • 1942502810 scopus 로고    scopus 로고
    • Regulation of tight junctions and loss of barrier function in pathophysiology
    • Harhaj N.S., Antonetti D.A. Regulation of tight junctions and loss of barrier function in pathophysiology. Int. J. Biochem. Cell Biol. 2004, 36:1206.
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 1206
    • Harhaj, N.S.1    Antonetti, D.A.2
  • 80
    • 0025854083 scopus 로고
    • Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: implications for clinical trials and natural history
    • Harris J.O., Frank J.A., Patronas N., McFarlin D.E., McFarland H.F. Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: implications for clinical trials and natural history. Ann. Neurol. 1991, 29:548.
    • (1991) Ann. Neurol. , vol.29 , pp. 548
    • Harris, J.O.1    Frank, J.A.2    Patronas, N.3    McFarlin, D.E.4    McFarland, H.F.5
  • 81
    • 33947723274 scopus 로고    scopus 로고
    • The impact of glia-derived extracellular matrices on the barrier function of cerebral endothelial cells: an in vitro study
    • Hartmann C., Zozulya A., Wegener J., Galla H.J. The impact of glia-derived extracellular matrices on the barrier function of cerebral endothelial cells: an in vitro study. Exp. Cell Res. 2007, 313:1318.
    • (2007) Exp. Cell Res. , vol.313 , pp. 1318
    • Hartmann, C.1    Zozulya, A.2    Wegener, J.3    Galla, H.J.4
  • 82
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins B.T., Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 2005, 57:173.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 173
    • Hawkins, B.T.1    Davis, T.P.2
  • 83
    • 7044260589 scopus 로고    scopus 로고
    • Effects of hypoxia on endothelial/pericytic co-culture model of the blood-brain barrier
    • Hayashi K., Nakao S., Nakaoke R., Nakagawa S., Kitagawa N., Niwa M. Effects of hypoxia on endothelial/pericytic co-culture model of the blood-brain barrier. Regul. Pept. 2004, 123:77.
    • (2004) Regul. Pept. , vol.123 , pp. 77
    • Hayashi, K.1    Nakao, S.2    Nakaoke, R.3    Nakagawa, S.4    Kitagawa, N.5    Niwa, M.6
  • 85
    • 73549089256 scopus 로고    scopus 로고
    • Multiple sclerosis: distribution of inflammatory cells in newly forming lesions
    • Henderson A.P., Barnett M.H., Parratt J.D., Prineas J.W. Multiple sclerosis: distribution of inflammatory cells in newly forming lesions. Ann. Neurol. 2009, 66:739.
    • (2009) Ann. Neurol. , vol.66 , pp. 739
    • Henderson, A.P.1    Barnett, M.H.2    Parratt, J.D.3    Prineas, J.W.4
  • 86
    • 5144235394 scopus 로고    scopus 로고
    • Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines
    • Hohlfeld R., Wekerle H. Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc. Natl Acad. Sci. USA 2004, 101(Suppl 2):14599.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.SUPPL. 2 , pp. 14599
    • Hohlfeld, R.1    Wekerle, H.2
  • 87
    • 1942455227 scopus 로고    scopus 로고
    • A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro
    • Hori S., Ohtsuki S., Hosoya K., Nakashima E., Terasaki T. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. J. Neurochem. 2004, 89:503.
    • (2004) J. Neurochem. , vol.89 , pp. 503
    • Hori, S.1    Ohtsuki, S.2    Hosoya, K.3    Nakashima, E.4    Terasaki, T.5
  • 89
    • 39749173780 scopus 로고    scopus 로고
    • The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells
    • Ifergan I., Kebir H., Bernard M., Wosik K., Dodelet-Devillers A., Cayrol R., Arbour N., Prat A. The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain 2008, 131:785.
    • (2008) Brain , vol.131 , pp. 785
    • Ifergan, I.1    Kebir, H.2    Bernard, M.3    Wosik, K.4    Dodelet-Devillers, A.5    Cayrol, R.6    Arbour, N.7    Prat, A.8
  • 94
    • 34548825637 scopus 로고    scopus 로고
    • The oxidase activity of vascular adhesion protein-1 (VAP-1) induces endothelial E- and P-selectins and leukocyte binding
    • Jalkanen S., Karikoski M., Mercier N., Koskinen K., Henttinen T., Elima K., Salmivirta K., Salmi M. The oxidase activity of vascular adhesion protein-1 (VAP-1) induces endothelial E- and P-selectins and leukocyte binding. Blood 2007, 110:1864.
    • (2007) Blood , vol.110 , pp. 1864
    • Jalkanen, S.1    Karikoski, M.2    Mercier, N.3    Koskinen, K.4    Henttinen, T.5    Elima, K.6    Salmivirta, K.7    Salmi, M.8
  • 95
    • 37549031262 scopus 로고    scopus 로고
    • VAP-1 and CD73, endothelial cell surface enzymes in leukocyte extravasation
    • Jalkanen S., Salmi M. VAP-1 and CD73, endothelial cell surface enzymes in leukocyte extravasation. Arterioscler. Thromb. Vasc. Biol. 2008, 28:18.
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 18
    • Jalkanen, S.1    Salmi, M.2
  • 99
    • 0037100456 scopus 로고    scopus 로고
    • Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis
    • Kerfoot S.M., Kubes P. Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis. J. Immunol. 2002, 169:1000.
    • (2002) J. Immunol. , vol.169 , pp. 1000
    • Kerfoot, S.M.1    Kubes, P.2
  • 100
    • 33646468932 scopus 로고    scopus 로고
    • Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis
    • Kerfoot S.M., Norman M.U., Lapointe B.M., Bonder C.S., Zbytnuik L., Kubes P. Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J. Immunol. 2006, 176:6225.
    • (2006) J. Immunol. , vol.176 , pp. 6225
    • Kerfoot, S.M.1    Norman, M.U.2    Lapointe, B.M.3    Bonder, C.S.4    Zbytnuik, L.5    Kubes, P.6
  • 101
    • 0141926694 scopus 로고    scopus 로고
    • Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination
    • Kirk J., Plumb J., Mirakhur M., McQuaid S. Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination. J. Pathol. 2003, 201:319.
    • (2003) J. Pathol. , vol.201 , pp. 319
    • Kirk, J.1    Plumb, J.2    Mirakhur, M.3    McQuaid, S.4
  • 104
    • 0033973460 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier
    • Kniesel U., Wolburg H. Tight junctions of the blood-brain barrier. Cell. Mol. Neurobiol. 2000, 20:57.
    • (2000) Cell. Mol. Neurobiol. , vol.20 , pp. 57
    • Kniesel, U.1    Wolburg, H.2
  • 105
    • 37349018717 scopus 로고    scopus 로고
    • Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions
    • Koning N., Bo L., Hoek R.M., Huitinga I. Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions. Ann. Neurol. 2007, 62:504.
    • (2007) Ann. Neurol. , vol.62 , pp. 504
    • Koning, N.1    Bo, L.2    Hoek, R.M.3    Huitinga, I.4
  • 106
    • 3843101531 scopus 로고    scopus 로고
    • Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitro
    • Kraus J., Ling A.K., Hamm S., Voigt K., Oschmann P., Engelhardt B. Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitro. Ann. Neurol. 2004, 56:192.
    • (2004) Ann. Neurol. , vol.56 , pp. 192
    • Kraus, J.1    Ling, A.K.2    Hamm, S.3    Voigt, K.4    Oschmann, P.5    Engelhardt, B.6
  • 108
    • 73349140140 scopus 로고    scopus 로고
    • CNS pericytes: concepts, misconceptions, and a way out
    • Krueger M., Bechmann I. CNS pericytes: concepts, misconceptions, and a way out. Glia 2010, 58:1.
    • (2010) Glia , vol.58 , pp. 1
    • Krueger, M.1    Bechmann, I.2
  • 109
    • 27744464054 scopus 로고    scopus 로고
    • Critical role of actin in modulating BBB permeability
    • Lai C.H., Kuo K.H., Leo J.M. Critical role of actin in modulating BBB permeability. Brain Res. Brain Res. Rev. 2005, 50:7.
    • (2005) Brain Res. Brain Res. Rev. , vol.50 , pp. 7
    • Lai, C.H.1    Kuo, K.H.2    Leo, J.M.3
  • 110
    • 33847732713 scopus 로고    scopus 로고
    • Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion
    • Lalor P.F., Sun P.J., Weston C.J., Martin-Santos A., Wakelam M.J., Adams D.H. Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion. Hepatology 2007, 45:465.
    • (2007) Hepatology , vol.45 , pp. 465
    • Lalor, P.F.1    Sun, P.J.2    Weston, C.J.3    Martin-Santos, A.4    Wakelam, M.J.5    Adams, D.H.6
  • 111
    • 40949088574 scopus 로고    scopus 로고
    • The control of endothelial cell functions by adherens junctions
    • Lampugnani M.G., Dejana E. The control of endothelial cell functions by adherens junctions. Novartis Found. Symp. 2007, 283:4.
    • (2007) Novartis Found. Symp. , vol.283 , pp. 4
    • Lampugnani, M.G.1    Dejana, E.2
  • 112
    • 23844506444 scopus 로고    scopus 로고
    • Multiple sclerosis pathology: evolution of pathogenetic concepts
    • Lassmann H. Multiple sclerosis pathology: evolution of pathogenetic concepts. Brain Pathol. 2005, 15:217.
    • (2005) Brain Pathol. , vol.15 , pp. 217
    • Lassmann, H.1
  • 113
    • 0035096330 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy
    • Lassmann H., Bruck W., Lucchinetti C. Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol. Med. 2001, 7:115.
    • (2001) Trends Mol. Med. , vol.7 , pp. 115
    • Lassmann, H.1    Bruck, W.2    Lucchinetti, C.3
  • 114
    • 34249879813 scopus 로고    scopus 로고
    • Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems
    • Lee G., Babakhanian K., Ramaswamy M., Prat A., Wosik K., Bendayan R. Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems. Pharm. Res. 2007, 24:1262.
    • (2007) Pharm. Res. , vol.24 , pp. 1262
    • Lee, G.1    Babakhanian, K.2    Ramaswamy, M.3    Prat, A.4    Wosik, K.5    Bendayan, R.6
  • 115
    • 14244257768 scopus 로고    scopus 로고
    • Hydrogen peroxide-induced alterations of tight junction proteins in bovine brain microvascular endothelial cells
    • Lee H.S., Namkoong K., Kim D.H., Kim K.J., Cheong Y.H., Kim S.S., Lee W.B., Kim K.Y. Hydrogen peroxide-induced alterations of tight junction proteins in bovine brain microvascular endothelial cells. Microvasc. Res. 2004, 68:231.
    • (2004) Microvasc. Res. , vol.68 , pp. 231
    • Lee, H.S.1    Namkoong, K.2    Kim, D.H.3    Kim, K.J.4    Cheong, Y.H.5    Kim, S.S.6    Lee, W.B.7    Kim, K.Y.8
  • 117
    • 33846134731 scopus 로고    scopus 로고
    • Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis
    • Leech S., Kirk J., Plumb J., McQuaid S. Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis. Neuropathol. Appl. Neurobiol. 2007, 33:86.
    • (2007) Neuropathol. Appl. Neurobiol. , vol.33 , pp. 86
    • Leech, S.1    Kirk, J.2    Plumb, J.3    McQuaid, S.4
  • 118
    • 34548230927 scopus 로고    scopus 로고
    • Getting to the site of inflammation: the leukocyte adhesion cascade updated
    • Ley K., Laudanna C., Cybulsky M.I., Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat. Rev. Immunol. 2007, 7:678.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 678
    • Ley, K.1    Laudanna, C.2    Cybulsky, M.I.3    Nourshargh, S.4
  • 119
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • Lindahl P., Johansson B.R., Leveen P., Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997, 277:242.
    • (1997) Science , vol.277 , pp. 242
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3    Betsholtz, C.4
  • 120
    • 0034658704 scopus 로고    scopus 로고
    • Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase C
    • Lippoldt A., Liebner S., Andbjer B., Kalbacher H., Wolburg H., Haller H., Fuxe K. Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase C. NeuroReport 2000, 11:1427.
    • (2000) NeuroReport , vol.11 , pp. 1427
    • Lippoldt, A.1    Liebner, S.2    Andbjer, B.3    Kalbacher, H.4    Wolburg, H.5    Haller, H.6    Fuxe, K.7
  • 121
    • 30044447736 scopus 로고    scopus 로고
    • Immune cell migration in inflammation: present and future therapeutic targets
    • Luster A.D., Alon R., von Andrian U.H. Immune cell migration in inflammation: present and future therapeutic targets. Nat. Immunol. 2005, 6:1182.
    • (2005) Nat. Immunol. , vol.6 , pp. 1182
    • Luster, A.D.1    Alon, R.2    von Andrian, U.H.3
  • 122
    • 0037356713 scopus 로고    scopus 로고
    • Longitudinal study of chemokine receptor expression on peripheral lymphocytes in multiple sclerosis: CXCR3 upregulation is associated with relapse
    • Mahad D.J., Lawry J., Howell S.J., Woodroofe M.N. Longitudinal study of chemokine receptor expression on peripheral lymphocytes in multiple sclerosis: CXCR3 upregulation is associated with relapse. Mult. Scler. 2003, 9:189.
    • (2003) Mult. Scler. , vol.9 , pp. 189
    • Mahad, D.J.1    Lawry, J.2    Howell, S.J.3    Woodroofe, M.N.4
  • 123
    • 33947543465 scopus 로고    scopus 로고
    • Inflammatory cell migration into the central nervous system: a few new twists on an old tale
    • Man S., Ubogu E.E., Ransohoff R.M. Inflammatory cell migration into the central nervous system: a few new twists on an old tale. Brain Pathol. 2007, 17:243.
    • (2007) Brain Pathol. , vol.17 , pp. 243
    • Man, S.1    Ubogu, E.E.2    Ransohoff, R.M.3
  • 125
    • 0035937810 scopus 로고    scopus 로고
    • Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells
    • Martinez-Estrada O.M., Villa A., Breviario F., Orsenigo F., Dejana E., Bazzoni G. Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells. J. Biol. Chem. 2001, 276:9291.
    • (2001) J. Biol. Chem. , vol.276 , pp. 9291
    • Martinez-Estrada, O.M.1    Villa, A.2    Breviario, F.3    Orsenigo, F.4    Dejana, E.5    Bazzoni, G.6
  • 126
    • 0028574882 scopus 로고
    • Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in the spinal cord of rats during acute experimental allergic encephalomyelitis
    • Matsuda M., Tsukada N., Koh C.S., Iwahashi T., Shimada K., Yanagisawa N. Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in the spinal cord of rats during acute experimental allergic encephalomyelitis. Autoimmunity 1994, 19:15.
    • (1994) Autoimmunity , vol.19 , pp. 15
    • Matsuda, M.1    Tsukada, N.2    Koh, C.S.3    Iwahashi, T.4    Shimada, K.5    Yanagisawa, N.6
  • 127
    • 0038273906 scopus 로고    scopus 로고
    • Holey barrier: claudins and the regulation of brain endothelial permeability
    • Matter K., Balda M.S. Holey barrier: claudins and the regulation of brain endothelial permeability. J. Cell Biol. 2003, 161:459.
    • (2003) J. Cell Biol. , vol.161 , pp. 459
    • Matter, K.1    Balda, M.S.2
  • 128
    • 0032966616 scopus 로고    scopus 로고
    • Serum soluble adhesion molecules in multiple sclerosis: raised sVCAM-1, sICAM-1 and sE-selectin in primary progressive disease
    • McDonnell G.V., McMillan S.A., Douglas J.P., Droogan A.G., Hawkins S.A. Serum soluble adhesion molecules in multiple sclerosis: raised sVCAM-1, sICAM-1 and sE-selectin in primary progressive disease. J. Neurol. 1999, 246:87.
    • (1999) J. Neurol. , vol.246 , pp. 87
    • McDonnell, G.V.1    McMillan, S.A.2    Douglas, J.P.3    Droogan, A.G.4    Hawkins, S.A.5
  • 129
    • 0032524504 scopus 로고    scopus 로고
    • Raised CSF levels of soluble adhesion molecules across the clinical spectrum of multiple sclerosis
    • McDonnell G.V., McMillan S.A., Douglas J.P., Droogan A.G., Hawkins S.A. Raised CSF levels of soluble adhesion molecules across the clinical spectrum of multiple sclerosis. J. Neuroimmunol. 1998, 85:186.
    • (1998) J. Neuroimmunol. , vol.85 , pp. 186
    • McDonnell, G.V.1    McMillan, S.A.2    Douglas, J.P.3    Droogan, A.G.4    Hawkins, S.A.5
  • 130
    • 34548133584 scopus 로고    scopus 로고
    • Multiple sclerosis: a complicated picture of autoimmunity
    • McFarland H.F., Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat. Immunol. 2007, 8:913.
    • (2007) Nat. Immunol. , vol.8 , pp. 913
    • McFarland, H.F.1    Martin, R.2
  • 131
    • 33744969133 scopus 로고    scopus 로고
    • CNS dendritic cells: critical participants in CNS inflammation?
    • McMahon E.J., Bailey S.L., Miller S.D. CNS dendritic cells: critical participants in CNS inflammation?. Neurochem. Int. 2006, 49:195.
    • (2006) Neurochem. Int. , vol.49 , pp. 195
    • McMahon, E.J.1    Bailey, S.L.2    Miller, S.D.3
  • 132
    • 59749101668 scopus 로고    scopus 로고
    • The effects of blood-brain barrier disruption on glial cell function in multiple sclerosis
    • McQuaid S., Cunnea P., McMahon J., FitzGerald U. The effects of blood-brain barrier disruption on glial cell function in multiple sclerosis. Biochem. Soc. Trans. 2009, 37:329.
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 329
    • McQuaid, S.1    Cunnea, P.2    McMahon, J.3    FitzGerald, U.4
  • 134
    • 33744908040 scopus 로고    scopus 로고
    • Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells
    • Nagasawa K., Chiba H., Fujita H., Kojima T., Saito T., Endo T., Sawada N. Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells. J. Cell. Physiol. 2006, 208:123.
    • (2006) J. Cell. Physiol. , vol.208 , pp. 123
    • Nagasawa, K.1    Chiba, H.2    Fujita, H.3    Kojima, T.4    Saito, T.5    Endo, T.6    Sawada, N.7
  • 135
    • 0141679018 scopus 로고    scopus 로고
    • Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complex
    • Naik M.U., Mousa S.A., Parkos C.A., Naik U.P. Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complex. Blood 2003, 102:2108.
    • (2003) Blood , vol.102 , pp. 2108
    • Naik, M.U.1    Mousa, S.A.2    Parkos, C.A.3    Naik, U.P.4
  • 136
    • 34748815589 scopus 로고    scopus 로고
    • Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells
    • Nakagawa S., Deli M.A., Nakao S., Honda M., Hayashi K., Nakaoke R., Kataoka Y., Niwa M. Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells. Cell. Mol. Neurobiol. 2007, 27:687.
    • (2007) Cell. Mol. Neurobiol. , vol.27 , pp. 687
    • Nakagawa, S.1    Deli, M.A.2    Nakao, S.3    Honda, M.4    Hayashi, K.5    Nakaoke, R.6    Kataoka, Y.7    Niwa, M.8
  • 137
    • 42449110795 scopus 로고    scopus 로고
    • Regulation of cell-cell adhesion by the cadherin-catenin complex
    • Nelson W.J. Regulation of cell-cell adhesion by the cadherin-catenin complex. Biochem. Soc. Trans. 2008, 36:149.
    • (2008) Biochem. Soc. Trans. , vol.36 , pp. 149
    • Nelson, W.J.1
  • 138
    • 0026393438 scopus 로고
    • Induction of blood-brain barrier characteristics in bovine brain endothelial cells by rat astroglial cells in transfilter coculture
    • Neuhaus J., Risau W., Wolburg H. Induction of blood-brain barrier characteristics in bovine brain endothelial cells by rat astroglial cells in transfilter coculture. Ann. NY Acad. Sci. 1991, 633:578.
    • (1991) Ann. NY Acad. Sci. , vol.633 , pp. 578
    • Neuhaus, J.1    Risau, W.2    Wolburg, H.3
  • 142
    • 33751534762 scopus 로고    scopus 로고
    • The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues
    • Nourshargh S., Krombach F., Dejana E. The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues. J. Leukoc. Biol. 2006, 80:714.
    • (2006) J. Leukoc. Biol. , vol.80 , pp. 714
    • Nourshargh, S.1    Krombach, F.2    Dejana, E.3
  • 143
    • 0033672942 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells
    • Nusrat A., Turner J.R., Madara J.L. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2000, 279:G851-G857.
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.279
    • Nusrat, A.1    Turner, J.R.2    Madara, J.L.3
  • 146
    • 0033565947 scopus 로고    scopus 로고
    • Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells
    • Ozaki H., Ishii K., Horiuchi H., Arai H., Kawamoto T., Okawa K., Iwamatsu A., Kita T. Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J. Immunol. 1999, 163:553.
    • (1999) J. Immunol. , vol.163 , pp. 553
    • Ozaki, H.1    Ishii, K.2    Horiuchi, H.3    Arai, H.4    Kawamoto, T.5    Okawa, K.6    Iwamatsu, A.7    Kita, T.8
  • 147
    • 33846515216 scopus 로고    scopus 로고
    • Differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: increasing evidence for the role of tight junction pathology
    • Padden M., Leech S., Craig B., Kirk J., Brankin B., McQuaid S. Differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: increasing evidence for the role of tight junction pathology. Acta Neuropathol. 2007, 113:177.
    • (2007) Acta Neuropathol. , vol.113 , pp. 177
    • Padden, M.1    Leech, S.2    Craig, B.3    Kirk, J.4    Brankin, B.5    McQuaid, S.6
  • 148
    • 4644269059 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization
    • Paik J.H., Skoura A., Chae S.S., Cowan A.E., Han D.K., Proia R.L., Hla T. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. 2004, 18:2392.
    • (2004) Genes Dev. , vol.18 , pp. 2392
    • Paik, J.H.1    Skoura, A.2    Chae, S.S.3    Cowan, A.E.4    Han, D.K.5    Proia, R.L.6    Hla, T.7
  • 151
    • 33747368249 scopus 로고    scopus 로고
    • Blood-brain barrier: structural components and function under physiologic and pathologic conditions
    • Persidsky Y., Ramirez S.H., Haorah J., Kanmogne G.D. Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J. Neuroimmune Pharmacol. 2006, 1:223.
    • (2006) J. Neuroimmune Pharmacol. , vol.1 , pp. 223
    • Persidsky, Y.1    Ramirez, S.H.2    Haorah, J.3    Kanmogne, G.D.4
  • 152
    • 0015256714 scopus 로고
    • The development of glio-vascular relationships in the rat spinal cord. An electron microscopic study
    • Phelps C.H. The development of glio-vascular relationships in the rat spinal cord. An electron microscopic study. Z. Zellforsch. Mikrosk. Anat. 1972, 128:555.
    • (1972) Z. Zellforsch. Mikrosk. Anat. , vol.128 , pp. 555
    • Phelps, C.H.1
  • 153
    • 0037083641 scopus 로고    scopus 로고
    • Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors
    • Piccio L., Rossi B., Scarpini E., Laudanna C., Giagulli C., Issekutz A.C., Vestweber D., Butcher E.C., Constantin G. Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors. J. Immunol. 2002, 168:1940.
    • (2002) J. Immunol. , vol.168 , pp. 1940
    • Piccio, L.1    Rossi, B.2    Scarpini, E.3    Laudanna, C.4    Giagulli, C.5    Issekutz, A.C.6    Vestweber, D.7    Butcher, E.C.8    Constantin, G.9
  • 154
    • 0036211141 scopus 로고    scopus 로고
    • Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis
    • Plumb J., McQuaid S., Mirakhur M., Kirk J. Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis. Brain Pathol. 2002, 12:154.
    • (2002) Brain Pathol. , vol.12 , pp. 154
    • Plumb, J.1    McQuaid, S.2    Mirakhur, M.3    Kirk, J.4
  • 156
    • 20444482731 scopus 로고    scopus 로고
    • Pathogenesis of multiple sclerosis
    • Prat A., Antel J. Pathogenesis of multiple sclerosis. Curr. Opin. Neurol. 2005, 18:225.
    • (2005) Curr. Opin. Neurol. , vol.18 , pp. 225
    • Prat, A.1    Antel, J.2
  • 157
    • 0033974426 scopus 로고    scopus 로고
    • B7 expression and antigen presentation by human brain endothelial cells: requirement for proinflammatory cytokines
    • Prat A., Biernacki K., Becher B., Antel J.P. B7 expression and antigen presentation by human brain endothelial cells: requirement for proinflammatory cytokines. J. Neuropathol. Exp. Neurol. 2000, 59:129.
    • (2000) J. Neuropathol. Exp. Neurol. , vol.59 , pp. 129
    • Prat, A.1    Biernacki, K.2    Becher, B.3    Antel, J.P.4
  • 158
    • 0035153208 scopus 로고    scopus 로고
    • Glial cell influence on the human blood-brain barrier
    • Prat A., Biernacki K., Wosik K., Antel J.P. Glial cell influence on the human blood-brain barrier. Glia 2001, 36:145.
    • (2001) Glia , vol.36 , pp. 145
    • Prat, A.1    Biernacki, K.2    Wosik, K.3    Antel, J.P.4
  • 159
    • 0030039226 scopus 로고    scopus 로고
    • Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions
    • Rajasekaran A.K., Hojo M., Huima T., Rodriguez-Boulan E. Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions. J. Cell Biol. 1996, 132:451.
    • (1996) J. Cell Biol. , vol.132 , pp. 451
    • Rajasekaran, A.K.1    Hojo, M.2    Huima, T.3    Rodriguez-Boulan, E.4
  • 160
    • 0036891091 scopus 로고    scopus 로고
    • The chemokine system in neuroinflammation: an update
    • Ransohoff R.M. The chemokine system in neuroinflammation: an update. J. Infect. Dis. 2002, 186(Suppl 2):S152-S156.
    • (2002) J. Infect. Dis. , vol.186 , Issue.SUPPL. 2
    • Ransohoff, R.M.1
  • 161
    • 34447099915 scopus 로고    scopus 로고
    • "Thinking without thinking" about natalizumab and PML
    • Ransohoff R.M. "Thinking without thinking" about natalizumab and PML. J. Neurol. Sci. 2007, 259:50.
    • (2007) J. Neurol. Sci. , vol.259 , pp. 50
    • Ransohoff, R.M.1
  • 162
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff R.M., Kivisakk P., Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 2003, 3:569.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 569
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 163
    • 33750371447 scopus 로고    scopus 로고
    • Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details
    • Rebenko-Moll N.M., Liu L., Cardona A., Ransohoff R.M. Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details. Curr. Opin. Immunol. 2006, 18:683.
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 683
    • Rebenko-Moll, N.M.1    Liu, L.2    Cardona, A.3    Ransohoff, R.M.4
  • 165
    • 0042343822 scopus 로고    scopus 로고
    • Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants
    • Reuss B., Dono R., Unsicker K. Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J. Neurosci. 2003, 23:6404.
    • (2003) J. Neurosci. , vol.23 , pp. 6404
    • Reuss, B.1    Dono, R.2    Unsicker, K.3
  • 168
    • 0026757630 scopus 로고
    • A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans
    • Salmi M., Jalkanen S. A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans. Science 1992, 257:1407.
    • (1992) Science , vol.257 , pp. 1407
    • Salmi, M.1    Jalkanen, S.2
  • 173
    • 33749004212 scopus 로고    scopus 로고
    • The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis
    • Schulz M., Engelhardt B. The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis. Cerebrospinal. Fluid Res 2005, 2:8.
    • (2005) Cerebrospinal. Fluid Res , vol.2 , pp. 8
    • Schulz, M.1    Engelhardt, B.2
  • 174
    • 0027284704 scopus 로고
    • Immunohistochemical localization of adherens junction components in blood-brain barrier microvessels of the rat
    • Schulze C., Firth J.A. Immunohistochemical localization of adherens junction components in blood-brain barrier microvessels of the rat. J. Cell Sci. 1993, 104(Pt 3):773.
    • (1993) J. Cell Sci. , vol.104 , Issue.PART 3 , pp. 773
    • Schulze, C.1    Firth, J.A.2
  • 175
    • 0027220007 scopus 로고
    • Extracellular and cerebrospinal fluids
    • Segal M.B. Extracellular and cerebrospinal fluids. J. Inherit. Metab. Dis. 1993, 16:617.
    • (1993) J. Inherit. Metab. Dis. , vol.16 , pp. 617
    • Segal, M.B.1
  • 177
    • 0027409052 scopus 로고
    • Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-alpha and blood-brain barrier damage
    • Sharief M.K., Noori M.A., Ciardi M., Cirelli A., Thompson E.J. Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-alpha and blood-brain barrier damage. J. Neuroimmunol. 1993, 43:15.
    • (1993) J. Neuroimmunol. , vol.43 , pp. 15
    • Sharief, M.K.1    Noori, M.A.2    Ciardi, M.3    Cirelli, A.4    Thompson, E.J.5
  • 178
    • 0028842163 scopus 로고
    • Measurement of immune markers in the serum and cerebrospinal fluid of multiple sclerosis patients during clinical remission
    • Shaw C.E., Dunbar P.R., Macaulay H.A., Neale T.J. Measurement of immune markers in the serum and cerebrospinal fluid of multiple sclerosis patients during clinical remission. J. Neurol. 1995, 242:53.
    • (1995) J. Neurol. , vol.242 , pp. 53
    • Shaw, C.E.1    Dunbar, P.R.2    Macaulay, H.A.3    Neale, T.J.4
  • 179
    • 0028819138 scopus 로고
    • The subarachnoid space as a site for precursor T cell proliferation and effector T cell selection in experimental autoimmune encephalomyelitis
    • Shin T., Kojima T., Tanuma N., Ishihara Y., Matsumoto Y. The subarachnoid space as a site for precursor T cell proliferation and effector T cell selection in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 1995, 56:171.
    • (1995) J. Neuroimmunol. , vol.56 , pp. 171
    • Shin, T.1    Kojima, T.2    Tanuma, N.3    Ishihara, Y.4    Matsumoto, Y.5
  • 180
    • 0035947768 scopus 로고    scopus 로고
    • Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis
    • Sixt M., Engelhardt B., Pausch F., Hallmann R., Wendler O., Sorokin L.M. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J. Cell Biol. 2001, 153:933.
    • (2001) J. Cell Biol. , vol.153 , pp. 933
    • Sixt, M.1    Engelhardt, B.2    Pausch, F.3    Hallmann, R.4    Wendler, O.5    Sorokin, L.M.6
  • 181
    • 0025301596 scopus 로고
    • Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system
    • Sobel R.A., Mitchell M.E., Fondren G. Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am. J. Pathol. 1990, 136:1309.
    • (1990) Am. J. Pathol. , vol.136 , pp. 1309
    • Sobel, R.A.1    Mitchell, M.E.2    Fondren, G.3
  • 182
    • 23044515978 scopus 로고    scopus 로고
    • Hyaluronate receptor (CD44) and integrin alpha4 (CD49d) are up-regulated on T cells during MS relapses
    • Soilu-Hanninen M., Laaksonen M., Hanninen A. Hyaluronate receptor (CD44) and integrin alpha4 (CD49d) are up-regulated on T cells during MS relapses. J. Neuroimmunol. 2005, 166:189.
    • (2005) J. Neuroimmunol. , vol.166 , pp. 189
    • Soilu-Hanninen, M.1    Laaksonen, M.2    Hanninen, A.3
  • 183
    • 70450233404 scopus 로고    scopus 로고
    • Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner
    • Sonobe Y., Takeuchi H., Kataoka K., Li H., Jin S., Mimuro M., Hashizume Y., Sano Y., Kanda T., Mizuno T., Suzumura A. Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner. J. Biol. Chem. 2009, 284:31834.
    • (2009) J. Biol. Chem. , vol.284 , pp. 31834
    • Sonobe, Y.1    Takeuchi, H.2    Kataoka, K.3    Li, H.4    Jin, S.5    Mimuro, M.6    Hashizume, Y.7    Sano, Y.8    Kanda, T.9    Mizuno, T.10    Suzumura, A.11
  • 186
    • 67650511699 scopus 로고    scopus 로고
    • Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells
    • Stamatovic S.M., Keep R.F., Wang M.M., Jankovic I., Andjelkovic A.V. Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells. J. Biol. Chem. 2009, 284:19053.
    • (2009) J. Biol. Chem. , vol.284 , pp. 19053
    • Stamatovic, S.M.1    Keep, R.F.2    Wang, M.M.3    Jankovic, I.4    Andjelkovic, A.V.5
  • 188
    • 51649122800 scopus 로고    scopus 로고
    • Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro
    • Stefanidakis M., Newton G., Lee W.Y., Parkos C.A., Luscinskas F.W. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood 2008, 112:1280.
    • (2008) Blood , vol.112 , pp. 1280
    • Stefanidakis, M.1    Newton, G.2    Lee, W.Y.3    Parkos, C.A.4    Luscinskas, F.W.5
  • 189
    • 0029952623 scopus 로고    scopus 로고
    • ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro
    • Steffen B.J., Breier G., Butcher E.C., Schulz M., Engelhardt B. ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro. Am. J. Pathol. 1996, 148:1819.
    • (1996) Am. J. Pathol. , vol.148 , pp. 1819
    • Steffen, B.J.1    Breier, G.2    Butcher, E.C.3    Schulz, M.4    Engelhardt, B.5
  • 190
    • 20844454381 scopus 로고    scopus 로고
    • Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab
    • Steinman L. Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab. Nat. Rev. Drug Discov. 2005, 4:510.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 510
    • Steinman, L.1
  • 191
    • 0023948101 scopus 로고
    • Development of membrane interactions between brain endothelial cells and astrocytes in vitro
    • Tao-Cheng J.H., Brightman M.W. Development of membrane interactions between brain endothelial cells and astrocytes in vitro. Int. J. Dev. Neurosci. 1988, 6:25.
    • (1988) Int. J. Dev. Neurosci. , vol.6 , pp. 25
    • Tao-Cheng, J.H.1    Brightman, M.W.2
  • 192
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: an immune or neurodegenerative disorder?
    • Trapp B.D., Nave K.A. Multiple sclerosis: an immune or neurodegenerative disorder?. Annu. Rev. Neurosci. 2008, 31:247.
    • (2008) Annu. Rev. Neurosci. , vol.31 , pp. 247
    • Trapp, B.D.1    Nave, K.A.2
  • 193
    • 85047682713 scopus 로고    scopus 로고
    • Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels
    • Vajkoczy P., Laschinger M., Engelhardt B. Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J. Clin. Invest. 2001, 108:557.
    • (2001) J. Clin. Invest. , vol.108 , pp. 557
    • Vajkoczy, P.1    Laschinger, M.2    Engelhardt, B.3
  • 194
    • 33750799589 scopus 로고    scopus 로고
    • Extensive extracellular matrix depositions in active multiple sclerosis lesions
    • van Horssen J., Bo L., Dijkstra C.D., de Vries H.E. Extensive extracellular matrix depositions in active multiple sclerosis lesions. Neurobiol. Dis. 2006, 24:484.
    • (2006) Neurobiol. Dis. , vol.24 , pp. 484
    • van Horssen, J.1    Bo, L.2    Dijkstra, C.D.3    de Vries, H.E.4
  • 195
    • 35448936315 scopus 로고    scopus 로고
    • The extracellular matrix in multiple sclerosis pathology
    • van Horssen J., Dijkstra C.D., de Vries H.E. The extracellular matrix in multiple sclerosis pathology. J. Neurochem. 2007, 103:1293.
    • (2007) J. Neurochem. , vol.103 , pp. 1293
    • van Horssen, J.1    Dijkstra, C.D.2    de Vries, H.E.3
  • 196
    • 4143102440 scopus 로고    scopus 로고
    • The role of claudins in determining paracellular charge selectivity
    • Van Itallie C.M., Anderson J.M. The role of claudins in determining paracellular charge selectivity. Proc. Am. Thorac. Soc. 2004, 1:38.
    • (2004) Proc. Am. Thorac. Soc. , vol.1 , pp. 38
    • Van Itallie, C.M.1    Anderson, J.M.2
  • 197
    • 67049099173 scopus 로고    scopus 로고
    • Preactive lesions in multiple sclerosis
    • van der Valk, Amor S. Preactive lesions in multiple sclerosis. Curr. Opin. Neurol. 2009, 22:207.
    • (2009) Curr. Opin. Neurol. , vol.22 , pp. 207
    • van der Valk1    Amor, S.2
  • 198
    • 0029016245 scopus 로고
    • T lymphocyte adhesion to human brain pericytes is mediated via very late antigen-4/vascular cell adhesion molecule-1 interactions
    • Verbeek M.M., Westphal J.R., Ruiter D.J., de Waal R.M. T lymphocyte adhesion to human brain pericytes is mediated via very late antigen-4/vascular cell adhesion molecule-1 interactions. J. Immunol. 1995, 154:5876.
    • (1995) J. Immunol. , vol.154 , pp. 5876
    • Verbeek, M.M.1    Westphal, J.R.2    Ruiter, D.J.3    de Waal, R.M.4
  • 200
    • 0038730794 scopus 로고    scopus 로고
    • Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view
    • Vorbrodt A.W., Dobrogowska D.H. Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view. Brain Res. Brain Res. Rev. 2003, 42:221.
    • (2003) Brain Res. Brain Res. Rev. , vol.42 , pp. 221
    • Vorbrodt, A.W.1    Dobrogowska, D.H.2
  • 201
    • 0033491912 scopus 로고    scopus 로고
    • Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition
    • Wachtel M., Frei K., Ehler E., Fontana A., Winterhalter K., Gloor S.M. Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition. J. Cell Sci. 1999, 112(Pt 23):4347.
    • (1999) J. Cell Sci. , vol.112 , Issue.PART 23 , pp. 4347
    • Wachtel, M.1    Frei, K.2    Ehler, E.3    Fontana, A.4    Winterhalter, K.5    Gloor, S.M.6
  • 202
    • 0028053052 scopus 로고
    • Expression of immunologically relevant endothelial cell activation antigens on isolated central nervous system microvessels from patients with multiple sclerosis
    • Washington R., Burton J., Todd R.F., Newman W., Dragovic L., Dore-Duffy P. Expression of immunologically relevant endothelial cell activation antigens on isolated central nervous system microvessels from patients with multiple sclerosis. Ann. Neurol. 1994, 35:89.
    • (1994) Ann. Neurol. , vol.35 , pp. 89
    • Washington, R.1    Burton, J.2    Todd, R.F.3    Newman, W.4    Dragovic, L.5    Dore-Duffy, P.6
  • 203
    • 33751074192 scopus 로고    scopus 로고
    • Biomarkers indicative of blood-brain barrier disruption in multiple sclerosis
    • Waubant E. Biomarkers indicative of blood-brain barrier disruption in multiple sclerosis. Dis. Markers 2006, 22:235.
    • (2006) Dis. Markers , vol.22 , pp. 235
    • Waubant, E.1
  • 204
    • 33845380864 scopus 로고    scopus 로고
    • Re-solving the cadherin-catenin-actin conundrum
    • Weis W.I., Nelson W.J. Re-solving the cadherin-catenin-actin conundrum. J. Biol. Chem. 2006, 281:35593.
    • (2006) J. Biol. Chem. , vol.281 , pp. 35593
    • Weis, W.I.1    Nelson, W.J.2
  • 205
    • 2642615752 scopus 로고    scopus 로고
    • Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells
    • Wojciak-Stothard B., Entwistle A., Garg R., Ridley A.J. Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells. J. Cell. Physiol. 1998, 176:150.
    • (1998) J. Cell. Physiol. , vol.176 , pp. 150
    • Wojciak-Stothard, B.1    Entwistle, A.2    Garg, R.3    Ridley, A.J.4
  • 207
    • 0036627211 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier: development, composition and regulation
    • Wolburg H., Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul. Pharmacol. 2002, 38:323.
    • (2002) Vascul. Pharmacol. , vol.38 , pp. 323
    • Wolburg, H.1    Lippoldt, A.2
  • 208
    • 77649192491 scopus 로고    scopus 로고
    • Choroid plexus: biology and pathology
    • Wolburg H., Paulus W. Choroid plexus: biology and pathology. Acta Neuropathol. 2010, 119:75.
    • (2010) Acta Neuropathol. , vol.119 , pp. 75
    • Wolburg, H.1    Paulus, W.2
  • 209
    • 0026650384 scopus 로고
    • Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide
    • Wong D., Dorovini-Zis K. Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide. J. Neuroimmunol. 1992, 39:11.
    • (1992) J. Neuroimmunol. , vol.39 , pp. 11
    • Wong, D.1    Dorovini-Zis, K.2
  • 210
    • 0033030208 scopus 로고    scopus 로고
    • In vitro adhesion and migration of T lymphocytes across monolayers of human brain microvessel endothelial cells: regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1
    • Wong D., Prameya R., Dorovini-Zis K. In vitro adhesion and migration of T lymphocytes across monolayers of human brain microvessel endothelial cells: regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1. J. Neuropathol. Exp. Neurol. 1999, 58:138.
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 138
    • Wong, D.1    Prameya, R.2    Dorovini-Zis, K.3
  • 211
    • 0033049920 scopus 로고    scopus 로고
    • Cadherin-5 redistribution at sites of TNF-alpha and IFN-gamma-induced permeability in mesenteric venules
    • Wong R.K., Baldwin A.L., Heimark R.L. Cadherin-5 redistribution at sites of TNF-alpha and IFN-gamma-induced permeability in mesenteric venules. Am. J. Physiol. 1999, 276:H736-H748.
    • (1999) Am. J. Physiol. , vol.276
    • Wong, R.K.1    Baldwin, A.L.2    Heimark, R.L.3
  • 215
    • 33947493391 scopus 로고    scopus 로고
    • Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    • Yang Y., Estrada E.Y., Thompson J.F., Liu W., Rosenberg G.A. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J. Cereb. Blood Flow Metab. 2007, 27:697.
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 697
    • Yang, Y.1    Estrada, E.Y.2    Thompson, J.F.3    Liu, W.4    Rosenberg, G.A.5
  • 216
    • 0008376732 scopus 로고    scopus 로고
    • Interferon beta in the treatment of multiple sclerosis: mechanisms of action
    • Yong V.W., Chabot S., Stuve O., Williams G. Interferon beta in the treatment of multiple sclerosis: mechanisms of action. Neurology 1998, 51:682.
    • (1998) Neurology , vol.51 , pp. 682
    • Yong, V.W.1    Chabot, S.2    Stuve, O.3    Williams, G.4
  • 217
    • 0032977248 scopus 로고    scopus 로고
    • Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin
    • Youakim A., Ahdieh M. Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am. J. Physiol. 1999, 276:G1279-G1288.
    • (1999) Am. J. Physiol. , vol.276
    • Youakim, A.1    Ahdieh, M.2
  • 218
    • 33645525311 scopus 로고    scopus 로고
    • Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
    • Zhadanov A.B., Provance D.W., Speer C.A., Coffin J.D., Goss D., Blixt J.A., Reichert C.M., Mercer J.A. Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development. Curr. Biol. 1999, 9:880.
    • (1999) Curr. Biol. , vol.9 , pp. 880
    • Zhadanov, A.B.1    Provance, D.W.2    Speer, C.A.3    Coffin, J.D.4    Goss, D.5    Blixt, J.A.6    Reichert, C.M.7    Mercer, J.A.8
  • 219
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57:178.
    • (2008) Neuron , vol.57 , pp. 178
    • Zlokovic, B.V.1


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