Jaks, Stats and the immune system

Immunobiology

Volumn 198, Issue 1-3, 1997, Pages 99-111

  Decker, Thomas ^a   Meinke, Andreas ^a  

^a Vienna Biocenter   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR;

ARTICLE; CELL NUCLEUS; GENE EXPRESSION; IMMUNE SYSTEM; IMMUNOREGULATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0031436585     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-2985(97)80031-9     Document Type: Article

References (67)

1. SCHINDLER, C., and J. E. DARNELL, Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64: 621-651.
2. DARNELL, J. E., Jr., I. M. KERR, and G. R. STARK. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415-1421.
3. MULLER, M., J. BRISCOE, C. LAXTON, D. GUSCHIN, A. ZIEMIECKI, O. SILVENNOINEN, A. G. HARPUR, G. BARBIERI, B. A. WITTHUHN, C. SCHINDLER, and et al. 1993. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 366: 129-135.
4. VAIMAN, D., S. PIETROKOVSKY, B. COHEN, P. BENECH, and J. CHEBATH. 1990. Synergism of type I and type II interferons in stimulating the activity of the same DNA enhancer. FEBS-Lett 265: 12-16.
5. VELAZQUEZ, L., M. FELLOUS, G. R. STARK, and S. PELLEGRINI. 1992. A protein tyrosine kinase in the interferon alpha/beta signalling pathway. Cell 70: 313-322.
6. WATLING, D., D. GUSCHIN, M. MULLER, O. SILVENNOINEN, B. A. WITTHUHN, F. W. QUELLE, N. C. ROGERS, C. SCHINDLER, G. R. STARK, J. N. IHLE, and et al. 1993. Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Natur 366: 166-170.
7. IHLE, J. N., and I. M. KERR. 1995. Jaks and Stats in signalling by the cytokine receptor superfamily. Trends-Genet 11: 69-74.
8. KOTENKO, S. V., L. S. IZOTOVA, B. P. POLLACK, T. M. MARIANO, R. J. DONELLY, G. MUTHUKUMARAN, J. R. COOK, G. GAROTTA, O. SILVENNOINEN, J. N. IHLE, and et al. 1995. Interaction between the components of the interferon gamma receptor complex. J-Biol-Chem 270: 20915-20921.
9. GREENLUND, A. C., M. A. FARRAR, B. L. VIVIANO, and R. D. SCHREIBER. 1994. Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). EMBO-J 13: 1591-1600.
10. GREENLUND, A. C., M. O. MORALES, B. L. VIVIANO, H. YAN, J. KROLEWSKI, and R. D. SCHREIBER. 1995. Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity 2: 677-687.
11. DECKER, T., P. KOVARIK, and A. MEINKE. 1997. Gas elements: a few nucleotides with a major impact on cytokine-induced gene expression. J. Interferon Cytokine Res. 17: 121-134.
12. FUJITANI, Y., M. HIBI, T. FUKADA, M. TAKAHASHI-TEZUKA, H. YOSHIDA, T. YAMAGUCHI, K. SUGIYAMA, Y. YAMANAKA, K. NAKAJIMA, and T. HIRANO. 1997. An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT. Oncogene 14: 751-761.
13. NICHOLSON, S. E., R. STARR, U. NOVAK, D. J. HILTON, and J. E. LAYTON. 1996. Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells. J-Biol-Chem 271: 26947-26953.
14. TIAN, S. S., P. TAPLEY, C. SINCICH, R. B. STEIN, J. ROSEN, and P. LAMB. 1996. Multiple signalling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes. Blood 88: 4435-4444.
15. WANG, Y. D., K. WONG, and W. I. WOOD. 1995. Intracellular tyrosine residues of the human growth hormone receptor are not required for the signalling of proliferation or Jak-STAT activation. J-Biol-Chem 270:7021-7024.
16. LEAMAN, D. W., S. LEUNG, X. LI, and G. R. STARK. 1996. Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB-J 10: 1578-1588.
17. PARK, O. K., T. S. SCHAEFER, and D. NATHANS. 1996. In vitro activation of Stat3 by epidermal growth factor receptor kinase. Proc-Natl-Acad-Sci-U-S-A 93: 13704-13708.
18. VINKEMEIER, U., S. L. COHEN, I. MOAREFI, B. T. CHAIT, J. KURIYAN, and J. E. DARNELL, Jr. 1996. DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO-J 15: 5616-5626.
19. BRISCOE, J., F. KOHLHUBER, and M. MULLER. 1996. JAKs and STATs branch out. Trends Cell. Biol. 6: 336-340.
20. CHO, S. S., C. M. BACON, C. SUDARSHAN, R. C. REES, D. FINBLOOM, R. PINE, and J. J. O'SHEA. 1996. Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosporylation. J-Immunol 157: 4781-4789.
21. BOULTON, T. G., Z. ZHONG, Z. WEN, J. E. DARNELL, Jr., N. STAHL, and G. D. YANCOPOULOS. 1995. STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc-Natl-Aca-Sci-U-S-A 92: 6915-6919.
22. LUTTICKEN C., P. COFFER, J. YUAN, C. SCHWARTZ, E. CALDENHOVEN, C. SCHINDLER, W. KRUIJER, P. C. HEINRICH, and F. HORN. 1995. Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. FEBS-Lett 360: 137-143.
23. WEN, Z., Z. ZHONG, and J. E. DARNELL, Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82: 241-250.
24. ZHAN, X., J. BLENIS, H. C. LI, C. SCHINDLER, and S. CHEN KIANG. 1995. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 267: 1990-1994.
25. BEADLING, C., J. NG, J. W. BABBAGE, and D. A. CANTRELL. 1996. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. EMBO J. 15: 1902-1913.
26. EILERS, A., D. GEORGELLIS, B. KLOSE, C. SCHINDLER, A. ZIEMIECKI, A. G. HARPUR, A. F. WILKS, and T. DECKER. 1995. Differentiation-regulated serine phosphorylation of STAT1 promotes GAF activation in macrophages. Mol-Cell-Biol 15: 3579-3586.
27. DAVID, M. E. R. PETRICOIN, C. BENJAMIN, R. PINE, M. J. WEBER, and A. C. LARNER. 1995. Requirement for MAP kinase (EKR2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science 269: 1721-1723.
28. STOCKLIN, E., M. WISSLER, F. GOUILLEUX, and B. GRONER. 1996. Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383: 726-728.
29. BHATTACHARYA, S., R. ECKNER, S. GROSSMAN, E. OLDREAD, Z. ARANY, A. D'ANDREA, and D. M. LIVINGSTON. 1996. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature 383: 344-347.
30. ZHANG, J. J., U. VINKEMEYER, W. GU, D. CHAKRAVARTI, C. M. HORVATH, and J. E. DARNELL, Jr. 1996. Two contact regions between Stat1 and CBP/p300 in interferon γ signalling. Proc. Natl. Acad. Sci. USA 93: 15092-15096.
31. DAVID, M., H. E. CHEN, S. GOELZ, A. C. LARNER, and B. G. NEEL. 1995. Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol-Cell-Biol 15: 7050-7058.
32. JIAO, H., K. BERRADA, W. YANG, M. TABRIZI, L. C. PLATANIAS, and T. YI. 1996. Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol-Cell-Biol 16: 6985-69992.
33. KLINGMULLER, U., U. LORENZ, L. C. CANTLEY, B. G. NEEL, and H. F. LODISH. 1995. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80: 729-738.
34. KIM, T. K., and T. MANIATIS. 1996. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science 273: 1717-1719.
35. DAVID, M., P. M. GRIMLEY, D. S. FINBLOOM, and A. C. LARNER. 1993. A nuclear tyrosine phosphatase downregulates interferon-induced gene expression. Mol. Cell. Biol. 13: 7515-7521.
36. HASPEL, R. L., M. SALDITT-GEORGIEFF, and J. E. DARNELL, Jr. 1996. The rapid inactivation of nucklear tyrosine-phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J. 15: 6262-6268.
37. ALI, S., Z. CHEN, J.-J. LEBRUN, W. VOGEL, A. KHARITONENKOV, P. A. KELLY, and A. ULLRICH. 1996. PTP1D is a positive regulator of the prolactin signal leading to β-Casein promoter activation. EMBO J. 15: 135-142.
38. DAVID, M., G. ZHOU, R. PINE, J. E. DIXON, and A. C. LARNER. 1996. The SH2 domain-containing tyrosine phosphatase PTP1D is required for interferon alpha/beta-induced gene expression. J-Biol-Chem 271: 15862-15865.
39. BROMBERG, J. F., C. M. HORVATH, Z. WEN, R. D. SCHREIBER, and J. E. DARNELL, Jr. 1996. Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc- Natl-Acad-Sci-U-S-A 93: 7673-7678.
40. HORVATH, C. M., and J. E. DARNELL, Jr. 1996. The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein. J-Virol 70: 647-650.
41. BRISCOE, J., N. C. ROGERS, B. A. WITTHUHN, D. WATLING, A. G. HARPUR, A. F. WILKS, G. R. STARK, J. N. IHLE, and I. M. KERR. 1996. Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but on an antiviral state. EMBO-J 15: 799-809.
42. DURBIN, J. E., R. HACKENMILLER, M. C. SIMON, and D. E. LEVY. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84: 443-450.
43. MERAZ, M. A., J. M. WHITE, K. C. SHEEHAN, E. A. BACH, S. J. RODIG, A. S. DIGHE, D. H. KAPLAN, J. K. RILEY, A. C. GREENLUND, D. CAMPBELL, K. CARVER MOORE, R. N. DUBOIS, R. CLARK, M. AGUET, and R. D. SCHREIBER. 1996. Targeted discruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signalling pathway. Cell 84: 431-442.
44. GUSCHIN, D., N. ROGERS, J. BRISCOE, B. WITTHUHN, D. WATLING, F. HORN, S. PELLEGRINI, K. YASUKAWA, P. HEINRICH, G. R. STARK, and et al. 1995. A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in reponse to interleukin-6. EMBO-J 14: 1421-1429.
45. WATANABE, S., and K.-I. ARAI. 1996. Roles of the JAK-STAT system in signal transduction via cytokine receptors. Curr. Opin. Genet. Dev. 6: 587-596.
46. EYNON, E. E. K. KUIDA, and R. A. FLAVELL. Discruption of cytokine signalling in lymphoid development: unique contributions of the common cytokine gamma chain and the Jak3 kinase. J. Interferon Cytokine Res.
47. MACCHI, P., A. VILLA, S. GILLANI, M. G. SACCO, A. FRATTINI, F. PORTA, A. G. UGAZIO, J. A. JOHNSTON, F. CANDOTTI, J. J. O'SHEA, and et al. 1995. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 376: 65-68.
48. RUSSEL, S. M., N. TAYEBI, H. NAKAJIMA, M. C. RIEDY, J. L. ROBERTS, M. J. AMAN, T.-S. MIGONE, M. NOGUCHI, M. L. MARKERT, R. H. BUCKLEY, J. J. O'SHEA, and W. J. LEONARD. 1995. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270: 797-800.
49. BACON, C. M., D. W. MCVICAR, J. R. ORTALDO, R. C. REES, J. J. O'SHEA, and J. A. JOHNSTON. 1995. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J-Exp-Med 181: 399-404.
50. FINBLOOM, D. S., and K. D. WINESTOCK. 1995. IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. J-Immunol 155: 1079-1090.
51. PARK, C., S. LI, A. M. PABLO, S. STREHLOW, and C. SCHINDLER. 1996. The role of Stat2 in signal transduction. Eur. Cytokine Netw. 7: 521.
52. NAKAJIMA, K., Y. YAMANAKA, K. NAKAE, H. KOJIMA, M. ICHIBA, N. KIUCHI, T. KITAOKA, T. FUKADA, M. HIBI, and T. HIRANO. 1996. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO-J 15: 3651-3658.
53. Y. YAMANAKA, K. NAKAJIMA, T. FUKADA, M. HIBI, and T. HIRANO. 1996. Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation. EMBO-J 15: 1557-1565.
54. TAKEDA, K., K. NOGUCHI, S. WEI, T. TANAKA, M. MATSUMOTO, N. YOSHIDA, T. KISHIMOTO, S. AKIRA. 1997. Targeted discruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA 94: 3801-3804.
55. KAPLAN, M. H., Y. L. SUN, T. HOEY, and M. J. GRUSBY. 1996. Impaired IL-12 responses and enhaced development of Th2 cells in Stat4-deficient mice. Nature 382: 174-177.
56. THIERFELDER, W. E., J. M. VAN DEURSEN, K. YAMAMOTO, R. A. TRIPP, S. R. SARAWAR, R. T. CARSON, M. Y. SANGSTER, D. A. VIGNALI, P. C. DOHERTY, G. C. GROSVELD, and J. N. IHLE. 1996. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382: 171-174.
57. MUI, A. L., H. WAKAO, A. M. O'FARRELL, N. HARADA, and A. MIYAJIMA. 1995. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO-J 14: 1166-1175.
58. GRONER, B., and F. GOUILLEUX. 1995. Prolactin-mediated gene activation in mammary epithelial cells. Curr-Opin-Genet-Dev 5: 587-594.
59. AZAM, M., H. ERDJUMENT BROMAGE, B. L. KREIDER, M. XIA, F. QUELLE, R. BASU, C. SARIS, P. TEMPST, J. N. IHLE, and C. SCHINDLER. 1995. Interleukin-3 signals through multiple isoforms of Stat5. EMBO-J 14: 1402-1411.
60. MEINKE A., F. BARAHMAND-POUR, S. WÖHRL, D. STOIBER, and T. DECKER. 1996. Activation of different Stat5 isoform contributes to cell-type-restricted signalling in response to interferons. Mol. Cell. Biol. 16: 6937-6944.
61. MELLITZER G., O. WESSELY, T. DECKER, A. MEINKE, M. J. HAYMAN, and H. BEUG. 1996. Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Proc-Natl-Acad-Sci-U-S-A 93: 9600-9605.
62. DAMEN, J. E., H. WAKAO, A. MIYAJIMA, J. KROSL, R. K. HUMPHRIES, R. L. CUTLER, and G. KRYSTAL. 1995. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J. 14: 5557-5568.
63. MUI, A. L.-F., H. WAKAO, T. KINOSHITA, T. KITAMURA, and A. MIYAJIMA. 1996. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat: role of Stat5 in proliferation. EMBO J. 15: 2425-2431.
64. WOLDMAN, I., G. MELLITZER, M. KIESLINGER, D. BUCHHART, A. MEINKE, H. BEUG, and T. DECKER. 1997. Stat5 involvement in the differentiation response of primary chicken myeloid progenitor cells to chicken myelomonocytic growth factor. J. Immunol. 59: 877-886.
65. LIU, X., G. W. ROBINSON, K. U. WAGNER, L. GARRETT, A. WYNSHAW BORIS, and L. HENNIGHAUSEN. 1997. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes-Dev 11: 179-186.
66. SHIMODA, K., J. VAN DEURSEN, M. Y. SANGSTER, S. R. SARAWAR, R. T. CARSON, R. A. TRIPP, C. CHU, F. W. QUELLE, T. NOSAKA, D. A. VIGNALI, P. C. DOHERTY, G. GROSVELD, W. E. PAUL, and J. N. IHLE. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380: 630-633.
67. TAKEDA, K., T. TANAKA, W. SHI, M. MAKOTO, M. MINAMI, S.-I. KASHIWAMURA, K. NAKANISHI, Y. NOBUYAKI, T. KISHIMOTO, and S. AKIRA. 1996. Essential role of Stat6 in IL-4 signalling. Nature 380: 627-630.