Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis

Journal of Immunology

Volumn 180, Issue 11, 2008, Pages 7097-7101

  Coquet, Jonathan M ^a   Chakravarti, Sumone ^a   Smyth, Mark J ^b   Godfrey, Dale I ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; INTERLEUKIN 17; INTERLEUKIN DERIVATIVE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH17 CELL; ANIMAL; C57BL MOUSE; CD4+ T LYMPHOCYTE; HELPER CELL; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; SIGNAL TRANSDUCTION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INTERLEUKIN-17; INTERLEUKINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN-21; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER; TRANSFORMING GROWTH FACTOR BETA;

EID: 46749156754     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.11.7097     Document Type: Article

References (21)

1. Weaver, C T., R. D. Hatton, P. R. Mangan, and L. E. Harrington. 2007. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25:821-852.
2. Stockinger, B., and M. Veldhoen. 2007. Differentiation and function of Th17 T cells. Curr. Opin. Immunol. 19: 281-286.
3. Spolski, R., and W. J. Leonard. 2007. Interleukin-21: basic biology and implications for cancer and autoimmuniry. Annu. Rev. Immunol. 26: 57-79.
4. H17 cells. Nature 448: 484-487.
5. Nurieva, R., X. O. Yang, G. Martinez, Y. Zhang, A. D. Panopoulos, L. Ma, K. Schluns, Q. Tian, S. S. Watowich, A. M. Jerten, and C. Dong. 2007. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448: 480-483.
6. H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8: 967-974.
7. Wei, L., A. Laurence, K. M. Elias, and J. O'Shea J. 2007. IL-21 is produced by Th17 cells and drives IL-17 production in aSTAT3-dependent manner. J. Biol Chem. 282: 34605-34610.
8. reg and Th17 cells. Eur. J. Immunol. 37: 3155-3163.
9. Kimura, A., T. Naka, and T. Kishimoto. 2007. IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proc. Natl. Acad. Sci. USA 104: 12099-12104.
10. Ozaki, K., R. Spolski, C. G. Feng, C. F. Qi, J. Cheng, A. Sher, H. C. Morse, III, C. Liu, P. L. Schwartzberg, and W. J. Leonard. 2002. A critical role for IL-21 in regulating immuhoglobulin production. Science 298: 1630-1634.
11. Umemura, M., A. Yahagi, S. Hamada, M. D. Begum, H. Watanabe, K. Kawakami, T. Suda, K. Sudo, S. Nakae, Y. Iwakura, and G. Matsuzaki. 2007. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection. J. Immunol. 178: 3786-3796.
12. King, C., A. Ilic, K. Koelsch, and N. Sarvetnick. 2004. Homeostatic expansion of T cells during immune insufficiency generates autoimmuniry. Cell 117: 265-277.
13. Young, D. A., M. Hegen, H. L. Ma, M. J. Whitters, L. M. Albert, L. Lowe, M. Senices, P. W. Wu, B. Sibley, Y. Leathurby, et al. 2007. Blockade of the interleukin-21/inter-leukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum. 56: 1152-1163.
14. Li, J., W. Shen, K. Kong, and Z. Liu. 2006. Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Scand. J. Immunol. 64:515-522.
15. Jungel, A., J. H. Distler, M. Kurowska-Stolarska, C. A. Scemayer, R. Seibl, A. Forster, B. A. Michel, R. E. Gay, F. Emmrich, S. Gay, and O. Distler. 2004. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum. 50: 1468-1476.
16. Monteleone, G., I. Monteleone, D. Fina, P. Vavassori, G. Del Vecchio Blanco, R. Caruso, R. Tersigni, L Alessandroni, L Biancone, et al. 2005. Interleukin-21 enhances T-helper cell type I signaling and interferon-γ production in Crohn's disease. Gastroenterology 128: 687-694.
17. Fina, D., M. C. Fanrini, F. Pallone, and G. Monteleone. 2007. Role of interleukin-21 in inflammation and allergy. Inflamm. Allergy Drug Targets 6: 63-68.
18. Monteleone, G., R. Caruso, D. Fina, I. Peluso, V. Gioia, C. Stolfi, M. C. Fantini, F. Caprioli, R. Tersigni, L Alessandroni, et al. 2006. Control of matrix metallopro-teinase production in human intestinal fibroblasts by interleukin 21. Gut 55: 1774-1780.
19. + regulatory T-cell homeostasis in experimental autoimmune encepha-lomyelitis. Scand. J. Immunol. 67: 37-46.
20. Frohlich, A., B. J. Marsland, I. Sonderegger, M. Kurrer, M. R. Hodge, N. L. Harris, and M. Kopf. 2007. IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood 109: 2023-2031.
21. Mehta, D. S., A. L. Wurster, and M. J. Grusby. 2004. Biology of IL-21 and the IL-21 receptor. Immunol. Rev. 202: 84-95.