IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo

European Journal of Immunology

Volumn 38, Issue 7, 2008, Pages 1833-1838

  Sonderegger, Ivo ^a   Kisielow, Jan ^a   Meier, Reto ^a   King, Cecile ^b   Kopf, Manfred ^a  

^a ETH ZURICH   (Switzerland)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Autoimmunity; EAE; IL 21; Myocarditis; Th17

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 6; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; INTERLEUKIN DERIVATIVE; ORPHAN NUCLEAR RECEPTOR ROR GAMMA; ORPHAN NUCLEAR RECEPTOR ROR-GAMMA; RETINOIC ACID RECEPTOR; THYROID HORMONE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; HELPER CELL; MOUSE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TH17 CELL; WILD TYPE; ANIMAL; AUTOIMMUNITY; BAGG ALBINO MOUSE; C57BL MOUSE; DISEASE MODEL; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; REGULATORY T LYMPHOCYTE;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INTERLEUKIN-17; INTERLEUKIN-6; INTERLEUKINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDITIS; NERVOUS SYSTEM AUTOIMMUNE DISEASE, EXPERIMENTAL; RECEPTORS, INTERLEUKIN-21; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 46749133961     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200838511     Document Type: Article

References (26)

1. Becher, B., Durell, B. G. and Noelle, R. J., Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 2002. 110: 493-497.
2. Eriksson, U., Kurrer, M. O., Sebald, W., Brombacher, F. and Kopf, M., Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: Induction by IL-12 and protection by IFN-gamma. J. Immunol. 2001. 167: 5464-5469.
3. Ferber, I. A., Brocke, S., Taylor-Edwards, C., Ridgway, W., Dinisco, C., Steinman, L., Dalton, D. and Fathman, C. G., Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 1996. 156: 5-7.
4. Gran, B., Zhang, G. X., Yu, S., Li, J., Chen, X. H., Ventura, E. S., Kamoun, M. and Rostami, A., IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 2002. 169: 7104-7110.
5. Willenborg, D. O., Fordham, S., Bernard, C. C., Cowden, W. B. and Ramshaw, I. A., IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 1996. 157: 3223-3227.
6. Zhang, G. X., Gran, B., Yu, S., Li, J., Siglienti, I., Chen, X., Kamoun, M. and Rostami, A., Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J. Immunol. 2003. 170: 2153-2160.
7. Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L. et al., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003. 421: 744-748.
8. Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T. et al., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 2005. 201: 233-240.
9. Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y. H., Wang, Y. et al., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005. 6: 1133-1141.
10. Nakae, S., Nambu, A., Sudo, K. and Iwakura, Y., Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 2003. 171: 6173-6177.
11. Sonderegger, I., Rohn, T. A., Kurrer, M. O., Iezzi, G., Zou, Y., Kastelein, R. A., Bachmann, M. F. and Kopf, M., Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur. J. Immunol. 2006. 36: 2849-2856.
12. Yen, D., Cheung, J., Scheerens, H., Poulet, F., McClanahan, T., McKenzie, B., Kleinschek, M. A. et al., IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 2006. 116: 1310-1316.
13. Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L. and Kuchroo, V. K., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006. 441: 235-238.
14. + T helper cells. Cell 2006. 126: 1121-1133.
15. Aggarwal, S., Ghilardi, N., Xie, M. H., de Sauvage, F. J. and Gurney, A. L., Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem 2003. 278: 1910-1914.
16. Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. and Stockinger, B., TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006. 24: 179-189.
17. Batten,M., Li, J., Yi, S., Kljavin, N.M., Danilenko, D. M., Lucas, S., Lee, J. et al., Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 2006. 7: 929-936.
18. Stumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V. et al., Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 2006. 7: 937-945.
19. Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B. et al., Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007. 26: 371-381.
20. Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M. and Cheroutre, H., Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007. 317: 256-260.
21. Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jager, A., Strom, T. B., Oukka, M. and Kuchroo, V. K., IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007. 448: 484-487.
22. Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K. et al., Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007. 448: 480-483.
23. Zhou, L., Ivanov, II, Spolski, R., Min, R., Shenderov, K., Egawa, T., Levy, D. E. et al., IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 2007. 8: 967-974.
24. Frohlich, A., Marsland, B. J., Sonderegger, I., Kurrer, M., Hodge, M. R., Harris, N. L. and Kopf, M., IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood 2007. 109: 2023-2031.
25. Leonard, W. J. and Spolski, R., Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 2005. 5: 688-698.
26. Wurster, A. L., Rodgers, V. L., Satoskar, A. R., Whitters, M. J., Young, D. A., Collins, M. and Grusby, M. J., Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J. Exp. Med. 2002. 196: 969-977.