Regulation of T-cell responses by CNS antigen-presenting cells: Different roles for microglia and astrocytes

Immunology Today

Volumn 21, Issue 3, 2000, Pages 141-147

  Aloisi, Francesca ^a   Ria, Francesco ^b   Adorini, Luciano ^c  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c ROCHE MILANO RICERCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ASTROCYTE; BLOOD BRAIN BARRIER; DENDRITIC CELL; IMMUNOMODULATION; IMMUNOSURVEILLANCE; LYMPHOCYTE ACTIVATION; MICROGLIA; MULTIPLE SCLEROSIS; NEUROIMMUNOLOGY; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; WHITE MATTER;

EID: 0033999887     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(99)01512-1     Document Type: Review

References (47)

1. T. Owens Inflammatory cytokines in the brain: does the CNS shape immune responses? Immunol. Today 15 1994 566 571
2. V.H. Perry A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation J. Neuroimmunol. 90 1998 113 121
3. P.G. McMenamin Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations J. Comp. Neurol. 405 1999 553 562
4. R.O. Weller Pathology of cerebrospinal fluid and interstitial fluid of the CNS: significance for Alzheimer disease, prion disorders and multiple sclerosis J. Neuropathol. Exp. Neurol 57 1998 885 894
5. M.B. Graeber Ultrastructural location of major histocompatibility complex (MHC) class II perivascular cells in histologically normal human brain J. Neuropathol. Exp. Neurol 51 1992 303 311
6. R. De Simone The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions J. Neuropathol. Exp. Neurol. 54 1995 175 187
7. H. Lassmann Bone marrow derived elements and microglia in brain inflammation Glia 7 1993 19 24
8. P. Shrikant E.N. Benveniste The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation J. Immunol 157 1996 1819 1822
9. D.N. Irani Regulation of brain-derived T cells during acute central nervous system inflammation J. Immunol. 158 1997 2318 2326
10. J. Bauer T-cell apoptosis in inflammatory brain lesions: destruction of T cells does not depend on antigen recognition Am. J. Pathol. 153 1998 715 724
11. S.L. Swain From naive to memory T cells Immunol. Rev. 150 1996 143 167
12. W.F. Hickey H. Kimura Perivascular microglial cells of the CNS are bone-marrow derived and present antigen in vivo Science 239 1988 290 292
13. + T cells compared J. Immunol. 154 1995 4309 4321
14. M.J. Carson Mature microglia resemble immature antigen presenting cells Glia 22 1998 72 85
15. G.W. Kreutzberg Microglia: a sensor for pathological events in the CNS Trends Neurosci 19 1996 312 318
16. K. Gerritse CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis Proc. Natl. Acad. Sci. U. S. A. 93 1996 2499 2504
17. S. Issazadeh Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo J. Immunol 161 1998 1104 1112
18. H. Li Microglia-derived macrophages in early multiple sclerosis plaques Neuropathol. Appl. Neurobiol 22 1996 207 215
19. L. Battistini CD1b is expressed in multiple sclerosis lesions J. Neuroimmunol 67 1996 145 151
20. A.L. Ford Microglia induce CD4 T lymphocyte final effector function and death J. Exp. Med. 184 1996 1737 1745
21. K. Frei Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells Eur. J. Immunol. 17 1987 1271 1278
22. K. Williams Induction of primary T cell responses by human glial cells J. Neurosci. Res. 36 1993 382 390
23. F. Aloisi Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation J. Immunol. 160 1998 4671 4680
24. Y. Matsumoto In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis. The role of astrocytes Immunology 79 1993 381 390
25. + T cell priming and Th1/Th2 restimulation Eur. J. Immunol 29 1999 2705 2714
26. H. Neumann H. Wekerle Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration J. Neuropathol. Exp. Neurol 57 1998 1 9
27. N.P. Hailer Astrocytic factors deactivate antigen presenting cells that invade the central nervous system Brain Pathol. 8 1998 459 474
28. A. Fontana Astrocytes present myelin basic protein to encephalitogenic T-cell lines Nature 307 1984 273 275
29. E. Meinl Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells Brain 117 1994 1323 1332
30. K.M. Nikcevich IFN-γ-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells J. Immunol. 158 1997 614 621
31. J.M. Soos Astrocytes express elements of the class II endocytic pathway and process central nervous system autoantigen for presentation to encephalitogenic T cells J. Immunol. 16 1998 5959 5966
32. T.R. Mosmann S. Sad The expanding universe of T-cell subsets: Th1, Th2 and more Immunol. Today 17 1996 138 146
33. + T cell cytokine profile in experimental allergic encephalomyelitis Eur. J. Immunol 27 1997 2840 2847
34. A.K. Stalder Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia J. Immunol 159 1997 1344 1351
35. F. Aloisi IL-12 production by central nervous system microglia is inhibited by astrocytes J. Immunol. 159 1997 1604 1612
36. B. Becher Soluble tumor necrosis factor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro J. Clin. Invest. 98 1996 1539 1543
37. C.S. Constantinescu Astrocytes and microglia produce interleukin-12 p40 Ann. New York Acad. Sci. 795 1996 328 333
38. L. Minghetti G. Levi Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide Progr. Neurobiol. 54 1998 99 125
39. Aloisi, F. et al. Glia–T cell dialogue . J. Neuroimmunol. (in press)
40. W.J. Karpus J.K. Kennedy MIP-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation J. Leuk. Biol 62 1997 681 687
41. R.M. Ransohoff Chemokines in neurological disease models: correlation between chemokine expression patterns and inflammatory pathology J. Leukoc. Biol. 62 1997 645 652
42. 2 secretion by microglia during antigen presentation to Th1 cells J. Immunol. 162 1999 1384 1391
43. F. Aloisi Functional maturation of adult mouse microglia into an antigen presenting cell is promoted by GM–CSF and interaction with Th1 cells J. Immunol 164 2000 1705 1712
44. S.D. Reid The control of T cell responses by dendritic cell subsets Curr. Opin. Immunol. 12 2000 114 121
45. T. Renno TNF-α expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis J. Immunol. 154 1995 944 953
46. P.M. Mathisen V.K. Tuohy Gene therapy in the treatment of autoimmune disease Immunol. Today 19 1998 103 105
47. R. Furlan Central nervous system delivery of interleukin 4 by a nonreplicative herpes symplex type 1 viral vector ameliorates autoimmune demyelination Human Gene Ther 9 1998 2605 2617