New insights into TGF-β-Smad signalling

Trends in Biochemical Sciences

Volumn 29, Issue 5, 2004, Pages 265-273

  Ten Dijke, Peter ^a   Hill, Caroline S ^b  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; EXPORTIN 1; LIGAND; NUCLEOPORIN; PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; ZINC ION;

CELL TYPE; CYTOPLASM; ENDOSOME; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIUM CELL; LIGAND BINDING; MUTAGENESIS; NUCLEAR LOCALIZATION SIGNAL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ACTIVIN RECEPTORS; CELL NUCLEUS; CYTOPLASM; DNA-BINDING PROTEINS; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; SMAD8 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 2342488852     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2004.03.008     Document Type: Review

References (69)

1. Blobe G.C., et al. Role of transforming growth factor β in human disease. N. Engl. J. Med. 342:2000;1350-1358
2. Shi Y., Massagué J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell. 113:2003;685-700
3. Miyazawa K., et al. Two major Smad pathways in TGF-β superfamily signalling. Genes Cells. 7:2002;1191-1204
4. Attisano L., Wrana J.L. Signal transduction by the TGF-β superfamily. Science. 296:2002;1646-1647
5. Shi W., et al. GADD34-PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor. J. Cell Biol. 164:2004;291-300
6. Lin X., et al. Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol. Cell. Biol. 23:2003;9081-9093
7. Moustakas A., et al. Smad regulation in TGF-β signal transduction. J. Cell Sci. 114:2001;4359-4369
8. Derynck R., Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature. 425:2003;577-584
9. Yamashita H., et al. Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-β J. Biol. Chem. 269:1994;20172-20178
10. Gilboa L., et al. Oligomeric structure of type I and type II transforming growth factor β receptors: homodimers form in the ER and persist at the plasma membrane. J. Cell Biol. 140:1998;767-777
11. Huse M., et al. Crystal structure of the cytoplasmic domain of the type I TGF β receptor in complex with FKBP12. Cell. 96:1999;425-436
12. Luo K., Lodish H.F. Signaling by chimeric erythropoietin-TGF-β receptors: homodimerization of the cytoplasmic domain of the type I TGF-β receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction. EMBO J. 15:1996;4485-4496
13. Weis-Garcia F., Massagué J. Complementation between kinase-defective and activation defective TGF-β receptors reveals a novel form of receptor cooperativity essential for signaling. EMBO J. 15:1996;276-289
14. Luo K., Lodish H.F. Positive and negative regulation of type II TGF-β receptor signal transduction by autophosphorylation on multiple serine residues. EMBO J. 16:1997;1970-1981
15. Oh S.P., et al. Activin receptor-like kinase 1 modulates transforming growth factor-β 1 signaling in the regulation of angiogenesis. Proc. Natl. Acad. Sci. U. S. A. 97:2000;2626-2631
16. Goumans M.J., et al. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling. Mol. Cell. 12:2003;817-828
17. Roelen B.A., et al. Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development. Dev. Dyn. 209:1997;418-430
18. Matsuyama S., et al. SB-431542 and Gleevec inhibit transforming growth factor-β-induced proliferation of human osteosarcoma cells. Cancer Res. 63:2003;7791-7798
19. Ward S.M., et al. Transforming growth factor β (TGFβ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. J. Biol. Chem. 277:2002;50183-50189
20. Rodriguez C., et al. Cooperative binding of transforming growth factor (TGF)-β 2 to the types I and II TGF-β receptors. J. Biol. Chem. 270:1995;15919-15922
21. Esparza-Lopez J., et al. Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-β superfamily. Specialized binding regions for transforming growth factor-β and inhibin A. J. Biol. Chem. 276:2001;14588-14596
22. Stenvers K.L., et al. Heart and liver defects and reduced transforming growth factor β2 sensitivity in transforming growth factor β type III receptor-deficient embryos. Mol. Cell. Biol. 23:2003;4371-4385
23. Chen W., et al. β-arrestin 2 mediates endocytosis of type III TGF-β receptor and down-regulation of its signaling. Science. 301:2003;1394-1397
24. Letamendia A., et al. Role of endoglin in cellular responses to transforming growth factor-β. A comparative study with betaglycan. J. Biol. Chem. 273:1998;33011-33019
25. van den Driesche S., et al. Hereditary hemorrhagic telangiectasia: an update on transforming growth factor β signaling in vasculogenesis and angiogenesis. Cardiovasc. Res. 58:2003;20-31
26. Tam B.Y., et al. Glycosylphosphatidylinositol-anchored proteins regulate transforming growth factor-β signaling in human keratinocytes. J. Biol. Chem. 278:2003;49610-49617
27. Tsukazaki T., et al. SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor. Cell. 95:1998;779-791
28. Wu J.W., et al. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-β signaling. Mol. Cell. 8:2001;1277-1289
29. Wu G., et al. Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Science. 287:2000;92-97
30. Chen X., et al. Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature. 389:1997;85-89
31. Chen X., et al. A transcriptional partner for MAD proteins in TGF-β signalling. Nature. 383:1996;691-696
32. Germain S., et al. Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev. 14:2000;435-451
33. Randall R.A., et al. Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. EMBO J. 21:2002;145-156
34. Xu L., et al. The nuclear import function of Smad2 is masked by SARA and unmasked by TGFβ-dependent phosphorylation. Nat. Cell Biol. 2:2000;559-562
35. Randall R.A., et al. Recognition of phosphorylated-Smad2-containing complexes by a novel Smad interaction motif. Mol. Cell. Biol. 24:2004;1106-1121
36. Xu L., et al. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFβ signaling complexes in the cytoplasm and nucleus. Mol. Cell. 10:2002;271-282
37. Xu L., et al. Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. J. Biol. Chem. 278:2003;42569-42577
38. Shi Y., et al. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling. Cell. 94:1998;585-594
39. Whitman M. Nodal signaling in early vertebrate embryos. Themes and variations. Dev. Cell. 1:2001;605-617
40. Cordenonsi M., et al. Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell. 113:2003;301-314
41. Qing J., et al. Transforming growth factor β/Smad3 signaling regulates IRF-7 function and transcriptional activation of the β interferon promoter. Mol. Cell. Biol. 24:2004;1411-1425
42. Sirard C., et al. Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor β-related signaling. J. Biol. Chem. 275:2000;2063-2070
43. Nicolás F.J., Hill C.S. Attenuation of the TGFβ-Smad signaling pathway in pancreatic tumor cells confers resistance to TGFβ-induced growth arrest. Oncogene. 22:2003;3698-3711
44. Inman G.J., et al. Nucleocytoplasmic shuttling of Smads 2, 3 and 4 permits sensing of TGF-β receptor activity. Mol. Cell. 10:2002;283-294
45. Watanabe M., et al. Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal. EMBO Rep. 1:2000;176-182
46. Pierreux C.E., et al. Transforming growth factor β-independent shuttling of Smad4 between the cytoplasm and nucleus. Mol. Cell. Biol. 20:2000;9041-9054
47. Xiao Z., et al. An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity. Oncogene. 22:2003;1057-1069
48. Reguly T., Wrana J.L. In or out? The dynamics of Smad nucleocytoplasmic shuttling. Trends Cell Biol. 13:2003;216-220
49. Xiao Z., et al. Importin β mediates nuclear translocation of Smad3. J. Biol. Chem. 275:2000;23425-23428
50. Kurisaki A., et al. Transforming growth factor-β induces nuclear import of Smad3 in an importin-β1 and Ran-dependent manner. Mol. Biol. Cell. 12:2001;1079-1091
51. Xiao Z., et al. A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation. Proc. Natl. Acad. Sci. U. S. A. 97:2000;7853-7858
52. Wilson P.A., et al. Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development. 124:1997;3177-3184
53. Dyson S., Gurdon J.B. The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors. Cell. 93:1998;557-568
54. Di Guglielmo G.M., et al. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nat. Cell Biol. 5:2003;410-421
55. Felici A., et al. TLP, a novel modulator of TGF-β signaling, has opposite effects on Smad2- and Smad3-dependent signaling. EMBO J. 22:2003;4465-4477
56. Kang Y., et al. A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell. 11:2003;915-926
57. Koinuma D., et al. Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7. EMBO J. 22:2003;6458-6470
58. Gunther C.V., et al. A Caenorhabditis elegans type I TGF β receptor can function in the absence of type II kinase to promote larval development. Development. 127:2000;3337-3347
59. Rebbapragada A., et al. Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis. Mol. Cell. Biol. 23:2003;7230-7242
60. Mazerbourg S., et al. Growth differentiation factor-9 (GDF-9) signaling is mediated by the type I receptor ALK5. Mol. Endocrinol. 18:2004;653-665
61. Zhu H., et al. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 400:1999;687-693
62. Gronroos E., et al. Control of Smad7 stability by competition between acetylation and ubiquitination. Mol. Cell. 10:2002;483-493
63. Lin X., et al. Activation of transforming growth factor-β signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4. J. Biol. Chem. 278:2003;18714-18719
64. Long J., et al. Repression of Smad4 transcriptional activity by SUMO modification. Biochem. J. 379:2004;23-29
65. Yan J., et al. Regulation of large-scale chromatin unfolding by Smad4. Biochem. Biophys. Res. Commun. 315:2004;330-335
66. Warner D.R., et al. Identification of three novel Smad binding proteins involved in cell polarity. FEBS Lett. 539:2003;167-173
67. Bonni S., et al. TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat. Cell Biol. 3:2001;587-595
68. Conery, A.R., et al. Akt physically interacts with Smad3 to regulate the sensitivity of TGFβ-induced apoptosis. Nat. Cell Biol. (in press).
69. Zhang L., et al. A Transforming growth factor β-induced Smad3/Smad4 complex directly activates protein kinase A. Mol. Cell. Biol. 24:2004;2169-2180