Cytokines and effector T cell subsets causing autoimmune CNS disease

FEBS Letters

Volumn 585, Issue 23, 2011, Pages 3747-3757

  Petermann, Franziska ^a   Korn, Thomas ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

T cell; Cytokine; Experimental autoimmune encephalomyelitis; T cell; Th17

Indexed keywords

AUTOANTIBODY; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 9; TUMOR NECROSIS FACTOR; USTEKINUMAB;

ADAPTIVE IMMUNITY; ALLERGIC ENCEPHALOMYELITIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE COURSE; EFFECTOR CELL; HELPER CELL; HISTOPATHOLOGY; HUMAN; IMMUNOMODULATION; IMMUNOPATHOGENESIS; INNATE IMMUNITY; LYMPHOCYTE FUNCTION; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; REVIEW; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL;

ANIMALS; AUTOIMMUNE DISEASES; CENTRAL NERVOUS SYSTEM DISEASES; CYTOKINES; HUMANS; LYMPHOCYTE SUBSETS; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES;

EID: 81755184012     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.03.064     Document Type: Review

References (223)

1. G. Kobelt, L. Jonsson, F. Henriksson, S. Fredrikson, and B. Jonsson Cost-utility analysis of interferon beta-1b in secondary progressive multiple sclerosis Int. J. Technol. Assess. Health Care 16 2000 768 780
2. B.G. Weinshenker, B. Bass, G.P. Rice, J. Noseworthy, W. Carriere, J. Baskerville, and G.C. Ebers The natural history of multiple sclerosis: A geographically based study. I. Clinical course and disability Brain 112 Pt 1 1989 133 146 (Pubitemid 19056478)
3. M. Sospedra, and R. Martin Immunology of multiple sclerosis Annu. Rev. Immunol. 23 2005 683 747 (Pubitemid 40563183)
4. A. Ascherio, and K.L. Munger Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors Ann. Neurol. 61 2007 504 513 (Pubitemid 47068132)
5. B. Serafini, B. Rosicarelli, D. Franciotta, R. Magliozzi, R. Reynolds, P. Cinque, L. Andreoni, P. Trivedi, M. Salvetti, and A. Faggioni Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain J. Exp. Med. 204 2007 2899 2912 (Pubitemid 350179559)
6. S.N. Willis, C. Stadelmann, S.J. Rodig, T. Caron, S. Gattenloehner, S.S. Mallozzi, J.E. Roughan, S.E. Almendinger, M.M. Blewett, and W. Bruck Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain Brain J. Neurol. 132 2009 3318 3328
7. P.L. De Jager, L.B. Chibnik, J. Cui, J. Reischl, S. Lehr, K.C. Simon, C. Aubin, D. Bauer, J.F. Heubach, and R. Sandbrink Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: A weighted genetic risk score Lancet Neurol. 8 2009 1111 1119
8. J. Rosenbluth Central myelin in the mouse mutant shiverer J. Comp. Neurol. 194 1980 639 648 (Pubitemid 11197743)
9. M. Klugmann, M.H. Schwab, A. Puhlhofer, A. Schneider, F. Zimmermann, I.R. Griffiths, and K.A. Nave Assembly of CNS myelin in the absence of proteolipid protein Neuron 18 1997 59 70 (Pubitemid 27053830)
10. C. Li, M.B. Tropak, R. Gerlai, S. Clapoff, W. Abramow-Newerly, B. Trapp, A. Peterson, and J. RoDer Myelination in the absence of myelin-associated glycoprotein Nature 369 1994 747 750 (Pubitemid 24225364)
11. C. Lappe-Siefke, S. Goebbels, M. Gravel, E. Nicksch, J. Lee, P.E. Braun, I.R. Griffiths, and K.A. Nave Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination Nat. Genet. 33 2003 366 374 (Pubitemid 36278853)
12. A.B. Keith, R. Arnon, D. Teitelbaum, E.A. Caspary, and H.M. Wisniewski The effect of Cop 1, a synthetic polypeptide, on chronic relapsing experimental allergic encephalomyelitis in guinea pigs J. Neurol. Sci. 42 1979 267 274 (Pubitemid 9183660)
13. K.P. Johnson, B.R. Brooks, J.A. Cohen, C.C. Ford, J. Goldstein, R.P. Lisak, L.W. Myers, H.S. Panitch, J.W. Rose, and R.B. Schiffer Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Copolymer 1 Multiple Sclerosis Study Group Neurology 50 1998 701 708
14. J.L. Baron, J.A. Madri, N.H. Ruddle, G. Hashim, and C.A. Janeway Jr. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma J. Exp. Med. 177 1993 57 68 (Pubitemid 23008085)
15. D.H. Miller, O.A. Khan, W.A. Sheremata, L.D. Blumhardt, G.P. Rice, M.A. Libonati, A.J. Willmer-Hulme, C.M. Dalton, K.A. Miszkiel, and P.W. O'Connor A controlled trial of natalizumab for relapsing multiple sclerosis N. Engl. J. Med. 348 2003 15 23 (Pubitemid 36026342)
16. H. Wekerle, K. Kojima, J. Lannes-Vieira, H. Lassmann, and C. Linington Animal models Ann. Neurol. 36 Suppl. 1994 S47 S53
17. R. Gold, C. Linington, and H. Lassmann Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research Brain 129 2006 1953 1971 (Pubitemid 44289062)
18. T. Korn, M. Mitsdoerffer, and V.K. Kuchroo Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis Results Probl. Cell Differ. 51 2010 43 74
19. B. Becher, I. Bechmann, and M. Greter Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain J. Mol. Med. 84 2006 532 543 (Pubitemid 43992845)
20. T.R. Mosmann, H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins J. Immunol. 136 1986 2348 2357 (Pubitemid 16136806)
21. + T cells through IL-12 produced by Listeria-induced macrophages Science 260 1993 547 549 (Pubitemid 23161621)
22. K.M. Murphy, W. Ouyang, J.D. Farrar, J. Yang, S. Ranganath, H. Asnagli, M. Afkarian, and T.L. Murphy Signaling and transcription in T helper development Annu. Rev. Immunol. 18 2000 451 494 (Pubitemid 30365388)
23. S.J. Szabo, S.T. Kim, G.L. Costa, X. Zhang, C.G. Fathman, and L.H. Glimcher A novel transcription factor, T-bet, directs Th1 lineage commitment Cell 100 2000 655 669
24. W. Zheng, and R.A. Flavell The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells Cell 89 1997 587 596 (Pubitemid 27511769)
25. E.S. Hwang, S.J. Szabo, P.L. Schwartzberg, and L.H. Glimcher T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3 Science 307 2005 430 433 (Pubitemid 40139989)
26. U. Traugott, and P. Lebon Interferon-gamma and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions J. Neurol. Sci. 84 1988 257 264 (Pubitemid 18087268)
27. H.S. Panitch, R.L. Hirsch, J. Schindler, and K.P. Johnson Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system Neurology 37 1987 1097 1102 (Pubitemid 17123439)
28. E. Bettelli, B. Sullivan, S.J. Szabo, R.A. Sobel, L.H. Glimcher, and V.K. Kuchroo Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis J. Exp. Med. 200 2004 79 87 (Pubitemid 38924730)
29. J.P. Leonard, K.E. Waldburger, and S.J. Goldman Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12 J. Exp. Med. 181 1995 381 386
30. I.A. Ferber, S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalton, and C.G. Fathman Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE) J. Immunol. 156 1996 5 7
31. D.O. Willenborg, S. Fordham, C.C. Bernard, W.B. Cowden, and I.A. Ramshaw IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis J. Immunol. 157 1996 3223 3227 (Pubitemid 126449130)
32. B. Becher, B.G. Durell, and R.J. Noelle Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12 J. Clin. Invest. 110 2002 493 497 (Pubitemid 34919703)
33. B. Oppmann, R. Lesley, B. Blom, J.C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, and K. Singh Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13 2000 715 725
34. Z. Yao, W.C. Fanslow, M.F. Seldin, A.M. Rousseau, S.L. Painter, M.R. Comeau, J.I. Cohen, and M.K. Spriggs Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor Immunity 3 1995 811 821 (Pubitemid 26091152)
35. E. Rouvier, M.F. Luciani, M.G. Mattei, F. Denizot, and P. Golstein CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene J. Immunol. 150 1993 5445 5456 (Pubitemid 23180658)
36. D.J. Cua, J. Sherlock, Y. Chen, C.A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, and T. Churakova Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 2003 744 748 (Pubitemid 36227625)
37. M. Veldhoen, R.J. Hocking, C.J. Atkins, R.M. Locksley, and B. Stockinger TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells Immunity 24 2006 179 189 (Pubitemid 43214587)
38. E. Bettelli, Y. Carrier, W. Gao, T. Korn, T.B. Strom, M. Oukka, H.L. Weiner, and V.K. Kuchroo Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 2006 235 238
39. I.I. Ivanov, B.S. McKenzie, L. Zhou, C.E. Tadokoro, A. Lepelley, J.J. Lafaille, D.J. Cua, and D.R. Littman The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17(+) T helper cells Cell 126 2006 1121 1133 (Pubitemid 44380299)
40. M. Pepper, J.L. Linehan, A.J. Pagan, T. Zell, T. Dileepan, P.P. Cleary, and M.K. Jenkins Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells Nat. Immunol. 11 2010 83 89
41. C. Lock, G. Hermans, R. Pedotti, A. Brendolan, E. Schadt, H. Garren, A. Langer-Gould, S. Strober, B. Cannella, and J. Allard Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis Nat. Med. 8 2002 500 508 (Pubitemid 34546753)
42. M.A. Lowes, T. Kikuchi, J. Fuentes-Duculan, I. Cardinale, L.C. Zaba, A.S. Haider, E.P. Bowman, and J.G. Krueger Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells J. Invest. Dermatol. 128 2008 1207 1211 (Pubitemid 351543220)
43. S. Fujino, A. Andoh, S. Bamba, A. Ogawa, K. Hata, Y. Araki, T. Bamba, and Y. Fujiyama Increased expression of interleukin 17 in inflammatory bowel disease Gut 52 2003 65 70 (Pubitemid 36020767)
44. M. Chabaud, J.M. Durand, N. Buchs, F. Fossiez, G. Page, L. Frappart, and P. Miossec Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium Arthritis Rheum. 42 1999 963 970 (Pubitemid 29215007)
45. M. Veldhoen, C. Uyttenhove, J. Van Snick, H. Helmby, A. Westendorf, J. Buer, B. Martin, C. Wilhelm, and B. Stockinger Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset Nat. Immunol. 9 2008 1341 1346
46. V. Dardalhon, A. Awasthi, H. Kwon, G. Galileos, W. Gao, R.A. Sobel, M. Mitsdoerffer, T.B. Strom, W. Elyaman, and I.C. Ho IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells Nat. Immunol. 9 2008 1347 1355
47. V. Staudt, E. Bothur, M. Klein, K. Lingnau, S. Reuter, N. Grebe, B. Gerlitzki, M. Hoffmann, A. Ulges, and C. Taube Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells Immunity 33 2010 192 202
48. S. Eyerich, K. Eyerich, D. Pennino, T. Carbone, F. Nasorri, S. Pallotta, F. Cianfarani, T. Odorisio, C. Traidl-Hoffmann, and H. Behrendt Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling J. Clin. Investig. 119 2009 3573 3585
49. A. Jager, V. Dardalhon, R.A. Sobel, E. Bettelli, and V.K. Kuchroo Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes J. Immunol. 183 2009 7169 7177
50. E.F. Wheelock Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin Science 149 1965 310 311
51. S.L. Naylor, A.Y. Sakaguchi, T.B. Shows, M.L. Law, D.V. Goeddel, and P.W. Gray Human immune interferon gene is located on chromosome 12 J. Exp. Med. 157 1983 1020 1027 (Pubitemid 13117078)
52. S.L. Naylor, P.W. Gray, and P.A. Lalley Mouse immune interferon (IFN-gamma) gene is on chromosome 10 Somat. Cell Mol. Genet. 10 1984 531 534 (Pubitemid 14039235)
53. P.W. Gray, and D.V. Goeddel Structure of the human immune interferon gene Nature 298 1982 859 863 (Pubitemid 12046058)
54. M. Aguet, Z. Dembic, and G. Merlin Molecular cloning and expression of the human interferon-gamma receptor Cell 55 1988 273 280
55. J. Soh, T.M. Mariano, J.K. Lim, L. Izotova, O. Mirochnitchenko, B. Schwartz, J.A. Langer, and S. Pestka Expression of a functional human type I interferon receptor in hamster cells: application of functional yeast artificial chromosome (YAC) screening J. Biol. Chem. 269 1994 18102 18110 (Pubitemid 24206209)
56. S. Hemmi, R. Bohni, G. Stark, F. Di Marco, and M. Aguet A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells Cell 76 1994 803 810 (Pubitemid 24085318)
57. E.A. Bach, M. Aguet, and R.D. Schreiber The IFN gamma receptor: A paradigm for cytokine receptor signaling Annu. Rev. Immunol. 15 1997 563 591 (Pubitemid 27169292)
58. K. Shuai, A. Ziemiecki, A.F. Wilks, A.G. Harpur, H.B. Sadowski, M.Z. Gilman, and J.E. Darnell Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins Nature 366 1993 580 583 (Pubitemid 24036000)
59. E.N. Benveniste, and D.J. Benos TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function FASEB 9 1995 1577 1584
60. H.A. Young, and K.J. Hardy Role of interferon-gamma in immune cell regulation J. Leukoc. Biol. 58 1995 373 381
61. R.A. Seder, and W.E. Paul Acquisition of lymphokine-producing phenotype by CD4+ T cells Annu. Rev. Immunol. 12 1994 635 673 (Pubitemid 24140427)
62. G. Degliantoni, M. Murphy, M. Kobayashi, M.K. Francis, B. Perussia, and G. Trinchieri Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon J. Exp. Med. 162 1985 1512 1530 (Pubitemid 16195356)
63. C.M. Snapper, and W.E. Paul Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production Science 236 1987 944 947 (Pubitemid 17107942)
64. R.D. Schreiber, L.J. Hicks, A. Celada, N.A. Buchmeier, and P.W. Gray Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity J. Immunol. 134 1985 1609 1618 (Pubitemid 15130279)
65. J.E. Merrill, D.H. Kono, J. Clayton, D.G. Ando, D.R. Hinton, and F.M. Hofman Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice Proc. Natl. Acad. Sci. USA 89 1992 574 578
66. Y. Refaeli, L. Van Parijs, S.I. Alexander, and A.K. Abbas Interferon gamma is required for activation-induced death of T lymphocytes J. Exp. Med. 196 2002 999 1005
67. C.Q. Chu, S. Wittmer, and D.K. Dalton Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis J. Exp. Med. 192 2000 123 128 (Pubitemid 30470813)
68. S. Aggarwal, and A.L. Gurney IL-17: prototype member of an emerging cytokine family J. Leukoc. Biol. 71 2002 1 8 (Pubitemid 34062767)
69. M. Kawaguchi, M. Adachi, N. Oda, F. Kokubu, and S.K. Huang IL-17 cytokine family J. Allergy Clin. Immunol. 114 2004 1265 1273 (Pubitemid 39585195)
70. X.O. Yang, S.H. Chang, H. Park, R. Nurieva, B. Shah, L. Acero, Y.H. Wang, K.S. Schluns, R.R. Broaddus, and Z. Zhu Regulation of inflammatory responses by IL-17F J. Exp. Med. 205 2008 1063 1075 (Pubitemid 351679682)
71. M.A. Kleinschek, A.M. Owyang, B. Joyce-Shaikh, C.L. Langrish, Y. Chen, D.M. Gorman, W.M. Blumenschein, T. McClanahan, F. Brombacher, and S.D. Hurst IL-25 regulates Th17 function in autoimmune inflammation J. Exp. Med. 204 2007 161 170 (Pubitemid 46148766)
72. R. Schwandner, K. Yamaguchi, and Z. Cao Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction J. Exp. Med. 191 2000 1233 1240
73. S.H. Chang, H. Park, and C. Dong Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor J. Biol. Chem. 281 2006 35603 35607 (Pubitemid 46041290)
74. Y. Qian, C. Liu, J. Hartupee, C.Z. Altuntas, M.F. Gulen, D. Jane-Wit, J. Xiao, Y. Lu, N. Giltiay, and J. Liu The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease Nat. Immunol. 8 2007 247 256 (Pubitemid 46745374)
75. Y. Iwakura, H. Ishigame, S. Saijo, and S. Nakae Functional specialization of interleukin-17 family members Immunity 34 2011 149 162
76. T. Carlson, M. Kroenke, P. Rao, T.E. Lane, and B. Segal The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease J. Exp. Med. 205 2008 811 823 (Pubitemid 351549880)
77. F. Fossiez, O. Djossou, P. Chomarat, L. Flores-Romo, S. Ait-Yahia, C. Maat, J.J. Pin, P. Garrone, E. Garcia, and S. Saeland T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines J. Exp. Med. 183 1996 2593 2603 (Pubitemid 26193037)
78. H. Kebir, K. Kreymborg, I. Ifergan, A. Dodelet-Devillers, R. Cayrol, M. Bernard, F. Giuliani, N. Arbour, B. Becher, and A. Prat Human T(H)17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation Nat. Med. 13 2007 1173 1175 (Pubitemid 47530640)
79. J. Huppert, D. Closhen, A. Croxford, R. White, P. Kulig, E. Pietrowski, I. Bechmann, B. Becher, H.J. Luhmann, and A. Waisman Cellular mechanisms of IL-17-induced blood-brain barrier disruption FASEB 24 2010 1023 1034
80. J. Kawanokuchi, K. Shimizu, A. Nitta, K. Yamada, T. Mizuno, H. Takeuchi, and A. Suzumura Production and functions of IL-17 in microglia J. Neuroimmunol. 194 2008 54 61
81. H. Ogura, M. Murakami, Y. Okuyama, M. Tsuruoka, C. Kitabayashi, M. Kanamoto, M. Nishihara, Y. Iwakura, and T. Hirano Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction Immunity 29 2008 628 636
82. R. Spolski, and W.J. Leonard Interleukin-21: basic biology and implications for cancer and autoimmunity Annu. Rev. Immunol. 26 2008 57 79 (Pubitemid 351600371)
83. M. Collins, M.J. Whitters, and D.A. Young IL-21 and IL-21 receptor: A new cytokine pathway modulates innate and adaptive immunity Immunol. Res. 28 2003 131 140 (Pubitemid 37465162)
84. K. Ozaki, R. Spolski, C.G. Feng, C.F. Qi, J. Cheng, A. Sher, H.C. Morse 3rd, C. Liu, P.L. Schwartzberg, and W.J. Leonard A critical role for IL-21 in regulating immunoglobulin production Science 298 2002 1630 1634 (Pubitemid 35387203)
85. K. Ozaki, R. Spolski, R. Ettinger, H.P. Kim, G. Wang, C.F. Qi, P. Hwu, D.J. Shaffer, S. Akilesh, and D.C. Roopenian Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6 J. Immunol. 173 2004 5361 5371 (Pubitemid 39392119)
86. M. Strengell, S. Matikainen, J. Siren, A. Lehtonen, D. Foster, I. Julkunen, and T. Sareneva IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells J. Immunol. 170 2003 5464 5469 (Pubitemid 36617833)
87. T. Korn, E. Bettelli, W. Gao, A. Awasthi, A. Jager, T.B. Strom, M. Oukka, and V.K. Kuchroo IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells Nature 448 2007 484 487 (Pubitemid 47123515)
88. R. Nurieva, X.O. Yang, G. Martinez, Y. Zhang, A.D. Panopoulos, L. Ma, K. Schluns, Q. Tian, S.S. Watowich, and A.M. Jetten Essential autocrine regulation by IL-21 in the generation of inflammatory T cells Nature 448 2007 480 483 (Pubitemid 47123514)
89. L. Zhou, I.I. Ivanov, R. Spolski, R. Min, K. Shenderov, T. Egawa, D.E. Levy, W.J. Leonard, and D.R. Littman IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nat. Immunol. 8 2007 967 974 (Pubitemid 47300011)
90. E. Schmitt, T. Germann, S. Goedert, P. Hoehn, C. Huels, S. Koelsch, R. Kuhn, W. Muller, N. Palm, and E. Rude IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma J. Immunol. 153 1994 3989 3996
91. J.C. Renauld, C. Druez, A. Kermouni, F. Houssiau, C. Uyttenhove, E. Van Roost, and J. Van Snick Expression cloning of the murine and human interleukin 9 receptor cDNAs Proc. Natl. Acad. Sci. USA 89 1992 5690 5694
92. J.H. Bauer, K.D. Liu, Y. You, S.Y. Lai, and M.A. Goldsmith Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis J. Biol. Chem. 273 1998 9255 9260 (Pubitemid 28176218)
93. J.B. Demoulin, C. Uyttenhove, E. Van Roost, B. DeLestre, D. Donckers, J. Van Snick, and J.C. Renauld A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 Mol. Cell. Biol. 16 1996 4710 4716 (Pubitemid 26272124)
94. J.B. Demoulin, E. Van Roost, M. Stevens, B. Groner, and J.C. Renauld Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9 J. Biol. Chem. 274 1999 25855 25861
95. J.C. Renauld, A. Goethals, F. Houssiau, E. Van Roost, and J. Van Snick Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40 Cytokine 2 1990 9 12
96. E.C. Nowak, C.T. Weaver, H. Turner, S. Begum-Haque, B. Becher, B. Schreiner, A.J. Coyle, L.H. Kasper, and R.J. Noelle IL-9 as a mediator of Th17-driven inflammatory disease J. Exp. Med. 206 2009 1653 1660
97. J.M. Townsend, G.P. Fallon, J.D. Matthews, P. Smith, E.H. Jolin, and N.A. McKenzie IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development Immunity 13 2000 573 583
98. W. Elyaman, E.M. Bradshaw, C. Uyttenhove, V. Dardalhon, A. Awasthi, J. Imitola, E. Bettelli, M. Oukka, J. Van Snick, and J.C. Renauld IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells Proc. Natl. Acad. Sci. USA 106 2009 12885 12890
99. Y. Zhou, Y. Sonobe, T. Akahori, S. Jin, J. Kawanokuchi, M. Noda, Y. Iwakura, T. Mizuno, and A. Suzumura IL-9 promotes Th17 cell migration into the central nervous system via CC chemokine ligand-20 produced by astrocytes J. Immunol. 2011 10.4049/jimmunol.1003307
100. H. Blumberg, D. Conklin, W.F. Xu, A. Grossmann, T. Brender, S. Carollo, M. Eagan, D. Foster, B.A. Haldeman, and A. Hammond Interleukin 20: discovery, receptor identification, and role in epidermal function Cell 104 2001 9 19 (Pubitemid 32144968)
101. G. Gallagher, H. Dickensheets, J. Eskdale, L.S. Izotova, O.V. Mirochnitchenko, J.D. Peat, N. Vazquez, S. Pestka, R.P. Donnelly, and S.V. Kotenko Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10) Genes Immun. 1 2000 442 450
102. S.V. Kotenko, G. Gallagher, V.V. Baurin, A. Lewis-Antes, M. Shen, N.K. Shah, J.A. Langer, F. Sheikh, H. Dickensheets, and R.P. Donnelly IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex Nat. Immunol. 4 2003 69 77 (Pubitemid 36109115)
103. S. Pestka, C.D. Krause, D. Sarkar, M.R. Walter, Y. Shi, and P.B. Fisher Interleukin-10 and related cytokines and receptors Annu. Rev. Immunol. 22 2004 929 979 (Pubitemid 38680445)
104. N.W. Bartlett, K. Buttigieg, S.V. Kotenko, and G.L. Smith Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model J. Gen. Virol. 86 2005 1589 1596 (Pubitemid 40766871)
105. A. Lasfar, A. Lewis-Antes, S.V. Smirnov, S. Anantha, W. Abushahba, B. Tian, K. Reuhl, H. Dickensheets, F. Sheikh, and R.P. Donnelly Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma Cancer Res. 66 2006 4468 4477
106. J.R. Schoenborn, M.O. Dorschner, M. Sekimata, D.M. Santer, M. Shnyreva, D.R. Fitzpatrick, J.A. Stamatoyannopoulos, and C.B. Wilson Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma Nat. Immunol. 8 2007 732 742 (Pubitemid 46965349)
107. L. Dumoutier, D. Lejeune, D. Colau, and J.C. Renauld Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22 J. Immunol. 166 2001 7090 7095 (Pubitemid 32525578)
108. S.V. Kotenko, L.S. Izotova, O.V. Mirochnitchenko, E. Esterova, H. Dickensheets, R.P. Donnelly, and S. Pestka Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes J. Biol. Chem. 276 2001 2725 2732
109. C.C. Wei, T.W. Ho, W.G. Liang, G.Y. Chen, and M.S. Chang Cloning and characterization of mouse IL-22 binding protein Genes Immun. 4 2003 204 211
110. W. Xu, S.R. Presnell, J. Parrish-Novak, W. Kindsvogel, S. Jaspers, Z. Chen, S.R. Dillon, Z. Gao, T. Gilbert, and K. Madden A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist Proc. Natl. Acad. Sci. USA 98 2001 9511 9516 (Pubitemid 32769334)
111. B. Weiss, K. Wolk, B.H. Grunberg, H.D. Volk, W. Sterry, K. Asadullah, and R. Sabat Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart Genes Immun. 5 2004 330 336 (Pubitemid 39139758)
112. K. Wolk, E. Witte, U. Hoffmann, W.D. Doecke, S. Endesfelder, K. Asadullah, W. Sterry, H.D. Volk, B.M. Wittig, and R. Sabat IL-22 induces lipopolysaccharide-binding protein in hepatocytes: A potential systemic role of IL-22 in Crohn's disease J. Immunol. 178 2007 5973 5981 (Pubitemid 46674395)
113. K. Wolk, S. Kunz, E. Witte, M. Friedrich, K. Asadullah, and R. Sabat IL-22 increases the innate immunity of tissues Immunity 21 2004 241 254 (Pubitemid 39094053)
114. L.A. Zenewicz, G.D. Yancopoulos, D.M. Valenzuela, A.J. Murphy, M. Karow, and R.A. Flavell Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation Immunity 27 2007 647 659 (Pubitemid 47615503)
115. Y. Zheng, P.A. Valdez, D.M. Danilenko, Y. Hu, S.M. Sa, Q. Gong, A.R. Abbas, Z. Modrusan, N. Ghilardi, and F.J. de Sauvage Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens Nat. Med. 14 2008 282 289 (Pubitemid 351347912)
116. K. Sugimoto, A. Ogawa, E. Mizoguchi, Y. Shimomura, A. Andoh, A.K. Bhan, R.S. Blumberg, R.J. Xavier, and A. Mizoguchi IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis J. Clin. Invest. 118 2008 534 544 (Pubitemid 351206544)
117. H. Chang, H. Hanawa, H. Liu, T. Yoshida, M. Hayashi, R. Watanabe, S. Abe, K. Toba, K. Yoshida, and R. Elnaggar Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats J. Immunol. 177 2006 3635 3643 (Pubitemid 44359895)
118. K. Wolk, E. Witte, E. Wallace, W.D. Docke, S. Kunz, K. Asadullah, H.D. Volk, W. Sterry, and R. Sabat IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis Eur. J. Immunol. 36 2006 1309 1323
119. K. Boniface, F.X. Bernard, M. Garcia, A.L. Gurney, J.C. Lecron, and F. Morel IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes J. Immunol. 174 2005 3695 3702 (Pubitemid 40354080)
120. Y. Zheng, D.M. Danilenko, P. Valdez, I. Kasman, J. Eastham-Anderson, J. Wu, and W. Ouyang Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis Nature 445 2007 648 651 (Pubitemid 46232884)
121. K. Kreymborg, R. Etzensperger, L. Dumoutier, S. Haak, A. Rebollo, T. Buch, F.L. Heppner, J.C. Renauld, and B. Becher IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis J. Immunol. 179 2007 8098 8104
122. M. Grell, H. Wajant, G. Zimmermann, and P. Scheurich The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor Proc. Natl. Acad. Sci. USA 95 1998 570 575 (Pubitemid 28083784)
123. M. Grell Tumor necrosis factor (TNF) receptors in cellular signaling of soluble and membrane-expressed TNF J. Inflamm. 47 1995 8 17 (Pubitemid 26376197)
124. J.L. Tchelingerian, M. Monge, F. Le Saux, B. Zalc, and C. Jacque Differential oligodendroglial expression of the tumor necrosis factor receptors in vivo and in vitro J. Neurochem. 65 1995 2377 2380
125. K.C. Sheehan, J.K. Pinckard, C.D. Arthur, L.P. Dehner, D.V. Goeddel, and R.D. Schreiber Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75 J. Exp. Med. 181 1995 607 617
126. F.M. Hofman, D.R. Hinton, K. Johnson, and J.E. Merrill Tumor necrosis factor identified in multiple sclerosis brain J. Exp. Med. 170 1989 607 612 (Pubitemid 19204288)
127. K. Selmaj, C.S. Raine, B. Cannella, and C.F. Brosnan Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions J. Clin. Investig. 87 1991 949 954
128. N.H. Ruddle, C.M. Bergman, K.M. McGrath, E.G. Lingenheld, M.L. Grunnet, S.J. Padula, and R.B. Clark An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis J. Exp. Med. 172 1990 1193 1200 (Pubitemid 20343220)
129. K. Selmaj, W. Papierz, A. Glabinski, and T. Kohno Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I J. Neuroimmunol. 56 1995 135 141
130. D. Baker, D. Butler, B.J. Scallon, J.K. O'Neill, J.L. Turk, and M. Feldmann Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins Eur. J. Immunol. 24 1994 2040 2048
131. Y. Kuroda, and Y. Shimamoto Human tumor necrosis factor-alpha augments experimental allergic encephalomyelitis in rats J. Neuroimmunol. 34 1991 159 164
132. L. Probert, K. Akassoglou, M. Pasparakis, G. Kontogeorgos, and G. Kollias Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha Proc. Natl. Acad. Sci. USA 92 1995 11294 11298
133. G.C. Suvannavejh, H.O. Lee, J. Padilla, M.C. Dal Canto, T.A. Barrett, and S.D. Miller Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis Cell. Immunol. 205 2000 24 33
134. J. Liu, M.W. Marino, G. Wong, D. Grail, A. Dunn, J. Bettadapura, A.J. Slavin, L. Old, and C.C. Bernard TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination Nat. Med. 4 1998 78 83 (Pubitemid 28133083)
135. H.A. Arnett, J. Mason, M. Marino, K. Suzuki, G.K. Matsushima, and J.P. Ting TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination Nat. Neurosci. 4 2001 1116 1122 (Pubitemid 34116557)
136. A.W. Burgess, and D. Metcalf The nature and action of granulocyte-macrophage colony stimulating factors Blood 56 1980 947 958 (Pubitemid 11205044)
137. K. Inaba, M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R.M. Steinman Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor J. Exp. Med. 176 1992 1693 1702
138. C.A. Sieff, C.M. Niemeyer, and D.V. Faller Human colony-stimulating factors and stromal cell function Soc. Gen. Physiol. Ser. 43 1988 47 55
139. J.A. Hamilton Colony-stimulating factors in inflammation and autoimmunity Nat. Rev. Immunol. 8 2008 533 544 (Pubitemid 351913679)
140. T. Kitamura, N. Sato, K. Arai, and A. Miyajima Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors Cell 66 1991 1165 1174 (Pubitemid 121001406)
141. J. Tavernier, R. Devos, S. Cornelis, T. Tuypens, J. Van Der Heyden, W. Fiers, and G. Plaetinck A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF Cell 66 1991 1175 1184 (Pubitemid 121001407)
142. J.L. McQualter, R. Darwiche, C. Ewing, M. Onuki, T.W. Kay, J.A. Hamilton, H.H. Reid, and C.C. Bernard Granulocyte macrophage colony-stimulating factor: A new putative therapeutic target in multiple sclerosis J. Exp. Med. 194 2001 873 882
143. M.A. Kroenke, T.J. Carlson, A.V. Andjelkovic, and B.M. Segal IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition J. Exp. Med. 205 2008 1535 1541 (Pubitemid 351962016)
144. S. Marusic, J.S. Miyashiro, J. Douhan 3rd, R.F. Konz, D. Xuan, J.W. Pelker, V. Ling, J.P. Leonard, and K.A. Jacobs Local delivery of granulocyte macrophage colony-stimulating factor by retrovirally transduced antigen-specific T cells leads to severe, chronic experimental autoimmune encephalomyelitis in mice Neurosci. Lett. 332 2002 185 189 (Pubitemid 35223479)
145. I. Sonderegger, G. Iezzi, R. Maier, N. Schmitz, M. Kurrer, and M. Kopf GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival J. Exp. Med. 205 2008 2281 2294
146. I.L. King, M.A. Kroenke, and B.M. Segal GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization J. Exp. Med. 207 2010 953 961
147. H. Park, Z. Li, X.O. Yang, S.H. Chang, R. Nurieva, Y.H. Wang, Y. Wang, L. Hood, Z. Zhu, and Q. Tian A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Nat. Immunol. 6 2005 1133 1141 (Pubitemid 41541791)
148. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nat. Immunol. 6 2005 1123 1132 (Pubitemid 41541790)
149. E. Murphy, K. Shibuya, N. Hosken, P. Openshaw, V. Maino, K. Davis, K. Murphy, and A. O'Garra Reversibility of T helper 1 and 2 populations is lost after long-term stimulation J. Exp. Med. 183 1996 901 913 (Pubitemid 26114795)
150. J.S. Stumhofer, A. Laurence, E.H. Wilson, E. Huang, C.M. Tato, L.M. Johnson, A.V. Villarino, Q. Huang, A. Yoshimura, and D. Sehy Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system Nat. Immunol. 7 2006 937 945 (Pubitemid 44263907)
151. J.S. Stumhofer, J.S. Silver, A. Laurence, P.M. Porrett, T.H. Harris, L.A. Turka, M. Ernst, C.J. Saris, J.J. O'Shea, and C.A. Hunter Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 Nat. Immunol. 8 2007 1363 1371 (Pubitemid 350131173)
152. Y.K. Lee, H. Turner, C.L. Maynard, J.R. Oliver, D. Chen, C.O. Elson, and C.T. Weaver Late developmental plasticity in the T helper 17 lineage Immunity 30 2009 92 107
153. A.N. Hegazy, M. Peine, C. Helmstetter, I. Panse, A. Frohlich, A. Bergthaler, L. Flatz, D.D. Pinschewer, A. Radbruch, and M. Lohning Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions Immunity 32 2010 116 128
154. M.H. Lexberg, A. Taubner, A. Forster, I. Albrecht, A. Richter, T. Kamradt, A. Radbruch, and H.D. Chang Th memory for interleukin-17 expression is stable in vivo Eur. J. Immunol. 38 2008 2654 2664
155. F.C. Kurschus, A.L. Croxford, A.P. Heinen, S. Wortge, D. Ielo, and A. Waisman Genetic proof for the transient nature of the Th17 phenotype Eur. J. Immunol. 40 2010 3336 3346
156. K. Hirota, J.H. Duarte, M. Veldhoen, E. Hornsby, Y. Li, D.J. Cua, H. Ahlfors, C. Wilhelm, M. Tolaini, and U. Menzel Fate mapping of IL-17-producing T cells in inflammatory responses Nat. Immunol. 12 2011 255 263
157. X. Zhang, T. Brunner, L. Carter, R.W. Dutton, P. Rogers, L. Bradley, T. Sato, J.C. Reed, D. Green, and S.L. Swain Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis J. Exp. Med. 185 1997 1837 1849 (Pubitemid 27242205)
158. S. Devadas, J. Das, C. Liu, L. Zhang, A.I. Roberts, Z. Pan, P.A. Moore, G. Das, and Y. Shi Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells Immunity 25 2006 237 247 (Pubitemid 44224145)
159. D.J. Cua, and C.M. Tato Innate IL-17-producing cells: the sentinels of the immune system Nat. Rev. Immunol. 10 2010 479 489
160. C.E. Sutton, S.J. Lalor, C.M. Sweeney, C.F. Brereton, E.C. Lavelle, and K.H. Mills Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity Immunity 31 2009 331 341
161. F. Petermann, V. Rothhammer, M.C. Claussen, J.D. Haas, L.R. Blanco, S. Heink, I. Prinz, B. Hemmer, V.K. Kuchroo, and M. Oukka Gammadelta T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism Immunity 33 2010 351 363
162. A.V. Rachitskaya, A.M. Hansen, R. Horai, Z. Li, R. Villasmil, D. Luger, R.B. Nussenblatt, and R.R. Caspi Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion J. Immunol. 180 2008 5167 5171
163. E. Pal, T. Tabira, T. Kawano, M. Taniguchi, S. Miyake, and T. Yamamura Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of V alpha 14 NK T cells J. Immunol. 166 2001 662 668 (Pubitemid 32038491)
164. K. Miyamoto, S. Miyake, and T. Yamamura A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells Nature 413 2001 531 534 (Pubitemid 32938752)
165. R. Furlan, A. Bergami, D. Cantarella, E. Brambilla, M. Taniguchi, P. Dellabona, G. Casorati, and G. Martino Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma Eur. J. Immunol. 33 2003 1830 1838 (Pubitemid 37120854)
166. A.K. Singh, M.T. Wilson, S. Hong, D. Olivares-Villagomez, C. Du, A.K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. Van Kaer Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis J. Exp. Med. 194 2001 1801 1811 (Pubitemid 34028659)
167. H. Yokote, S. Miyake, J.L. Croxford, S. Oki, H. Mizusawa, and T. Yamamura NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora Am. J. Pathol. 173 2008 1714 1723
168. L.T. Mars, A.S. Gautron, J. Novak, L. Beaudoin, J. Diana, R.S. Liblau, and A. Lehuen Invariant NKT cells regulate experimental autoimmune encephalomyelitis and infiltrate the central nervous system in a CD1d-independent manner J. Immunol. 181 2008 2321 2329
169. G.X. Zhang, B. Gran, S. Yu, J. Li, I. Siglienti, X. Chen, M. Kamoun, and A. Rostami Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice. IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system J. Immunol. 170 2003 2153 2160 (Pubitemid 36197439)
170. Y. Komiyama, S. Nakae, T. Matsuki, A. Nambu, H. Ishigame, S. Kakuta, K. Sudo, and Y. Iwakura IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis J. Immunol. 177 2006 566 573 (Pubitemid 43939170)
171. I. Sonderegger, J. Kisielow, R. Meier, C. King, and M. Kopf IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo Eur. J. Immunol. 38 2008 1833 1838
172. A. Awasthi, L. Riol-Blanco, A. Jager, T. Korn, C. Pot, G. Galileos, E. Bettelli, V.K. Kuchroo, and M. Oukka Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells J. Immunol. 182 2009 5904 5908
173. T. Korn, M. Mitsdoerffer, A.L. Croxford, A. Awasthi, V.A. Dardalhon, G. Galileos, P. Vollmar, G.L. Stritesky, M.H. Kaplan, and A. Waisman IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells Proc. Natl. Acad. Sci. USA 105 2008 18460 18465
174. N. Berghmans, C. Dillen, and H. Heremans Exogenous IL-12 suppresses experimental autoimmune encephalomyelitis (EAE) by tuning IL-10 and IL-5 levels in an IFN-gamma-dependent way J. Neuroimmunol. 176 2006 63 75 (Pubitemid 44080341)
175. D. Jankovic, M.C. Kullberg, C.G. Feng, R.S. Goldszmid, C.M. Collazo, M. Wilson, T.A. Wynn, M. Kamanaka, R.A. Flavell, and A. Sher Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection J. Exp. Med. 204 2007 273 283 (Pubitemid 46294544)
176. H.D. Chang, C. Helbig, L. Tykocinski, S. Kreher, J. Koeck, U. Niesner, and A. Radbruch Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3 Eur. J. Immunol. 37 2007 807 817 (Pubitemid 46916947)
177. L. Gabrysova, K.S. Nicolson, H.B. Streeter, J. Verhagen, C.A. Sabatos-Peyton, D.J. Morgan, and D.C. Wraith Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells J. Exp. Med. 206 2009 1755 1767
178. K.L. Kemp, S.D. Levin, and P.L. Stein Lck regulates IL-10 expression in memory-like Th1 cells Eur. J. Immunol. 40 2010 3210 3219
179. B.M. Segal, C.S. Constantinescu, A. Raychaudhuri, L. Kim, R. Fidelus-Gort, and L.H. Kasper Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: A phase II, double-blind, placebo-controlled, randomised, dose-ranging study Lancet Neurol. 7 2008 796 804
180. B. Perussia, L. Mangoni, H.D. Engers, and G. Trinchieri Interferon production by human and murine lymphocytes in response to alloantigens J. Immunol. 125 1980 1589 1595 (Pubitemid 10018567)
181. R.B. Herberman, and J.R. Ortaldo Natural killer cells: their roles in defenses against disease Science 214 1981 24 30 (Pubitemid 11031354)
182. N. Sato, T. Yahata, K. Santa, A. Ohta, Y. Ohmi, S. Habu, and T. Nishimura Functional characterization of NK1.1 + Ly-6C+ cells Immunol. Lett. 54 1996 5 9 (Pubitemid 27062171)
183. A. Celada The interferon gamma receptor Lymphokine Res. 7 1988 61 73
184. C.L. Langrish, Y. Chen, W.M. Blumenschein, J. Mattson, B. Basham, J.D. Sedgwick, T. McClanahan, R.A. Kastelein, and D.J. Cua IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J. Exp. Med. 201 2005 233 240 (Pubitemid 40189432)
185. S.J. Liu, J.P. Tsai, C.R. Shen, Y.P. Sher, C.L. Hsieh, Y.C. Yeh, A.H. Chou, S.R. Chang, K.N. Hsiao, and F.W. Yu Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6 J. Leukoc. Biol. 82 2007 354 360
186. E. Lockhart, A.M. Green, and J.L. Flynn IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection J. Immunol. 177 2006 4662 4669 (Pubitemid 44469799)
187. S. Ferretti, O. Bonneau, G.R. Dubois, C.E. Jones, and A. Trifilieff IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger J. Immunol. 170 2003 2106 2112 (Pubitemid 36197433)
188. S. Molet, Q. Hamid, F. Davoine, E. Nutku, R. Taha, N. Page, R. Olivenstein, J. Elias, and J. Chakir IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines J. Allergy Clin. Immunol. 108 2001 430 438 (Pubitemid 32881066)
189. Q. Zhou, T. Desta, M. Fenton, D.T. Graves, and S. Amar Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein Infect. Immun. 73 2005 935 943 (Pubitemid 40165752)
190. R.E. Kuestner, D.W. Taft, A. Haran, C.S. Brandt, T. Brender, K. Lum, B. Harder, S. Okada, C.D. Ostrander, and J.L. Kreindler Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F J. Immunol. 179 2007 5462 5473
191. D. Toy, D. Kugler, M. Wolfson, T. Vanden Bos, J. Gurgel, J. Derry, J. Tocker, and J. Peschon Cutting edge: interleukin 17 signals through a heteromeric receptor complex J. Immunol. 177 2006 36 39 (Pubitemid 43939112)
192. T. Chtanova, S.G. Tangye, R. Newton, N. Frank, M.R. Hodge, M.S. Rolph, and C.R. Mackay T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells J. Immunol. 173 2004 68 78 (Pubitemid 38797327)
193. J. Parrish-Novak, S.R. Dillon, A. Nelson, A. Hammond, C. Sprecher, J.A. Gross, J. Johnston, K. Madden, W. Xu, and J. West Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function Nature 408 2000 57 63
194. W.J. Leonard, and R. Spolski Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation Nat. Rev. Immunol. 5 2005 688 698 (Pubitemid 43086171)
195. T. Takeshita, H. Asao, K. Ohtani, N. Ishii, S. Kumaki, N. Tanaka, H. Munakata, M. Nakamura, and K. Sugamura Cloning of the gamma chain of the human IL-2 receptor Science 257 1992 379 382
196. A. Svetic, F.D. Finkelman, Y.C. Jian, C.W. Dieffenbach, D.E. Scott, K.F. McCarthy, A.D. Steinberg, and W.C. Gause Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody J. Immunol. 147 1991 2391 2397
197. M. Stassen, M. Arnold, L. Hultner, C. Muller, C. Neudorfl, T. Reineke, and E. Schmitt Murine bone marrow-derived mast cells as potent producers of IL-9: costimulatory function of IL-10 and kit ligand in the presence of IL-1 J. Immunol. 164 2000 5549 5555 (Pubitemid 30389793)
198. B.R. Lauwerys, N. Garot, J.C. Renauld, and F.A. Houssiau Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18 J. Immunol. 165 2000 1847 1853 (Pubitemid 30643135)
199. Y. Kimura, T. Takeshita, M. Kondo, N. Ishii, M. Nakamura, J. Van Snick, and K. Sugamura Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex Int. Immunol. 7 1995 115 120
200. C. Druez, P. Coulie, C. Uyttenhove, and J. Van Snick Functional and biochemical characterization of mouse P40/IL-9 receptors J. Immunol. 145 1990 2494 2499 (Pubitemid 20374569)
201. L.M. Fawaz, E. Sharif-Askari, O. Hajoui, A. Soussi-Gounni, Q. Hamid, and B.D. Mazer Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion J. Allergy Clin. Immunol. 120 2007 1208 1215 (Pubitemid 350029906)
202. M. Longphre, D. Li, M. Gallup, E. Drori, C.L. Ordonez, T. Redman, S. Wenzel, D.E. Bice, J.V. Fahy, and C. Basbaum Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells J. Clin. Investig. 104 1999 1375 1382
203. R.H. Fontaine, O. Cases, V. Lelievre, B. Mesples, J.C. Renauld, G. Loron, V. Degos, P. Dournaud, O. Baud, and P. Gressens IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis Cell Death Differ. 15 2008 1542 1552
204. S.C. Liang, X.Y. Tan, D.P. Luxenberg, R. Karim, K. Dunussi-Joannopoulos, M. Collins, and L.A. Fouser Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides J. Exp. Med. 203 2006 2271 2279 (Pubitemid 44498362)
205. K.W. Moore, R. de Waal Malefyt, R.L. Coffman, and A. O'Garra Interleukin-10 and the interleukin-10 receptor Annu. Rev. Immunol. 19 2001 683 765 (Pubitemid 32368050)
206. B. Martin, K. Hirota, D.J. Cua, B. Stockinger, and M. Veldhoen Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals Immunity 31 2009 321 330
207. M. Goto, M. Murakawa, K. Kadoshima-Yamaoka, Y. Tanaka, K. Nagahira, Y. Fukuda, and T. Nishimura Murine NKT cells produce Th17 cytokine interleukin-22 Cell. Immunol. 254 2009 81 84
208. H. Takatori, Y. Kanno, W.T. Watford, C.M. Tato, G. Weiss, I.I. Ivanov, D.R. Littman, and J.J. O'Shea Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22 J. Exp. Med. 206 2009 35 41
209. S. Buonocore, P.P. Ahern, H.H. Uhlig, I.I. Ivanov, D.R. Littman, K.J. Maloy, and F. Powrie Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology Nature 464 2010 1371 1375
210. K. Takeda, S. Iwamoto, H. Sugimoto, T. Takuma, N. Kawatani, M. Noda, A. Masaki, H. Morise, H. Arimura, and K. Konno Identity of differentiation inducing factor and tumour necrosis factor Nature 323 1986 338 340 (Pubitemid 16033131)
211. S.S. Sung, L.K. Jung, J.A. Walters, W. Chen, C.Y. Wang, and S.M. Fu Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells J. Exp. Med. 168 1988 1539 1551 (Pubitemid 19023245)
212. R. Philip, and L.B. Epstein Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma-interferon and interleukin-1 Nature 323 1986 86 89 (Pubitemid 16012356)
213. J.W. Larrick, V. Morhenn, Y.L. Chiang, and T. Shi Activated Langerhans cells release tumor necrosis factor J. Leukoc. Biol. 45 1989 429 433 (Pubitemid 19135465)
214. M. Sawada, N. Kondo, A. Suzumura, and T. Marunouchi Production of tumor necrosis factor-alpha by microglia and astrocytes in culture Brain Res. 491 1989 394 397 (Pubitemid 19163393)
215. W. Fiers Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level FEBS Lett. 285 1991 199 212
216. M.J. Cline, and D.W. Golde Production of colony-stimulating activity by human lymphocytes Nature 248 1974 703 704
217. B. Thorens, J.J. Mermod, and P. Vassalli Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation Cell 48 1987 671 679 (Pubitemid 18096945)
218. A. Wodnar-Filipowicz, C.H. Heusser, and C. Moroni Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation Nature 339 1989 150 152 (Pubitemid 19122273)
219. R. Munker, J. Gasson, M. Ogawa, and H.P. Koeffler Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor Nature 323 1986 79 82 (Pubitemid 16012354)
220. G.C. Baldwin The biology of granulocyte-macrophage colony-stimulating factor: effects on hematopoietic and nonhematopoietic cells Dev. Biol. 151 1992 352 367
221. A.F. Lopez, A.B. Lyons, J.M. Eglinton, L.S. Park, L.B. To, S.C. Clark, and M.A. Vadas Specific binding of human interleukin-3 and granulocyte- macrophage colony-stimulating factor to human basophils J. Allergy Clin. Immunol. 85 1990 99 102 (Pubitemid 20058889)
222. M.J. Elliott, M.A. Vadas, J.M. Eglinton, L.S. Park, L.B. To, L.G. Cleland, S.C. Clark, and A.F. Lopez Recombinant human interleukin-3 and granulocyte-macrophage colony-stimulating factor show common biological effects and binding characteristics on human monocytes Blood 74 1989 2349 2359 (Pubitemid 19286452)
223. T. Magnus, T. Korn, and S. Jung Chronically stimulated microglial cells do no longer alter their immune functions in response to the phagocytosis of apoptotic cells J. Neuroimmunol. 155 2004 64 72 (Pubitemid 39165778)