Differential permeability of the BBB in acute EAE: Enhanced transport of TNF-α

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 4 34-4, 1996, Pages

  Pan, Weihong ^b   Banks, William A ^a   Kennedy, Mary K ^b   Gutierrez, Enrique G ^b   Kastin, Abba J ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

blood brain barrier; experimental autoimmune encephalomyelitis; tumor necrosis factor

Indexed keywords

ALBUMIN; SUCROSE; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; ISOTOPE LABELING; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSPORT KINETICS;

EID: 0029908222     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.4.e636     Document Type: Article

References (27)

1. Baker, D., D. Butler, B. J. Scallon, J. K. O'Neill, and J. L. Truck. Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins. Eur. J. Immunol. 24: 2040-2048, 1994.
2. Banks, W. A., A. J. Kastin, and E. G. Gutierrez. Interleukin-1α in blood has direct access to cortical brain cells. Neurosci. Lett. 163: 41-44, 1993.
3. Banks, W. A., A. J. Kastin, and E. G. Gutierrez. Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci. Lett. 179: 53-56, 1994.
4. Blasberg, R. G., J. D. Fenstermacher, and C. S. Patlak. Transport of α-aminoisobutyric acid across brain capillary and cellular membranes. J. Cereb. Blood Flow Metab. 3: 8-32, 1983.
5. Charity, Y., and Y. Shimamoto. Human tumor necrosis factor-α augments experimental allergic encephalomyelitis in rats. J. Neuroimmunol. 34: 159-164, 1991.
6. Claudiio, L., Y. Kress, W. T. Norton, and C. F. Brosnan. Increased vesicular transport and decreased mitochondrial content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis. Am. J. Pathol. 135: 1157-1168, 1989.
7. Daniel, P. M., D. K. C. Lam, and O. E. Pratt. Changes in the effectiveness of the blood-brain and blood-spinal cord barriers in experimental allergic encephalomyelitis. J. Neurol. Sci. 52: 211-219, 1981.
8. Gutierrez, E. G., W. A. Banks, and A. J. Kastin. Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J. Neuroimmunol. 47: 169-176, 1993.
9. Hawkins, C. P., F. Mackenzie, P. Tofts, E. P. G. H. du Boulay, and W. I. McDonald. Patterns of blood-brain barrier breakdown in inflammatory demyelination. Brain 114: 801-810, 1991
10. Juhler, M., D. I. Barry, H. Offner, G. Konat, L. Klinken, and O. B. Paulson. Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat. Brain Res. 302: 347-355, 1984.
11. Kato, S., and H. Nakamura. Ultrastructural and ultracytochemical studies on the blood-brain barrier in chronic relapsing experimental allergic encephalomyelitis. Acta Neuropathol. 77: 455-464, 1989.
12. Koh, C.-S., J. Gausas, and P. Y. Paterson. Neurovascular permeability and fibrin deposition in the central neuraxis of Lewis rats with cell-transferred experimental allergic encephalomyelitis in relationship to clinical and histopathological features of the disease. J. Neuroimmunol. 47: 141-146, 1993.
13. Kuroda, Y., and Y. Shimamoto. Human tumor necrosis factor-α augments experimental allergic encephalomyelitis in rats. J. Neuroimmunol. 34: 159-164, 1991.
14. Lossinsky, A. S., V. Badmajew, J. A. Robson, R. C. Moretz, and H. M. Wisniewski. Sites of egress of inflammatory cells and horseradish peroxidase transport across the blood-brain barrier in a murine model of chronic relapsing experimental allergic encephalomyelitis. Acta Neuropathol. 78: 359-371, 1989.
15. Malawian, J. M., and K. V. Snock. Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability Cancer Res. 50: 2172-2176, 1990.
16. McRae, B. L., M. K, Kennedy, L. J. Tan, M. C. Dal Canto, K. S. Picha, and S. D. Miller. Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein. J. Neuroimmunol. 38: 229-240, 1992.
17. Megyeri, P., C. S. Abraham, P. Temesvari, J. Kovacs, T. Vas, and C. P. Speer. Recombinant human tumor necrosis factor α constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets. Neurosci. Lett. 148: 137-140, 1992.
18. Munoz-Fernandez, M. A., R. Armas-Portela, and J. Duaz-Nido. Differential effects of tumor necrosis factor on the growth and differentiation of neuroblastoma and glioma cells. Exp. Cell Res. 194: 161-164, 1991.
19. Patlak, C. S., R. G. Blasberg, and J. D. Fenstermacher. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data J. Cereb. Blood Flow Metab. 3: 1-7, 1983.
20. Pober, J. S. Cytokine-mediated activation of vascular endothelium, physiology and pathology. Am. J. Pathol. 133: 426-433, 1988.
21. Schwartz, M., A. Solomon, V. Lavie, S. Ben-Bassat, M. Belkin, and A. Cohen. Tumor necrosis factor facilitates regeneration of injured central nervous system axons. Brain Res. 545: 334-338, 1991.
22. Selmaj, K., C. S. Raine, and A. H. Cross. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination Ann. Neurol. 30: 694-700, 1991.
23. Sharief, M. K., M. A. Noori, A, Cirelli, and E. J. Thompson. Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-α and blood-brain barrier damage. J. Neuroimmunol. 43: 15-22, 1993.
24. Smith, R. A., and C. Baglioni. The active form of tumor necrosis factor is a trimer. J. Biol. Chem. 262: 6951-6954, 1987.
25. Tuohy, V. K., Z. Lu, R. A. Sobel, R. A. Laursen, and M. B. Lees. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol. 142: 1523-1527, 1989.
26. 3H]inulin after osmotic opening in the rat. Exp. Neurol. 79: 845-857, 1983
27. Ziylan, Y. Z., P. J. Robinson, and S. I. Rapoport. Blood-brain barrier permeability to sucrose and dextran after osmotic opening. Am. J. Physiol. 247 (Regulatory Integrative Comp. Physiol. 16): R634-R638, 1984.