STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 19, 2002, Pages 12281-12286

  Morinobu, Akio ^a   Gadina, Massimo ^a   Strober, Warren ^b   Visconti, Roberta ^a,e   Fornace, Albert ^c   Montagna, Cristina ^c   Feldman, Gerald M ^d   Nishikomori, Ryuta ^b,f   O'Shea, John J ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE; STAT4 PROTEIN; TYROSINE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE MUTATION; GENETIC TRANSDUCTION; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SPLEEN CELL; TH1 CELL;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CELLS, CULTURED; DNA-BINDING PROTEINS; INTERFERON TYPE II; INTERLEUKIN-12; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE KINASE 6; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENESIS, SITE-DIRECTED; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEINS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; RECOMBINANT PROTEINS; SERINE; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR; TH1 CELLS; TRANS-ACTIVATORS; TYROSINE;

ANIMALIA;

EID: 0037125988     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.182618999     Document Type: Article

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