Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease

Journal of Experimental Medicine

Volumn 186, Issue 2, 1997, Pages 307-312

  Lafaille, Juan J ^a,d   Van De Keere, Fabienne ^a   Hsu, Albert L ^b   Baron, Jody L ^a,e   Haas, Werner ^a   Raine, Cedric S ^b   Tonegawa, Susumu ^a,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN BASIC PROTEIN;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; HELPER CELL; HISTOPATHOLOGY; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; IMMUNOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNOCOMPROMISED HOST; MAST CELLS; MICE; MICE, INBRED C57BL; MYELIN BASIC PROTEINS; NEUTROPHILS; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030739650     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.2.307     Document Type: Article

References (39)

1. Mosmann, T.R., and R.L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 7:145-173.
2. Abbas, A.K., K.M. Murphy, and A. Sher. 1996. Functional diversity of helper lymphocytes. Nature (Lond). 383:787-793.
3. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091-1098.
4. Hsieh, C.S., A.B. Heimberger, J.S. Gold, A. O'Garra, and K.M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell receptor transgenic system. Proc. Natl. Acad. Sci. USA. 89: 6065-6069.
5. + T cells through IL-12 produced by Listeria-induced macrophages. Science (Wash. DC). 260:547-549.
6. Scott, B., R. Liblau, S. Degermann, L.A. Marconi, L. Ogata, A.J. Caton, H.O. McDevitt, and D. Lo. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity. 1:73-83.
7. + cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today. 16:34-38.
8. Rocken, M., M. Racke, and E.M. Shevach. 1996. IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today. 17:225-231.
9. Zamvil, S.S., and L. Steinman. 1990. The T lymphocyte in experimental allergic encephalomyelitis. Ann. Rev. Immunol. 8:579-621.
10. Racke, M.K., A. Bonomo, D.E. Scott, B. Cannella, P.S. Albert, C.S. Raine, E.M. Shevach, and M. Rocken. 1994. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180:1961-1966.
11. Brocke, S., K. Gijbels, M. Allegretta, I. Ferber, C. Piercy, T. Blankenstein, R. Martin, U. Utz, N. Karin, D. Mitchell et al. 1996. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature (Lond.). 379: 343-346.
12. Leonard, J.P., K.E. Waldburger, and S.J. Goldman. 1995. Prevention of experimental autoimmune encephalitis by antibodies against interleukin 12. J. Exp. Med. 181:381-386.
13. Billiau, A., H. Heremans, F. Vandekerckhove, R. Dijkmans, H. Sobis, E. Meulepas, and H. Carton. 1988. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-γ. J. Immunol. 140:1506-1510.
14. Steinman, L. 1996. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. Proc. Natl. Acad. Sci. USA. 93:2253-2256.
15. Cannella, B., Y.L. Gao, C. Brosnan, and C.S. Raine. 1996. IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J. Neurosci. Res. 45:735-746.
16. Lafaille, J.J., K. Nagashima, M. Katsuki, and S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 78:399-408.
17. Mombaerts, P., J. Iacomini, R.S. Johnson, K. Herrup, S. Tonegawa, and V. Papaiannou. 1992. RAG-1 deficient mice have no mature B and T lymphocytes. Cell. 68:869-877.
18. Mombaerts, P., A.R. Clarke, M.A. Rudnicki, J. Iacomini, S. Itohara, J.J. Lafaille, L. Wang, Y. Ishikawa, R. Jaenisch, M.L. Hooper, and S. Tonegawa. 1992. Mutations in T-cell antigen receptor genes α and β blocks thymocyte development at different stages. Nature (Lond.). 360:225-231.
19. Itohara, S., P. Mombaerts, J.J. Lafaille, J. Iacomini, A. Nelson, A.R. Clarke, M.L. Hooper, A. Farr, and S. Tonegawa. 1993. T cell receptor δ KO mice: independent generation of αβ T cells and programmed rearrangements of δγ TCR genes. Cell. 72:337-348.
20. Baron, J.L., J.A. Madri, N.H. Ruddle, G. Hashim, and C.A. Janeway, Jr. 1993. Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 177:57-68.
21. Perez, V.L., J.A. Lederer, A.H. Lichtman, and A.K. Abbas. 1995. Stability of Th1 and Th2 populations. Int. Immunol. 7:869-875.
22. Szabo, S.J., N.G. Jacobson, A.S. Dighe, U. Gubler, and K.M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 2:665-675.
23. Murphy, E., K. Shibuya, N. Hosken, P. Openshaw, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1996. Reversibility of T helper 1 and 2 populations is lost after long- term stimulation. J. Exp. Med. 183:901-913.
24. Ferber, I.A., S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalton, and C.G. Fathman. 1996. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156:5-7.
25. Ruddle, N.H., C.M. Bergman, K.M. McGrath, E.G. Lingenheld, M.L. Grunnet, S.J. Padula, and R.B. Clark. 1990. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J. Exp. Med. 172:1193-1200.
26. Selmaj, K., C.S. Raine, and A.H. Cross. 1991. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann. Neurol. 30:694-700.
27. Powell, M.B., D. Mitchell, J. Lederman, J. Buckmeier, S.S. Zamvil, M. Graham, N.H. Ruddle, and L. Steinman. 1990. Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int. Immunol. 2:539-544.
28. Probert, L., K. Akassoglou, M. Pasparakis, G. Kontogeorgos, and G. Kollias. 1995. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor α. Proc. Natl. Acad. Sci. USA. 92:11294-11298.
29. Katz, J.D., C. Benoist, and D. Mathis. 1995. T helper cell subsets in insulin-dependent diabetes. Science (Wash. DC). 268:1185-1188.
30. Khoruts, A., S.D. Miller, and M.K. Jenkins. 1995. Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells. J. Immunol. 155:5011-5017.
31. Chen, Y., V.K. Kuchroo, J.-I. Inobe, D.A. Hafler, and H.L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science (Wash. DC). 265:1237-1240.
32. Kuchroo, V.K., M.P. Das, J.A. Brown, A.M. Ranger, S.S. Zamvil, R.A. Sobel, H.L. Weiner, N. Nabavi, and L.H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 80:707-718.
33. Guler, M.L., J.D. Gorham, C.S. Hsieh, A.J. Mackey, R.G. Steen, W.F. Dietrich, and K.M. Murphy. 1996. Genetic susceptibility to Leishmania: IL-12 responsiveness in Th1 cell development. Science (Wash. DC). 271:984-987.
34. Theoharides, T.C. 1996. The mast cell: a neuroimmunoendocrine master player. J. Tiss. React. 18:1-21.
35. Silver, R., A.-J. Silverman, L. Vitkoviv, and I.I. Lederhendler. 1996. Mast cells in the brain: evidence and functional significance. Trends Neurosci. 19:25-31.
36. Purcell, W.M., and C.K. Atterwill. 1995. Mast cells in neuroimmune function: neurotoxicological and neuropharmacological perspectives. Neurochem. Res. 20:521-532.
37. McFarland, H.F. 1996. Complexities in the treatment of autoimmune disease. Science (Wash. DC). 274:2037-2038.
38. Genain, C.P., K. Abel, N. Belmar, F. Villinger, D.P. Rosenberg, C. Linington, C.S. Raine, and S.L. Hauser. 1996. Late complications of immune deviation therapy in a nonhuman primate. Science (Wash. DC). 274:2054-2057.
39. Chilosi, M., F. Facchetti, L.D. Notarangelo, S. Romagnani, G. Del Prete, F. Almerigogna, M. De Carli, and G. Pizzolo. 1996. CD30 cell expression and abnormal soluble CD30 serum accumulation in Omenn's syndrome: evidence for a T helper 2-mediated condition. Eur. J. Immunol. 26:329-334.