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Volumn 53, Issue 3, 1999, Pages 457-465

TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOPHOSPHAMIDE; HYBRID PROTEIN; IMMUNOGLOBULIN G; INTERFERON; LENERCEPT; PROTEIN P55; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 0033546665     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.53.3.457     Document Type: Article
Times cited : (956)

References (29)
  • 1
    • 0024366885 scopus 로고
    • Tumor necrosis factor identified in multiple sclerosis brain
    • Hofman FM, Hinton DR, Johnson K, Merrill JE. Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med 1989;170:607-612.
    • (1989) J Exp Med , vol.170 , pp. 607-612
    • Hofman, F.M.1    Hinton, D.R.2    Johnson, K.3    Merrill, J.E.4
  • 3
    • 0025092159 scopus 로고
    • Proliferation of astrocytes in vitro in response to cytokine: A primary role for tumor necrosis factor
    • Selmaj KW, Farooq M, Norton WT, Raine CS, Brosnan CF. Proliferation of astrocytes in vitro in response to cytokine: a primary role for tumor necrosis factor. J Immunol 1990;144: 129-135.
    • (1990) J Immunol , vol.144 , pp. 129-135
    • Selmaj, K.W.1    Farooq, M.2    Norton, W.T.3    Raine, C.S.4    Brosnan, C.F.5
  • 4
    • 0025773147 scopus 로고
    • Association between tumor necrosis factor-alpha and disease and disease progression in patients with multiple sclerosis
    • Sharief MK, Hentges R. Association between tumor necrosis factor-alpha and disease and disease progression in patients with multiple sclerosis. N Engl J Med 1991;325:467-472.
    • (1991) N Engl J Med , vol.325 , pp. 467-472
    • Sharief, M.K.1    Hentges, R.2
  • 5
    • 0026066932 scopus 로고
    • Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis
    • Maimone D, Gregory S, Arnason BGW, Reder AT. Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J Neuroimmunol 1991;32:67-74.
    • (1991) J Neuroimmunol , vol.32 , pp. 67-74
    • Maimone, D.1    Gregory, S.2    Arnason, B.G.W.3    Reder, A.T.4
  • 6
    • 0023794099 scopus 로고
    • Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?
    • Beck J, Rondot P, Catinot L, Falcoff E, Kirchner H, Wietzerbin J. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations? Acta Neurol Scand 1988;78:318-323.
    • (1988) Acta Neurol Scand , vol.78 , pp. 318-323
    • Beck, J.1    Rondot, P.2    Catinot, L.3    Falcoff, E.4    Kirchner, H.5    Wietzerbin, J.6
  • 7
    • 0027934602 scopus 로고
    • Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis
    • Rieckmann P, Albrecht M, Kitze B, et al. Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology 1994;44:1523-1526.
    • (1994) Neurology , vol.44 , pp. 1523-1526
    • Rieckmann, P.1    Albrecht, M.2    Kitze, B.3
  • 8
    • 0028985320 scopus 로고
    • Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity
    • Rieckmann P, Albrecht M, Kitze B, et al. Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity. Ann Neurol 1995;37:82-88.
    • (1995) Ann Neurol , vol.37 , pp. 82-88
    • Rieckmann, P.1    Albrecht, M.2    Kitze, B.3
  • 9
    • 0025999081 scopus 로고
    • Human tumor necrosis factor-alpha augments experimental allergic encephalomyelitis in rats
    • Kuroda Y, Shimamoto Y. Human tumor necrosis factor-alpha augments experimental allergic encephalomyelitis in rats. J Neuroimmunol 1991;34:159-164.
    • (1991) J Neuroimmunol , vol.34 , pp. 159-164
    • Kuroda, Y.1    Shimamoto, Y.2
  • 10
    • 0025000863 scopus 로고
    • An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis
    • Ruddle NH, Bergman CM, McGrath KM, et al. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J Exp Med 1990;172: 1193-1200.
    • (1990) J Exp Med , vol.172 , pp. 1193-1200
    • Ruddle, N.H.1    Bergman, C.M.2    McGrath, K.M.3
  • 11
    • 0026094706 scopus 로고
    • Anti-tumor necrosis factor abrogates autoimmune demyelination
    • Selmaj K, Raine CS, Cross AH. Anti-tumor necrosis factor abrogates autoimmune demyelination. Ann Neurol 1991;30: 694-700.
    • (1991) Ann Neurol , vol.30 , pp. 694-700
    • Selmaj, K.1    Raine, C.S.2    Cross, A.H.3
  • 12
    • 0028066844 scopus 로고
    • Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins
    • Baker D, Butler D, Scallon BJ, O'Neill JK, Turk JL, Feldmann M. Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins. Eur J Immunol 1994;24:2040-2048.
    • (1994) Eur J Immunol , vol.24 , pp. 2040-2048
    • Baker, D.1    Butler, D.2    Scallon, B.J.3    O'Neill, J.K.4    Turk, J.L.5    Feldmann, M.6
  • 13
    • 0031040849 scopus 로고    scopus 로고
    • TNF-alpha receptor fusion protein prevents experimental autoimmune encephalomyelitis and demyelination in Lewis rats: An overview
    • Klinkert WE, Kojima K, Lesslauer W, Rinner W, Lassmann H, Wekerle H. TNF-alpha receptor fusion protein prevents experimental autoimmune encephalomyelitis and demyelination in Lewis rats: an overview. J Neuroimmunol 1997;72: 163-168.
    • (1997) J Neuroimmunol , vol.72 , pp. 163-168
    • Klinkert, W.E.1    Kojima, K.2    Lesslauer, W.3    Rinner, W.4    Lassmann, H.5    Wekerle, H.6
  • 14
    • 0025721017 scopus 로고
    • Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesion
    • Ashkenazi A, Marsters SA, Capon DJ, et al. Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesion. Proc Natl Acad Sci USA 1991;88:10535-10539.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10535-10539
    • Ashkenazi, A.1    Marsters, S.A.2    Capon, D.J.3
  • 15
    • 0025943512 scopus 로고
    • Recombinant soluble TNF receptor proteins protect mice from LPS-induced lethality
    • Lesslauer W, Tabuchi H, Gentz R, et al. Recombinant soluble TNF receptor proteins protect mice from LPS-induced lethality. Eur J Immunol 1991;21:2883-2886.
    • (1991) Eur J Immunol , vol.21 , pp. 2883-2886
    • Lesslauer, W.1    Tabuchi, H.2    Gentz, R.3
  • 16
    • 9044245703 scopus 로고    scopus 로고
    • Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis
    • Miller DH, Albert PS, Barkhof F, et al. Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis. Ann Neurol 1996;39:6-16.
    • (1996) Ann Neurol , vol.39 , pp. 6-16
    • Miller, D.H.1    Albert, P.S.2    Barkhof, F.3
  • 17
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993;43:655-661.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 18
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
    • Paty DW, Li DKB, the UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993;43:662-667.
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.W.1    Li, D.K.B.2
  • 20
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis
    • PRISMS (Prevention of Relapses and Disability by Interferon β-1a Subcutaneously in Multiple Sclerosis) Study Group. Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis. Lancet 1998; 352:1498-1504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 21
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-1452.
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 22
    • 0025805329 scopus 로고
    • Multiple testing in clinical trials
    • Bauer P. Multiple testing in clinical trials. Stat Med 1991;10: 871-890.
    • (1991) Stat Med , vol.10 , pp. 871-890
    • Bauer, P.1
  • 24
    • 0001646484 scopus 로고
    • Cox's regression model for counting processes: A large sample study
    • Andersen PK, Gill RD. Cox's regression model for counting processes: a large sample study. Ann Stat 1982;10:1100-1120.
    • (1982) Ann Stat , vol.10 , pp. 1100-1120
    • Andersen, P.K.1    Gill, R.D.2
  • 25
    • 0029751983 scopus 로고    scopus 로고
    • Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2
    • Van Oosten BW, Barkhof F, Truyen L, et al. Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2. Neurology 1996;47:1531-1534.
    • (1996) Neurology , vol.47 , pp. 1531-1534
    • Van Oosten, B.W.1    Barkhof, F.2    Truyen, L.3
  • 26
    • 0031916192 scopus 로고    scopus 로고
    • TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
    • Liu J, Marino MW, Wong G, et al. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat Med 1998;4:78-83.
    • (1998) Nat Med , vol.4 , pp. 78-83
    • Liu, J.1    Marino, M.W.2    Wong, G.3
  • 27
    • 0023126661 scopus 로고
    • Exacerbations of multiple sclerosis in patients treated with gamma interferon
    • Panitch HS, Hirsch RL, Haley AS, Johnson KP. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 1987;1:893-895.
    • (1987) Lancet , vol.1 , pp. 893-895
    • Panitch, H.S.1    Hirsch, R.L.2    Haley, A.S.3    Johnson, K.P.4
  • 28
    • 0030701533 scopus 로고    scopus 로고
    • Immune complexes are potent inhibitors of interleukin-12 secretion by human monocytes
    • Berger S, Chandra R, Balló H, Hildebrand R, Stutte HJ. Immune complexes are potent inhibitors of interleukin-12 secretion by human monocytes. Eur J Immunol 1997;27:2994-3000.
    • (1997) Eur J Immunol , vol.27 , pp. 2994-3000
    • Berger, S.1    Chandra, R.2    Balló, H.3    Hildebrand, R.4    Stutte, H.J.5
  • 29
    • 0000462090 scopus 로고    scopus 로고
    • Neutralization of TNF by lenercept (TNFR55-IgG, Ro 45-2081) in patients with rheumatoid arthritis treated for 3 months: Results of a European phase II trial
    • Sanders O, Ran R, van Riel P, et al. Neutralization of TNF by lenercept (TNFR55-IgG, Ro 45-2081) in patients with rheumatoid arthritis treated for 3 months: results of a European phase II trial. Arthritis Rheum 1996;39(suppl 9):242.
    • (1996) Arthritis Rheum , vol.39 , Issue.9 SUPPL. , pp. 242
    • Sanders, O.1    Ran, R.2    Van Riel, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.