Inflammatory Cytokines IFN-γ Plus TNF-α Induce Regulated Expression of CD80 (B7-1) but Not CD86 (B7-2) on Murine Fibroblasts

Journal of Immunology

Volumn 158, Issue 10, 1997, Pages 4921-4929

  Pechhold, Klaus ^a   Patterson, Noelle B ^a   Craighead, Nancy ^a   Lee, Kelvin P ^a   June, Carl H ^a   Harlan, David M ^a  

^a NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CD86 PROTEIN, MOUSE; GAMMA INTERFERON; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ANTIGEN PRESENTING CELL; ARTICLE; C57BL MOUSE; CELL CULTURE; DRUG POTENTIATION; FIBROBLAST; FLOW CYTOMETRY; GENE EXPRESSION; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; T LYMPHOCYTE; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; CELLS, CULTURED; DRUG SYNERGISM; FIBROBLASTS; FLOW CYTOMETRY; GENE EXPRESSION; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RNA, MESSENGER; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0031570123     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. June, C. H., J. A. Ledbetter, P. S. Linsley, and C. B. Thompson. 1990. Role of the CD28 receptor in T-cell activation. Immunol. Today 11:211.
2. Linsley, P. S., and J. A. Ledbetter. 1993. The Role of the CD28 receptor during T-cell responses to antigen. Annu. Rev. Immunol. 11:191.
3. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
4. Linsley, P. S., J. L. Greene, W. Brady, J. Bajorath, J. A. Ledbetter, and R. Peach. 1994. Human B7-1 (CD80) and B7-2 (CD86) hind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1:793.
5. Linsley, P. S., J. L. Greene, P. Tan, J. Bradshaw, J. A. Ledbetter, C. Anasetti, and N. K. Damle. 1992. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J. Exp. Med. 176:1595.
6. Walunas, T. L., D. J. Lenschow, C. Y. Bakker, P. S. Linsley, G. J. Freeman, J. M. Green, C. B. Thompson, and J. A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
7. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270:985.
8. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
9. Gribben, J. G., C. J. Freeman, V. A. Boussiotis, P. Rennert, C. L. Jellis, E. Greenfield, M. Barber, V. A. Restivo, Jr., X. Ke, G. S. Gray, and L. M. Nadler. 1995. CTLA4 mediates antigen-specific apoptosis of human T cells. Proc. Natl. Acad. Sci. USA 92:811.
10. Krummel, M. F., and J. P. Allison. 1995. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:459.
11. Leach, D. R., M. F. Krummel, and J. P. Allison. 1996. Enhancement of Antitumor Immunity by CTLA-4 Blockade. Science 271:1734.
12. Hathcock, K. S., G. Laszlo, C. Pucillo, P. Linsley, and R. J. Hodes. 1994. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J. Exp. Med. 180:631.
13. Larsen, C. P., S. C. Ritchie, R. Hendrix, P. S. Linsley, K. S. Hathcock, R. J. Hodes, R. P. Lowry, and T. C. Pearson. 1994. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J. Immunol. 152:5208.
14. Azuma, M., H. Yssel, J. H. Phillips, H. Spits, and L. L. Lanier. 1993. Functional expression of B7/BB1 on activated T lymphocytes. J. Exp. Med. 177:845.
15. Sansom, D. M., and N. D. Hall. 1993. B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro. Eur. J. Immunol. 23:295.
16. Freedman, A. S., G. J. Freeman, K. Rhynhart, and L. M. Nadler. 1991. Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell. Immunol. 137:429.
17. Lenschow, D. J., G. H. Su, L. A. Zuckerman, N. Nabavi, C. L. Jellis, G. S. Gray, J. Miller, and J. A. Bluestone. 1993. Expression and functional significance of an additional ligand for CTLA-4. Proc. Natl. Acad. Sci. USA 90:11054.
18. Lenschow, D. J., A. I. Sperling, M. P. Cooke, G. Freeman, L. Rhee, DC. Decker, G. Gray, L. M. Nadler, C. C. Goodnow, and J. A. Bluestone. 1994. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J. Immunol. 153:1990.
19. Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel. H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
20. Freeman, G. J., V. A. Boussiotis, A. Anumanthan, G. M. Bernstein, X. Y. Ke, P. D. Rennert, G. S. Gray, J. G. Gribben, and L. M. Nadler. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523.
21. Lanier, L. L., S. O'Fallon, C. Somoza, J. H. Phillips, P. S. Linsley, K. Okumura, D. Ito, and M. Azuma. 1995. CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154:97.
22. + T cells and induce similar patterns of cytokine secretion in vitro. Int. Immunol. 7:891.
23. Natesan, M., Z. Razi Wolf, and H. Reiser. 1996. Costimulation of IL-4 production by murine B7-1 and B7-2 molecules. J. Immunol. 156:2783.
24. Chen, L., S. Ashe, W. A. Brady, I. Hellstroem, K. E. Hellstroem, J. A. Ledbetter, P. Mcgowan, and P. S. Linsley. 1992. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 71:1093.
25. + T cells by B7-transfected melanoma cells. Science 259:368.
26. Baskar, S., S. Ostrand-Rosenberg, N. Nabavi, L. M. Nadler, G. J. Freeman, and L. H. Glimcher. 1993. Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules. Proc. Natl. Acad. Sci. USA 90:5687.
27. + T cells: ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response. J. Immunol. 155:45.
28. Cavallo, F., A. Martin Fontecha, M. Bellone, S. Heltai, E. Gatti, P. Tornaghi, M. Freschi, G. Forni, P. Dellabona, and G. Casorati. 1995. Co-expression of B7-1 and ICAM-1 on tumors is required for rejection and the establishment of a memory response. Eur. J. Immunol. 25:1154.
29. Allison, J. P., A. A. Hurwitz, and D. R. Leach. 1995. Manipulation of costimulatory signals to enhance antitumor T-cell responses. Curr. Opin. Immunol. 7:682.
30. Williams, I. R., R. S. Ort, and T. S. Kupper. 1994. Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens. Proc. Natl. Acad. Sci. USA 91:12780.
31. Nasir, A., B. Ferbel, W. Salminen, R. K. Barth, and A. A. Gaspari. 1994. Exaggerated and persistent cutaneous delayed-type hypersensitivity in transgenic mice whose epidermal keratinocytes constitutively express B7-1 antigen. J. Clin. Invest. 94:892.
32. Harlan, D. M., H. Hengartner, M. L. Huang, Y. H. Kang, R. Abe, R. W. Moreadith, H. Pircher, G. S. Gray, P. S. Ohashi, G. J. Freeman, L. M. Nadler, C. H. June, and P. Aichele. 1994. Mice expressing both B7-1 and viral glycoprotein on pancreatic β-cells along with glycoprotein-specific transgenic T-cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc. Natl. Acad. Sci. USA 91:3137.
33. Guerder, S., J. Meyerhoff, and R. Flavell. 1994. The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen. Immunity 1:155.
34. Windhagen, A., J. Newcombe, F. Dangond, C. Strand, M. N. Woodroofe, M. L. Cuzner, and D. A. Hafler. 1995. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cyrokine in multiple sclerosis lesions. J. Exp. Med. 182:1985.
35. Simon, J. C., A. Dietrich, V. Mielke, C. Wuttig, W. Vanscheidt, P. S. Linsley, E. Schopf, and W. Sterry. 1994. Expression of the B7/BB1 activation antigen and its ligand CD28 in T-cell-mediated skin diseases. J. Invest. Dermatol. 103:539.
36. Imagawa, A., T. Hanafusa, N. Itoh, J. Miyagawa, H. Nakajima, M. Kuwajima, M. Namba, S. Tamura, S. Kawata, Y. Matsuzawa, and D. M. Harlan. 1996. Islet infiltrating T-lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2). J. Autoimmun. 9:191-396.
37. Antonia, S. J., T. Munoz Antonia, G. Soldevila, J. Miller, and R. A. Flavell. 1995. B7-1 expression by a non-antigen presenting cell-derived tumor. Cancer Res. 55:2253.
38. Baskar, S., V. K. Clements, L. H. Glimcher, N. Nabavi, and S. Ostrand-Rosenberg. 1996. Rejection of MHC class II-transfected tumor cells requires induction of tumor-encoded B7-1 and/or B7-2 costimulatory molecules. J. Immunol. 156:3821.
39. Seino, K., M. Azuma, H. Bashuda, K. Fukao, H. Yagita, and K. Okumura. 1995. CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4+ T cells. Int. Immunol. 7:1331.
40. Davis, T. A., N. Craighead, L. L. Williams, A. Scadron, C. H. June, and K. P. Lee. 1996. Primary porcine endothelial cells express membrane-bound B7-2 (CD86) und a soluble factor that costimulate cyclosporin A-resistant and CD28-dependent human T cell proliferation. Int. Immunol. 8:1099-1111.
41. Ohashi, P. S., S. Oehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
42. Aichele, P., D. Kyburz, P. S. Ohashi, B. Odermatt, R. M. Zinkernagel, H. Hengartner, and H. Pircher. 1994. Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model. Proc. Natl. Acad. Sci. USA 91:444.
43. Huang, X., B. Hultgren, N. Dybdal, and T. A. Stewart. 1994. Islet expression of interferon-alpha precedes diabetes in both the BB rat and streptozotocin-treated mice. Immunity 1:469.
44. Herold, K. C., V. Vezys, Q. Sun, D. Viktora, E. Seung, S. Reiner, and D. R. Brown. 1996. Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin. J. Immunol. 156:3521.
45. Higuchi, Y., P. Herrera, P. Muniesa, J. Huarte, D. Belin, P. S. Ohashi, P. Aichele, L. Orci, J. D. Vassalli, and P. Vassalli. 1992. Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta ceils results in severe and permanent insulitis without evolution towards diabetes. J. Exp. Med. 176:1719.
46. Pujol Borrell, R., G. Soldevila, M. Buscema, M. Vives, J. Badenas, R. Marakian, and G. F. Bottazzo. 1989. Inappropriate expression of HLA class II molecules in endocrine epithelial cells: the phenomenon, the new experimental data and comparison with animal models. J. Autoimmun. 2(Suppl.):163.
47. Vives, M., G. Soldevila, L. Alcalde, C. Lorenzo, N. Somoza, and R. Pujol Borrell. 1991. Adhesion molecules in human islet beta-cells: de novo induction of ICAM-1 but not LFA-3. Diabetes 40:1382.
48. Aggarwal, B. B., and W. J. Kohr. 1985. Human necrosis factor. Methods Enzymol. 116:448.
49. Racke, M. K., D. E. Scott, L. Quigley, G. S. Gray, R. Abe, C. H. June, and P. J. Perrin. 1995. Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis. J. Clin. Invest. 96:2195.
50. Guerder, S., S. R. Carding, and R. A. Flavell. 1995. B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors. J. Immunol. 155:5167.
51. Jenkins, M. K., and J. G. Johnson. 1993. Molecules involved in T-cell costimulation. Curr. Opin. Immunol. 5:361.
52. L. Immunity 3:87.
53. Kündig, T. M., M. F. Bachmann, C. DiPaolo, J. J. Simard, M. Battegay, H. Lother, A. Gessner, K. Kuhlcke, P. S. Ohashi, H. Hengartner, and R. M. Zinkernagel. 1995. Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science 268:1343.