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Volumn 104, Issue 5, 1999, Pages 599-610

Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DEMYELINATION; EPITOPE MAPPING; FEMALE; MOUSE; MULTIPLE SCLEROSIS; MURINE ENCEPHALOMYELITIS VIRUS; MYELINATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032752573     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7292     Document Type: Article
Times cited : (122)

References (74)
  • 1
    • 0027488445 scopus 로고
    • Experimental autoimmune encephalomyelitis as a model of immune-mediated CNS disease
    • Wekerle, H. 1993. Experimental autoimmune encephalomyelitis as a model of immune-mediated CNS disease. Curr. Opin. Neurobiol. 3:779-784.
    • (1993) Curr. Opin. Neurobiol. , vol.3 , pp. 779-784
    • Wekerle, H.1
  • 2
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • Ota, K., et al. 1990. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 346:183-187.
    • (1990) Nature , vol.346 , pp. 183-187
    • Ota, K.1
  • 3
    • 0026147769 scopus 로고
    • Immunopathological recognition of autoantigens in multiple sclerosis
    • Bernard, C.C., and de Rosbo, N.K. 1991. Immunopathological recognition of autoantigens in multiple sclerosis. Acta Neurol. (Napoli). 13:171-178.
    • (1991) Acta Neurol. (Napoli) , vol.13 , pp. 171-178
    • Bernard, C.C.1    De Rosbo, N.K.2
  • 4
    • 0030697438 scopus 로고    scopus 로고
    • Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: Reactivity to the extracellular domain of MOG is directed against three main regions
    • de Rosbo, N.K., et al. 1997. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur. J. Immunol. 27:3059-3069.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3059-3069
    • De Rosbo, N.K.1
  • 5
    • 0027421126 scopus 로고
    • Epidemiologic evidence for multiple sclerosis as an infection
    • Kurtzke, J.F. 1993. Epidemiologic evidence for multiple sclerosis as an infection. Clin. Microbiol. Rev. 6:382-427.
    • (1993) Clin. Microbiol. Rev. , vol.6 , pp. 382-427
    • Kurtzke, J.F.1
  • 6
    • 0022375427 scopus 로고
    • Amino acid homology between the encephalitogenic site of myelin basic protein and virus: Mechanism for autoimmunity
    • Fujinami, R.S., and Oldstone, M.B. 1985. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science. 230:1043-1045.
    • (1985) Science , vol.230 , pp. 1043-1045
    • Fujinami, R.S.1    Oldstone, M.B.2
  • 8
    • 0001045439 scopus 로고
    • Immunologic aspects of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease
    • Miller, S.D., and Gerety, S.J. 1990. Immunologic aspects of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. Semin. Virol. 1:263-272.
    • (1990) Semin. Virol. , vol.1 , pp. 263-272
    • Miller, S.D.1    Gerety, S.J.2
  • 9
    • 0028990465 scopus 로고
    • Evolution of the T cell repertoire during the course of experimental autoimmune encephalomyelitis
    • Miller, S.D., et al. 1995. Evolution of the T cell repertoire during the course of experimental autoimmune encephalomyelitis. Immunol. Rev. 144:225-244.
    • (1995) Immunol. Rev. , vol.144 , pp. 225-244
    • Miller, S.D.1
  • 11
    • 17344363488 scopus 로고    scopus 로고
    • The functional significance of epitope spreading and its regulation by costimulatory interactions
    • Vanderlugt, C.L., Karandikar, N.J., Bluestone, J.A., and Miller, S.D. 1998. The functional significance of epitope spreading and its regulation by costimulatory interactions. Immunol. Rev. 164:63-72.
    • (1998) Immunol. Rev. , vol.164 , pp. 63-72
    • Vanderlugt, C.L.1    Karandikar, N.J.2    Bluestone, J.A.3    Miller, S.D.4
  • 12
    • 0026721247 scopus 로고
    • Induction of active and adoptive chronic-relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein
    • McRae, B.L., Kennedy, M.K., Tan, L.J., Dal Canto, M.C., and Miller, S.D. 1992. Induction of active and adoptive chronic-relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein. J. Neuroimmunol. 38:229-240.
    • (1992) J. Neuroimmunol. , vol.38 , pp. 229-240
    • McRae, B.L.1    Kennedy, M.K.2    Tan, L.J.3    Dal Canto, M.C.4    Miller, S.D.5
  • 13
    • 0029000750 scopus 로고
    • Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
    • McRae, B.L., Vanderlugt, C.L., Dal Canto, M.C., and Miller, S.D. 1995. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J. Exp. Med. 182:75-85.
    • (1995) J. Exp. Med. , vol.182 , pp. 75-85
    • McRae, B.L.1    Vanderlugt, C.L.2    Dal Canto, M.C.3    Miller, S.D.4
  • 14
    • 0030796646 scopus 로고    scopus 로고
    • Persistent infection with Theiler's virus leads to CNS autoimmunity via epirope spreading
    • Miller, S.D., et al. 1997. Persistent infection with Theiler's virus leads to CNS autoimmunity via epirope spreading. Nat. Med. 3:1133-1136.
    • (1997) Nat. Med. , vol.3 , pp. 1133-1136
    • Miller, S.D.1
  • 15
    • 0021256645 scopus 로고
    • Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection
    • Lipton, H.L., Kratochvil, J., Sethi, P., and Dal Canto, M.C. 1984. Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection. Neurology. 34:1117-1119.
    • (1984) Neurology , vol.34 , pp. 1117-1119
    • Lipton, H.L.1    Kratochvil, J.2    Sethi, P.3    Dal Canto, M.C.4
  • 16
    • 0025304856 scopus 로고
    • Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV)
    • Clatch, R.J., Miller, S.D., Metzner, R., Dal Canto, M.C., and Lipton, H.L. 1990. Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV). Virology. 176:244-254.
    • (1990) Virology , vol.176 , pp. 244-254
    • Clatch, R.J.1    Miller, S.D.2    Metzner, R.3    Dal Canto, M.C.4    Lipton, H.L.5
  • 17
    • 0028902180 scopus 로고
    • The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease
    • Lipton, H.L., Twaddle, G., and Jelachich, M.L. 1995. The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease. J. Virol. 69:2525-2533.
    • (1995) J. Virol. , vol.69 , pp. 2525-2533
    • Lipton, H.L.1    Twaddle, G.2    Jelachich, M.L.3
  • 18
    • 0017893354 scopus 로고
    • Central nervous system immunity in mice infected with Theiler's virus. I. Local neutralizing antibody response
    • Lipton, H.L., and Gonzalez-Scarano, F. 1978. Central nervous system immunity in mice infected with Theiler's virus. I. Local neutralizing antibody response. J. Infect. Dis. 137:145-151.
    • (1978) J. Infect. Dis. , vol.137 , pp. 145-151
    • Lipton, H.L.1    Gonzalez-Scarano, F.2
  • 19
    • 0020042791 scopus 로고
    • Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler's virus infection
    • Dal Canto, M.C., and Lipton, H.L. 1982. Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler's virus infection. Am. J. Pathol. 106:20-29.
    • (1982) Am. J. Pathol. , vol.106 , pp. 20-29
    • Dal Canto, M.C.1    Lipton, H.L.2
  • 20
    • 0022411745 scopus 로고
    • Immunocytochemical localization of MAG, MBP and P0 protein in acute and relapsing demyelinating lesions of Theiler's virus infection
    • Dal Canto, M.C., and Barbano, R.L. 1985. Immunocytochemical localization of MAG, MBP and P0 protein in acute and relapsing demyelinating lesions of Theiler's virus infection. J. Neuroimmunol. 10:129-140.
    • (1985) J. Neuroimmunol. , vol.10 , pp. 129-140
    • Dal Canto, M.C.1    Barbano, R.L.2
  • 21
    • 0018713491 scopus 로고
    • Susceptibility of inbred mice to chronic central nervous system infection by Theiler's murine encephalomyelitis virus
    • Lipton, H.L., and Dal Canto, M.C. 1979. Susceptibility of inbred mice to chronic central nervous system infection by Theiler's murine encephalomyelitis virus. Infect. Immun. 26:369-374.
    • (1979) Infect. Immun. , vol.26 , pp. 369-374
    • Lipton, H.L.1    Dal Canto, M.C.2
  • 22
    • 0025155943 scopus 로고
    • Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. III. Failure of neuroantigen-specific immune tolerance to affect the clinical course of demyelination
    • Miller, S.D., et al. 1990. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. III. Failure of neuroantigen-specific immune tolerance to affect the clinical course of demyelination. J. Neuroimmunol. 26:9-23.
    • (1990) J. Neuroimmunol. , vol.26 , pp. 9-23
    • Miller, S.D.1
  • 23
    • 0023194093 scopus 로고
    • Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Cross-specificity among TMEV substrains and related picornaviruses, but not myelin proteins
    • Miller, S.D., Clatch, R.J., Pevear, D.C., Trotter, J.L., and Lipton, H.L. 1987. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Cross-specificity among TMEV substrains and related picornaviruses, but not myelin proteins. J. Immunol. 138:3776-3784.
    • (1987) J. Immunol. , vol.138 , pp. 3776-3784
    • Miller, S.D.1    Clatch, R.J.2    Pevear, D.C.3    Trotter, J.L.4    Lipton, H.L.5
  • 25
    • 0029056669 scopus 로고
    • Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction
    • Karpus, W.J., Pope, J.G., Peterson, J.D., Dal Canto, M.C., and Miller, S.D. 1995. Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction. J. Immunol. 155:947-957.
    • (1995) J. Immunol. , vol.155 , pp. 947-957
    • Karpus, W.J.1    Pope, J.G.2    Peterson, J.D.3    Dal Canto, M.C.4    Miller, S.D.5
  • 27
    • 0030696797 scopus 로고    scopus 로고
    • Immune tolerance mediated by recombinant proteolipid protein prevents experimental autoimmune encephalomyelitis
    • Elliott, E.A., et al. 1997. Immune tolerance mediated by recombinant proteolipid protein prevents experimental autoimmune encephalomyelitis. J. Neuroimmunol. 79:1-11.
    • (1997) J. Neuroimmunol. , vol.79 , pp. 1-11
    • Elliott, E.A.1
  • 28
    • 0029845685 scopus 로고    scopus 로고
    • Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein
    • Elliott, E.A., et al. 1996. Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein. J. Clin. Invest. 98:1602-1612.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1602-1612
    • Elliott, E.A.1
  • 29
    • 0021321862 scopus 로고
    • Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice
    • Lipton, H.L., and Melvold, R. 1984. Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice. J. Immunol. 132:1821-1825.
    • (1984) J. Immunol. , vol.132 , pp. 1821-1825
    • Lipton, H.L.1    Melvold, R.2
  • 30
    • 0017085526 scopus 로고
    • Chronic neurologic disease in Theiler's virus infection of SJL/J mice
    • Lipton, H.L., and Dal Canto, M.C. 1976. Chronic neurologic disease in Theiler's virus infection of SJL/J mice. J. Neurol. Sci. 30:201-207.
    • (1976) J. Neurol. Sci. , vol.30 , pp. 201-207
    • Lipton, H.L.1    Dal Canto, M.C.2
  • 31
    • 0031667213 scopus 로고    scopus 로고
    • Characterization of and functional antigen presentation by central nervous system mononudear cells from mice infected with Theiler's murine encephalomyelitis virus
    • Pope, J.G., Vanderlugt, C.L., Lipton, H.L., Rahbe, S.M., and Miller, S.D. 1998. Characterization of and functional antigen presentation by central nervous system mononudear cells from mice infected with Theiler's murine encephalomyelitis virus. J. Virol. 72:7762-7771.
    • (1998) J. Virol. , vol.72 , pp. 7762-7771
    • Pope, J.G.1    Vanderlugt, C.L.2    Lipton, H.L.3    Rahbe, S.M.4    Miller, S.D.5
  • 32
    • 0031802828 scopus 로고    scopus 로고
    • Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis
    • Karandikar, N.J., et al. 1998. Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis. J. Immunol. 161:192-199.
    • (1998) J. Immunol. , vol.161 , pp. 192-199
    • Karandikar, N.J.1
  • 34
    • 0022387412 scopus 로고
    • Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
    • Perry, V.H., Hume, D.A., and Gordon, S. 1985. Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience. 15:313-326.
    • (1985) Neuroscience , vol.15 , pp. 313-326
    • Perry, V.H.1    Hume, D.A.2    Gordon, S.3
  • 35
    • 0029002659 scopus 로고
    • Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared
    • Ford, A.L., Goodsall, A.L., Hickey, W.F., and Sedgwick, J.D. 1995. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared. J. Immunol. 154:4309-4321.
    • (1995) J. Immunol. , vol.154 , pp. 4309-4321
    • Ford, A.L.1    Goodsall, A.L.2    Hickey, W.F.3    Sedgwick, J.D.4
  • 36
    • 0027195068 scopus 로고
    • The geographic distribution of multiple sclerosis: A review
    • Ebers, G.C., and Sadovnick, A.D. 1993. The geographic distribution of multiple sclerosis: a review. Neuroepidemiology. 12:1-5.
    • (1993) Neuroepidemiology , vol.12 , pp. 1-5
    • Ebers, G.C.1    Sadovnick, A.D.2
  • 37
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig, K.W., and Strominger, J.L. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:695-705.
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 38
    • 0032570826 scopus 로고    scopus 로고
    • Molecular mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection
    • Zhao, Z.-S., Granucci, E., Yeh, L., Schaffer, P.A., and Cantor, H. 1998. Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection. Science. 279:1344-1347.
    • (1998) Science , vol.279 , pp. 1344-1347
    • Zhao, Z.-S.1    Granucci, E.2    Yeh, L.3    Schaffer, P.A.4    Cantor, H.5
  • 39
    • 0032476612 scopus 로고    scopus 로고
    • In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis
    • Ufret-Vincenty, R.L., et al. 1998. In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis. J. Exp. Med. 188:1725-1738.
    • (1998) J. Exp. Med. , vol.188 , pp. 1725-1738
    • Ufret-Vincenty, R.L.1
  • 40
    • 0026664422 scopus 로고
    • Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
    • Lehmann, P.V., Forsthuber, T., Miller, A., and Sercarz, E.E. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature. 358:155-157.
    • (1992) Nature , vol.358 , pp. 155-157
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3    Sercarz, E.E.4
  • 41
    • 0029975898 scopus 로고    scopus 로고
    • A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: A basis for peptide-specific therapy after onset of clinical disease
    • Yu, M., Johnson, J.M., and Tuohy, V.K. 1996. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. J. Exp. Med. 183:1777-1788.
    • (1996) J. Exp. Med. , vol.183 , pp. 1777-1788
    • Yu, M.1    Johnson, J.M.2    Tuohy, V.K.3
  • 42
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch, R., et al. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature. 366:72-75.
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1
  • 43
    • 0027368141 scopus 로고
    • Spontaneous loss of T cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
    • Kaufman, D.L., et al. 1993. Spontaneous loss of T cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature. 366:69-72.
    • (1993) Nature , vol.366 , pp. 69-72
    • Kaufman, D.L.1
  • 44
    • 0029923430 scopus 로고    scopus 로고
    • Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
    • Tian, J., et al. 1996. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J. Exp. Med. 183:1561-1567.
    • (1996) J. Exp. Med. , vol.183 , pp. 1561-1567
    • Tian, J.1
  • 45
    • 0031874342 scopus 로고    scopus 로고
    • Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
    • Horwitz, M.S., et al. 1998. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat. Med. 4:781-786.
    • (1998) Nat. Med. , vol.4 , pp. 781-786
    • Horwitz, M.S.1
  • 46
    • 0032214715 scopus 로고    scopus 로고
    • Local expression of TNFα in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
    • Green, E.A., Eynon, E.E., and Flavell, R.A. 1998. Local expression of TNFα in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. Immunity. 9:733-743.
    • (1998) Immunity , vol.9 , pp. 733-743
    • Green, E.A.1    Eynon, E.E.2    Flavell, R.A.3
  • 47
    • 0031452948 scopus 로고    scopus 로고
    • Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens
    • Tian, J., Lehmann, P.V., and Kaufman, D.L. 1997. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. J. Exp. Med. 186:2039-2043.
    • (1997) J. Exp. Med. , vol.186 , pp. 2039-2043
    • Tian, J.1    Lehmann, P.V.2    Kaufman, D.L.3
  • 48
    • 0028912625 scopus 로고
    • Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PGMRPP and PGIRGP induce spliceosome autoimmunity
    • James, J.A., Gross, T., Scofield, R.H., and Harley, J.B. 1995. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PGMRPP and PGIRGP induce spliceosome autoimmunity. J. Exp. Med. 181:453-461.
    • (1995) J. Exp. Med. , vol.181 , pp. 453-461
    • James, J.A.1    Gross, T.2    Scofield, R.H.3    Harley, J.B.4
  • 49
    • 0028809117 scopus 로고
    • Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A)
    • Topfer, F., Gordon, T., and McCluskey, J. 1995. Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A). Proc. Natl. Acad. Sci. USA. 92:875-879.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 875-879
    • Topfer, F.1    Gordon, T.2    McCluskey, J.3
  • 50
    • 0031882357 scopus 로고    scopus 로고
    • Epitope spreading: Lessons from autoimmune skin diseases
    • Chan, L.S., et al. 1998. Epitope spreading: lessons from autoimmune skin diseases. J. Invest. Dermatol. 110:103-109.
    • (1998) J. Invest. Dermatol. , vol.110 , pp. 103-109
    • Chan, L.S.1
  • 51
    • 0030899404 scopus 로고    scopus 로고
    • Diversity and plasticity of self recognition during the development of multiple sclerosis
    • Tuohy, V.K., Yu, M., Weinstock-Guttman, B., and Kinkel, R.P. 1997. Diversity and plasticity of self recognition during the development of multiple sclerosis. J. Clin. Invest. 99:1682-1690.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1682-1690
    • Tuohy, V.K.1    Yu, M.2    Weinstock-Guttman, B.3    Kinkel, R.P.4
  • 52
    • 0029553431 scopus 로고
    • Blockade of CD28/B7-I interaction prevents epitope spreading and clinical relapses of murine EAE
    • Miller, S.D., et al. 1995. Blockade of CD28/B7-I interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity. 3:739-745.
    • (1995) Immunity , vol.3 , pp. 739-745
    • Miller, S.D.1
  • 53
    • 0032953939 scopus 로고    scopus 로고
    • Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis
    • Howard, L.M., et al. 1999. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis. J. Clin. Invest. 103:281-290.
    • (1999) J. Clin. Invest. , vol.103 , pp. 281-290
    • Howard, L.M.1
  • 54
    • 0026557522 scopus 로고
    • Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition
    • Tan, L.J., Kennedy, M.K., and Miller, S.D. 1992. Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition. J. Immunol. 148:2748-2755.
    • (1992) J. Immunol. , vol.148 , pp. 2748-2755
    • Tan, L.J.1    Kennedy, M.K.2    Miller, S.D.3
  • 55
    • 0032532022 scopus 로고    scopus 로고
    • Differential expression of inflammatory cytokines parallels progression of CNS pathology in two clinically distinct models of MS
    • Smith Begolka, W., Vanderlugt, C.L., Rahbe, S.M., and Miller, S.D. 1998. Differential expression of inflammatory cytokines parallels progression of CNS pathology in two clinically distinct models of MS. J. Immunol. 4437-4446.
    • (1998) J. Immunol. , pp. 4437-4446
    • Smith Begolka, W.1    Vanderlugt, C.L.2    Rahbe, S.M.3    Miller, S.D.4
  • 56
    • 0021191999 scopus 로고
    • Astrocytes present myelin basic protein to encephalitogenic T-cell lines
    • Fontana, A., Fierz, W., and Wekerle, H. 1984. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature. 307:273-276.
    • (1984) Nature , vol.307 , pp. 273-276
    • Fontana, A.1    Fierz, W.2    Wekerle, H.3
  • 57
    • 0032080658 scopus 로고    scopus 로고
    • Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes
    • Tan, L.J., Gordon, K.B., Mueller, J.P., Matis, L.A., and Miller, S.D. 1998. Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes. J. Immunol. 160:4271-4279.
    • (1998) J. Immunol. , vol.160 , pp. 4271-4279
    • Tan, L.J.1    Gordon, K.B.2    Mueller, J.P.3    Matis, L.A.4    Miller, S.D.5
  • 58
    • 0023618311 scopus 로고
    • Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells
    • Frei, K., et al. 1987. Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells. Eur. J. Immunol. 17:1271-1278.
    • (1987) Eur. J. Immunol. , vol.17 , pp. 1271-1278
    • Frei, K.1
  • 59
    • 0027970495 scopus 로고
    • + T lymphocytes in the central nervous system
    • + T lymphocytes in the central nervous system. Clin. Exp. Immunol. 98:313-318.
    • (1994) Clin. Exp. Immunol. , vol.98 , pp. 313-318
    • Cash, E.1    Rott, O.2
  • 60
    • 0023514995 scopus 로고
    • Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element
    • Hinrichs, D.J., Wegmann, K.W., and Dietsch, G.N. 1987. Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element. J. Exp. Med. 166:1906-1911.
    • (1987) J. Exp. Med. , vol.166 , pp. 1906-1911
    • Hinrichs, D.J.1    Wegmann, K.W.2    Dietsch, G.N.3
  • 61
    • 0023949553 scopus 로고
    • Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
    • Hickey, W.F., and Kimura, H. 1988. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science. 239:290-292.
    • (1988) Science , vol.239 , pp. 290-292
    • Hickey, W.F.1    Kimura, H.2
  • 62
    • 0027177927 scopus 로고
    • In vivo antigen presentation by both brain parenchymal cells and hematopoietically derived cells during the induction of experimental autoimmune encephalomyelitis
    • Myers, K.J., Dougherty, J.P., and Ron, Y. 1993. In vivo antigen presentation by both brain parenchymal cells and hematopoietically derived cells during the induction of experimental autoimmune encephalomyelitis. J. Immunol. 151:2252-2260.
    • (1993) J. Immunol. , vol.151 , pp. 2252-2260
    • Myers, K.J.1    Dougherty, J.P.2    Ron, Y.3
  • 63
    • 0026476657 scopus 로고
    • Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: A new view
    • Cserr, H.F., and Knopf, P.M. 1992. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. Immunol. Today. 13:507-512.
    • (1992) Immunol. Today , vol.13 , pp. 507-512
    • Cserr, H.F.1    Knopf, P.M.2
  • 64
    • 0028265143 scopus 로고
    • Allografts of CNS tissue possess a blood-brain barrier. III. Neuropathological, methodological, and immunological considerations
    • Broadwell, R.D., Baker, B.J., Ebert, P.S., and Mickey, W.F. 1994. Allografts of CNS tissue possess a blood-brain barrier. III. Neuropathological, methodological, and immunological considerations. Microsc. Res. Tech. 27:471-494.
    • (1994) Microsc. Res. Tech. , vol.27 , pp. 471-494
    • Broadwell, R.D.1    Baker, B.J.2    Ebert, P.S.3    Mickey, W.F.4
  • 65
    • 0028872064 scopus 로고
    • Two models of multiple sclerosis: Experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection: A pathological and immunological comparison
    • Dal Canto, M.C., Melvold, R.W., Kim, B.S., and Miller, S.D. 1995. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection: a pathological and immunological comparison. Microsc. Res. Tech. 32:215-229.
    • (1995) Microsc. Res. Tech. , vol.32 , pp. 215-229
    • Dal Canto, M.C.1    Melvold, R.W.2    Kim, B.S.3    Miller, S.D.4
  • 66
    • 0032925357 scopus 로고    scopus 로고
    • Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation
    • In press
    • Carson, M.J., Sutcliffe, J.G., and Campbell, I.L. 1999. Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation. J. Neurosci. Res. In press.
    • (1999) J. Neurosci. Res.
    • Carson, M.J.1    Sutcliffe, J.G.2    Campbell, I.L.3
  • 67
    • 0032524997 scopus 로고    scopus 로고
    • Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 activation
    • Aloisi, F., Ria, F., Penna, G., and Adorini, L. 1998. Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 activation. J. Immunol. 160:4671-4680.
    • (1998) J. Immunol. , vol.160 , pp. 4671-4680
    • Aloisi, F.1    Ria, F.2    Penna, G.3    Adorini, L.4
  • 68
    • 0022651246 scopus 로고
    • Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain
    • Hofman, F.M., et al. 1986. Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain. J. Immunol. 136:3239-3245.
    • (1986) J. Immunol. , vol.136 , pp. 3239-3245
    • Hofman, F.M.1
  • 69
    • 0020676803 scopus 로고
    • Multiple sclerosis: Distribution of T cell subsets within active chronic lesions
    • Traugott, U., Reinherz, E.L., and Raine, C.S. 1983. Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science. 219:308-310.
    • (1983) Science , vol.219 , pp. 308-310
    • Traugott, U.1    Reinherz, E.L.2    Raine, C.S.3
  • 70
    • 0023230316 scopus 로고
    • Multiple sclerosis: Relevance of class I and class II MHC-expressing cells to lesion development
    • Traugott, U. 1987. Multiple sclerosis: relevance of class I and class II MHC-expressing cells to lesion development. J. Neuroimmunol. 16:283-302.
    • (1987) J. Neuroimmunol. , vol.16 , pp. 283-302
    • Traugott, U.1
  • 71
    • 0028809507 scopus 로고
    • Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD80), and interleukin 12 cytokine in multiple sclerosis lesions
    • Windhagen, A., et al. 1995. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD80), and interleukin 12 cytokine in multiple sclerosis lesions. J. Exp. Med. 182:1985-1996.
    • (1995) J. Exp. Med. , vol.182 , pp. 1985-1996
    • Windhagen, A.1
  • 72
    • 0028964455 scopus 로고
    • The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions
    • De Simone, R., et al. 1995. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J. Neuropathol. Exp. Neurol. 54:175-187.
    • (1995) J. Neuropathol. Exp. Neurol. , vol.54 , pp. 175-187
    • De Simone, R.1
  • 73
    • 0028578704 scopus 로고
    • B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ
    • Williams, K., Ulvestad, E., and Antel, J.P. 1994. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ. Eur. J. Immunol. 24:3031-3037.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 3031-3037
    • Williams, K.1    Ulvestad, E.2    Antel, J.P.3
  • 74
    • 0024217787 scopus 로고
    • Demonstration of alpha, beta, and gamma interferon in active chronic multiple sclerosis lesions
    • Traugott, U., and Lebon, P. 1988. Demonstration of alpha, beta, and gamma interferon in active chronic multiple sclerosis lesions. Ann. NY Acad. Sci. 540:309-311.
    • (1988) Ann. NY Acad. Sci. , vol.540 , pp. 309-311
    • Traugott, U.1    Lebon, P.2


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