Signal transduction pathways induced by GM-CSF in microglia: Significance in the control of proliferation

GLIA

Volumn 26, Issue 4, 1999, Pages 344-352

  Liva, Stephanie M ^a   Kahn, Michelle A ^a   Dopp, Joel M ^a   De Vellis, Jean ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BV 2; ERK; Jak; MAPK; STAT

Indexed keywords

DNA BINDING PROTEIN; GAMMA INTERFERON ACTIVATION FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERFERON STIMULATED GENE FACTOR 3; JAK1 PROTEIN, RAT; JAK2 PROTEIN, RAT; JAK3 PROTEIN, RAT; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; MILK PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ONCOPROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE TYK2; PROTEIN TYROSINE KINASE; STAT3 PROTEIN; STAT3 PROTEIN, RAT; STAT5 PROTEIN; STAT5A PROTEIN, RAT; STAT5B PROTEIN, RAT; STAT6 PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TYK2 PROTEIN, RAT;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CELL LINE; CELL NUCLEUS; CYTOLOGY; DRUG EFFECT; METABOLISM; MICROGLIA; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; DNA-BINDING PROTEINS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERFERON-STIMULATED GENE FACTOR 3; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; MICROGLIA; MILK PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BIOSYNTHESIS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TYK2 KINASE;

EID: 0033151937     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(199906)26:4<344::AID-GLIA8>3.0.CO;2-L     Document Type: Article

References (53)

1. Aloisi F, Care A, Borsellino G, Gallo P, Rosa S, Bassani A, Cabibbo A, Testa U, Levi G, Peschle C. 1992. Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha. J Immunol 149:2358-2366.
2. Al-Shami A, Mahanna W, Naccache PH. 1998. Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Selective activation of Jak2, Stat3, and Stat5b. J Biol Chem 273:1058-1063.
3. Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F. 1990. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 27:229-237.
4. Brizzi MF, Zini MG, Aronica MG, Blechman JM, Yarden Y, Pegoraro L. 1994. Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase. J Biol Chem 269:31680-31684.
5. Brizzi MF, Aronica MG, Rosso A, Bagnara GP, Yarden Y, Pegoraro L. 1996. Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes. J Biol Chem 271:3562-3567.
6. Castano A, Lawson LJ, Fearn S, Perry VH. 1996. Activation and proliferation of murine microglia are insensitive to glucocorticoids in Wallerian degeneration. Eur J Neurosci 8:581-588.
7. Cattaneo E, De Fraja C, Conti L, Reinach B, Bolis L, Govoni S, Liboi E. 1996. Activation of the JAK/STAT pathway leads to proliferation of ST14A central nervous system progenitor cells. J Biol Chem 271: 23374-23379.
8. Chai SK, Nichols GL, Rothman P. 1997. Constitutive activation of JAKs and STATs in BCR-Abl-expresaing cell lines and peripheral blood cells derived from leukemic patients. J Immunol 159:4720-4728.
9. Chao CC, Hu S, Kravitz FH, Tsang M, Anderson WR, Peterson PK. 1994. Transforming growth factor-beta protects human neurons against beta-amyloid-induced injury. Mol Chem Neuropathol 23:159-178.
10. Cole R, de Vellis J. 1990 Preparation of astrocyte and oligodendrocyte cultures from primary rat glial cultures. In: Shahar A, de Vellis J, Vernadakis A, Haber B, editors. A dissection and tissue culture manual of the nervous system. New York: Alan R. Liss. p121-133.
11. Dell'Albani P, Kahn MA, Cole R, Condorelli DF, Giuffrida-Stella AM, de Vellis J.(in press) Oligodendroglial survival factors, PDGF-AA and CNTF, activate similar Jak/STAT signaling pthways. J Neurosci Res.
12. Feldman GM, Rosenthal LA, Liu X, Hayes MP, Wynshaw-Boris A, Leonard WJ, Hennighausen L, Finbloom DS. 1997. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood 90:1768-1776.
13. Fujita H, Tanaka J, Toku K, Tateishi N, Suzuki Y, Matsuda S, Sakanaka M, Maeda N. 1996. Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: a morphometrical study. Glia 18:269-281.
14. Ganter S, Northoff H, Mannel D, Gebicke-Harter PJ. 1992. Growth control of cultured microglia. J Neurosci Res 33:218-230.
15. Gehrmann J, Schoen SW, Kreutzberg GW. 1991. Lesion of the rat entorhinal cortex leads to a rapid microglial reaction in the dentate gyrus. A light and electron microscopical study. Acta Neuropathol 82:442-455.
16. Giordana MT, Attanasio A, Cavalla P, Migheli A, Vigliani MC, Schiffer D. 1994. Reactive cell proliferation and microglia following injury to the rat brain. Neuropathol Appl Neurobiol 20:163-174.
17. Giulian D, Ingeman JE. 1988. Colony-stimulating factors as promoters of ameboid microglia. J Neurosci 8:4707-4717.
18. Graeber MB, Tetzlaff W, Streit WJ, Kreutzberg GW. 1988. Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy. Neurosci Lett 85:317-321.
19. Johnston JA, Kawamura M, Kirken RA, Chen YQ, Blake TB, Shibuya K, Ortaldo JR, McVicar DW, O'Shea JJ. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151-153.
20. Kloss CU, Kreutzberg GW, Raivich G. 1997. Proliferation of ramified microglia on an astrocyte monolayer: characterization of stimulatory and inhibitory cytokines. J Neurosci Res 49:248-254.
21. Lee SC, Liu W, Brosnan CF, Dickson DW. 1994. GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia 12:309-318.
22. Lehtonen A, Matikainen S, Julkunen I. 1997. Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages. J Immunol 159:794-803.
23. Ling EA, Wong WC. 1993. The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia 7:9-18.
24. Malipiero UV, Frei K, Fontana A. 1990. Production of hemopoietic colony-stimulating factors by astrocytes. J Immunol 144:3816-3821.
25. Matsumoto Y, Ohmori K, Fujiwara M. 1992. Microglial and astroglial reactions to inflammatory lesions of experimental autoimmune encephalomyelitis in the rat central nervous system. J Neuroimmunol 37:23-33.
26. McCarthy KD, de Vellis J. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85:890-902.
27. Mui AL, Wakao H, O'Farrell AM, Harada N, Miyajima A. 1995. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J 14:1166-1175.
28. Mui AL, Wakao H, Kinoshita T, Kitamura T, Miyajima A. 1996. Suppression of interleukin-3-induced gene expression by a C-terminal truncated StatS: role of Stat5 in proliferation. EMBO J 15:2425-2433.
29. Musso T, Johnston JA, Linnekin D, Varesio L, Rowe TK, O'Shea JJ, McVicar DW. 1995. Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7. J Exp Med 181:1425-1431.
30. Ohno K, Suzumura A, Sawada M, Marunouchi T. 1990. Production of granulocyte/macrophage colony-stimulating factor by cultured astrocytes. Biochem Biophys Res Commun 169:719-724.
31. Okuda K, Sanghera JS, Pelech SL, Kanakura Y, Hallek M, Griffin JD, Druker BJ. 1992. Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase. Blood 79:2880-2887.
32. Quelle FW, Sato N, Witthuhn BA, Inborn RC, Eder M, Miyajima A, Griffin JD, Ihle JN. 1994. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol 14:4335-4341.
33. Raivich G, Gehrmann J, Kreutzberg GW. 1991. Increase of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor receptors in the regenerating rat facial nucleus. J Neurosci Res 30:682-686.
34. Rajotte D, Sadowski HB, Haman A, Gopalbhai K, Meloche S, Liu L, Krystal G, Hoang T. 1996. Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor. Blood 88:2906-2916.
35. Rosen RL, Winestock KD, Chen G, Liu X, Hennighausen L, Finbloom DS. 1996. Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes. Blood 88:1206-1214.
36. Sakai I, Kraft AS. 1997. The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells. J Biol Chem 272:12350-12358.
37. Sakamoto KM, Mignacca RC, Gasson JC. 1994. Signal transduction by granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors. Receptors Channels 2:175-181.
38. Schaefer TS, Sanders LK, Nathans D. 1995. Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. Proc Natl Acad Sci USA 92:9097-9101.
39. Shuai K, Stark GR, Kerr IM, Darnell JE Jr. 1993. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 261:1744-1746.
40. Shuai K, Halpern J, ten Hoeve J, Rao X, Sawyers CL. 1996. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 13:247-254.
41. Streit WJ, Kreutzberg GW. 1988. Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin. J Comp Neurol 268:248-263.
42. Suzumura A, Sawada M, Yamamoto H, Marunouchi T. 1990. Effects of colony stimulating factors on isolated microglia in vitro. J Neuroimmunol 30:111-120.
43. Tanaka J, Fujita H, Matsuda S, Toku K, Sakanaka M, Maeda N. 1997. Glucocorticoid-and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. Glia 20:23-37.
44. Traverse S, Gomez N, Paterson H, Marshall C, Cohen P. 1992. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem J 288:351-355.
45. Watanabe S, Itoh T, Aral K. 1997. Roles of JAK kinase in human GM-CSF receptor signals. Leukemia Suppl 3:76-78.
46. Wegenka UM, Lutticken C, Buschmann J, Yuan J, Lottspeich F, Muller-Esterl W, Schindler C, Roeb E, Heinrich PC, Horn F. 1994. The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. Mol Cell Biol 14:3186-3196.
47. Wesselingh SL, Gough NM, Finlay-Jones JJ, McDonald PJ. 1990. Detection of cytokine mRNA in astrocyte cultures using the polymerase chain reaction. Lymphokine Res 9:177-185.
48. Weite T, Koch F, Schuler G, Lechner J, Doppler W, Heufler C. 1997. Granulocyte-macrophage colony-stimulating factor induces a unique set of STAT factors in murine dendritic cells. Eur J Immunol 27:2737-2740.
49. Wheadon H, Roberts PJ, Linch DC. 1998. Differentiation-linked changes in granulocyte-macrophage colony-stimulating factor receptor mediated signalling in the HL-60 promyelocytic cell line. Br J Haematol 101:82-89.
50. Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR. 1990. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343:76-79.
51. Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, IhIe JN. 1994. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153-157.
52. Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ, Jenkins NA, Copeland NG, Silvennoinen O, IhIe JN. 1994. Stat4, a novel gamma Interferon activation site-binding protein expressed in early myeloid differentiation. Mol Cell Biol 14:4342-4349.
53. Zhong Z, Wen Z, Darnell JE Jr. 1994. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci USA 91:4806-4810.