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Volumn 160, Issue 10, 1998, Pages 4671-4680

Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4;

EID: 0032524997     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (228)

References (71)
  • 1
    • 0026476657 scopus 로고
    • Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: A new view
    • Cserr, H. F., and P. M. Knopf. 1992. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. Immunol. Today 13:507.
    • (1992) Immunol. Today , vol.13 , pp. 507
    • Cserr, H.F.1    Knopf, P.M.2
  • 2
    • 0028792323 scopus 로고
    • CNS antigen presentation
    • Hart, M. N., and Z. Fabry. 1995. CNS antigen presentation. Trends Neurosci. 18:475.
    • (1995) Trends Neurosci. , vol.18 , pp. 475
    • Hart, M.N.1    Fabry, Z.2
  • 4
    • 0025981021 scopus 로고
    • T-lymphocyte entry into the central nervous system
    • Hickey, W. F., B. L. Hsu, and H. Kimura. 1991. T-lymphocyte entry into the central nervous system J. Neurosci. Res. 28:254.
    • (1991) J. Neurosci. Res. , vol.28 , pp. 254
    • Hickey, W.F.1    Hsu, B.L.2    Kimura, H.3
  • 5
    • 0028990462 scopus 로고
    • Immunologic mechanisms and therapy in multiple sclerosis
    • Hafler, D. A., and H. L. Weiner. 1995. Immunologic mechanisms and therapy in multiple sclerosis. Immunol. Rev. 144:75.
    • (1995) Immunol. Rev. , vol.144 , pp. 75
    • Hafler, D.A.1    Weiner, H.L.2
  • 6
    • 0028990465 scopus 로고
    • Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases
    • Miller, S. D., B. L. McRae, C. L. Vanderlugt, K. M. Nikcevich, J. G. Pope, and W. J. Karpus. 1995. Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases. Immunol. Rev. 144:225.
    • (1995) Immunol. Rev. , vol.144 , pp. 225
    • Miller, S.D.1    McRae, B.L.2    Vanderlugt, C.L.3    Nikcevich, K.M.4    Pope, J.G.5    Karpus, W.J.6
  • 7
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
    • (1996) Nature , vol.383 , pp. 787
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 8
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets: Th1, Th2 and more
    • Mosmann, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
    • (1996) Immunol. Today , vol.17 , pp. 138
    • Mosmann, T.R.1    Sad, S.2
  • 10
    • 0029093933 scopus 로고
    • The role of IL-12 in the induction of organ-specific autoimmune diseases
    • Trembleau, S., T. Germann, M. K. Gately, and L. Adorini. 1995. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol. Today 16:383.
    • (1995) Immunol. Today , vol.16 , pp. 383
    • Trembleau, S.1    Germann, T.2    Gately, M.K.3    Adorini, L.4
  • 11
    • 0025820259 scopus 로고
    • Restricted T cell expression of IL-2/IFN-γ mRNA in human inflammatory disease
    • Brod, S. A., D. Benjamin, and D. A. Hafler. 1991. Restricted T cell expression of IL-2/IFN-γ mRNA in human inflammatory disease. J. Immunol. 147:810.
    • (1991) J. Immunol. , vol.147 , pp. 810
    • Brod, S.A.1    Benjamin, D.2    Hafler, D.A.3
  • 12
    • 0024368359 scopus 로고
    • Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype
    • Ando, D. G., J. Clayton, D. Kono, J. L. Urban, and E. E. Sercarz. 1989. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell. Immunol. 124:132.
    • (1989) Cell. Immunol. , vol.124 , pp. 132
    • Ando, D.G.1    Clayton, J.2    Kono, D.3    Urban, J.L.4    Sercarz, E.E.5
  • 15
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyielitis
    • Chen, Y., V. K. Kuchroo, J. Inobe, D. A. Hafler, and H. L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyielitis. Science 265:1237.
    • (1994) Science , vol.265 , pp. 1237
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 18
    • 0023279097 scopus 로고
    • Microglia are the major cell type expressing MHC class II in human white matter
    • Hayes, G. M., M. N. Woodroofe, and M. L. Cuzner. 1987. Microglia are the major cell type expressing MHC class II in human white matter. J. Neurol. Sci. 80:25.
    • (1987) J. Neurol. Sci. , vol.80 , pp. 25
    • Hayes, G.M.1    Woodroofe, M.N.2    Cuzner, M.L.3
  • 19
    • 0027139705 scopus 로고
    • Microglia in the immune surveillance of the brain: Human microglia consitutively express HLA-DR molecules
    • Gehrmann, J., R. B. Banati, and G. W. Kreutzberg. 1993. Microglia in the immune surveillance of the brain: human microglia consitutively express HLA-DR molecules. J. Neuroimmunol. 48:189.
    • (1993) J. Neuroimmunol. , vol.48 , pp. 189
    • Gehrmann, J.1    Banati, R.B.2    Kreutzberg, G.W.3
  • 20
    • 0027447712 scopus 로고
    • Resident macrophages (ramified microglia) of the BN-strain rat central nervous system are constitutively MHC class II-positive
    • Sedgwick, J. D., S. Schwender, R. Gregersen, R. Dorries, and V. ter Meulen. 1993. Resident macrophages (ramified microglia) of the BN-strain rat central nervous system are constitutively MHC class II-positive. J. Exp. Med. 177:1145.
    • (1993) J. Exp. Med. , vol.177 , pp. 1145
    • Sedgwick, J.D.1    Schwender, S.2    Gregersen, R.3    Dorries, R.4    Ter Meulen, V.5
  • 21
    • 0024199439 scopus 로고
    • Functional plasticity of microglia: A review
    • Streit, W. J., M. B., Graeber, and G. W. Kreutzberg. 1988. Functional plasticity of microglia: a review. Glia 1:301.
    • (1988) Glia , vol.1 , pp. 301
    • Streit, W.J.1    Graeber, M.B.2    Kreutzberg, G.W.3
  • 22
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg, G. W. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:312.
    • (1996) Trends Neurosci. , vol.19 , pp. 312
    • Kreutzberg, G.W.1
  • 23
    • 0023618311 scopus 로고
    • Antigen presentation and tumor cytotoxicity by Interferon-γ-treated microglial cells
    • Frei, K., C. Siepl, P. Groscurth, S. Bodmer, C. Schwerdel, and A. Fontana. 1987. Antigen presentation and tumor cytotoxicity by Interferon-γ-treated microglial cells. Eur. J. Immunol. 17:1271.
    • (1987) Eur. J. Immunol. , vol.17 , pp. 1271
    • Frei, K.1    Siepl, C.2    Groscurth, P.3    Bodmer, S.4    Schwerdel, C.5    Fontana, A.6
  • 26
    • 0029847274 scopus 로고    scopus 로고
    • Soluble tumor necrosis factor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
    • Becher, B., V. Dodelet, V. Fedorowicz, and J. P. Antel. 1996. Soluble tumor necrosis factor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro. J. Clin. Invest. 98:1539.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1539
    • Becher, B.1    Dodelet, V.2    Fedorowicz, V.3    Antel, J.P.4
  • 27
    • 0031571317 scopus 로고    scopus 로고
    • IL-12 production by central nervous system microglia is inhibited by astrocytes
    • Aloisi, F., G. Penna, J. Cerase, B. Menèndez Iglesias, and L. Adorini. 1997. IL-12 production by central nervous system microglia is inhibited by astrocytes. J. Immunol. 159:1604.
    • (1997) J. Immunol. , vol.159 , pp. 1604
    • Aloisi, F.1    Penna, G.2    Cerase, J.3    Menèndez Iglesias, B.4    Adorini, L.5
  • 28
    • 0027970495 scopus 로고
    • + T lymphocytes in the central nervous system
    • + T lymphocytes in the central nervous system. Clin. Exp. Immunol. 98:313.
    • (1994) Clin. Exp. Immunol. , vol.98 , pp. 313
    • Cash, E.1    Rott, O.2
  • 29
    • 0026628844 scopus 로고
    • Immune regulation by brain cells in the central nervous system: Microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions
    • Matsumoto, Y., Ohmori, K., and M. Fujiwara. 1992. Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions. Immunology 76:209.
    • (1992) Immunology , vol.76 , pp. 209
    • Matsumoto, Y.1    Ohmori, K.2    Fujiwara, M.3
  • 30
    • 0029848128 scopus 로고    scopus 로고
    • Microglia induce CD4 T lymphocyte final effector function and death
    • Ford, A. L., E. Foulcher, F. A. Lemckert, and J. D. Sedgwick. 1996. Microglia induce CD4 T lymphocyte final effector function and death. J. Exp. Med. 184: 1737.
    • (1996) J. Exp. Med. , vol.184 , pp. 1737
    • Ford, A.L.1    Foulcher, E.2    Lemckert, F.A.3    Sedgwick, J.D.4
  • 31
    • 0028941871 scopus 로고
    • The adhesion molecule and cytokine profile of multiple sclerosis lesions
    • Cannella, B,. and C. S. Raine. 1995. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann. Neurol. 37:424.
    • (1995) Ann. Neurol. , vol.37 , pp. 424
    • Cannella, B.1    Raine, C.S.2
  • 33
    • 0028578704 scopus 로고
    • B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ
    • Williams, K., E. Ulvestad, and J. P. Antel. 1994. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ. Eur. J. Immunol. 24:3031.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 3031
    • Williams, K.1    Ulvestad, E.2    Antel, J.P.3
  • 34
    • 0022591581 scopus 로고
    • Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia-positive cells with dendritic morphology
    • Matsumoto, Y., N. Hara, R. Tanaka, and M. Fujiwara. 1986. Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia-positive cells with dendritic morphology. J. Immunol. 136:3668.
    • (1986) J. Immunol. , vol.136 , pp. 3668
    • Matsumoto, Y.1    Hara, N.2    Tanaka, R.3    Fujiwara, M.4
  • 35
    • 0023858304 scopus 로고
    • Interferon-gamma and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions
    • Traugott, U., and P. Lebon. 1988. Interferon-gamma and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions. J. Neurol. Sci. 84:257.
    • (1988) J. Neurol. Sci. , vol.84 , pp. 257
    • Traugott, U.1    Lebon, P.2
  • 36
    • 0025278577 scopus 로고
    • Multiple sclerosis: A role for astroglia in active demyelination suggested by class II MHC expression and ultrastructural study
    • Lee, S. C., G. R. W. Moore, G. Golenwsky, and C. S. Raine. 1990. Multiple sclerosis: a role for astroglia in active demyelination suggested by class II MHC expression and ultrastructural study. J. Neuropathol. Exp. Neurol. 49:122.
    • (1990) J. Neuropathol. Exp. Neurol. , vol.49 , pp. 122
    • Lee, S.C.1    Moore, G.R.W.2    Golenwsky, G.3    Raine, C.S.4
  • 38
    • 0028231281 scopus 로고
    • Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions
    • Bö, L., S. Mö, P. A. Kong, H. Nyland, C. A. Pardo, and B. D. Trapp. 1994. [Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions. J. Neuroimmunol. 51:135.
    • (1994) J. Neuroimmunol. , vol.51 , pp. 135
    • Bö, L.1    Mö, S.2    Kong, P.A.3    Nyland, H.4    Pardo, C.A.5    Trapp, B.D.6
  • 39
    • 0025104589 scopus 로고
    • Intrathecal application of interferon-gamma: Progressive appearance of MHC antigens within the rat nervous system
    • Vass, K., and H. Lassmann. 1990. Intrathecal application of interferon-gamma: progressive appearance of MHC antigens within the rat nervous system. Am. J. Pathol. 137:789.
    • (1990) Am. J. Pathol. , vol.137 , pp. 789
    • Vass, K.1    Lassmann, H.2
  • 41
    • 0021191999 scopus 로고
    • Astrocytes present myelin basic protein to encephalitogenic T-ccll lines
    • Fontana, A., W. Fierz, and H. Wekerle. 1984. Astrocytes present myelin basic protein to encephalitogenic T-ccll lines. Nature 307:273.
    • (1984) Nature , vol.307 , pp. 273
    • Fontana, A.1    Fierz, W.2    Wekerle, H.3
  • 42
    • 0024409242 scopus 로고
    • The induction of intercellular adhesion molecule-1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma. tumor necrosis factor-alpha, lymphotoxin, and interleukin-1: Relevance to intracerebral antigen presentation
    • Frohman, E. M., T. C. Frohman, M. L. Dustin, B. Vayuvegula, B. Choi, A. Gupta, S. van den Noort, and S. Gupta. 1989. The induction of intercellular adhesion molecule-1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma. tumor necrosis factor-alpha, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation. J. Neuroimmunol. 23:117.
    • (1989) J. Neuroimmunol. , vol.23 , pp. 117
    • Frohman, E.M.1    Frohman, T.C.2    Dustin, M.L.3    Vayuvegula, B.4    Choi, B.5    Gupta, A.6    Van den Noort, S.7    Gupta, S.8
  • 43
    • 0028326439 scopus 로고
    • Human astrocytes are only partially competent antigen presenting cells: Possible implications for lesion development in multiple sclerosis
    • Weber, F., E. Meinl, F. Aloisi, C. Nevinny-Stickel, E. Albert, H. Wekerle, and R. Hohlfeld. 1994. Human astrocytes are only partially competent antigen presenting cells: possible implications for lesion development in multiple sclerosis. Brain 117:59.
    • (1994) Brain , vol.117 , pp. 59
    • Weber, F.1    Meinl, E.2    Aloisi, F.3    Nevinny-Stickel, C.4    Albert, E.5    Wekerle, H.6    Hohlfeld, R.7
  • 44
    • 0027285330 scopus 로고
    • In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis: The role of astrocytes
    • Matsumoto, Y., H. Hanawa, M. Tsuchida, and T. Abo. 1993. In situ inactivation of infiltrating T cells in the central nervous system with autoimmune encephalomyelitis: the role of astrocytes. Immunology 79:381.
    • (1993) Immunology , vol.79 , pp. 381
    • Matsumoto, Y.1    Hanawa, H.2    Tsuchida, M.3    Abo, T.4
  • 47
    • 0031568084 scopus 로고    scopus 로고
    • IFN-γ-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells
    • Nikcevich, K. M., K. B. Gordon, L. Tan, S. D. Hurst, J. F. Kroepfl, M. Gardinier, T. A. Barrett, and S. D. Miller. 1997. IFN-γ-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells. J. Immunol. 158:614.
    • (1997) J. Immunol. , vol.158 , pp. 614
    • Nikcevich, K.M.1    Gordon, K.B.2    Tan, L.3    Hurst, S.D.4    Kroepfl, J.F.5    Gardinier, M.6    Barrett, T.A.7    Miller, S.D.8
  • 52
    • 0024206747 scopus 로고
    • Mechanisms influencing the immunodominance of T cell determinants
    • Adorini, L., E. Appella, G. Doria, and Z. A. Nagy. 1988. Mechanisms influencing the immunodominance of T cell determinants. J. Exp. Med. 168:2091.
    • (1988) J. Exp. Med. , vol.168 , pp. 2091
    • Adorini, L.1    Appella, E.2    Doria, G.3    Nagy, Z.A.4
  • 53
    • 0028297657 scopus 로고
    • Monoclonal antibody 2D10 recognizes a novel T cell costimulatory molecule on activated murine B lymphocytes
    • Chen, C., D. A. Faherty, A. Gault, S. E. Connaughton, G. D. Powers, D. I. Godfrey, and N. Nabavi. 1994. Monoclonal antibody 2D10 recognizes a novel T cell costimulatory molecule on activated murine B lymphocytes. J. Immunol. 152:2105.
    • (1994) J. Immunol. , vol.152 , pp. 2105
    • Chen, C.1    Faherty, D.A.2    Gault, A.3    Connaughton, S.E.4    Powers, G.D.5    Godfrey, D.I.6    Nabavi, N.7
  • 54
    • 0030062937 scopus 로고    scopus 로고
    • Selective development of Th2 cells induced by continuous administration of low dose soluble proteins to normal and β2-microglobulin-deficient BALB/c mice
    • Guéry, J-C., F. Galbiati, S. Smiroldo, and L. Adorini. 1996. Selective development of Th2 cells induced by continuous administration of low dose soluble proteins to normal and β2-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:485.
    • (1996) J. Exp. Med. , vol.183 , pp. 485
    • Guéry, J.-C.1    Galbiati, F.2    Smiroldo, S.3    Adorini, L.4
  • 56
    • 0023622458 scopus 로고
    • Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
    • Cherwinski, H., J. Shumacher, K. Brown, and T. Mosmann. 1987. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166:1229.
    • (1987) J. Exp. Med. , vol.166 , pp. 1229
    • Cherwinski, H.1    Shumacher, J.2    Brown, K.3    Mosmann, T.4
  • 57
    • 0028877056 scopus 로고
    • Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations
    • Openshaw, P. E., E. E. Murphy, N. A. Hoksen, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182:1357.
    • (1995) J. Exp. Med. , vol.182 , pp. 1357
    • Openshaw, P.E.1    Murphy, E.E.2    Hoksen, N.A.3    Maino, V.4    Davis, K.5    Murphy, K.6    O'Garra, A.7
  • 58
    • 84915932769 scopus 로고
    • Nonparametric tests for repeated measures and matched samples for multiple samples: The Friedman model
    • Brooks/Cole Publishing Company, Monterey, CA
    • Marascuilo, L. A., and M. McSweeney. 1977. Nonparametric tests for repeated measures and matched samples for multiple samples: the Friedman model. In Nonparametric and Distribution-Free Methods for the Social Sciences. Brooks/Cole Publishing Company, Monterey, CA, p. 354.
    • (1977) Nonparametric and Distribution-Free Methods for the Social Sciences , pp. 354
    • Marascuilo, L.A.1    McSweeney, M.2
  • 59
    • 0027030806 scopus 로고
    • Determination of the origin and nature of brain macrophages and microglial cells in mouse central nervous system, using non-radioactive in situ hybridization and immunoperoxidase techniques
    • De Groot, C. J. A., W. Huppes, T. Sminia, G. Kraal, and C. D. Dijkstra. 1992. Determination of the origin and nature of brain macrophages and microglial cells in mouse central nervous system, using non-radioactive in situ hybridization and immunoperoxidase techniques. Glia 6:301.
    • (1992) Glia , vol.6 , pp. 301
    • De Groot, C.J.A.1    Huppes, W.2    Sminia, T.3    Kraal, G.4    Dijkstra, C.D.5
  • 60
    • 0015523554 scopus 로고
    • Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence
    • Bignami, A., L. F. Eng, D. Dahl, and C. T. Uyeda. 1972. Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res. 43:429.
    • (1972) Brain Res. , vol.43 , pp. 429
    • Bignami, A.1    Eng, L.F.2    Dahl, D.3    Uyeda, C.T.4
  • 62
    • 0030729502 scopus 로고    scopus 로고
    • Ia expression and antigen presentation by glia: Strain and cell type-specific differences among rat astrocytes and microglia
    • Klyushnekova, E. N., and P. Vanguri. 1997. Ia expression and antigen presentation by glia: strain and cell type-specific differences among rat astrocytes and microglia. J. Neuroimmunol. 79:190.
    • (1997) J. Neuroimmunol. , vol.79 , pp. 190
    • Klyushnekova, E.N.1    Vanguri, P.2
  • 64
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    • Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
    • (1996) J. Exp. Med. , vol.184 , pp. 747
    • Cella, M.1    Scheidegger, D.2    Palmer-Lehmann, K.3    Lane, P.4    Lanzavecchia, A.5    Alber, G.6
  • 65
    • 0028970060 scopus 로고
    • Inteleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri, G. 1995. Inteleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 251
    • Trinchieri, G.1
  • 66
    • 0029762023 scopus 로고    scopus 로고
    • Review: Cytokines and the pathogenesis of multiple sclerosis
    • Navikas, V., and H. Link. 1996. Review: cytokines and the pathogenesis of multiple sclerosis. J. Neurosci. Res. 45:322.
    • (1996) J. Neurosci. Res. , vol.45 , pp. 322
    • Navikas, V.1    Link, H.2
  • 67
    • 0002032877 scopus 로고
    • Demyelinating diseases
    • R. L. Davis and D. M. Robertson, eds. Williams & Wilkins, Baltimore
    • Raine, C. S. 1991. Demyelinating diseases. In Textbook of Neuropathology. R. L. Davis and D. M. Robertson, eds. Williams & Wilkins, Baltimore, p. 535.
    • (1991) Textbook of Neuropathology , pp. 535
    • Raine, C.S.1
  • 68
    • 43949158868 scopus 로고
    • Immunological functions of non-professional antigen-presenting cells: New insights from studies of T-cell interactions with keratinocytes
    • Nickoloff, B. J., and L. A. Turka. 1994. Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes. Immunol. Today 15:464.
    • (1994) Immunol. Today , vol.15 , pp. 464
    • Nickoloff, B.J.1    Turka, L.A.2
  • 70
    • 0025077080 scopus 로고
    • Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain
    • Styren, S. D., W. H. Civin, and J. Rogers. 1990. Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain. Exp. Neurol. 110:93.
    • (1990) Exp. Neurol. , vol.110 , pp. 93
    • Styren, S.D.1    Civin, W.H.2    Rogers, J.3
  • 71
    • 0029897979 scopus 로고    scopus 로고
    • Investigation of major histocompatibility complex class II and cytokines and detection of HIV-1 DNA within brains of asymptomatic and symptomatic HIV-1 positive patients
    • An, S. F., A. Ciardi, B. Giometto, T. Scaravilli, F. Gray, and F. Scaravilli. 1996. Investigation of major histocompatibility complex class II and cytokines and detection of HIV-1 DNA within brains of asymptomatic and symptomatic HIV-1 positive patients. Acta Neuropathol. 91:494.
    • (1996) Acta Neuropathol. , vol.91 , pp. 494
    • An, S.F.1    Ciardi, A.2    Giometto, B.3    Scaravilli, T.4    Gray, F.5    Scaravilli, F.6


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