Demyelination occurring during anti-tumor necrosis factor α therapy for inflammatory arthritides

Arthritis and Rheumatism

Volumn 44, Issue 12, 2001, Pages 2862-2869

  Mohan, Niveditha ^a   Edwards, Evelyne T ^b   Cupps, Thomas R ^a   Oliverio, Patrick J ^a   Sandberg, Glenn ^c   Crayton, Heidi ^a   Richert, John R ^a   Siegel, Jeffrey N ^b  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ALENDRONIC ACID; ALLOPURINOL; ALPHA INTERFERON; ALPRAZOLAM; ATENOLOL; CEFTRIAXONE; CORTISONE; DEXAMETHASONE; DEXTROPROPOXYPHENE; ETANERCEPT; FENTANYL; FLUOXETINE; GLATIRAMER; INFLIXIMAB; METHOTREXATE; METHYLPREDNISOLONE; METRONIDAZOLE; NABUMETONE; NAPROXEN; OMEPRAZOLE; PIROXICAM; PREDNISOLONE; PREDNISONE; PROBENECID; RANITIDINE; STEROID; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR RECEPTOR; UNINDEXED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONFUSION; DEMYELINATION; DRUG SAFETY; FEMALE; FOOD AND DRUG ADMINISTRATION; HUMAN; MALE; NEUROLOGIC DISEASE; PRIORITY JOURNAL; RECURRENT DISEASE; RHEUMATOID ARTHRITIS; RISK FACTOR; SAFETY;

ADULT; ADVERSE DRUG REACTION REPORTING SYSTEMS; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; BIOPSY; BRAIN; DEMYELINATING DISEASES; FEMALE; HUMANS; IMMUNOGLOBULIN G; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035674613     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200112)44:12<2862::AID-ART474>3.0.CO;2-W     Document Type: Article

References (30)

1. The pathophysiology of tumor necrosis factors
2. Two tumor necrosis factor receptors: Structure and function
3. Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type (TNFR1)-IgG1-treated and TNFR1-deficient mice
4. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
5. Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
6. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination
7. Tumor necrosis factor identified in multiple sclerosis brain
8. Association between tumor necrosis factor alpha and disease progression in patients with multiple sclerosis
9. Approaches for identifying and defining environmentally associated rheumatic disorders
10. Multiple sclerosis
11. The rationale for the current boom in anti-TNFα treatment: Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFα and minimize hazards?
12. On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease
13. TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
14. Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2
15. Multiple sclerosis and chronic inflammatory disease: A case-control study
16. Autoimmune diseases in families of French patients with multiple sclerosis
17. Effects of interferon β-1B in rheumatoid arthritis: A case report
18. New onset of rheumatoid arthritis during interferon β-1B treatment in a patient with multiple sclerosis
19. Interferon-β1A-induced polyarthritis in a patient with the HLA-DRB1*0404 allele
20. Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis
21. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
22. Inhibition of p75 TNF receptor by antisense oligonucleotides increases hypoxic injury and β-amyloid toxicity in human neuronal cell line
23. Experimental autoimmune encephalomyelitis: Immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors
24. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
25. A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin a, or the p55TNF-R
26. The function of tumor necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease
27. Transgenic mice expressing human TNF: A predictive genetic model of arthritis
28. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice models for multiple sclerosis with primary oligodendrogliopathy
29. Circulating adhesion molecules and tumor necrosis factor receptor in multiple sclerosis: Correlation with magnetic resonance imaging
30. Ligand passing: The 75-kDa TNF receptor recruits TNF for signaling by the 55-kDa TNF receptor