Role of apoptosis in disease

Aging

Volumn 4, Issue 5, 2012, Pages 330-349

  Favaloro, B ^a,b   Allocati, N ^a   Graziano, V ^a,b   Di Ilio, C ^a,b   De Laurenzi, V ^a,b,c  

^a UNIVERSITY OF CHIETI   (Italy)

^b Centro Studi sull'Invecchiamento   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

Author keywords

Aging; Apoptosis; Cancer; Caspases; Cell death; Diseases

Indexed keywords

CASPASE;

ANIMAL; APOPTOSIS; AUTOIMMUNE DISEASE; COMMUNICABLE DISEASE; DISEASES; HEART DISEASE; HUMAN; METABOLISM; NEOPLASM; NEUROLOGIC DISEASE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; AUTOIMMUNE DISEASES; CASPASES; COMMUNICABLE DISEASES; DISEASE; HEART DISEASES; HUMANS; NEOPLASMS; NERVOUS SYSTEM DISEASES; SIGNAL TRANSDUCTION;

EID: 84867451139     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100459     Document Type: Review

References (218)

1. Knight RA and Melino G. Cell death in disease: from 2010 onwards. Cell Death Dis. 2011; 2:e202.
2. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2011.
3. Wickman G, Julian L and Olson MF. How apoptotic cells aid in the removal of their own cold dead bodies. Cell Death Differ. 2012; 19:735-742.
4. Ai X, Butts B, Vora K, Li W, Tache-Talmadge C, Fridman A and Mehmet H. Generation and characterization of antibodies specific for caspase-cleaved neo-epitopes: a novel approach. Cell Death Dis. 2011; 2:e205.
5. Luthi AU and Martin SJ. The CASBAH: a searchable database of caspase substrates. Cell Death Differ. 2007; 14:641-650.
6. Tadokoro D, Takahama S, Shimizu K, Hayashi S, Endo Y and Sawasaki T. Characterization of a caspase-3-substrate kinome using an N- and C-terminally tagged protein kinase library produced by a cell-free system. Cell Death Dis. 2010; 1:e89.
7. Lavrik IN and Krammer PH. Regulation of CD95/Fas signaling at the DISC. Cell Death Differ. 2012; 19:36-41.
8. Gavathiotis Eand Walensky LD. Tracking BAX once its trigger is pulled. Cell Cycle. 2011; 10:868-870.
9. Green DR,and Kroemer G. The pathophysiology of mitochondrial cell death. Science. 2004; 305:626-629.
10. Yivgi-Ohana N, Eifer M, Addadi Y, Neeman Mand Gross A. Utilizing mitochondrial events as biomarkers for imaging apoptosis. Cell Death Dis. 2011; 2:e166.
11. Chipuk JEand Green DR. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol. 2008; 18:157-164.
12. Kaufmann T, Strasser Aand Jost PJ. Fas death receptor signalling: roles of Bidand XIAP. Cell Death Differ. 2012; 19:42- 50.
13. Goldberg AA, Beach A, Davies GF, Harkness TA, Leblanc Aand Titorenko VI. Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget. 2011; 2:761-782.
14. Eberhard Y, Gronda M, Hurren R, Datti A, MacLean N, Ketela T, Moffat J, Wrana JLand Schimmer AD. Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget. 2011; 2:186-196.
15. Neznanov N, Komarov AP, Neznanova L, Stanhope-Baker Pand Gudkov AV. Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib. Oncotarget. 2011; 2:209- 221.
16. Burz C, Berindan-Neagoe I, Balacescu Oand Irimie A. Apoptosis in cancer: key molecular signaling pathwaysand therapy targets. Acta Oncol. 2009; 48:811-821.
17. Jazirehi AR. Regulation of apoptosis-associated genes by histone deacetylase inhibitors: implications in cancer therapy. Anticancer Drugs. 2010; 21:805-813.
18. Egle A, Harris AW, Bath ML, O'Reilly Land Cory S. VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. Blood. 2004; 103:2276-2283.
19. Gascoyne RD, Adomat SA, Krajewski S, Krajewska M, Horsman DE, Tolcher AW, O'Reilly SE, Hoskins P, Coldman AJ, Reed JCand Connors JM. Prognostic significance of Bcl-2 protein expressionand Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. Blood. 1997; 90:244-251.
20. Tawfik K, Kimler BF, Davis MK, Fan Fand Tawfik O. Prognostic significance of Bcl-2 in invasive mammary carcinomas: a comparative clinicopathologic study between "triple-negative"and non-"triple-negative" tumors. Hum Pathol. 2011.
21. Han H, Landreneau RJ, Santucci TS, Tung MY, Macherey RS, Shackney SE, Sturgis CD, Raab SSand Silverman JF. Prognostic value of immunohistochemical expressions of p53, HER-2/neu,and bcl-2 in stage I non-small-cell lung cancer. Hum Pathol. 2002; 33:105-110.
22. Gobe G, Rubin M, Williams G, Sawczuk Iand Buttyan R. Apoptosisand expression of Bcl-2, Bcl-XL,and Bax in renal cell carcinomas. Cancer Invest. 2002; 20:324-332.
23. El Hindy N, Bachmann HS, Lambertz N, Adamzik M, Nuckel H, Worm K, Zhu Y, Sure U, Siffert Wand Sandalcioglu IE. Association of the CC genotype of the regulatory BCL2 promoter polymorphism (-938C>A) with better 2-year survival in patients with glioblastoma multiforme. J Neurosurg. 2011; 114:1631- 1639.
24. Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JCand Perucho M. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science. 1997; 275:967-969.
25. Yin C, Knudson CM, Korsmeyer SJand Van Dyke T. Bax suppresses tumorigenesisand stimulates apoptosis in vivo. Nature. 1997; 385:637-640. 26. Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross Aand Korsmeyer SJ. A role for proapoptotic BID in the DNA-damage response. Cell. 2005; 122:579-591.
26. Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross Aand Korsmeyer SJ. A role for proapoptotic BID in the DNA-damage response. Cell. 2005; 122:579-591.
27. Esposti MD. Bcl-2 antagonistsand cancer: from the clinic, back to the bench. Cell Death Dis. 2010; 1:e37.
28. Placzek WJ, Wei J, Kitada S, Zhai D, Reed JCand Pellecchia M. A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy. Cell Death Dis. 2010; 1:e40.
29. Kelly PNand Strasser A. The role of Bcl-2and its pro-survival relatives in tumourigenesisand cancer therapy. Cell Death Differ. 2011; 18:1414-1424.
30. Strand S, Hofmann WJ, Hug H, Muller M, Otto G, Strand D, Mariani SM, Stremmel W, Krammer PHand Galle PR. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligandexpressing tumor cells--a mechanism of immune evasion? Nat Med. 1996; 2:1361-1366.
31. Gratas C, Tohma Y, Barnas C, Taniere P, Hainaut Pand Ohgaki H. Up-regulation of Fas (APO-1/CD95) ligandand downregulation of Fas expression in human esophageal cancer. Cancer Res. 1998; 58:2057-2062.
32. Butler LM, Hewett PJ, Butler WJand Cowled PA. Downregulation of Fas gene expression in colon cancer is not a result of allelic loss or gene rearrangement. Br J Cancer. 1998; 77:1454-1459.
33. Bullani RR, Wehrli P, Viard-Leveugle I, Rimoldi D, Cerottini JC, Saurat JH, Tschopp Jand French LE. Frequent downregulation of Fas (CD95) expressionand function in melanoma. Melanoma Res. 2002; 12:263-270.
34. Viard-Leveugle I, Veyrenc S, French LE, Brambilla Cand Brambilla E. Frequent loss of Fas expressionand function in human lung tumours with overexpression of FasL in small cell lung carcinoma. J Pathol. 2003; 201:268-277.
35. Hahne M, Rimoldi D, Schroter M, Romero P, Schreier M, French LE, Schneider P, Bornand T, Fontana A, Lienard D, Cerottini Jand Tschopp J. Melanoma cell expression of Fas(Apo- 1/CD95) ligand: implications for tumor immune escape. Science. 1996; 274:1363-1366.
36. Ueno T, Toi Mand Tominaga T. Circulating soluble Fas concentration in breast cancer patients. Clin Cancer Res. 1999; 5:3529-3533.
37. Kavathia N, Jain A, Walston J, Beamer BAand Fedarko NS. Serum markers of apoptosis decrease with ageand cancer stage. Aging (Albany NY). 2009; 1:652-663.
38. Shin MS, Kim HS, Lee SH, Lee JW, Song YH, Kim YS, Park WS, Kim SY, Lee SN, Park JY, Lee JH, Xiao W, Jo KH, et al. Alterations of Fas-pathway genes associated with nodal metastasis in nonsmall cell lung cancer. Oncogene. 2002; 21:4129-4136.
39. Chen G, Bhojani MS, Heaford AC, Chang DC, Laxman B, Thomas DG, Griffin LB, Yu J, Coppola JM, Giordano TJ, Lin L, Adams D, Orringer MB, et al. Phosphorylated FADD induces NFkappaB, perturbs cell cycle,and is associated with poor outcome in lung adenocarcinomas. Proc Natl Acad Sci U S A. 2005; 102:12507-12512.
40. Johnstone RW, Frew AJand Smyth MJ. The TRAIL apoptotic pathway in cancer onset, progressionand therapy. Nat Rev Cancer. 2008; 8:782-798.
41. Liu Y, Lang F, Xie X, Prabhu S, Xu J, Sampath D, Aldape K, Fuller Gand Puduvalli VK. Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice cultureand glioma xenografts. Cell Death Dis. 2011; 2:e121.
42. Olsson Mand Zhivotovsky B. Caspasesand cancer. Cell Death Differ. 2011; 18:1441-1449.
43. Gyrd-Hansen Mand Meier P. IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammationand cancer. Nat Rev Cancer. 2010; 10:561-574.
44. Cheung HH, St Jean M, Beug ST, Lejmi-Mrad R, LaCasse E, Baird SD, Stojdl DF, Screaton RAand Korneluk RG. SMG1and NIK regulate apoptosis induced by Smac mimetic compounds. Cell Death Dis. 2011; 2:e146.
45. Hengartner MO. The biochemistry of apoptosis. Nature. 2000; 407:770-776.
46. Ranger AM, Malynn BAand Korsmeyer SJ. Mouse models of cell death. Nat Genet. 2001; 28:113-118.
47. Duyckaerts C, Delatour Band Potier MC. Classificationand basic pathology of Alzheimer disease. Acta Neuropathol. 2009; 118:5-36.
48. Garwood CJ, Pooler AM, Atherton J, Hanger DPand Noble W. Astrocytes are important mediators of Abeta-induced neurotoxicityand tau phosphorylation in primary culture. Cell Death Dis. 2011; 2:e167.
49. Ciavardelli D, Silvestri E, Viscovo AD, Bomba M, Gregorio DD, Moreno M, Ilio CD, Goglia F, Canzoniero LMand Sensi SL. Alterations of brainand cerebellar proteomes linked to Abetaand tau pathology in a female triple-transgenic murine model of Alzheimer's disease. Cell Death Dis. 2010; 1:e90.
50. Rohn TT. The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities. Apoptosis. 2010; 15:1403-1409.
51. Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, et al. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor proteinand amyloidogenic A beta peptide formation. Cell. 1999; 97:395-406.
52. Shang YC, Chong ZZ, Wang Sand Maiese K. Prevention of beta-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad,and Bcl-xL. Aging (Albany NY). 2012; 4:187-201.
53. Noble W, Garwood C, Stephenson J, Kinsey AM, Hanger DPand Anderton BH. Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease. FASEB J. 2009; 23:739-750.
54. Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EHand Bredesen DE. C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis. 2008; 13:1-16.
55. Nikolaev A, McLaughlin T, O'Leary DDand Tessier-Lavigne M. APP binds DR6 to trigger axon pruningand neuron death via distinct caspases. Nature. 2009; 457:981-989.
56. Rohn TT, Vyas V, Hernandez-Estrada T, Nichol KE, Christie LAand Head E. Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the antiapoptotic protein Bcl-2. J Neurosci. 2008; 28:3051-3059.
57. Corona C, Pensalfini A, Frazzini Vand Sensi SL. New therapeutic targets in Alzheimer's disease: brain deregulation of calciumand zinc. Cell Death Dis. 2011; 2:e176.
58. Samantaray S, Knaryan VH, Guyton MK, Matzelle DD, Ray SKand Banik NL. The parkinsonian neurotoxin rotenone activates calpainand caspase-3 leading to motoneuron degeneration in spinal cord of Lewis rats. Neuroscience. 2007; 146:741-755.
59. Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Yand Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature. 1998; 392:605-608.
60. Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, Albanese A, Nussbaum R, Gonzalez-Maldonado R, et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science. 2004; 304:1158-1160.
61. Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, et al. PINK1 is necessary for long term survivaland mitochondrial function in human dopaminergic neurons. PLoS One. 2008; 3:e2455.
62. Simunovic F, Yi M, Wang Y, Macey L, Brown LT, Krichevsky AM, Andersen SL, Stephens RM, Benes FMand Sonntag KC. Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology. Brain. 2009; 132:1795-1809.
63. Barcia C, Ros CM, Annese V, Gomez A, Ros-Bernal F, Aguado-Yera D, Martinez-Pagan ME, de Pablos V, Fernandez-Villalba Eand Herrero MT. IFN-gamma signaling, with the synergistic contribution of TNF-alpha, mediates cell specific microglialand astroglial activation in experimental models of Parkinson's disease. Cell Death Dis. 2011; 2:e142.
64. Kremer B, Goldberg P, Andrew SE, Theilmann J, Telenius H, Zeisler J, Squitieri F, Lin B, Bassett A, Almqvist Eand et al. A worldwide study of the Huntington's disease mutation. The sensitivityand specificity of measuring CAG repeats. N Engl J Med. 1994; 330:1401-1406.
65. Ross CAand Poirier MA. Protein aggregationand neurodegenerative disease. Nat Med. 2004; 10 Suppl:S10-17.
66. Bano D, Zanetti F, Mende Yand Nicotera P. Neurodegenerative processes in Huntington's disease. Cell Death Dis. 2011; 2:e228.
67. Goldberg YP, Nicholson DW, Rasper DM, Kalchman MA, Koide HB, Graham RK, Bromm M, Kazemi-Esfarjani P, Thornberry NA, Vaillancourt JPand Hayden MR. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nat Genet. 1996; 13:442-449.
68. Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin Nand DiFiglia M. Caspase 3-cleaved N-terminal fragments of wild-typeand mutant huntingtin are present in normaland Huntington's disease brains, associate with membranes,and undergo calpain-dependent proteolysis. Proc Natl Acad Sci U S A. 2001; 98:12784-12789.
69. Graham RK, Deng Y, Carroll J, Vaid K, Cowan C, Pouladi MA, Metzler M, Bissada N, Wang L, Faull RL, Gray M, Yang XW, Raymond LA, et al. Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo. J Neurosci. 2010; 30:15019-15029.
70. Bhattacharyya NP, Banerjee Mand Majumder P. Huntington's disease: roles of huntingtin-interacting protein 1 (HIP-1)and its molecular partner HIPPI in the regulation of apoptosisand transcription. FEBS J. 2008; 275:4271-4279.
71. Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, et al. Recruitmentand activation of caspase-8 by the Huntingtin-interacting protein Hip-1and a novel partner Hippi. Nat Cell Biol. 2002; 4:95-105.
72. Vucic Sand Kiernan MC. Pathophysiology of neurodegeneration in familial amyotrophic lateral sclerosis. Curr Mol Med. 2009; 9:255-272.
73. Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 1993; 362:59-62.
74. Pasinelli Pand Brown RH. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci. 2006; 7:710-723.
75. Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD, Caliendo J, Hentati A, Kwon YW, Deng HXand et al.Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science. 1994; 264:1772-1775.
76. Kim EKand Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 2010; 1802:396-405.
77. Raoul C, Estevez AG, Nishimune H, Cleveland DW, deLapeyriere O, Henderson CE, Haase Gand Pettmann B. Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. Neuron. 2002; 35:1067-1083.
78. Bacman SR, Bradley WGand Moraes CT. Mitochondrial involvement in amyotrophic lateral sclerosis: trigger or target? Mol Neurobiol. 2006; 33:113-131.
79. Meissner F, Molawi Kand Zychlinsky A. Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis. Proc Natl Acad Sci U S A. 2010; 107:13046-13050.
80. Pasinelli P, Houseweart MK, Brown RH, Jr.and Cleveland DW. Caspase-1and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2000; 97:13901-13906.
81. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng ZJ, Flegal K, O'Donnell C, Kittner S, Lloyd-Jones D, Goff DC, Jr., Hong Y, et al. Heart diseaseand stroke statistics--2006 update: a report from the American Heart Association Statistics Committeeand Stroke Statistics Subcommittee. Circulation. 2006; 113:e85-151.
82. Downes CEand Crack PJ. Neural injury following stroke: are Toll-like receptors the link between the immune systemand the CNS? Br J Pharmacol. 2010; 160:1872-1888.
83. Yuan J. Neuroprotective strategies targeting apoptoticand necrotic cell death for stroke. Apoptosis. 2009; 14:469-477.
84. Muralikrishna Adibhatla Rand Hatcher JF. Phospholipase A2, reactive oxygen species,and lipid peroxidation in cerebral ischemia. Free Radic Biol Med. 2006; 40:376-387.
85. Takadera T, Shiraishi Yand Ohyashiki T. Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons. Neurochem Int. 2004; 45:713-719.
86. Saleem S, Kim YT, Maruyama T, Narumiya Sand Dore S. Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia. J Neuroimmunol. 2009; 208:87-93.
87. Ikeda-Matsuo Y, Tanji H, Narumiya Sand Sasaki Y. Inhibition of prostaglandin E(2) EP3 receptors improves stroke injury via anti-inflammatoryand anti-apoptotic mechanisms. J Neuroimmunol. 2011.
88. Martin-Villalba A, Hahne M, Kleber S, Vogel J, Falk W, Schenkel Jand Krammer PH. Therapeutic neutralization of CD95-ligandand TNF attenuates brain damage in stroke. Cell Death Differ. 2001; 8:679-686.
89. Tian L, Rauvala Hand Gahmberg CG. Neuronal regulation of immune responses in the central nervous system. Trends Immunol. 2009; 30:91-99.
90. Yu WR, Baptiste DC, Liu T, Odrobina E, Stanisz GJand Fehlings MG. Molecular mechanisms of spinal cord dysfunctionand cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy. Neurobiol Dis. 2009; 33:149-163.
91. Cao J, Semenova MM, Solovyan VT, Han J, Coffey ETand Courtney MJ. Distinct requirements for p38alphaand c-Jun Nterminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. J Biol Chem. 2004; 279:35903-35913.
92. Okuno S, Saito A, Hayashi Tand Chan PH. The c-Jun Nterminal protein kinase signaling pathway mediates Bax activationand subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. J Neurosci. 2004; 24:7879-7887.
93. Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RAand Moskowitz MA. Caspase activationand neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemiaand in vitro oxygen glucose deprivation. Proc Natl Acad Sci U S A. 2002; 99:15188-15193.
94. Schielke GP, Yang GY, Shivers BDand Betz AL. Reduced ischemic brain injury in interleukin-1 beta converting enzymedeficient mice. J Cereb Blood Flow Metab. 1998; 18:180-185.
95. Betz AL, Yang GYand Davidson BL. Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain. J Cereb Blood Flow Metab. 1995; 15:547-551.
96. Benchoua A, Guegan C, Couriaud C, Hosseini H, Sampaio N, Morin Dand Onteniente B. Specific caspase pathways are activated in the two stages of cerebral infarction. J Neurosci. 2001; 21:7127-7134.
97. Pan J, Konstas AA, Bateman B, Ortolano GAand Pile-Spellman J. Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging,and potential therapies. Neuroradiology. 2007; 49:93-102.
98. Jung JE, Kim GS, Chen H, Maier CM, Narasimhan P, Song YS, Niizuma K, Katsu M, Okami N, Yoshioka H, Sakata H, Goeders CEand Chan PH. Reperfusionand neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Mol Neurobiol. 2010; 41:172-179.
99. Whelan RS, Kaplinskiy Vand Kitsis RN. Cell death in the pathogenesis of heart disease: mechanismsand significance. Annu Rev Physiol. 2010; 72:19-44.
100. Cuadrado I, Fernandez-Velasco M, Bosca Land de Las Heras B. Labdane diterpenes protect against anoxia/reperfusion injury in cardiomyocytes: involvement of AKT activation. Cell Death Dis. 2011; 2:e229.
101. Gough DRand Cotter TG. Hydrogen peroxide: a Jekylland Hyde signalling molecule. Cell Death Dis. 2011; 2:e213.
102. Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S, Factor SM, Shirani J, Armstrong RCand Kitsis RN. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest. 2003; 111:1497-1504.
103. Nishida Kand Otsu K. Cell death in heart failure. Circ J. 2008; 72 Suppl A:A17-21.
104. Rice KCand Bayles KW. Molecular control of bacterial deathand lysis. Microbiol Mol Biol Rev. 2008; 72:85-109.
105. Häcker G, Kirschnek Sand Fischer SF. Apoptosis in infectious disease: how bacteria interfere with the apoptotic apparatus. Med Microbiol Immunol. 2006; 195:11-19.
106. Dao DN, Kremer L, Guerardel Y, Molano A, Jacobs WR, Jr., Porcelli SAand Briken V. Mycobacterium tuberculosis lipomannan induces apoptosisand interleukin-12 production in macrophages. Infect Immun. 2004; 72:2067-2074.
107. Tesh VL. Induction of apoptosis by Shiga toxins. Future Microbiol. 2010; 5:431-453.
108. Carrero JA, Calderon Band Unanue ER. Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule. J Immunol. 2004; 172:4866-4874.
109. Ring A, Braun JS, Pohl J, Nizet V, Stremmel Wand Shenep JL. Group B streptococcal beta-hemolysin induces mortalityand liver injury in experimental sepsis. J Infect Dis. 2002; 185:1745-1753.
110. Russell DG. Mycobacterium tuberculosisand the intimate discourse of a chronic infection. Immunol Rev. 2011; 240:252-268.
111. Lee J, Hartman Mand Kornfeld H. Macrophage apoptosis in tuberculosis. Yonsei Med J. 2009; 50:1-11.
112. Lee J, Remold HG, Ieong MHand Kornfeld H. Macrophage apoptosis in response to high intracellular burden of Mycobacterium tuberculosis is mediated by a novel caspaseindependent pathway. J Immunol. 2006; 176:4267-4274.
113. Lopez M, Sly LM, Luu Y, Young D, Cooper Hand Reiner NE. The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2. J Immunol. 2003; 170:2409-2416.
114. Driscoll JA, Brody SLand Kollef MH. The epidemiology, pathogenesisand treatment of Pseudomonas aeruginosa infections. Drugs. 2007; 67:351-368.
115. Grassmé H, Jendrossek Vand Gulbins E. Molecular mechanisms of bacteria induced apoptosis. Apoptosis. 2001; 6:441-445.
116. Pan Y, Teng D, Burke AC, Haase EMand Scannapieco FA. Oral bacteria modulate invasionand induction of apoptosis in HEp-2 cells by Pseudomonas aeruginosa. Microb Pathog. 2009; 46:73-79.
117. Burillo Aand Bouza E. Chlamydophila pneumoniae. Infect Dis Clin North Am. 2010; 24:61-71.
118. Dean Dand Powers VC. Persistent Chlamydia trachomatis infections resist apoptotic stimuli. Infect Immun. 2001; 69:2442-2447.
119. Fischer SF, Vier J, Kirschnek S, Klos A, Hess S, Ying Sand Häcker G. Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins. J Exp Med. 2004; 200:905-916.
120. Gyles CL. Shiga toxin-producing Escherichia coli: an overview. J Anim Sci. 2007; 85(13 Suppl):E45-62.
121. Lingwood CA. Shiga toxin receptor glycolipid binding. Pathologyand utility. Methods Mol Med. 2003; 73:165-186.
122. Iordanov MS, Pribnow D, Magun JL, Dinh TH, Pearson JA, Chen SLand Magun BE. Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reactionand by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA. Mol Cell Biol. 1997; 17:3373-3381.
123. Johansson D, Kosovac E, Moharer J, Ljuslinder I, Brannstrom T, Johansson Aand Behnam-Motlagh P. Expression of verotoxin-1 receptor Gb3 in breast cancer tissueand verotoxin-1 signal transduction to apoptosis. BMC Cancer. 2009; 9:67.
124. Blaser MJand Atherton JC. Helicobacter pylori persistence: biologyand disease. J Clin Invest. 2004; 113:321-333.
125. Yamasaki E, Wada A, Kumatori A, Nakagawa I, Funao J, Nakayama M, Hisatsune J, Kimura M, Moss Jand Hirayama T. Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Baxand Bak, leading to cytochrome c releaseand cell death, independent of vacuolation. J Biol Chem. 2006; 281:11250-11259.
126. Esen M, Schreiner B, Jendrossek V, Lang F, Fassbender K, Grassme Hand Gulbins E. Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells. Apoptosis. 2001; 6:431-439.
127. Marriott HM, Ali F, Read RC, Mitchell TJ, Whyte MKand Dockrell DH. Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J. 2004; 18:1126-1128.
128. Little SFand Ivins BE. Molecular pathogenesis of Bacillus anthracis infection. Microbes Infect. 1999; 1:131-139.
129. Southwick FSand Purich DL. Intracellular pathogenesis of listeriosis. N Engl J Med. 1996; 334:770-776.
130. Ulett GCand Adderson EE. Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversityand Consequences for Immunity. Curr Immunol Rev. 2006; 2:119-141.
131. Poxton IR, McCoubrey Jand Blair G. The pathogenicity of Clostridium difficile. Clin Microbiol Infect. 2001; 7:421-427.
132. He D, Hagen SJ, Pothoulakis C, Chen M, Medina ND, Warny Mand LaMont JT. Clostridium difficile toxin A causes early damage to mitochondria in cultured cells. Gastroenterology. 2000; 119:139-150.
133. Hay Sand Kannourakis G. A time to kill: viral manipulation of the cell death program. J Gen Virol. 2002; 83:1547-1564.
134. Danthi P. Enter the kill zone: initiation of death signaling during virus entry. Virology. 2011; 411:316-324.
135. Brazeau E, Mahalingam R, Gilden D, Wellish M, Kaufer BB, Osterrieder Nand Pugazhenthi S. Varicella-zoster virus-induced apoptosis in MeWo cells is accompanied by down-regulation of Bcl-2 expression. J Neurovirol. 2010; 16:133-140. 136. Brune W. Inhibition of programmed cell death by cytomegaloviruses. Virus Res. 2011; 157:144-150.
136. Brune W. Inhibition of programmed cell death by cytomegaloviruses. Virus Res. 2011; 157:144-150.
137. Pauleau AL, Larochette N, Giordanetto F, Scholz SR, Poncet D, Zamzami N, Goldmacher VSand Kroemer G. Structurefunction analysis of the interaction between Baxand the cytomegalovirus-encoded protein vMIA. Oncogene. 2007; 26:7067-7080.
138. Smith GBand Mocarski ES. Contribution of GADD45 family members to cell death suppression by cellular Bcl-xLand cytomegalovirus vMIA. J Virol. 2005; 79:14923-14932.
139. Poncet D, Larochette N, Pauleau AL, Boya P, Jalil AA, Cartron PF, Vallette F, Schnebelen C, Bartle LM, Skaletskaya A, Boutolleau D, Martinou JC, Goldmacher VS, et al. An antiapoptotic viral protein that recruits Bax to mitochondria. J Biol Chem. 2004; 279:22605-22614.
140. Andoniou CE. Suicide watch: how cytomegalovirus interferes with the cell-death pathways of infected cells. Tissue Antigens. 2010; 76:1-8.
141. Assrir N, Soussan P, Kremsdorf Dand Rossignol JM. Role of the hepatitis B virus proteins in pro-and anti-apoptotic processes. Front Biosci. 2010; 15:12-24.
142. Foo NC, Ahn BY, Ma X, Hyun Wand Yen TS. Cellular vacuolizationand apoptosis induced by hepatitis B virus large surface protein. Hepatology. 2002; 36:1400-1407.
143. Liang X, Du J, Liu Y, Cui M, Ma C, Han L, Qu Z, Zhang Z, Sun Z, Zhang L, Chen YHand Sun W. The hepatitis B virus protein MHBs(t) sensitizes hepatoma cells to TRAIL-induced apoptosis through ERK2. Apoptosis. 2007; 12:1827-1836.
144. Bouchard MJand Schneider RJ. The enigmatic X gene of hepatitis B virus. J Virol. 2004; 78:12725-12734.
145. Clippinger AJ, Gearhart TLand Bouchard MJ. Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-kappaBand the mitochondrial permeability transition pore. J Virol. 2009; 83:4718-4731.
146. Lu YW, Tan TL, Chan Vand Chen WN. The HBSP gene is expressed during HBV replication,and its coded BH3-containingspliced viral protein induces apoptosis in HepG2 cells. Biochem Biophys Res Commun. 2006; 351:64-70.
147. Fischer R, Baumert Tand Blum HE. Hepatitis C virus infectionand apoptosis. World J Gastroenterol. 2007; 13:4865-4872.
148. Ludwig S, Pleschka S, Planz Oand Wolff T. Ringing the alarm bells: signallingand apoptosis in influenza virus infected cells. Cell Microbiol. 2006; 8:375-386.
149. Holm GHand Gabuzda D. Distinct mechanisms of CD4+and CD8+ T-cell activationand bystander apoptosis induced by human immunodeficiency virus type 1 virions. J Virol. 2005; 79:6299-6311.
150. Cummins NWand Badley AD. Mechanisms of HIVassociated lymphocyte apoptosis: 2010. Cell Death Dis. 2010; 1:e99.
151. Nie Z, Bren GD, Vlahakis SR, Schimnich AA, Brenchley JM, Trushin SA, Warren S, Schnepple DJ, Kovacs CM, Loutfy MR, Douek DCand Badley AD. Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo. J Virol. 2007; 816947-6956.
152. Nagata S. Apoptosisand autoimmune diseases. IUBMB Life. 2006; 58:358-362.
153. Nagata S. Autoimmune diseases caused by defects in clearing dead cellsand nuclei expelled from erythroid precursors. Immunological reviews. 2007; 220:237-250.
154. Madkaikar M, Mhatre S, Gupta Mand Ghosh K. Advances in autoimmune lymphoproliferative syndromes. Eur J Haematol. 2011; 87:1-9.
155. Tischner D, Woess C, Ottina Eand Villunger A. Bcl-2-regulated cell death signalling in the prevention of autoimmunity. Cell Death Dis. 2010; 1:e48.
156. Fadeel Band Orrenius S. Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med. 2005; 258:479-517.
157. Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JMand Strasser A. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis,and to preclude autoimmunity. Science. 1999; 286:1735-1738.
158. Ren Y, Tang J, Mok MY, Chan AW, Wu Aand Lau CS. Increased apoptotic neutrophilsand macrophagesand impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus. Arthritis Rheum. 2003; 48:2888-2897.
159. Munoz LE, Janko C, Schulze C, Schorn C, Sarter K, Schett Gand Herrmann M. Autoimmunityand chronic inflammation -two clearance-related steps in the etiopathogenesis of SLE. Autoimmun Rev. 2010; 10:38-42.
160. Bachmann HS, Otterbach F, Callies R, Nuckel H, Bau M, Schmid KW, Siffert Wand Kimmig R. The AA genotype of the regulatory BCL2 promoter polymorphism ( 938C>A) is associated with a favorable outcome in lymph node negative invasive breast cancer patients. Clin Cancer Res. 2007; 13:5790-5797.
161. Janes KA. RUNX1and its understudied role in breast cancer. Cell Cycle. 2011; 10:3461-3465.
162. Pujals A, Renouf B, Robert A, Chelouah S, Hollville Eand Wiels J. Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis. Cell Death Dis. 2011; 2:e184.
163. Egea V, von Baumgarten L, Schichor C, Berninger B, Popp T, Neth P, Goldbrunner R, Kienast Y, Winkler F, Jochum Mand Ries C. TNF-alpha respecifies human mesenchymal stem cells to a neural fateand promotes migration toward experimental glioma. Cell Death Differ. 2011; 18:853-863.
164. Hervouet E, Vallette FMand Cartron PF. Impact of the DNA methyltransferases expression on the methylation status of apoptosis-associated genes in glioblastoma multiforme. Cell Death Dis. 2010; 1:e8.
165. Stegh AHand DePinho RA. Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle. 2011; 10:33-38.
166. D'Errico I, Lo Sasso G, Salvatore L, Murzilli S, Martelli N, Cristofaro M, Latorre D, Villani Gand Moschetta A. Bax is necessary for PGC1alpha pro-apoptotic effect in colorectal cancer cells. Cell Cycle. 2011; 10:2937-2945.
167. D'Agostino Land Giordano A. A novel dual signaling axis for NSP 5a3a induced apoptosis in headand neck carcinoma. Oncotarget. 2011; 2:1055-1074.
168. Tomic T, Botton T, Cerezo M, Robert G, Luciano F, Puissant A, Gounon P, Allegra M, Bertolotto C, Bereder JM, Tartare-Deckert S, Bahadoran P, Auberger P, et al. Metformin inhibits melanoma development through autophagyand apoptosis mechanisms. Cell Death Dis. 2011; 2:e199.
169. Botton T, Puissant A, Cheli Y, Tomic T, Giuliano S, Fajas L, Deckert M, Ortonne JP, Bertolotto C, Tartare-Deckert S, Ballotti Rand Rocchi S. Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth. Cell Death Differ. 2011; 18:109-121.
170. Jiang CC, Lai F, Tay KH, Croft A, Rizos H, Becker TM, Yang F, Liu H, Thorne RF, Hersey Pand Zhang XD. Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS. Cell Death Dis. 2010; 1:e69.
171. Tamiya S, Etoh K, Suzushima H, Takatsuki Kand Matsuoka M. Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells. Blood. 1998; 91:3935-3942.
172. Dunkle A, Dzhagalov Iand He YW. Cytokine-dependentand cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes. Cell Death Dis. 2011; 2:e214.
173. Gao N, Budhraja A, Cheng S, Liu EH, Chen J, Yang Z, Chen D, Zhang Zand Shi X. Phenethyl isothiocyanate exhibits antileukemic activity in vitroand in vivo by inactivation of Aktand activation of JNK pathways. Cell Death Dis. 2011; 2:e140.
174. Heidari N, Hicks MAand Harada H. GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosisand autophagy. Cell Death Dis. 2010; 1:e76.
175. Bleumink M, Kohler R, Giaisi M, Proksch P, Krammer PHand Li-Weber M. Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression. Cell Death Differ. 2011; 18:362-370.
176. Campos-Sanchez E, Toboso-Navasa A, Romero-Camarero I, Barajas-Diego M, Sanchez-Garcia Iand Cobaleda C. Acute lymphoblastic leukemiaand developmental biology: A crucial interrelationship. Cell Cycle. 2011; 10:3473-3486.
177. Boehrer S, Galluzzi L, Lainey E, Bouteloup C, Tailler M, Harper F, Pierron G, Ades L, Thepot S, Sebert M, Gardin C, de Botton S, Fenaux P, et al. Erlotinib antagonizes constitutive activation of SRC family kinasesand mTOR in acute myeloid leukemia. Cell Cycle. 2011; 10:3168-3175.
178. Greaves M. Leukemogenesisand ageing: 'fit for transformation'? Aging (Albany NY). 2011; 3:79-80.
179. Crews L, Patrick C, Adame A, Rockenstein Eand Masliah E. Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. Cell Death Dis. 2011; 2:e120.
180. Lee MH, Lin SR, Chang JY, Schultz L, Heath J, Hsu LJ, Kuo YM, Hong Q, Chiang MF, Gong CX, Sze CIand Chang NS. TGF-beta induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid beta plaques in Alzheimer's disease. Cell Death Dis. 2010; 1:e110.
181. Cordeiro MF, Guo L, Coxon KM, Duggan J, Nizari S, Normando EM, Sensi SL, Sillito AM, Fitzke FW, Salt TEand Moss SE. Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo. Cell Death Dis. 2010; 1:e3.
182. Song B, Davis K, Liu XS, Lee HG, Smith Mand Liu X. Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease. Aging (Albany NY). 2011; 3:846-851.
183. Stanga S, Lanni C, Govoni S, Uberti D, D'Orazi Gand Racchi M. Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link? Aging (Albany NY). 2010; 2:545-554.
184. Berry C, La Vecchia Cand Nicotera P. Paraquatand Parkinson's disease. Cell Death Differ. 2010; 17:1115-1125.
185. da Costa CAand Checler F. A novel parkin-mediated transcriptional function links p53 to familial Parkinson's disease. Cell Cycle. 2010; 9:16-17.
186. Sassone J, Colciago C, Marchi P, Ascardi C, Alberti L, Di Pardo A, Zippel R, Sipione S, Silani Vand Ciammola A. Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3). Cell Death Dis. 2010; 1:e7.
187. Richards P, Didszun C, Campesan S, Simpson A, Horley B, Young KW, Glynn P, Cain K, Kyriacou CP, Giorgini Fand Nicotera P. Dendritic spine lossand neurodegeneration is rescued by Rab11 in models of Huntington's disease. Cell Death Differ. 2011; 18:191-200.
188. Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin Nand DiFiglia M. Caspase 3-cleaved N-terminal fragments of wild-typeand mutant huntingtin are present in normaland Huntington's disease brains, associate with membranes,and undergo calpain-dependent proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98:12784-12789.
189. Genestine M, Caricati E, Fico A, Richelme S, Hassani H, Sunyach C, Lamballe F, Panzica GC, Pettmann B, Helmbacher F, Raoul C, Maina Fand Dono R. Enhanced neuronal Met signalling levels in ALS mice delay disease onset. Cell Death Dis. 2011; 2:e130.
190. Pasinelli Pand Brown RH. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci. 2006; 7:710-723.
191. Meissner F, Molawi Kand Zychlinsky A. Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107:13046-13050.
192. Chauvier D, Renolleau S, Holifanjaniaina S, Ankri S, Bezault M, Schwendimann L, Rousset C, Casimir R, Hoebeke J, Smirnova M, Debret G, Trichet AP, Carlsson Y, et al. Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor. Cell Death Dis. 2011; 2:e203.
193. Lanzillotta A, Sarnico I, Ingrassia R, Boroni F, Branca C, Benarese M, Faraco G, Blasi F, Chiarugi A, Spano Pand Pizzi M. The acetylation of RelA in Lys310 dictates the NF-kappaBdependent response in post-ischemic injury. Cell Death Dis. 2010; 1:e96.
194. Martin-Villalba A, Hahne M, Kleber S, Vogel J, Falk W, Schenkel Jand Krammer PH. Therapeutic neutralization of CD95-ligandand TNF attenuates brain damage in stroke. Cell deathand differentiation. 2001; 8:679-686.
195. Degli Esposti D, Sebagh M, Pham P, Reffas M, Pous C, Brenner C, Azoulay Dand Lemoine A. Ischemic preconditioning induces autophagyand limits necrosis in human recipients of fatty liver grafts, decreasing the incidence of rejection episodes. Cell Death Dis. 2011; 2:e111.
196. Machado NG, Alves MG, Carvalho RAand Oliveira PJ. Mitochondrial involvement in cardiac apoptosis during ischemiaand reperfusion: can we close the box? Cardiovasc Toxicol. 2009; 9:211-227.
197. Lopez-Neblina F, Toledo AHand Toledo-Pereyra LH. Molecular biology of apoptosis in ischemiaand reperfusion. J Invest Surg. 2005; 18:335-350.
198. Martins I, Galluzzi Land Kroemer G. Hormesis, cell deathand aging. Aging (Albany NY). 2011; 3:821-828.
199. Fujita Tand Ishikawa Y. Apoptosis in heart failure. -The role of the beta-adrenergic receptor-mediated signaling pathwayand p53-mediated signaling pathway in the apoptosis of cardiomyocytes. Circ J. 2011; 75:1811-1818.
200. Kelk P, Abd H, Claesson R, Sandstrom G, Sjostedt Aand Johansson A. Cellularand molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin. Cell Death Dis. 2011; 2:e126.
201. Gorvel L, Al Moussawi K, Ghigo E, Capo C, Mege JLand Desnues B. Tropheryma whipplei, the Whipple's disease bacillus, induces macrophage apoptosis through the extrinsic pathway. Cell Death Dis. 2010; 1:e34.
202. Vazquez CLand Colombo MI. Coxiella burnetii modulates Beclin 1and Bcl-2, preventing host cell apoptosis to generate a persistent bacterial infection. Cell Death Differ. 2010; 17:421-438.
203. Hacker G, Kirschnek Sand Fischer SF. Apoptosis in infectious disease: how bacteria interfere with the apoptotic apparatus. Medical microbiologyand immunology. 2006; 195:11-19.
204. Tesh VL. Induction of apoptosis by Shiga toxins. Future Microbiol. 2010; 5:431-453.
205. Pan Y, Teng D, Burke AC, Haase EMand Scannapieco FA. Oral bacteria modulate invasionand induction of apoptosis in HEp-2 cells by Pseudomonas aeruginosa. Microb Pathog. 2009; 46:73-79.
206. Calore F, Genisset C, Casellato A, Rossato M, Codolo G, Esposti MD, Scorrano Land de Bernard M. Endosomemitochondria juxtaposition during apoptosis induced by H. pylori VacA. Cell Death Differ. 2010; 17:1707-1716.
207. Halder UC, Bagchi P, Chattopadhyay S, Dutta Dand Chawla-Sarkar M. Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway. Cell Death Dis. 2011; 2:e197.
208. Krzyzowska M, Shestakov A, Eriksson Kand Chiodi F. Role of Fas/FasL in regulation of inflammation in vaginal tissue during HSV-2 infection. Cell Death Dis. 2011; 2:e132.
209. Knoll S, Furst K, Thomas S, Villanueva Baselga S, Stoll A, Schaefer Sand Putzer BM. Dissection of cell context-dependentinteractions between HBxand p53 family members in regulation of apoptosis: a role for HBV-induced HCC. Cell Cycle. 2011; 10:3554-3565.
210. Brune W. Inhibition of programmed cell death by cytomegaloviruses. Virus Res. 2011; 157:144-150.
211. Liang X, Du J, Liu Y, Cui M, Ma C, Han L, Qu Z, Zhang Z, Sun Z, Zhang L, Chen YHand Sun W. The hepatitis B virus protein MHBs(t) sensitizes hepatoma cells to TRAIL-induced apoptosis through ERK2. Apoptosis. 2007; 12:1827-1836.
212. Fischer R, Baumert Tand Blum HE. Hepatitis C virus infectionand apoptosis. World journal of gastroenterology : WJG. 2007; 13:4865-4872.
213. Abou-Kandil A, Chamias R, Huleihel M, Godbey WTand Aboud M. Role of caspase 9 in activation of HTLV-1 LTR expression by DNA damaging agents. Cell Cycle. 2011; 10:3337-3345.
214. Mukerjee R, Claudio PP, Chang JR, Del Valle Land Sawaya BE. Transcriptional regulation of HIV-1 gene expression by p53. Cell Cycle. 2010; 9:4569-4578.
215. Nagata S. Apoptosisand autoimmune diseases. Ann N Y Acad Sci. 2010; 1209:10-16.
216. Qiao G, Li Z, Minto AW, Shia J, Yang L, Bao L, Tschopp J, Gao JX, Wang J, Quigg RJand Zhang J. Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain. Cell Death Differ. 2010; 17:522-533.
217. Eguchi K. Apoptosis in autoimmune diseases. Intern Med. 2001; 40:275-284.
218. Kawakami A, Matsuoka N, Tsuboi M, Koji T, Urayama S, Sera N, Hida A, Usa T, Kimura H, Yokoyama N, Nakashima T, Ishikawa N, Ito K, et al. CD4+ T cell-mediated cytotoxicity toward thyrocytes: the importance of Fas/Fas ligand interaction inducing apoptosis of thyrocytesand the inhibitory effect of thyroid-stimulating hormone. Lab Invest. 2000; 80:471-484