Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: Implications for the pathophysiology of human cervical spondylotic myelopathy

Neurobiology of Disease

Volumn 33, Issue 2, 2009, Pages 149-163

  Yu, Wen Ru ^a   Baptiste, Darryl C ^a   Liu, Tianyi ^a   Odrobina, Ewa ^b   Stanisz, Greg J ^b,c   Fehlings, Michael G ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Apoptosis; Caspase; Fas; Ossification of the posterior longitudinal ligament; Spinal cord injury

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; FAS ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DENSITY; CERVICAL SPONDYLOSIS; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; HYPEROSTOSIS; LIGAMENTUM FLAVUM; MOUSE; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OLIGODENDROGLIA; OSSIFICATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD COMPRESSION; SPINAL CORD DISEASE; SPINAL CORD INJURY;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; DISEASE MODELS, ANIMAL; FAS LIGAND PROTEIN; HYPEROSTOSIS; MICE; MICE, MUTANT STRAINS; NERVE TISSUE PROTEINS; NEURONS; OLIGODENDROGLIA; OSSIFICATION, HETEROTOPIC; PARESIS; SPINAL CORD COMPRESSION; SPINAL CORD DISEASES; SPONDYLOSIS;

EID: 58249118699     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.09.024     Document Type: Article

References (41)

1. Baba H., Furusawa N., Fukuda M., Maezawa Y., Imura S., Kawahara N., Nakahashi K., and Tomita K. Potential role of streptozotocin in enhancing ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy). Eur J Histochem 41 (1997) 191-202
2. Baba H., Maezawa Y., Imura S., Kawahara N., Nakahashi K., and Tomita K. Quantitative analysis of the spinal cord motoneuron under chronic compression: an experimental observation in the mouse. J Neurol 243 (1996) 109-116
3. Baptiste D.C., and Fehlings M.G. Pathophysiology of cervical myelopathy. Spine J 6 (2006) 190S-197S
4. Blight A.R. Delayed demyelination and macrophage invasion: a candidate for secondary cell damage in spinal cord injury. Cent Nerv Syst Trauma 2 (1985) 299-315
5. Bohlman H.H., and Emery S.E. The pathophysiology of cervical spondylosis and myelopathy. Spine 13 (1988) 843-846
6. Bracken M.B., Shepard M.J., Holford T.R., Leo-Summers L., Aldrich E.F., Fazl M., Fehlings M.G., Herr D.L., Hitchon P.W., Marshall L.F., Nockels R.P., Pascale V., Perot Jr. P.L., Piepmeier J., Sonntag V.K., Wagner F., Wilberger J.E., Winn H.R., and Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg 89 (1998) 699-706
7. Breig A., Turnbull I., and Hassler O. Effects of mechanical stresses on the spinal cord in cervical spondylosis. A study on fresh cadaver material. J Neurosurg 25 (1966) 45-56
8. Bunge R.P., Puckett W.R., Becerra J.L., Marcillo A., and Quencer R.M. Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination. Adv Neurol 59 (1993) 75-89
9. Cao Q., Xu X.M., Devries W.H., Enzmann G.U., Ping P., Tsoulfas P., Wood P.M., Bunge M.B., and Whittemore S.R. Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J Neurosci 25 (2005) 6947-6957
10. Casha S., Yu W.R., and Fehlings M.G. Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat. Neuroscience 103 (2001) 203-218
11. Casha S., Yu W.R., and Fehlings M.G. FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury. Exp Neurol 196 (2005) 390-400
12. Charriaut-Marlangue C. Apoptosis: a target for neuroprotection. Therapie 59 (2004) 185-190
13. Cutuli M., Cristiani S., Lipton J.M., and Catania A. Antimicrobial effects of alpha-MSH peptides. J Leukoc Biol 67 (2000) 233-239
14. Davis A.R., Lotocki G., Marcillo A.E., Dietrich W.D., and Keane R.W. FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury. J Neurotrauma 24 (2007) 823-834
15. de Medinaceli L., Freed W.J., and Wyatt R.J. An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol 77 (1982) 634-643
16. Demjen D., Klussmann S., Kleber S., Zuliani C., Stieltjes B., Metzger C., Hirt U.A., Walczak H., Falk W., Essig M., Edler L., Krammer P.H., and Martin-Villalba A. Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury. Nat Med 10 (2004) 389-395
17. Doppman J.L. The mechanism of ischemia in anteroposterior compression of the spinal cord. Invest Radiol 10 (1975) 543-551
18. Dougherty K.D., Dreyfus C.F., and Black I.B. Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury. Neurobiol Dis 7 (2000) 574-585
19. Dowling P., Shang G., Raval S., Menonna J., Cook S., and Husar W. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain. J Exp Med 184 (1996) 1513-1518
20. Emery E., Aldana P., Bunge M.B., Puckett W., Srinivasan A., Keane R.W., Bethea J., and Levi A.D. Apoptosis after traumatic human spinal cord injury. J Neurosurg 89 (1998) 911-920
21. Fehlings M.G., and Skaf G. A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury. Spine 23 (1998) 2730-2737
22. Gooding M.R., Wilson C.B., and Hoff J.T. Experimental cervical myelopathy. Effects of ischemia and compression of the canine cervical spinal cord. J Neurosurg 43 (1975) 9-17
23. Hukuda S., and Wilson C.B. Experimental cervical myelopathy: effects of compression and ischemia on the canine cervical cord. J Neurosurg 37 (1972) 631-652
24. Kuwana T., Smith J.J., Muzio M., Dixit V., Newmeyer D.D., and Kornbluth S. Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. J Biol Chem 273 (1998) 16589-16594
25. Matsushita K., Wu Y., Qiu J., Lang-Lazdunski L., Hirt L., Waeber C., Hyman B.T., Yuan J., and Moskowitz M.A. Fas receptor and neuronal cell death after spinal cord ischemia. J Neurosci 20 (2000) 6879-6887
26. McCormack B.M., and Weinstein P.R. Cervical spondylosis. An update. West J Med 165 (1996) 43-51
27. Nakamura I., Ikegawa S., Okawa A., Okuda S., Koshizuka Y., Kawaguchi H., Nakamura K., Koyama T., Goto S., Toguchida J., Matsushita M., Ochi T., Takaoka K., and Nakamura Y. Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Hum Genet 104 (1999) 492-497
28. Okawa A., Ikegawa S., Nakamura I., Goto S., Moriya H., and Nakamura Y. Mapping of a gene responsible for twy (tip-toe walking Yoshimura), a mouse model of ossification of the posterior longitudinal ligament of the spine (OPLL). Mamm Genome 9 (1998) 155-156
29. Okawa A., Nakamura I., Goto S., Moriya H., Nakamura Y., and Ikegawa S. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 19 (1998) 271-273
30. Stennicke H.R., Jurgensmeier J.M., Shin H., Deveraux Q., Wolf B.B., Yang X., Zhou Q., Ellerby H.M., Ellerby L.M., Bredesen D., Green D.R., Reed J.C., Froelich C.J., and Salvesen G.S. Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem 273 (1998) 27084-27090
31. Swagerty, D.L. Jr., 1994. Cervical spondylotic myelopathy: a cause of gait disturbance and falls in the elderly. Kans Med, 95, 226-227, 229.
32. Tanno T. Experimental study on the spinal lesions in hyperostotic mouse (twy/twy): special reference to the pathogenesis of the ossification of the spinal ligaments and to the action of ethane-1-hydroxy-1, 1-diphosphonate (EHDP)]. Nippon Seikeigeka Gakkai Zasshi 66 (1992) 1073-1083
33. Takenouchi T., Setoguchi T., Yone K., and Komiya S. Expression of apoptosis signal-regulating kinase 1 in mouse spinal cord under chronic mechanical compression: possible involvement of the stress-activated mitogen-activated protein kinase pathways in spinal cord cell apoptosis. Spine 33 (2008) 1943-1950
34. Uchida K., Baba H., Maezawa Y., Furukawa S., Furusawa N., and Imura S. Histological investigation of spinal cord lesions in the spinal hyperostotic mouse (twy/twy): morphological changes in anterior horn cells and immunoreactivity to neurotropic factors. J Neurol 245 (1998) 781-793
35. Uchida K., Baba H., Maezawa Y., and Kubota C. Progressive changes in neurofilament proteins and growth-associated protein-43 immunoreactivities at the site of cervical spinal cord compression in spinal hyperostotic mice. Spine 27 (2002) 480-486
36. West D.A., Valentim L.M., Lythgoe M.F., Stephanou A., Proctor E., van der Weerd L., Ordidge R.J., Latchman D.S., and Gadian D.G. MR image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischemia. Neuroscience 127 (2004) 333-339
37. Yamaura I., Yone K., Nakahara S., Nagamine T., Baba H., Uchida K., and Komiya S. Mechanism of destructive pathologic changes in the spinal cord under chronic mechanical compression. Spine 27 (2002) 21-26
38. Yew D.T., Ping Li W., and Liu W.K. Fas and activated caspase 8 in normal, Alzheimer and multiple infarct brains. Neurosci Lett 367 (2004) 113-117
39. Yoshino O., Matsuno H., Nakamura H., Yudoh K., Abe Y., Sawai T., Uzuki M., Yonehara S., and Kimura T. The role of Fas-mediated apoptosis after traumatic spinal cord injury. Spine 29 (2004) 1394-1404
40. Yu Y.L., and Leong J.C. Cervical myelopathy due to ossification of the posterior longitudinal ligament. A clinical, radiological and evoked potentials study in six Chinese patients. Brain 111 (1988) 769-783
41. Zurita M., Vaquero J., and Zurita I. Presence and significance of CD-95 (Fas/APO1) expression after spinal cord injury. J Neurosurg 94 (2001) 257-264