The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia

Journal of Neuroscience

Volumn 24, Issue 36, 2004, Pages 7879-7887

  Okuno, Shuzo ^a   Saito, Atsushi ^a   Hayashi, Takeshi ^a   Chan, Pak H ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Apoptosis; Bax; Bim; c Jun N terminal kinase; Cerebral ischemia; SP600125

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOPTOGENIC PROTEIN; APOPTOSIS INDUCING FACTOR; BIM PROTEIN; BIML PROTEIN; DNA FRAGMENT; MITOCHONDRIAL PROTEIN; PHOSPHO STRESS ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOASSAY; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CELL PROTECTION; COIMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOSOL; DNA FRAGMENTATION ASSAY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IMMUNOPRECIPITATION; INTRACELLULAR TRANSPORT; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; TRANSIENT FOCAL CEREBRAL ISCHEMIA;

ANIMALS; ANTHRACENES; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CARRIER PROTEINS; DYNEIN ATPASE; INFARCTION, MIDDLE CEREBRAL ARTERY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR MOTOR PROTEINS; NEURONS; PHOSPHORYLATION; PROTEIN INTERACTION MAPPING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 4544255383     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1745-04.2004     Document Type: Article

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