Apoptosis and autoimmune diseases

IUBMB Life

Volumn 58, Issue 5-6, 2006, Pages 358-362

  Nagata, Shigekazu ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Apoptosis; Autoimmune disease; Caspase; DNA degradation; Erythropoiesis; Macrophages

Indexed keywords

CASPASE 3; DNA; DNA FRAGMENT; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; PROCASPASE 8; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; CANCER CELL DESTRUCTION; CELL DEATH; CELL DESTRUCTION; CELL LINE; CELL ULTRASTRUCTURE; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; DNA DEGRADATION; DNA STRAND BREAKAGE; ERYTHROID CELL; GAMMA IRRADIATION; GENE DELETION; GENETIC DISORDER; HEMATOPOIETIC STEM CELL; KNOCKOUT GENE; LANGERHANS CELL; LIVER CELL; NATURAL KILLER T CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FAMILY; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION;

ANIMALS; APOPTOSIS; AUTOIMMUNE DISEASES; HUMANS;

EID: 33745064268     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1080/15216540600746401     Document Type: Conference Paper

References (33)

1. Vaux, D. L., and Korsmeyer, S. J. (1999) Cell death in development. Cell 96, 245-254.
2. Jacobson, M. D., Weil, M., and Raff, M. C. (1997) Programmed cell death in animal development. Cell 88, 347-354.
3. Kerr, J. F., Wyllie, A. H., and Currie, A. R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.
4. Danial, N. N., and Korsmeyer, S. J. (2004) Cell death: critical control points. Cell 116, 205-219.
5. Nagata, S. (1997) Apoptosis by death factor. Cell 88, 355-365.
6. Krammer, P. H. (2000) CD95's deadly mission in the immune system. Nature 407, 789-795.
7. Thornberry, N. A., and Lazebnik, Y. (1998) Caspases: enemies within. Science 281, 1312-1316.
8. Fischer, U., Janicke, R. U., and Schulze-Osthoff, K. (2003) Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death & Differ. 10, 76-100.
9. Enari, M., Sakahira, H., Yokoyama, H., Okawa, H., Iwamatsu, A., and Nagata, S. (1998) A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 43-50.
10. Woo, E.-J., Kim, Y.-G., Kim, M.-S., Han, W.-D., Shin, S., Robinson, H., Park, S.-Y., and Oh, B.-H. (2004) Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway. Mol. Cell 14, 531-539.
11. Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A., and Nagata, S. (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317.
12. Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T., and Nagata, S. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76, 969-976.
13. Yeh, W. C., Pompa, J. L., McCurrach, M. E., Shu, H. B., Elia, A. J., Shahinian, A., Ng, M., Wakeham, A., Khoo, W., Mitchell, K., El-Deiry, W. S., Lowe, S. W., Goeddel, D. V., and Mak, T. W. (1998) FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279, 1954-1958.
14. Varfolomeev, E. E., Schuchmann, M., Luria, V., Chiannikulchai, N., Beckmann, J. S., Mett, I. L., Rebrikov, D., Brodianski, V. M., Kemper, O. C., Kollet, O., Lapidot, T., Soffer, D., Sobe, T., Avraham, K. B., Goncharov, T., Holtmann, H., Lonai, P., and Wallach, D. (1998) Target disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9, 267-276.
15. Lakhani, S. A., Masud, A., Kuida, K., Porter, G. A., Jr., Booth, C. J., Mehal, W. Z., Inayat, I., and Flavell, R. A. (2006) Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311, 847-851.
16. Kawane, K., Fukuyama, H., Yoshida, H., Nagase, H., Ohsawa, Y., Uchiyama, Y., Iida, T., Okada, K., and Nagata, S. (2003) Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat. Immunol. 4, 138-144.
17. Cohen, P. L., and Eisenberg, R. A. (1992) The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane. Immunol. Today 13, 427-428.
18. Kang, T. B., Ben-Moshe, T., Varfolomeev, E. E., Pewzner-Jung, Y., Yogev, N., Jurewicz, A., Waisman, A., Brenner, O., Haffner, R., Gustafsson, E., Ramakrishnan, P., Lapidot, T., and Wallach, D. (2004) Caspase-8 serves both apoptotic and nonapoptotic roles. J. Immunol. 173, 2976-2984.
19. Irvine, R. A., Adachi, N., Shibata, D. K., Cassell, G. D., Yu, K., Karanjawala, Z. E., Hsieh, C. L., and Lieber, M. R. (2005) Generation and characterization of endonuclease G null mice. Mol. Cell Biol. 25, 294-302.
20. Nagata, S., Nagase, H., Kawane, K., Mukae, N., and Fukuyama, H. (2003) Degradation of chromosomal DNA during apoptosis. Cell Death Differ. 10, 108-116.
21. Nagase, H., Fukuyama, H., Tanaka, M., Kawane, K., and Nagata, S. (2003) Mutually regulated expression of caspase-activated DNase and its inhibitor for apoptotic DNA fragmentation. Cell Death Differ. 10, 142-143.
22. McIlroy, D., Tanaka, M., Sakahira, H., Fukuyama, H., Suzuki, M., Yamamura, K., Ohsawa, Y., Uchiyama, Y., and Nagata, S. (2000) An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes. Genes Dev. 14, 549-558.
23. Mukae, N., Yokoyama, H., Yokokura, T., Sakoyama, Y., and Nagata, S. (2002) Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation. Genes Dev. 16, 2662-2671.
24. Kawane, K., Fukuyama, H., Kondoh, G., Takeda, J., Ohsawa, Y., Uchiyama, Y., and Nagata, S. (2001) Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science 292, 1546-1549.
25. Krieser, R. J., MacLea, K. S., Longnecker, D. S., Fields, J. L., Fiering, S., and Eastman, A. (2002) Deoxyribonuclease IIa is required during the phagocytic phase of apoptosis and its loss causes lethality. Cell Death Differ. 9, 956-962.
26. Yoshida, H., Okabe, Y., Kawane, K., Fukuyama, H., and Nagata, S. (2005) Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat. Immunol. 6, 49-56.
27. Savill, J., Dransfield, I., Gregory, C., and Haslett, C. (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nat. Rev. Immunol. 2, 965-975.
28. Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., and Nagata, S. (2002) Identification of a factor that links apoptotic cells to phagocytes. Nature 417, 182-187.
29. Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., and Nagata, S. (2004) Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 304, 1147-1150.
30. Miyasaka, K., Hanayama, R., Tanaka, M., and Nagata, S. (2004) Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells. Eur. J. Immunol. 34, 1414-1422.
31. Yoshida, H., Kawane, K., Koike, M., Mori, Y., Uchiyama, Y., and Nagata, S. (2005) Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells. Nature 437, 754-758.
32. Rieux-Laucat, F., Le Deist, F., Hivroz, C., Roberts, I. A. G., Denatin, K. M., Fischer, A., and de Villarty, J. P. (1995) Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268, 1347-1349.
33. Fisher, G. H., Rosenberg, F. J., Straus, S. E., Dale, J. K., Middelton, L. A., Lin, A. Y., Strober, W., Lenardo, M. J., and Puck, J. M. (1995) Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81, 935-946.