Group B streptococcal β-hemolysin induces mortality and liver injury in experimental sepsis

Journal of Infectious Diseases

Volumn 185, Issue 12, 2002, Pages 1745-1753

  Ring, Axel ^a   Braun, Johann S ^d   Pohl, Jürgen ^c   Nizet, Victor ^b   Stremmel, Wolfgang ^c   Shenep, Jerry L ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; CASPASE 3; HEMOLYSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HISTOPATHOLOGY; LIVER ABSCESS; LIVER CELL; LIVER INJURY; LIVER NECROSIS; MORTALITY; NICK END LABELING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT; SEPSIS; SEROTYPE; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS INFECTION;

ANIMALS; BACTERIAL PROTEINS; BLOOD PRESSURE; CASPASE 3; CASPASES; ENZYME ACTIVATION; HEMOLYSIN PROTEINS; IN SITU NICK-END LABELING; LIVER; RABBITS; SHOCK, SEPTIC; STREPTOCOCCUS AGALACTIAE; TRANSAMINASES;

EID: 0037097516     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/340818     Document Type: Article

References (36)

1. Gram-positive organisms and sepsis
2. Transposon mutagenesis of type III group B streptococcus: Correlation of capsule expression with virulence
3. Roles of the bacterial cell wall and capsule in induction of tumor necrosis factor α by type III group B streptococci
4. Pneumococci stimulate the production of the inducible nitric oxide synthase and nitric oxide by murine macrophages
5. Structure and function of streptococcal and staphylococcal superantigens in septic shock
6. Toxin involvement in toxic shock syndrome
7. Transposon mutagenesis of group B streptococcus β-hemolysin biosynthesis
8. Identification of genetic determinants for the hemolytic activity of Streptococcus agalactiae by ISS1 transposition
9. Identification of a novel insertion sequence element in Streptococcus agalactiae
10. Genetic basis for the β-haemolytic/cytolytic activity of group B streptococcus
11. Group B streptococcal hemolysin expression is associated with injury of lung epithelial cells
12. Group B streptococcal β-hemolysin promotes injury of lung microvascular endothelial cells
13. Invasion of brain microvascular endothelial cells by group B streptococci
14. Pathogenic mechanisms and virulence factors of group B streptococci
15. Streptococcus agalactiae β-hemolysin induces nitric oxide production in murine macrophages
16. Group B streptococcal β-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8
17. Severity of group B streptococcal arthritis is correlated with β-hemolysin expression
18. Effects of haemolysins of groups A and B streptococci on cardiovascular system
19. The role of group B streptococci β-hemolysin expression in newborn lung injury
20. Type III capsule and virulence of group B streptococci
21. A study of the genetic material determining an enzyme activity in pneumococcus
22. Nitric-oxide synthase assays
23. Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages
24. Inducible nitric oxide synthase of macrophages: Present knowledge and evidence for species-specific regulation
25. Cytokine stimulation of nitric oxide formation and differential regulation in hepatocytes and nonparenchymal cells of endotoxemic rats
26. Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (iNOS) activity in murine endotoxemia
27. The role of nitric oxide in experimental murine sepsis due to pyrogenic exotoxin A-producing Streptococcus pyogenes
28. Deregulation of cyclooxygenase and nitric oxide synthase gene expression in the inflammatory cascade triggered by experimental group B streptococcal meningitis in the newborn brain and cerebral microvessels
29. Induction of severe vascular leakage by low doses of Escherichia coli hemolysin in perfused rabbit lungs
30. Staphylococcal α-toxin elicits hypertension in isolated rabbit lungs
31. Organ-specific disposition of group B streptococci in piglets: Evidence for a direct interaction with target cells in the pulmonary circulation
32. Pathophysiology and histopathology of Group B streptococcal sepsis in Macaca nemestrina primates induced after intra-amniotic inoculation: Evidence for bacterial cellular invasion
33. The clearance, tissue distribution, and cellular localization of intravenously injected lipopolysaccharide in rabbits
34. Activation of Kupffer cells and caspase-3 involved in rat hepatocyte apoptosis induced by endotoxin
35. Role of lipopolysaccharide and tumor necrosis factor-α in induction of hepatocyte necrosis
36. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis