Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia

Journal of Neuroimmunology

Volumn 208, Issue 1-2, 2009, Pages 87-93

  Saleem, Sofiyan ^a   Kim, Yun Tai ^a   Maruyama, Takayuki ^b   Narumiya, Shuh ^c   Doré, Sylvain ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ONO PHARMACEUTICAL CO   (Japan)

^c KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

EP3 receptor; Focal cerebral ischemia; Oxygen glucose deprivation; Prostanoids

Indexed keywords

PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN E3; PROSTAGLANDIN E3 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; BLOOD GAS; BODY TEMPERATURE; BRAIN BLOOD FLOW; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN SLICE; CELL DEATH; COGNITION; CONTROLLED STUDY; GENOTYPE; HIPPOCAMPUS; IN VITRO STUDY; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; MOUSE; NEUROLOGIC EXAMINATION; NONHUMAN; OUTCOME ASSESSMENT; PH; PRIORITY JOURNAL; REPERFUSION; WILD TYPE;

ANIMALS; BRAIN INJURIES; BRAIN ISCHEMIA; DINOPROSTONE; GENE DELETION; GLUCOSE; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXYGEN; RECEPTORS, PROSTAGLANDIN E; REPERFUSION INJURY;

EID: 62549089661     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2009.01.015     Document Type: Article

References (52)

1. Ahmad A.S., Ahmad M., de Brum-Fernandes A.J., and Doré S. Prostaglandin EP4 receptor agonist protects against acute neurotoxicity. Brain Res. 1066 (2005) 71-77
2. Ahmad A.S., Saleem S., Ahmad M., and Doré S. Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage. Toxicol. Sci. 89 (2006) 265-270
3. Ahmad M., Saleem S., Zhuang H., Ahmad A.S., Echeverria V., Sapirstein A., and Doré S. 1-HydroxyPGE1 reduces infarction volume in mouse transient cerebral ischemia. Eur. J. Neurosci. 23 (2006) 35-42
4. Ahmad M., Ahmad A.S., Zhuang H., Maruyama T., Narumiya S., and Doré S. Stimulation of prostaglandin E2-EP3 receptors exacerbates stroke and excitotoxic injury. J. Neuroimmunol. 184 (2007) 172-179
5. Ahmad, A.S., Kim, Y.T., Ahmad, M., Maruyama, T., Dore, S., 2008. Selective blockade of PGE2 EP1 receptor protects brain against experimental ischemia and excitotoxicity, and hippocampal slice cultures against oxygen-glucose deprivation. Neurotox. Res. 14, 343-351.
6. Allen Brain Atlas [Internet]. Allen Brain Atlas Vol. 2008 (2007), Allen Institute for Brain Science, Seattle (WA)
7. An S., Yang J., So S.W., Zeng L., and Goetzl E.J. Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. Biochemistry 33 (1994) 14496-14502
8. Audoly L.P., Ma L., Feoktistov I., de Foe S.K., Breyer M.D., and Breyer R.M. Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription. J. Pharmacol. Exp. Ther. 289 (1999) 140-148
9. Audoly L.P., Tilley S.L., Goulet J., Key M., Nguyen M., Stock J.L., McNeish J.D., Koller B.H., and Coffman T.M. Identification of specific EP receptors responsible for the hemodynamic effects of PGE2. Am. J. Physiol. 277 (1999) H924-930
10. Audoly L.P., Ruan X., Wagner V.A., Goulet J.L., Tilley S.L., Koller B.H., Coffman T.M., and Arendshorst W.J. Role of EP2 and EP3 PGE2 receptors in control of murine renal hemodynamics. Am. J. Physiol. Heart Circ. Physiol. 280 (2001) H327-333
11. Barber P.A., Hoyte L., Colbourne F., and Buchan A.M. Temperature-regulated model of focal ischemia in the mouse: a study with histopathological and behavioral outcomes. Stroke 35 (2004) 1720-1725
12. Bilak M., Wu L., Wang Q., Haughey N., Conant K., St Hillaire C., and Andreasson K. PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis. Ann. Neurol. 56 (2004) 240-248
13. Breyer R.M., Bagdassarian C.K., Myers S.A., and Breyer M.D. Prostanoid receptors: subtypes and signaling. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 661-690
14. Candelario-Jalil E., Slawik H., Ridelis I., Waschbisch A., Akundi R.S., Hull M., and Fiebich B.L. Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum. J. Mol. Neurosci. 27 (2005) 303-310
15. Doré S. GPCR antagonists as an alternative to COX-2 inhibitors: a case for the PGE2 EP1 receptor. Trends Pharmacol. Sci. 27 (2006) 458-460
16. Doré S., Otsuka T., Mito T., Sugo N., Hand T., Wu L., Hurn P.D., Traystman R.J., and Andreasson K. Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. Ann. Neurol. 54 (2003) 155-162
17. Echeverria V., Clerman A., and Doré S. Stimulation of PGE2 receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following b-amyloid exposure. Eur. J. Neurosci. 22 (2005) 2199-2206
18. Ek M., Arias C., Sawchenko P., and Ericsson-Dahlstrand A. Distribution of the EP3 prostaglandin E2 receptor subtype in the rat brain: relationship to sites of interleukin-1-induced cellular responsiveness. J. Comp. Neurol. 428 (2000) 5-20
19. Gendron T.F., Brunette E., Tauskela J.S., and Morley P. The dual role of prostaglandin E2 in excitotoxicity and preconditioning-induced neuroprotection. Eur. J. Pharmacol. 517 (2005) 17-27
20. Hatae N., Yamaoka K., Sugimoto Y., Negishi M., and Ichikawa A. Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbg subunit- independent manner. Biochem. Biophys. Res. Commun. 290 (2002) 162-168
21. Hoehn B.D., Palmer T.D., and Steinberg G.K. Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin. Stroke 36 (2005) 2718-2724
22. Huang J., Upadhyay U.M., and Tamargo R.J. Inflammation in stroke and focal cerebral ischemia. Surg. Neurol. 66 (2006) 232-245
23. Iadecola C., and Gorelick P.B. The Janus face of cyclooxygenase-2 in ischemic stroke: shifting toward downstream targets. Stroke 36 (2005) 182-185
24. Iadecola C., Niwa K., Nogawa S., Zhao X., Nagayama M., Araki E., Morham S., and Ross M.E. Reduced susceptibility to ischemic brain injury and N-methyl-d-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 1294-1299
25. Irie A., Segi E., Sugimoto Y., Ichikawa A., and Negishi M. Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells. Biochem. Biophys. Res. Commun. 204 (1994) 303-309
26. Jadhav V., Jabre A., Lin S.Z., and Lee T.J. EP1- and EP3-receptors mediate prostaglandin E2-induced constriction of porcine large cerebral arteries. J. Cereb. Blood Flow. Metab. 24 (2004) 1305-1316
27. Kawano T., Anrather J., Zhou P., Park L., Wang G., Frys K.A., Kunz A., Cho S., Orio M., and Iadecola C. Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nat. Med. 12 (2006) 225-229
28. Kotani M., Tanaka I., Ogawa Y., Suganami T., Matsumoto T., Muro S., Yamamoto Y., Sugawara A., Yoshimasa Y., Sagawa N., Narumiya S., and Nakao K. Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus. J. Clin. Endocrinol. Metab. 85 (2000) 4315-4322
29. Kotani M., Tanaka I., Ogawa Y., Usui T., Tamura N., Mori K., Narumiya S., Yoshimi T., and Nakao K. Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). Genomics 40 (1997) 425-434
30. Lee J.J., Li L., Jung H.H., and Zuo Z. Postconditioning with isoflurane reduced ischemia-induced brain injury in rats. Anesthesiology 108 (2008) 1055-1062
31. Li J., Liang X., Wang Q., Breyer R.M., McCullough L., and Andreasson K. Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia. Neurosci. Lett. 438 (2008) 210-215
32. Li L., Peng L., and Zuo Z. Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain. Eur. J. Pharmacol. 586 (2008) 106-113
33. Li X., Blizzard K.K., Zeng Z., DeVries A.C., Hurn P.D., and McCullough L.D. Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender. Exp. Neurol. 187 (2004) 94-104
34. Liu D., Wu L., Breyer R., Mattson M.P., and Andreasson K. Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia. Ann. Neurol. 57 (2005) 758-761
35. Martin M., Meyer-Kirchrath J., Kaber G., Jacoby C., Flogel U., Schrader J., Ruther U., Schror K., and Hohlfeld T. Cardiospecific overexpression of the prostaglandin EP3 receptor attenuates ischemia-induced myocardial injury. Circulation 112 (2005) 400-406
36. McCullough L., Wu L., Haughey N., Liang X., Hand T., Wang Q., Breyer R.M., and Andreasson K. Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J. Neurosci. 24 (2004) 257-268
37. Muralikrishna Adibhatla R., and Hatcher J.F. Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia. Free Radic. Biol. Med. 40 (2006) 376-387
38. Nakamura K., Kaneko T., Yamashita Y., Hasegawa H., Katoh H., and Negishi M. Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system. J. Comp. Neurol. 421 (2000) 543-569
39. Nakamura Y., Nakamura K., Matsumura K., Kobayashi S., Kaneko T., and Morrison S.F. Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus. Eur. J. Neurosci. 22 (2005) 3137-3146
40. Narumiya S., Sugimoto Y., and Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79 (1999) 1193-1226
41. Oka T., Oka K., Kobayashi T., Sugimoto Y., Ichikawa A., Ushikubi F., Narumiya S., and Saper C.B. Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors. J. Physiol. 551 (2003) 945-954
42. Oka T., Oka K., Scammell T.E., Lee C., Kelly J.F., Nantel F., Elmquist J.K., and Saper C.B. Relationship of EP(1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses. J. Comp. Neurol. 428 (2000) 20-32
43. Saleem S., Zhuang H., de Brum-Fernandes A.J., Maruyama T., Narumiya S., and Doré S. PGD2 DP1 receptor protects brain from ischemia-reperfusion injury. Eur. J. Neurosci. 26 (2007) 73-78
44. Shah Z.A., Namiranian K., Klaus J., Kibler K., and Dore S. Use of an optimized transient occlusion of the middle cerebral artery protocol for the mouse stroke model. J. Stroke. Cerebrovasc. Dis. 15 (2006) 133-138
45. Slawik H., Volk B., Fiebich B., and Hull M. Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum. Neurochem. Int. 45 (2004) 653-660
46. Sugimoto K., and Iadecola C. Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia. Brain Res. 960 (2003) 273-276
47. Sugimoto Y., Negishi M., Hayashi Y., Namba T., Honda A., Watabe A., Hirata M., Narumiya S., and Ichikawa A. Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins. J. Biol. Chem. 268 (1993) 2712-2718
48. Takadera T., and Ohyashiki T. Prostaglandin E2 deteriorates N-methyl-d-aspartate receptor-mediated cytotoxicity possibly by activating EP2 receptors in cultured cortical neurons. Life Sci. 78 (2006) 1878-1883
49. Toh H., Ichikawa A., and Narumiya S. Molecular evolution of receptors for eicosanoids. FEBS Lett. 361 (1995) 17-21
50. Wang D., Mann J.R., and Dubois R.N. The role of prostaglandins and other eicosanoids in the gastrointestinal tract. Gastroenterology 128 (2005) 1445-1461
51. Zhang J., and Rivest S. Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation. Eur. J. Neurosci. 11 (1999) 2651-2668
52. Zhou P., Qian L., Chou T., and Iadecola C. Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway. Neurobiol. Dis. 29 (2008) 543-551