Role of caspase 9 in activation of HTLV-1 LTR expression by DNA damaging agents

Cell Cycle

Volumn 10, Issue 19, 2011, Pages 3337-3345

  Abou Kandil, Ammar ^a   Chamias, Rachel ^a   Huleihel, Mahmoud ^a   Godbey, W T ^b   Aboud, Mordechai ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b Tulane University   (United States)

Author keywords

ATL; Caspase 9; Complex; HTLV 1 LTR; Latent HTLV 1; Mitochondrial apoptotic cascade; MOMP; Sp1 p53

Indexed keywords

CASPASE 2; CASPASE 3; CASPASE 7; CASPASE 9; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SP1;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; DNA DAMAGE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LONG TERMINAL REPEAT; MITOCHONDRION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 80053454208     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.19.17620     Document Type: Article

References (47)

1. Yasunaga J, Matsuoka M. Human T-cell leukemia virus type I induces adult T-cell leukemia: from clinical aspects to molecular mechanisms. Cancer Control 2007; 14:133-40; PMID:17387298.
2. Matsuoka M, Jeang KT. Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy. Oncogene 2011; 30:1379-89; PMID:21119600; DOI:10.1038/ onc.2010.537.
3. Matsuoka M, Green PL. The HBZ gene, a key player in HTLV-1 pathogenesis. Retrovirology 2009; 6:71; PMID:19650892; DOI:10.1186/1742-4690-6-71.
4. Matsuoka M, Jeang KT. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 2007; 7:270-80; PMID:17384582; DOI:10.1038/nrc2111.
5. Jeang KT. Human T cell leukemia virus type 1 (HTLV- 1) and oncogene or oncomiR addiction? Oncotarget 2010; 1:453-6; PMID:21311101.
6. Ruggero K, Corradin A, Zanovello P, Amadori A, Bronte V, Ciminale V, et al. Role of microRNAs in HTLV-1 infection and transformation. Mol Aspects Med 2010; 31:367-82; PMID:20600265; DOI:10.1016/j.mam.2010.05.001.
7. Azran I, Schavinsky-Khrapunsky Y, Aboud M. Role of Tax protein in human T-cell leukemia virus type- I leukemogenicity. Retrovirology 2004; 1:20-43; PMID:15310405; DOI:10.1186/1742-4690-1-20.
8. Giam CZ, Jeang KT. HTLV-1 Tax and adult T-cell leukemia. Front Biosci 2007; 12:1496-507; PMID:17127397; DOI:10.2741/2163.
9. Pise-Masison CA, Jeong SJ, Brady JN. Human T cell leukemia virus type 1: the role of Tax in leukemogenesis. Arch Immunol Ther Exp (Warsz) 2005; 53:283- 96; PMID:16088313.
10. Asquith B, Hanon E, Taylor GP, Bangham CRM. Is human T-cell lymphotropic virus type I really silent? Philos Trans R Soc Lond B Biol Sci 2000; 1013-9; PMID:11186302; DOI:10.1098/rstb.2000.0638.
11. Torgeman A, Ben-Aroya Z, Grunspan A, Zelin E, Butovsky E, Hallak M, et al. Activation of HTLV-I long terminal repeat by stress-inducing agents and protection of HTLV-I infected T cells from apoptosis by the viral Tax protein. Exptl Cell Res 2001; 271:169-79; PMID:11697893; DOI:10.1006/excr.2001.5363.
12. Torgeman A, Mor-Vaknin N, Zelin E, Ben-Aroya Z, Lochelt M, Flugel RM, et al. Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C. Virology 2001; 281:10-20; PMID:11222091; DOI:10.1006/viro.2000.0779.
13. Keeble JA, Gilmore AP. Apoptosis commitment-translating survival signals into decisions on mitochondria. Cell Res 2007; 17:976-84; PMID:18071367; DOI:10.1038/cr.2007.101.
14. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407:770-6; PMID:11048727; DOI: 10.1038/35037710.
15. Contassot E, Gaide O, French LE. Death Receptors and Apoptosis. Dermatol Clin 2007; 25:487-501; PMID:17903608; DOI:10.1016/j.det.2007.06.010.
16. Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998; 281:1305- 8; PMID:9721089; DOI:10.1126/science. 281.5381.1305.
17. Xu G, Shi Y. Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res 2007; 17:759-71; PMID:17576411; DOI:10.1038/cr.2007.52.
18. Cory S, Adams JM. The Bcl-2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002; 2:647-56; PMID:12209154; DOI:10.1038/nrc883.
19. Danial NN. BCL-2 Family Proteins: Critical Checkpoints of Apoptotic Cell Death. Clin Cancer Res 2007; 13:7254-63; PMID:18094405; DOI:10.1158/1078-0432. CCR-07-1598.
20. Zhivotovsky B, Orrenius S. Caspase-2 function in response to DNA damage. Biochem Biophys Res Commun 2005; 331:859-67; PMID:15865942; DOI:10.1016/j.bbrc. 2005.03.191.
21. Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J Biol Chem 2002; 277:13430-7; PMID:11832478; DOI:10.1074/jbc. M108029200.
22. Robertson JD, Enoksson M, Suomela M, Zhivotovsky B, Orrenius S. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposideinduced apoptosis. J Biol Chem 2002; 277:29803-9; PMID:12065594; DOI:10.1074/jbc.M204185200.
23. Hunter AM, LaCasse EC, Korneluk RG. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 2007; 12:1543-68; PMID:17573556; DOI:10.1007/ s10495-007-0087-3.
24. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: structure, activation, substrates and functions during apoptosis. Annu Rev Biochem 1999; 68:383-424; PMID:10872455; DOI:10.1146/ annurev.biochem.68.1.383.
25. Schwerk C, Schulze-Osthoff K. Non-apoptotic functions of caspases in cellular proliferation and differentiation. Biochem Pharmacol 2003; 66:1453- 8; PMID:14555221; DOI:10.1016/S0006- 2952(03)00497-0.
26. Launay S, Hermine O, Fontenay M, Kroemer G, Solary E, Garrido C. Vital functions for lethal caspases 2005; 24:5137-48.
27. Chamias R, Huleihel M, Aboud M. The mechanism of HTLV-1 LTR activation by TPA varies in different human T-cell lines: Role of specific PKC isoforms. Leuk Res 2010; 34:93-9; PMID:19406475; DOI:10.1016/j.leukres.2009.03.032.
28. Paroni G, Henderson C, Schneider C, Claudio Brancolini C. Caspase-2 can trigger cytochrome c release and apoptosis from the nucleus. J Biol Chem 2002; 277:15147-61; PMID:11823470; DOI:10.1074/jbc.M112338200.
29. Tabakin-Fix Y, Azran-Shaish I, Levy O, Aboud M. Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: Mechanisms and clinical implications. Carcinogenesis 2006; 27:673-81; PMID:16308315; DOI:10.1093/carcin/bgi274.
30. Tinel A, Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 2004; 304:843-6; PMID:15073321; DOI:10.1126/science.1095432.
31. Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene 2006; 25:5683-92; PMID:16652156; DOI:10.1038/sj.onc.1209569.
32. Saggioro D, Acquasaliente L, Daprai L, Chieco-Bianchi L. Inhibition of apoptosis by human T-lymphotropic virus type-1 tax protein. Ann NY Acad Sci 2003; 1010:591-7; PMID:15033798; DOI:10.1196/ annals.1299.111.
33. Kawakami A, Nakashima T, Sakai H, Urayama S, Yamasaki S, Hida A, Tsuboi M, et al. Inhibition of caspase cascade by HTLV-I Tax through inhibition of NFκB nuclear translocation. Blood 1999; 94:3847-54; PMID:10572100.
34. Nakashima K, Kawakami A, Hida A, Yamasaki S, Nakamura H, Kamachi M, et al. Protection of mitochondrial perturbation by human T-lymphotropic virus type 1 tax through induction of Bcl-xL expression. J Lab Clin Med 2003; 142:341-7; PMID:14647038; DOI:10.1016/S0022-2143(03)00134-3.
35. Nicot C, Astier-Gin T, Guillemain B. Activation of Bcl-2 expression in human endothelial cells chronically expressing the human T-cell lymphotropic virus type I. Virology 1997; 236:47-53; PMID:9299616; DOI:10.1006/viro.1997. 8720.
36. Vakifahmetoglu-Norberg H, Zhivotovsky B. The unpredictable caspase-2: what can it do? Trends Cell Biol 2010; 20:150-9; PMID:20061149; DOI:10.1016/j.tcb.2009.12.006.
37. Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A. The enigma of caspase-2: the laymen's view. Cell Death Differ 2009; 16:195-207; PMID:19023332; DOI:10.1038/cdd.2008.170.
38. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001; 7:673-82; PMID:11463391; DOI:10.1016/S1097-2765(01)00213-1.
39. Bouchier-Hayes L. The role of caspase-2 in stressinduced apoptosis. J Cell Mol Med 2010; 14:1212- 4; PMID:20158568; DOI:10.1111/j.1582- 4934.2010.01037.x.
40. Kitevska T, Spencer DM, Hawkins CJ. Caspase-2: controversial killer or checkpoint controller? Apoptosis 2009; 14:829-48; PMID:19479377; DOI:10.1007/ s10495-009-0365-3.
41. Robertson JD, Gogvadze V, Kropotov A, Vakifahmetoglu H, Zhivotovsky B, Orrenius S. Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity. EMBO Rep 2004; 5:643-8; PMID:15153933; DOI:10.1038/sj.embor.7400153.
42. Godbey WT, Atala A. Directed apoptosis in Cox-2- overexpressing cancer cells through expression-targeted gene delivery. Gene Ther 2003; 10:1519-27; PMID:12900768; DOI:10.1038/sj.gt.3302012.
43. Ghosh N, Chaki R, Mandal V, Mandal SC. COX-2 as a target for cancer chemotherapy. Pharmacol Rep 2010; 62:233-44; PMID:20508278.
44. Subhashini J, Mahipal SV, Reddanna P. Antiproliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro. Cancer Lett 2005; 224:31-43; PMID:15911099; DOI:10.1016/j. canlet.2004.11.002.
45. Xu L, Zhang L, Bertucci AM, Pope RM, Datta SK. Apigenin, a dietary flavonoid, sensitizes human T cells for activation-induced cell death by inhibiting PKB/ Akt and NFκB activation pathway. Immunol Lett 2008; 121:74-83; PMID:18812189; DOI:10.1016/j. imlet.2008.08.004.
46. Zhang X, Turner C, Godbey WT. Comparison of caspase genes for the induction of apoptosis following gene delivery. Mol Biotechnol 2009; 41:236-46; PMID:19067254; DOI:10.1007/s12033-008-9133-9.
47. Mor-Vaknin N, Torgeman A, Galron D, Lochelt M, Flugel RM, Aboud M. The long terminal repeats of human immunodeficiency virus type-1 and human T-cell leukemia virus type-I are activated by 12-O-tetradecanoylphorbol-13-acetate through different pathways. Virology 1997; 232:337-44; PMID:9191847; DOI:10.1006/viro.1997.8566.