A time to kill: Viral manipulation of the cell death program

Journal of General Virology

Volumn 83, Issue 7, 2002, Pages 1547-1564

  Hay, Stewart ^a   Kannourakis, George ^a  

^a UNIVERSITY OF BALLARAT   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; GENE PRODUCT;

ADENOVIRUS; AFRICAN SWINE FEVER VIRUS; ANIMAL CELL; APOPTOSIS; AVIAN LYMPHOMATOSIS HERPETOVIRUS; BACULOVIRUS; BOVINE HERPES VIRUS; CELL DEATH; CELL KILLING; CIRCOVIRIDAE; CONTROLLED STUDY; ECTROMELIA VIRUS; EQUINE HERPES VIRUS; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HOST CELL; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; MOUSE; NONHUMAN; PESTIVIRUS; POXVIRUS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; RUBELLA VIRUS; SEMLIKI FOREST ALPHAVIRUS; SIMIAN VIRUS 40; SINDBIS VIRUS; WART VIRUS;

ADENOVIRIDAE; AFRICAN SWINE FEVER VIRUS; ALPHAVIRUS; ANIMALIA; AVES; BOVINAE; CIRCOVIRIDAE; CLASSICAL SWINE FEVER VIRUS; CYTOMEGALOVIRUS; ECTROMELIA VIRUS; EQUIDAE; EQUINE HERPESVIRUS 1; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HERPESVIRIDAE; HUMAN HERPESVIRUS 5; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN PAPILLOMAVIRUS TYPES; MARDIVIRUS; PESTIVIRUS; POXVIRIDAE; RUBELLA VIRUS; SEMLIKI FOREST VIRUS; SIMIAE; SIMIAN VIRUS 40; SINDBIS VIRUS; SUS SCROFA; UNIDENTIFIED BACULOVIRUS;

EID: 0036289047     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-83-7-1547     Document Type: Review

References (199)

1. The Bcl-2 protein family: Arbiters of cell survival
2. An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death
3. Vaccinia virus strains Lister, USSR and Evans express soluble and cell-surface tumour necrosis factor receptors
4. Virus infection induces neuronal apoptosis: A comparison with tropic factor withdrawal
5. HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor κB
6. α/β Interferons potentiate virus-induced apoptosis through activation of the FADD/caspase-8 death signalling pathway
7. The hepatitis B virus X protein enhances the DNA binding potential and transcription efficacy of bZip transcription factors
8. The myxoma virus M-T4 gene encodes a novel RDEL-containing protein that is retained within the endoplasmic reticulum and is important for the productive infection of lymphocytes
9. Apoptosis regulators from DNA viruses
10. Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8
11. Three adenovirus E3 proteins cooperate to evade apoptosis by tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and - 2
12. Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease
13. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis
14. HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons
15. + T lymphoblastoid Jurkat cells
16. African swine fever virus gene A179L, a viral homologue of bcl-2, protects cells from programmed cell death
17. Functionality and cell anchorage dependence of the African swine fever virus gene A179L, a viral bcl-2 homolog, in insect cells
18. rns of pestiviruses induces apoptosis in lymphocytes of several species
19. Oxidative stress as a mediator of apoptosis
20. 134.5 genes precludes shutoff of protein synthesis by blocking the phosphorylation of eIF-2α
21. The African swine fever virus IAP homolog is a late structural polypeptide
22. Differential apoptosis effects of primate lentiviral Vpr and Vpx in mammalian cells
23. Bcl-2 family: Regulators of cell death
24. The hepatitis B virus X gene induces p53-mediated programmed cell death
25. 134.5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells
26. Prevention of apoptosis by a baculovirus gene during infection of insect cells
27. Dual role of the HIV-1 Vpr protein in the modulation of the apoptotic response of T cells
28. Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen
29. Regulation of lymphocyte survival by the bcl-2 gene family
30. Enhanced cell survival and tumorigenesis
31. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif
32. Tumor necrosis factor receptors encoded by poxviruses
33. The chicken anemia virus-derived protein apoptin requires activation of caspases for induction of apoptosis in human tumor cells
34. Cytokine response modifier A (CrmA): A strategically deployed viral weapon
35. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
36. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
37. Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis
38. Papillomavirus E2 induces p53-independent apoptosis in HeLa cells
39. IAP family proteins: Suppressors of apoptosis
40. X-linked IAP is a direct inhibitor of cell-death proteases
41. Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: Role in NF-κB activation
42. Persisting viruses and chronic inflammation: Understanding their relation to autoimmunity
43. Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells
44. Adenovirus E3-10.4K/14.5K protein complex inhibits tumor necrosis factor-induced translocation of cytosolic phospholipase A2 to membranes
45. The inhibitor of death receptor signalling, FLICE-inhibitory protein defines a new class of tumor progression factors
46. Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product
47. Rubella virus capsid protein induces apoptosis in transfected RK13 cells
48. Caspase inhibitors
49. Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2
50. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis
51. M11L: A novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes
52. Analyzing the mechanisms of interferon-induced apoptosis using CrmA and hepatitis C virus NS5A
53. Suppression of c-Myc-induced apoptosis by the Epstein-Barr virus gene product BHRF1
54. Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K
55. The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice
56. The HIV-1 Vpr displays strong anti-apoptotic activity
57. Tat-expressing Jurkat cells show an increased resistance to different apoptotic stimuli, including acute human immunodeficiency virus-type 1 (HIV-1) infection
58. + Jurkat T lymphoblastoid cells from apoptosis mediated by TNF-related apoptosis-inducing ligand
59. MC159L protein from the poxvirus molluscum contagiosum virus inhibits NF-κB activation and apoptosis induced by PKR
60. Latent membrane protein I of Epstein-Barr virus mimics a constitutively active receptor molecule
61. A 14,700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor
62. The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor
63. Interaction of viral proteins with host cell death machinery
64. BCL-2 family members and the mitochondria in apoptosis
65. An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy
66. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death
67. Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death
68. Ultrastructural localization of BHRF1: An Epstein-Barr virus gene product which has homology with bcl-2
69. Role of the C-terminal RDEL motif of the myxoma virus M-T4 protein in terms of apoptosis regulation and viral pathogenesis
70. A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis
71. Human papillomavirus type 16 E7 protein sensitizes cervical keratinocytes to apoptosis and release of interleukin-1α
72. The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB
73. Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide
74. Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3
75. Chicken anemia virus causes apoptosis of thymocytes after in vivo infection and of cell lines after in vitro infection
76. The transmembrane domains of Sindbis virus envelope glycoproteins induce cell death
77. Directed egress of animal viruses promotes cell-to-cell spread
78. Suppression of interleukin-1β converting enzyme (ICE)-induced apoptosis by SV40 large T antigen
79. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases
80. Expression of Epstein-Barr virus latent membrane protein 1 protects Jurkat T cells from apoptosis induced by serum deprivation
81. Viral vectors for gene therapy: The art of turning infectious agents into vehicles of therapeutics
82. Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1β-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1β-induced fever
83. BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barr virus isolates
84. Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells
85. X-gene product of hepatitis B virus induces apoptosis in liver cells
86. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants
87. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
88. A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis
89. Inhibition of SV40 large T antigen induced apoptosis by small T antigen
90. Induction of apoptotic DNA fragmentation by the infection of vesicular stomatitis virus
91. The adenovirus E3-14.7K protein and the E3-10.4K/14.5K complex of proteins, which independently inhibit tumor necrosis factor (TNF)-induced apoptosis, also independently inhibit TNF-induced release of arachidonic acid
92. Influenza virus overcomes apoptosis by rapid multiplication
93. An Epstein-Barr virus protein interacts with Notch
94. The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor κB
95. Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells
96. The hepatitis B virus X protein up-regulates tumor necrosis factor α gene expression in hepatocytes
97. Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells
98. + target cells
99. Rubella virus E2 signal peptide is required for perinuclear localization of capsid protein and virus assembly
100. Four deaths and a funeral: From caspases to alternative mechanisms
101. The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus
102. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
103. Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor α-inducible cellular protein containing leucine zipper domains
104. The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct
105. Transforming potential of the herpesvirus oncoprotein MEQ: Morphological transformation, serum-independent growth, and inhibition of apoptosis
106. Caspase activation by adenovirus e4orf4 protein is cell line specific and is mediated by the death receptor pathway
107. T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-κB
108. Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein
109. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
110. Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53
111. Dual role of HIV Tat in regulation of apoptosis in T cells
112. Expression of the myxoma virus tumor necrosis factor receptor homologue and M11L genes is required to prevent virus-induced apoptosis in infected rabbit T lymphocytes
113. How poxviruses oppose apoptosis
114. Virus-encoded receptors for cytokines and chemokines
115. Reactive oxygen intermediate(s) (ROI): Common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis
116. Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1
117. Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein
118. Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
119. Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak
120. Serp2, an inhibitor of the interleukin-1β-converting enzyme, is critical in the pathobiology of myxoma virus
121. rns of the pestivirus classical swine fever virus lead to virus attenuation
122. Induced apoptosis supports spread of adenovirus vectors in tumors
123. Baculovirus interaction with host apoptotic pathways
124. The Epstein-Barr virus transforming protein LMP1 engages signalling proteins for the tumor necrosis factor receptor family
125. Immune-defense molecules of molluscum contagiosum virus, a human poxvirus
126. Inhibition of human lung carcinoma cell growth by apoptosis induction using Semliki Forest virus recombinant particles
127. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
128. An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1
129. A conserved African swine fever virus IκB homolog, 5EL, is nonessential for growth in vitro and virulence in domestic swine
130. HIV-1 Tat induces neuronal death via tumor necrosis factor-α and activation of non-N-methyl-D-aspartate receptors by a NFκB-independent mechanism
131. Epstein-Barr virus infection in oral hairy leukoplakia: Virus replication in the absence of a detectable latent phase
132. African swine fever virus IAP homologue inhibits caspase activation and promotes cell survival in mammalian cells
133. Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development
134. HIV-1 Tat induces microvascular endothelial apoptosis through caspase activation
135. Persisting viruses and autoimmunity
136. Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells
137. TNF-α signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K
138. Rubella virus induces apoptosis in culture cells
139. Herpes simplex virus 1716, an ICP 34.5 null mutant, is unable to replicate in CV-1 cells due to a translational block that can be overcome by coinfection with SV40
140. The E1B 19K protein associates with lamins in vivo and its proper localization is required for inhibition of apoptosis
141. Inhibition of apoptosis by the African swine fever virus Bcl-2 homologue: Role of the BH1 domain
142. Activation of a ras-MAPK-dependent pathway by Epstein-Barr virus latent membrane protein 1 is essential for cellular transformation
143. Viruses and apoptosis
144. The baculovirus antiapoptotic p35 gene also functions via an oxidant-dependent pathway
145. Identification of a structural glycoprotein of an RNA virus as a ribonuclease
146. Distinct domains of M-T2 the myxoma virus tumor necrosis factor (TNF) receptor homolog, mediate extracellular TNF binding and intracellular apoptosis inhibition
147. A structural view of mitochondria-mediated apoptosis
148. The adenovirus E3-10.4K/14.5K complex mediates loss of cell surface Fas (CD95) and resistance to Fas-induced apoptosis
149. Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein
150. Ultraviolet-induced cell death blocked by a selenoprotein from a human dermatotropic poxvirus
151. Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells
152. Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A
153. A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation
154. Simian virus 40 large T antigen domain and Rb-binding motif are sufficient to block apoptosis induced by growth factor withdrawal in a neural stem cell line
155. How cells respond to interferons
156. Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest
157. The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
158. Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells
159. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor α
160. Role of NF-κB and myc proteins in apoptosis induced by hepatitis B virus HBx protein
161. Intracellular mechanisms of TRAIL: Apoptosis through mitochondrial-dependent and -independent pathways
162. Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes
163. HIV-induced T cell syncytia are self-perpetuating and the primary cause of T cell death in culture
164. Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells
165. Epstein-Barr virus BHRF1 protein protects against cell death induced by DNA-damaging agents and heterologous viral infection
166. Regulation of apoptosis by viral gene products
167. Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5
168. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus CrmA gene product
169. Inhibition of Bak-induced apoptosis by HPV-18 E6
170. Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types
171. Apoptosis in the pathogenesis and treatment of disease
172. Commuting the death sentence: How oocytes strive to survive
173. Simian virus 40 large T antigen binds a novel Bcl-2 homology domain 3-containing proapoptosis protein in the cytoplasm
174. Requirement of cooperative functions of two repeated death effector domains in caspase-8 and in MC159 for induction and inhibition of apoptosis, respectively
175. Myxoma virus Serp2 is a weak inhibitor of granzyme B and interleukin-1β-converting enzyme in vitro and unlike CrmA cannot block apoptosis in cowpox virus-infected cells
176. Characterization of the ectromelia virus serpin, SPI-2
177. Gene therapy: Promises, problems and prospects
178. Transgenic mice neuronally expressing baculoviral p35 are resistant to diverse types of induced apoptosis, including seizure-associated neurodegeneration
179. The Epstein-Barr virus latent membrane protein 1 induces interleukin-10 in Burkitt's lymphoma cells but not in Hodgkin's cells involving the p38/SAPK2 pathway
180. Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
181. Abrogation of p53-induced apoptosis by the hepatitis B virus X gene
182. Vaccinia virus infection disarms the mitochondrion-mediated pathway of the apoptotic cascade by modulating the permeability transition pore
183. The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway
184. HIV-1 Tat potentiates TNF-induced NF-κB activation and cytotoxicity by altering the cellular redox state
185. The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor α
186. Myxoma virus expresses a TNF receptor homolog with two distinct functions
187. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
188. Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53
189. Epstein-Barr virus and apoptosis: Viral mimicry of cellular pathways
190. Human immunodeficiency virus type 1 Tat protein protects lymphoid, epithelial, and neuronal cell lines from death by apoptosis
191. HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway
192. Selenium-dependent glutathione peroxidase modules encoded by RNA viruses
193. Molecular modeling and in vitro activity of an HIV-1-encoded glutathione peroxidase
194. Target protease specificity of the viral serpin CrmA. Analysis of five caspases
195. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex
196. Human cytomegalovirus IE1 and IE2 proteins block apoptosis
197. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis
198. agm and human immunodeficiency virus type 1 vpr genes
199. Cell transformation by the E7 oncoprotein of human papillomavirus type 16: Interactions with nuclear and cytoplasmic target proteins