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Volumn 75, Issue 8, 2011, Pages 1811-1818

Apoptosis in Heart Failure: The role of the β-adrenergic receptor-mediated signaling pathway and p53-mediated signaling pathway in the apoptosis of cardiomyocytes

Author keywords

Adrenergic signaling; Apoptosis; Heart failure; p53

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM ION; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP; GLYCOGEN SYNTHASE KINASE 3BETA; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; INDUCIBLE CAMP EARLY REPRESSOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

EID: 79960815174     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-11-0025     Document Type: Review
Times cited : (75)

References (78)
  • 2
    • 0031044250 scopus 로고    scopus 로고
    • The adenylyl cyclases as integrators of transmembrane signal transduction
    • Ishikawa Y, Homcy CJ. The adenylyl cyclases as integrators of transmembrane signal transduction. Circ Res 1997; 80: 297-304.
    • (1997) Circ Res , vol.80 , pp. 297-304
    • Ishikawa, Y.1    Homcy, C.J.2
  • 3
    • 33646514473 scopus 로고    scopus 로고
    • Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice
    • Matsusaka H, Ide T, Matsushima S, Ikeuchi M, Kubota T, Sunagawa K, et al. Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice. Cardiovasc Res 2006; 70: 457-465.
    • (2006) Cardiovasc Res , vol.70 , pp. 457-465
    • Matsusaka, H.1    Ide, T.2    Matsushima, S.3    Ikeuchi, M.4    Kubota, T.5    Sunagawa, K.6
  • 4
    • 77953809546 scopus 로고    scopus 로고
    • Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury
    • Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, et al. Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury. Circ Res 2010; 106: 1692-1702.
    • (2010) Circ Res , vol.106 , pp. 1692-1702
    • Naito, A.T.1    Okada, S.2    Minamino, T.3    Iwanaga, K.4    Liu, M.L.5    Sumida, T.6
  • 5
    • 77954768186 scopus 로고    scopus 로고
    • Influence of p53 in the transition of myotrophin-induced cardiac hypertrophy to heart failure
    • Das B, Young D, Vasanji A, Gupta S, Sarkar S, Sen S. Influence of p53 in the transition of myotrophin-induced cardiac hypertrophy to heart failure. Cardiovasc Res 2010; 87: 524-534.
    • (2010) Cardiovasc Res , vol.87 , pp. 524-534
    • Das, B.1    Young, D.2    Vasanji, A.3    Gupta, S.4    Sarkar, S.5    Sen, S.6
  • 6
    • 71449099642 scopus 로고    scopus 로고
    • Activator of G protein signaling 8 (AGS8) is required for hypoxiainduced apoptosis of cardiomyocytes: Role of G betagamma and connexin 43 (CX43)
    • Sato M, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, et al. Activator of G protein signaling 8 (AGS8) is required for hypoxiainduced apoptosis of cardiomyocytes: Role of G betagamma and connexin 43 (CX43). J Biol Chem 2009; 284: 31431-31440.
    • (2009) J Biol Chem , vol.284 , pp. 31431-31440
    • Sato, M.1    Jiao, Q.2    Honda, T.3    Kurotani, R.4    Toyota, E.5    Okumura, S.6
  • 7
    • 0034698118 scopus 로고    scopus 로고
    • Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation
    • Kang PM, Haunstetter A, Aoki H, Usheva A, Izumo S. Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation. Circ Res 2000; 87: 118-125.
    • (2000) Circ Res , vol.87 , pp. 118-125
    • Kang, P.M.1    Haunstetter, A.2    Aoki, H.3    Usheva, A.4    Izumo, S.5
  • 8
    • 0033535974 scopus 로고    scopus 로고
    • Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis
    • von Harsdorf R, Li PF, Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation 1999; 99: 2934-2941.
    • (1999) Circulation , vol.99 , pp. 2934-2941
    • von Harsdorf, R.1    Li, P.F.2    Dietz, R.3
  • 9
    • 33845573616 scopus 로고    scopus 로고
    • Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes
    • Liao X, Liu JM, Du L, Tang A, Shang Y, Wang SQ, et al. Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J 2006; 20: 1883-1885.
    • (2006) FASEB J , vol.20 , pp. 1883-1885
    • Liao, X.1    Liu, J.M.2    Du, L.3    Tang, A.4    Shang, Y.5    Wang, S.Q.6
  • 10
    • 33745400562 scopus 로고    scopus 로고
    • Rapid electrical stimulation induces early activation of kinase signal transduction pathways and apoptosis in adult rat ventricular myocytes
    • Kuramochi Y, Guo X, Sawyer DB, Lim CC. Rapid electrical stimulation induces early activation of kinase signal transduction pathways and apoptosis in adult rat ventricular myocytes. Exp Physiol 2006; 91: 773-780.
    • (2006) Exp Physiol , vol.91 , pp. 773-780
    • Kuramochi, Y.1    Guo, X.2    Sawyer, D.B.3    Lim, C.C.4
  • 11
    • 77954931464 scopus 로고    scopus 로고
    • Differential roles of Epac in regulating cell death in neuronal and myocardial cells
    • Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kato Y, et al. Differential roles of Epac in regulating cell death in neuronal and myocardial cells. J Biol Chem 2010; 285: 24248-24259.
    • (2010) J Biol Chem , vol.285 , pp. 24248-24259
    • Suzuki, S.1    Yokoyama, U.2    Abe, T.3    Kiyonari, H.4    Yamashita, N.5    Kato, Y.6
  • 13
    • 85047691575 scopus 로고    scopus 로고
    • Altered intracellular Ca2+ handling in heart failure
    • Yano M, Ikeda Y, Matsuzaki M. Altered intracellular Ca2+ handling in heart failure. J Clin Invest 2005; 115: 556-564.
    • (2005) J Clin Invest , vol.115 , pp. 556-564
    • Yano, M.1    Ikeda, Y.2    Matsuzaki, M.3
  • 14
    • 0029937949 scopus 로고    scopus 로고
    • The effect of carvedilol on morbidity and mortality in patients with chronic heart failure: U.S. Carvedilol Heart Failure Study Group
    • Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM, et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure: U.S. Carvedilol Heart Failure Study Group. N Engl J Med 1996; 334: 1349-1355.
    • (1996) N Engl J Med , vol.334 , pp. 1349-1355
    • Packer, M.1    Bristow, M.R.2    Cohn, J.N.3    Colucci, W.S.4    Fowler, M.B.5    Gilbert, E.M.6
  • 15
    • 0032578406 scopus 로고    scopus 로고
    • Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway
    • Communal C, Singh K, Pimentel DR, Colucci WS. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. Circulation 1998; 98: 1329-1334.
    • (1998) Circulation , vol.98 , pp. 1329-1334
    • Communal, C.1    Singh, K.2    Pimentel, D.R.3    Colucci, W.S.4
  • 17
    • 0034682578 scopus 로고    scopus 로고
    • Beta-adrenergic receptor subtypes differentially affect apoptosis in adult rat ventricular myocytes
    • Zaugg M, Xu W, Lucchinetti E, Shafiq SA, Jamali NZ, Siddiqui MA. Beta-adrenergic receptor subtypes differentially affect apoptosis in adult rat ventricular myocytes. Circulation 2000; 102: 344-350.
    • (2000) Circulation , vol.102 , pp. 344-350
    • Zaugg, M.1    Xu, W.2    Lucchinetti, E.3    Shafiq, S.A.4    Jamali, N.Z.5    Siddiqui, M.A.6
  • 18
    • 0035852634 scopus 로고    scopus 로고
    • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes
    • Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci USA 2001; 98: 1607-1612.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1607-1612
    • Zhu, W.Z.1    Zheng, M.2    Koch, W.J.3    Lefkowitz, R.J.4    Kobilka, B.K.5    Xiao, R.P.6
  • 19
    • 4844228660 scopus 로고    scopus 로고
    • Beneficial effects of chronic pharmacological manipulation of betaadrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy
    • Ahmet I, Krawczyk M, Heller P, Moon C, Lakatta EG, Talan MI. Beneficial effects of chronic pharmacological manipulation of betaadrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy. Circulation 2004; 110: 1083-1090.
    • (2004) Circulation , vol.110 , pp. 1083-1090
    • Ahmet, I.1    Krawczyk, M.2    Heller, P.3    Moon, C.4    Lakatta, E.G.5    Talan, M.I.6
  • 20
    • 0035957302 scopus 로고    scopus 로고
    • Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium
    • Moniotte S, Kobzik L, Feron O, Trochu JN, Gauthier C, Balligand JL. Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium. Circulation 2001; 103: 1649-1655.
    • (2001) Circulation , vol.103 , pp. 1649-1655
    • Moniotte, S.1    Kobzik, L.2    Feron, O.3    Trochu, J.N.4    Gauthier, C.5    Balligand, J.L.6
  • 21
    • 0032189129 scopus 로고    scopus 로고
    • The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle
    • Gauthier C, Leblais V, Kobzik L, Trochu JN, Khandoudi N, Bril A, et al. The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. J Clin Invest 1998; 102: 1377-1384.
    • (1998) J Clin Invest , vol.102 , pp. 1377-1384
    • Gauthier, C.1    Leblais, V.2    Kobzik, L.3    Trochu, J.N.4    Khandoudi, N.5    Bril, A.6
  • 22
    • 0033023630 scopus 로고    scopus 로고
    • Nitric oxide can function as either a killer molecule or an antiapoptotic effector in cardiomyocytes
    • Stefanelli C, Pignatti C, Tantini B, Stanic I, Bonavita F, Muscari C, et al. Nitric oxide can function as either a killer molecule or an antiapoptotic effector in cardiomyocytes. Biochim Biophys Acta 1999; 1450: 406-413.
    • (1999) Biochim Biophys Acta , vol.1450 , pp. 406-413
    • Stefanelli, C.1    Pignatti, C.2    Tantini, B.3    Stanic, I.4    Bonavita, F.5    Muscari, C.6
  • 23
    • 26844504704 scopus 로고    scopus 로고
    • A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis
    • Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, et al. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci USA 2005; 102: 14771-14776.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14771-14776
    • Ding, B.1    Abe, J.2    Wei, H.3    Xu, H.4    Che, W.5    Aizawa, T.6
  • 24
    • 0038300673 scopus 로고    scopus 로고
    • Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation
    • Tomita H, Nazmy M, Kajimoto K, Yehia G, Molina CA, Sadoshima J. Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circ Res 2003; 93: 12-22.
    • (2003) Circ Res , vol.93 , pp. 12-22
    • Tomita, H.1    Nazmy, M.2    Kajimoto, K.3    Yehia, G.4    Molina, C.A.5    Sadoshima, J.6
  • 25
    • 0037332597 scopus 로고    scopus 로고
    • Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II
    • Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, et al. Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest 2003; 111: 617-625.
    • (2003) J Clin Invest , vol.111 , pp. 617-625
    • Zhu, W.Z.1    Wang, S.Q.2    Chakir, K.3    Yang, D.4    Zhang, T.5    Brown, J.H.6
  • 26
    • 0034602273 scopus 로고    scopus 로고
    • Beta-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes
    • Saito S, Hiroi Y, Zou Y, Aikawa R, Toko H, Shibasaki F, et al. beta-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes. J Biol Chem 2000; 275: 34528-34533.
    • (2000) J Biol Chem , vol.275 , pp. 34528-34533
    • Saito, S.1    Hiroi, Y.2    Zou, Y.3    Aikawa, R.4    Toko, H.5    Shibasaki, F.6
  • 27
    • 74149088545 scopus 로고    scopus 로고
    • Beta-adrenergic receptor signaling in the heart: Role of CaMKII
    • Grimm M, Brown JH. Beta-adrenergic receptor signaling in the heart: Role of CaMKII. J Mol Cell Cardiol 2010; 48: 322-330.
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 322-330
    • Grimm, M.1    Brown, J.H.2
  • 28
    • 0041836339 scopus 로고    scopus 로고
    • Epac: A new cAMP target and new avenues in cAMP research
    • Bos JL. Epac: A new cAMP target and new avenues in cAMP research. Nat Rev Mol Cell Biol 2003; 4: 733-738.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 733-738
    • Bos, J.L.1
  • 30
    • 33845270990 scopus 로고    scopus 로고
    • Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
    • Toledo F, Wahl GM. Regulating the p53 pathway: In vitro hypotheses, in vivo veritas. Nat Rev Cancer 2006; 6: 909-923.
    • (2006) Nat Rev Cancer , vol.6 , pp. 909-923
    • Toledo, F.1    Wahl, G.M.2
  • 31
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X. Live or let die: The cell's response to p53. Nat Rev Cancer 2002; 2: 594-604.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 33
    • 33645643078 scopus 로고    scopus 로고
    • Differential regulation of cardiomyocyte survival and hypertrophy by MDM2, an E3 ubiquitin ligase
    • Toth A, Nickson P, Qin LL, Erhardt P. Differential regulation of cardiomyocyte survival and hypertrophy by MDM2, an E3 ubiquitin ligase. J Biol Chem 2006; 281: 3679-3689.
    • (2006) J Biol Chem , vol.281 , pp. 3679-3689
    • Toth, A.1    Nickson, P.2    Qin, L.L.3    Erhardt, P.4
  • 34
    • 0035800882 scopus 로고    scopus 로고
    • Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy
    • Cesselli D, Jakoniuk I, Barlucchi L, Beltrami AP, Hintze TH, Nadal-Ginard B, et al. Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ Res 2001; 89: 279-286.
    • (2001) Circ Res , vol.89 , pp. 279-286
    • Cesselli, D.1    Jakoniuk, I.2    Barlucchi, L.3    Beltrami, A.P.4    Hintze, T.H.5    Nadal-Ginard, B.6
  • 35
    • 0001739436 scopus 로고    scopus 로고
    • Stretchmediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell
    • Leri A, Claudio PP, Li Q, Wang X, Reiss K, Wang S, et al. Stretchmediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. J Clin Invest 1998; 101: 1326-1342.
    • (1998) J Clin Invest , vol.101 , pp. 1326-1342
    • Leri, A.1    Claudio, P.P.2    Li, Q.3    Wang, X.4    Reiss, K.5    Wang, S.6
  • 36
    • 0031893042 scopus 로고    scopus 로고
    • Pacing- induced heart failure in dogs enhances the expression of p53 and p53-dependent genes in ventricular myocytes
    • Leri A, Liu Y, Malhotra A, Li Q, Stiegler P, Claudio PP, et al. Pacing- induced heart failure in dogs enhances the expression of p53 and p53-dependent genes in ventricular myocytes. Circulation 1998; 97: 194-203.
    • (1998) Circulation , vol.97 , pp. 194-203
    • Leri, A.1    Liu, Y.2    Malhotra, A.3    Li, Q.4    Stiegler, P.5    Claudio, P.P.6
  • 37
    • 57049095435 scopus 로고    scopus 로고
    • ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes
    • Liu J, Mao W, Ding B, Liang CS. ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. Am J Physiol Heart Circ Physiol 2008; 295: H1956-H1965.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Liu, J.1    Mao, W.2    Ding, B.3    Liang, C.S.4
  • 39
    • 12144291084 scopus 로고    scopus 로고
    • Cardiac stem cell and myocyte aging, heart failure, and insulinlike growth factor-1 overexpression
    • Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, et al. Cardiac stem cell and myocyte aging, heart failure, and insulinlike growth factor-1 overexpression. Circ Res 2004; 94: 514-524.
    • (2004) Circ Res , vol.94 , pp. 514-524
    • Torella, D.1    Rota, M.2    Nurzynska, D.3    Musso, E.4    Monsen, A.5    Shiraishi, I.6
  • 40
    • 0032728077 scopus 로고    scopus 로고
    • Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53
    • Webster KA, Discher DJ, Kaiser S, Hernandez O, Sato B, Bishopric NH. Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53. J Clin Invest 1999; 104: 239-252.
    • (1999) J Clin Invest , vol.104 , pp. 239-252
    • Webster, K.A.1    Discher, D.J.2    Kaiser, S.3    Hernandez, O.4    Sato, B.5    Bishopric, N.H.6
  • 42
    • 20144366284 scopus 로고    scopus 로고
    • Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice
    • Shizukuda Y, Matoba S, Mian OY, Nguyen T, Hwang PM. Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice. Mol Cell Biochem 2005; 273: 25-32.
    • (2005) Mol Cell Biochem , vol.273 , pp. 25-32
    • Shizukuda, Y.1    Matoba, S.2    Mian, O.Y.3    Nguyen, T.4    Hwang, P.M.5
  • 44
    • 33947520124 scopus 로고    scopus 로고
    • p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
    • Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, et al. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 2007; 446: 444-448.
    • (2007) Nature , vol.446 , pp. 444-448
    • Sano, M.1    Minamino, T.2    Toko, H.3    Miyauchi, H.4    Orimo, M.5    Qin, Y.6
  • 45
    • 33748336937 scopus 로고    scopus 로고
    • Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle
    • Zhou B, Wu LJ, Tashiro S, Onodera S, Uchiumi F, Ikejima T. Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle. Biol Pharm Bull 2006; 29: 1900-1905.
    • (2006) Biol Pharm Bull , vol.29 , pp. 1900-1905
    • Zhou, B.1    Wu, L.J.2    Tashiro, S.3    Onodera, S.4    Uchiumi, F.5    Ikejima, T.6
  • 46
    • 0027989893 scopus 로고
    • Tumor suppressor gene expression during normal and pathologic myocardial growth
    • Kim KK, Soonpaa MH, Daud AI, Koh GY, Kim JS, Field LJ. Tumor suppressor gene expression during normal and pathologic myocardial growth. J Biol Chem 1994; 269: 22607-22613.
    • (1994) J Biol Chem , vol.269 , pp. 22607-22613
    • Kim, K.K.1    Soonpaa, M.H.2    Daud, A.I.3    Koh, G.Y.4    Kim, J.S.5    Field, L.J.6
  • 47
    • 68149166465 scopus 로고    scopus 로고
    • GSK-3β, a therapeutic target for cardiomyocyte protection
    • Miura T, Miki T. GSK-3β, a therapeutic target for cardiomyocyte protection. Circ J 2009; 73: 1184-1192.
    • (2009) Circ J , vol.73 , pp. 1184-1192
    • Miura, T.1    Miki, T.2
  • 48
    • 14844321901 scopus 로고    scopus 로고
    • Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways
    • Yin H, Chao L, Chao J. Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways. J Biol Chem 2005; 280: 8022-8030.
    • (2005) J Biol Chem , vol.280 , pp. 8022-8030
    • Yin, H.1    Chao, L.2    Chao, J.3
  • 49
    • 33847413222 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins
    • Menon B, Johnson JN, Ross RS, Singh M, Singh K. Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins. J Mol Cell Cardiol 2007; 42: 653-661.
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 653-661
    • Menon, B.1    Johnson, J.N.2    Ross, R.S.3    Singh, M.4    Singh, K.5
  • 50
    • 0034640299 scopus 로고    scopus 로고
    • The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by betaadrenergic receptor stimulation in cardiac myocytes
    • Morisco C, Zebrowski D, Condorelli G, Tsichlis P, Vatner SF, Sadoshima J. The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by betaadrenergic receptor stimulation in cardiac myocytes. J Biol Chem 2000; 275: 14466-14475.
    • (2000) J Biol Chem , vol.275 , pp. 14466-14475
    • Morisco, C.1    Zebrowski, D.2    Condorelli, G.3    Tsichlis, P.4    Vatner, S.F.5    Sadoshima, J.6
  • 52
    • 0034651983 scopus 로고    scopus 로고
    • Akt promotes survival of cardiomyocytes in vitro and protects against ischemiareperfusion injury in mouse heart
    • Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemiareperfusion injury in mouse heart. Circulation 2000; 101: 660-667.
    • (2000) Circulation , vol.101 , pp. 660-667
    • Fujio, Y.1    Nguyen, T.2    Wencker, D.3    Kitsis, R.N.4    Walsh, K.5
  • 53
    • 0035918149 scopus 로고    scopus 로고
    • Inhibits Akt activity by blocking the membrane localization of PDK1
    • Kim S, Jee K, Kim D, Koh H, Chung J. Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. J Biol Chem 2001; 276: 12864-12870.
    • (2001) J Biol Chem , vol.276 , pp. 12864-12870
    • Kim, S.1    Jee, K.2    Kim, D.3    Koh, H.4    Chung, J.5    Cyclic, A.M.P.6
  • 54
    • 37349001294 scopus 로고    scopus 로고
    • Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress
    • Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, et al. Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. Circulation 2007; 116: 1776-1783.
    • (2007) Circulation , vol.116 , pp. 1776-1783
    • Okumura, S.1    Vatner, D.E.2    Kurotani, R.3    Bai, Y.4    Gao, S.5    Yuan, Z.6
  • 55
    • 0035929596 scopus 로고    scopus 로고
    • The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival
    • Schwartzbauer G, Robbins J. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J Biol Chem 2001; 276: 35786-35793.
    • (2001) J Biol Chem , vol.276 , pp. 35786-35793
    • Schwartzbauer, G.1    Robbins, J.2
  • 56
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • Oren M. Decision making by p53: Life, death and cancer. Cell Death Differ 2003; 10: 431-442.
    • (2003) Cell Death Differ , vol.10 , pp. 431-442
    • Oren, M.1
  • 57
    • 23844477888 scopus 로고    scopus 로고
    • The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway
    • Rivera A, Maxwell SA. The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway. J Biol Chem 2005; 280: 29346-29354.
    • (2005) J Biol Chem , vol.280 , pp. 29346-29354
    • Rivera, A.1    Maxwell, S.A.2
  • 58
    • 70449115552 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor-associated protein prevents vascular smooth muscle cell senescence via inactivation of calcineurin/nuclear factor of activated T cells pathway
    • Min LJ, Mogi M, Tamura K, Iwanami J, Sakata A, Fujita T, et al. Angiotensin II type 1 receptor-associated protein prevents vascular smooth muscle cell senescence via inactivation of calcineurin/nuclear factor of activated T cells pathway. J Mol Cell Cardiol 2009; 47: 798-809.
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 798-809
    • Min, L.J.1    Mogi, M.2    Tamura, K.3    Iwanami, J.4    Sakata, A.5    Fujita, T.6
  • 60
    • 0034130329 scopus 로고    scopus 로고
    • p53 recruitment of CREB binding protein mediated through phosphorylated CREB: A novel pathway of tumor suppressor regulation
    • Giebler HA, Lemasson I, Nyborg JK. p53 recruitment of CREB binding protein mediated through phosphorylated CREB: A novel pathway of tumor suppressor regulation. Mol Cell Biol 2000; 20: 4849-4858.
    • (2000) Mol Cell Biol , vol.20 , pp. 4849-4858
    • Giebler, H.A.1    Lemasson, I.2    Nyborg, J.K.3
  • 61
    • 33749077960 scopus 로고    scopus 로고
    • Signaling pathways regulating murine cardiac CREB phosphorylation
    • Li B, Kaetzel MA, Dedman JR. Signaling pathways regulating murine cardiac CREB phosphorylation. Biochem Biophys Res Commun 2006; 350: 179-184.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 179-184
    • Li, B.1    Kaetzel, M.A.2    Dedman, J.R.3
  • 62
    • 0035884701 scopus 로고    scopus 로고
    • HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
    • Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 2001; 61: 6669-6673.
    • (2001) Cancer Res , vol.61 , pp. 6669-6673
    • Sowter, H.M.1    Ratcliffe, P.J.2    Watson, P.3    Greenberg, A.H.4    Harris, A.L.5
  • 63
    • 0038529602 scopus 로고    scopus 로고
    • Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
    • Chen D, Li M, Luo J, Gu W. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem 2003; 278: 13595-13598.
    • (2003) J Biol Chem , vol.278 , pp. 13595-13598
    • Chen, D.1    Li, M.2    Luo, J.3    Gu, W.4
  • 64
    • 12144257637 scopus 로고    scopus 로고
    • Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury
    • Date T, Mochizuki S, Belanger AJ, Yamakawa M, Luo Z, Vincent KA, et al. Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury. Am J Physiol Cell Physiol 2005; 288: C314-C320.
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Date, T.1    Mochizuki, S.2    Belanger, A.J.3    Yamakawa, M.4    Luo, Z.5    Vincent, K.A.6
  • 65
    • 28244446238 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse
    • Kido M, Du L, Sullivan CC, Li X, Deutsch R, Jamieson SW, et al. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol 2005; 46: 2116-2124.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 2116-2124
    • Kido, M.1    Du, L.2    Sullivan, C.C.3    Li, X.4    Deutsch, R.5    Jamieson, S.W.6
  • 66
    • 71049145363 scopus 로고    scopus 로고
    • The human urocortin 2 gene is regulated by hypoxia: Identification of a hypoxia-responsive element in the 3'-flanking region
    • Buhler K, Plaisance I, Dieterle T, Brink M. The human urocortin 2 gene is regulated by hypoxia: Identification of a hypoxia-responsive element in the 3'-flanking region. Biochem J 2009; 424: 119-127.
    • (2009) Biochem J , vol.424 , pp. 119-127
    • Buhler, K.1    Plaisance, I.2    Dieterle, T.3    Brink, M.4
  • 67
    • 16344390192 scopus 로고    scopus 로고
    • Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non-hypoxic induction of HIF-1alpha
    • Kakinuma Y, Ando M, Kuwabara M, Katare RG, Okudela K, Kobayashi M, et al. Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non-hypoxic induction of HIF-1alpha. FEBS Lett 2005; 579: 2111-2118.
    • (2005) FEBS Lett , vol.579 , pp. 2111-2118
    • Kakinuma, Y.1    Ando, M.2    Kuwabara, M.3    Katare, R.G.4    Okudela, K.5    Kobayashi, M.6
  • 68
    • 79953227087 scopus 로고    scopus 로고
    • The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1{alpha} (HIF-1{alpha}) in breast cancer cells and cardiomyocytes
    • Recchia AG, De Francesco EM, Vivacqua A, Sisci D, Panno ML, Ando S, et al. The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1{alpha} (HIF-1{alpha}) in breast cancer cells and cardiomyocytes. J Biol Chem 2010; 286: 10773-10782.
    • (2010) J Biol Chem , vol.286 , pp. 10773-10782
    • Recchia, A.G.1    de Francesco, E.M.2    Vivacqua, A.3    Sisci, D.4    Panno, M.L.5    Ando, S.6
  • 69
    • 44149095751 scopus 로고    scopus 로고
    • Hypoxiainducible factor-1alpha is a critical mediator of hypoxia induced apoptosis in cardiac H9c2 and kidney epithelial HK-2 cells
    • Malhotra R, Tyson DW, Rosevear HM, Brosius FC 3rd. Hypoxiainducible factor-1alpha is a critical mediator of hypoxia induced apoptosis in cardiac H9c2 and kidney epithelial HK-2 cells. BMC Cardiovasc Disord 2008; 8: 9.
    • (2008) BMC Cardiovasc Disord , vol.8 , pp. 9
    • Malhotra, R.1    Tyson, D.W.2    Rosevear, H.M.3    Brosius III, F.C.4
  • 70
    • 67649814136 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in angiogenesis and tumorigenesis
    • Jiang BH, Liu LZ. PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res 2009; 102: 19-65.
    • (2009) Adv Cancer Res , vol.102 , pp. 19-65
    • Jiang, B.H.1    Liu, L.Z.2
  • 71
    • 79953223742 scopus 로고    scopus 로고
    • Norepinephrine induces VEGF expression and angiogenesis by a hypoxiainducible factor-1alpha protein-dependent mechanism
    • Park SY, Kang JH, Jeong KJ, Lee J, Han JW, Choi WS, et al. Norepinephrine induces VEGF expression and angiogenesis by a hypoxiainducible factor-1alpha protein-dependent mechanism. Int J Cancer 2011; 128: 2306-2316.
    • (2011) Int J Cancer , vol.128 , pp. 2306-2316
    • Park, S.Y.1    Kang, J.H.2    Jeong, K.J.3    Lee, J.4    Han, J.W.5    Choi, W.S.6
  • 72
    • 73649094752 scopus 로고    scopus 로고
    • PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2
    • Choy MK, Movassagh M, Bennett MR, Foo RS. PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. J Cell Physiol 2010; 222: 635-639.
    • (2010) J Cell Physiol , vol.222 , pp. 635-639
    • Choy, M.K.1    Movassagh, M.2    Bennett, M.R.3    Foo, R.S.4
  • 75
    • 0032978142 scopus 로고    scopus 로고
    • The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
    • Guevara NV, Kim HS, Antonova EI, Chan L. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat Med 1999; 5: 335-339.
    • (1999) Nat Med , vol.5 , pp. 335-339
    • Guevara, N.V.1    Kim, H.S.2    Antonova, E.I.3    Chan, L.4
  • 76
  • 77
    • 4644330950 scopus 로고    scopus 로고
    • Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration
    • Iwatsubo K, Minamisawa S, Tsunematsu T, Nakagome M, Toya Y, Tomlinson JE, et al. Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration. J Biol Chem 2004; 279: 40938-40945.
    • (2004) J Biol Chem , vol.279 , pp. 40938-40945
    • Iwatsubo, K.1    Minamisawa, S.2    Tsunematsu, T.3    Nakagome, M.4    Toya, Y.5    Tomlinson, J.E.6
  • 78
    • 3142776467 scopus 로고    scopus 로고
    • Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): Randomised controlled trial
    • Poole-Wilson PA, Swedberg K, Cleland JG, Di Lenarda A, Hanrath P, Komajda M, et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): Randomised controlled trial. Lancet 2003; 362: 7-13.
    • (2003) Lancet , vol.362 , pp. 7-13
    • Poole-Wilson, P.A.1    Swedberg, K.2    Cleland, J.G.3    Di Lenarda, A.4    Hanrath, P.5    Komajda, M.6


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