Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo

Journal of Neuroscience

Volumn 30, Issue 45, 2010, Pages 15019-15029

  Graham, Rona K ^a   Deng, Yu ^a   Carroll, Jeffery ^a   Vaid, Kuljeet ^a   Cowan, Catherine ^b   Pouladi, Mahmoud A ^a   Metzler, Martina ^a   Bissada, Nagat ^a   Wang, Lili ^a   Faull, Richard L M ^c   Gray, Michelle ^d   Yang, X William ^d   Raymond, Lynn A ^b   Hayden, Michael R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 6; CASPASE INHIBITOR; HUNTINGTIN; N METHYL DEXTRO ASPARTIC ACID;

ADULT; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN; CAG REPEAT; CELL DEATH; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXCITOTOXICITY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; IN VIVO STUDY; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 6; CORPUS STRIATUM; DISEASE PROGRESSION; HUMANS; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; N-METHYLASPARTATE; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS;

EID: 78149487690     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2071-10.2010     Document Type: Article

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