Enhanced neuronal Met signalling levels in ALS mice delay disease onset

Cell Death and Disease

Volumn 2, Issue 3, 2011, Pages

  Genestine, M ^a   Caricati, E ^a   Fico, A ^a   Richelme, S ^a   Hassani, H ^a   Sunyach, C ^b   Lamballe, F ^a   Panzica, G C ^c   Pettmann, B ^b   Helmbacher, F ^a   Raoul, C ^b   Maina, F ^a   Dono, R ^a  

^a INSERM   (France)

^b Turing Center for Living Systems CENTURI Aix Marseille University   (France)

^c Departments of Anatomy   (Italy)

Author keywords

ALS; Conditional transgenesis; HGF Met; Neuro degenerative disease; RTK signalling

Indexed keywords

CRE RECOMBINASE; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL LOSS; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; LIFESPAN; MALE; MOTONEURON; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PARALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; DISEASE MODEL; GENETICS; HUMAN; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MICE; MICE, TRANSGENIC; MOTOR NEURONS; PROTO-ONCOGENE PROTEINS C-MET; SIGNAL TRANSDUCTION;

EID: 79959978620     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.11     Document Type: Article

References (40)

1. Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2010; 141: 1117-1134.
2. Maina F, Pante G, Helmbacher F, Andres R, Porthin A, Davies AM et al. CouplingMet to specific pathways results in distinct developmental outcomes. Mol Cell 2001; 7: 1293-1306. (Pubitemid 32607362)
3. Furlan A, Stagni V, Hussain A, Richelme S, Conti F, Prodosmo A et al. Abl interconnects oncogenic Met and p53 core pathways in cancer cells. Cell Death Differ 2011 in press.
4. Connor B, Dragunow M. The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res Brain Res Rev 1998; 27: 1-39. (Pubitemid 28300281)
5. Snider WD, Zhou FQ, Zhong J, Markus A. Signaling the pathway to regeneration. Neuron 2002; 35: 13-16. (Pubitemid 34804317)
6. Siegel GJ, Chauhan NB. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res Brain Res Rev 2000; 33: 199-227.
7. Kanning KC, Kaplan A, Henderson CE. Motor neuron diversity in development and disease. Annu Rev Neurosci 2010; 33: 409-440.
8. Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G et al. Onset and progression in inherited ALS determined by motor neurons and microglia. Science 2006; 312: 1389-1392. (Pubitemid 43839552)
9. Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH et al. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 2008; 11: 251-253. (Pubitemid 351311795)
10. Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH et al. Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Ann Neurol 2005; 57: 773-776. (Pubitemid 40628872)
11. Ralph GS, Radcliffe PA, Day DM, Carthy JM, Leroux MA, Lee DC et al. Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model. Nat Med 2005; 11: 429-433. (Pubitemid 40562334)
12. Gould TW, Buss RR, Vinsant S, Prevette D, Sun W, Knudson CM et al. Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J Neurosci 2006; 26: 8774-8786. (Pubitemid 44319413)
13. Guillot S, Azzouz M, Deglon N, Zurn A, Aebischer P. Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice. Neurobiol Dis 2004; 16: 139-149. (Pubitemid 38569805)
14. Li W, Brakefield D, Pan Y, Hunter D, Myckatyn TM, Parsadanian A. Muscle-derived but not centrally derived transgene GDNF is neuroprotective in G93A-SOD1 mouse model of ALS. Exp Neurol 2007; 203: 457-471. (Pubitemid 46149591)
15. Maina F, Hilton MC, Andres R, Wyatt S, Klein R, Davies AM. Multiple roles for hepatocyte growth factor in sympathetic neuron development. Neuron 1998; 20: 835-846. (Pubitemid 28247390)
16. Maina F, Klein R. Hepatocyte growth factor-a versatile signal for developing neurons. Nat Neurosci 1999; 2: 213-217. (Pubitemid 30491290)
17. Ebens A, Brose K, Leonardo ED, Hanson MG, Bladt F, Birchmeier C et al. Hepatocyte growth factor/Scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron 1996; 17: 1157-1172. (Pubitemid 27021101)
18. Maina F, Hilton MC, Ponzetto C, Davies AM, Klein R. Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons. Genes Dev 1997; 11: 3341-3350. (Pubitemid 28023958)
19. Yamamoto Y, Livet J, Pollock RA, Garces A, Arce V, deLapeyriere O et al. Hepatocyte growth factor (HGF/SF) is a muscle-derived survival factor for a subpopulation of embryonic motoneurons. Development 1997; 124: 2903-2913. (Pubitemid 27370906)
20. Helmbacher F, Dessaud E, Arber S, deLapeyriere O, Henderson CE, Klein R et al. Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools. Neuron 2003; 39: 767-777. (Pubitemid 37088089)
21. Kato N, Nemoto K, Nakanishi K, Morishita R, Kaneda Y, Uenoyama M et al. Nonviral HVJ (hemagglutinating virus of Japan) liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve. Neurosci Res 2005; 52: 299-310. (Pubitemid 40917208)
22. Kitamura K, Iwanami A, Nakamura M, Yamane J, Watanabe K, Suzuki Y et al. Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury. J Neurosci Res 2007; 85: 2332-2342. (Pubitemid 47204748)
23. Sun W, Funakoshi H, Nakamura T. Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS. J Neurosci 2002; 22: 6537-6548. (Pubitemid 35386410)
24. Kadoyama K, Funakoshi H, Ohya W, Nakamura T. Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS. Neurosci Res 2007; 59: 446-456. (Pubitemid 350007815)
25. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 1999; 23: 99-103. (Pubitemid 29418797)
26. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999; 21: 70-71 (Pubitemid 29036285)
27. Raoul C, Abbas-Terki T, Bensadoun JC, Guillot S, Haase G, Szulc J et al. Lentiviralmediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med 2005; 11: 423-428. (Pubitemid 40562333)
28. Huh CG, Factor VM, Sanchez A, Uchida K, Conner EA, Thorgeirsson SS. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci USA 2004; 101: 4477-4482. (Pubitemid 38437436)
29. Chmielowiec J, Borowiak M, Morkel M, Stradal T, Munz B, Werner S et al. c-Met is essential for wound healing in the skin. J Cell Biol 2007; 177: 151-162. (Pubitemid 46588409)
30. Ishigaki A, Aoki M, Nagai M, Warita H, Kato S, Kato M et al. Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model. J Neuropathol Exp Neurol 2007; 66: 1037-1044. (Pubitemid 350060371)
31. Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 1995; 376: 768-771.
32. Maina F, Casagranda F, Audero E, Simeone A, Comoglio P, Klein R et al. Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell 1996; 87: 531-542. (Pubitemid 26374326)
33. Madhavan R, Peng HB. HGF induction of postsynaptic specializations at the neuromuscular junction. J Neurobiol 2006; 66: 134-147. (Pubitemid 43100727)
34. Chiu AY, Zhai P, Dal Canto MC, Peters TM, Kwon YW, Prattis SM et al. Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis. Mol Cell Neurosci 1995; 6: 349-362.
35. Dono R. Fibroblast growth factors as regulators of central nervous system development and function. Am J Physiol Regul Integr Comp Physiol 2003; 284: R867-R881. (Pubitemid 36406845)
36. Zuniga A, Michos O, Spitz F, Haramis AP, Panman L, Galli A et al. Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev 2004; 18: 1553-1564. (Pubitemid 38868907)
37. Segarra J, Balenci L, Drenth T, Maina F, Lamballe F. Combined Signaling through ERK, PI3K/AKT, and RAC1/p38 Is Required for Met-triggered Cortical Neuron Migration. J Biol Chem 2006; 281: 4771-4778. (Pubitemid 43847738)
38. Moumen A, Ieraci A, Patane S, Sole C, Comella JX, Dono R et al. Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent manner. Hepatology 2007; 45: 1210-1217. (Pubitemid 46775784)
39. Moumen A, Patane S, Porras A, Dono R, Maina F. Met acts on Mdm2 via mTOR to signal cell survival during development. Development 2007; 134: 1443-1451. (Pubitemid 46706049)
40. Aebischer J, Cassina P, Otsmane B, Moumen A, Seilhean D, Meininger V et al. IFNgamma triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cellautonomous effects ofmutant SOD1. Cell Death Differ, e-pub ahead of print 12 November 2010..