Tropheryma whipplei, the Whipple's disease bacillus, induces macrophage apoptosis through the extrinsic pathway

Cell Death and Disease

Volumn 1, Issue 4, 2010, Pages

  Gorvel, L ^a   Al Moussawi, K ^a   Ghigo, E ^a   Capo, C ^a   Mege, J L ^a   Desnues, B ^a  

^a CNRS   (France)

Author keywords

Bacterial strategies; Human macrophages; Whipple's disease

Indexed keywords

BACTERIAL PROTEIN; CASPASE 2; CASPASE 3; CASPASE 6; CASPASE 8; CASPASE 9; CYTOCHROME C; INTERLEUKIN 16; APOPTOSIS REGULATORY PROTEIN; CASPASE;

APOPTOSIS; ARTICLE; BACILLUS; BACTERIAL VIABILITY; BACTERIAL VIRULENCE; DEGRADATION; HUMAN; INTESTINE LIPODYSTROPHY; MACROPHAGE; MITOCHONDRION; PATHOPHYSIOLOGY; POLARIZATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; CYTOLOGY; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; MICROBIOLOGY; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOCYTE; PHYSIOLOGY; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TROPHERYMA; ULTRASTRUCTURE;

BACILLUS (BACTERIUM); BACTERIA (MICROORGANISMS); TROPHERYMA WHIPPLEI;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASES; ENZYME ACTIVATION; HUMANS; MACROPHAGES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MONOCYTES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; TROPHERYMA; WHIPPLE DISEASE;

EID: 78649890863     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2010.11     Document Type: Article

References (40)

1. Schneider T, Moos V, Loddenkemper C, Marth T, Fenollar F, Raoult D. Whipple's disease: new aspects of pathogenesis and treatment. Lancet Infect Dis 2008;8:179-190. (Pubitemid 351249251)
2. Rolain JM, Fenollar F, Raoult D. False positive PCR detection of Tropheryma whipplei in the saliva of healthy people. BMC Microbiol 2007;7:48.
3. Desnues B, Lepidi H, Raoult D, Mege JL. Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages. J Infect Dis 2005;192:1642-1646. (Pubitemid 41504701)
4. Desnues B, Raoult D, Mege JL. IL-16 is critical for Tropheryma whipplei replication in Whipple's disease. J Immunol 2005;175:4575-4582. (Pubitemid 41361996)
5. Benoit M, Fenollar F, Raoult D, Mege JL. Increased levels of circulating IL-16 and apoptosis markers are related to the activity of Whipple's disease. PloS One 2007;2:e494.
6. Kurokawa M, Kornbluth S. Caspases and kinases in a death grip. Cell 2009;138:838-854.
7. Clifton DR, Goss RA, Sahni SK, van Antwerp D, Baggs RB, Marder VJ et al. NF-kappa B-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection. Proc Natl Acad Sci USA 1998;95:4646-4651. (Pubitemid 28207967)
8. Fan T, Lu H, Hu H, Shi L, McClarty GA, Nance DM et al. Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J Exp Med 1998;187:487-496. (Pubitemid 28093351)
9. Hanna PC, Acosta D, Collier RJ. On the role of macrophages in anthrax. Proc Natl Acad Sci USA 1993;90:10198-10201. (Pubitemid 23328279)
10. Riedl SJ, Salvesen GS. The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 2007;8:405-413. (Pubitemid 46643237)
11. Matsuyama S, Reed JC. Mitochondria-dependent apoptosis and cellular pH regulation. Cell Death Differ 2000;7:1155-1165. (Pubitemid 32042222)
12. Desnues B, Ihrig M, Raoult D, Mege JL. Whipple's disease: a macrophage disease. Clin Vaccine Immunol 2006;13:170-178. (Pubitemid 43383783)
13. Voth DE, Howe D, Heinzen RA. Coxiella burnetii inhibits apoptosis in human THP-1 cells and monkey primary alveolar macrophages. Infect Immun 2007;75:4263-4271. (Pubitemid 47378082)
14. Loeuillet C, Martinon F, Perez C, Munoz M, Thome M, Meylan PR. Mycobacterium tuberculosis subverts innate immunity to evade specific effectors. J Immunol 2006;177:6245-6255. (Pubitemid 44628842)
15. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997;37:517-554. (Pubitemid 27238886)
16. Lang D, Reuter S, Buzescu T, August C, Heidenreich S. Heme-induced heme oxygenase-1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation. Int Immunol 2005;17:155-165. (Pubitemid 40246580)
17. Turkseven S, Drummond G, Rezzani R, Rodella L, Quan S, Ikehara S et al. Impact of silencing HO-2 on EC-SOD and the mitochondrial signaling pathway. J Cell Biochem 2007;100:815-823.
18. Abarca-Rojano E, Rosas-Medina P, Zamudio-Cortez P, Mondragon-Flores R, Sanchez-Garcia FJ. Mycobacterium tuberculosis virulence correlates with mitochondrial cytochrome c release in infected macrophages. Scand J Immunol 2003;58:419-427. (Pubitemid 37215056)
19. Chen Q, Crosby M, Almasan A. Redox regulation of apoptosis before and after cytochrome c release. Korean J Biol Sci 2003;7:1-9.
20. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997;91:479-489. (Pubitemid 27508237)
21. Mishra OP, Delivoria-Papadopoulos M. ATP and cytochrome c-dependent inhibition of caspase-9 activity in the cerebral cortex of newborn piglets. Neurosci Lett 2004;364:119-123. (Pubitemid 38766179)
22. Lakhani SA, Masud A, Kuida K, Porter Jr GA, Booth CJ, Mehal WZ et al. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 2006;311:847-851. (Pubitemid 43228848)
23. Samraj AK, Sohn D, Schulze-Osthoff K, Schmitz I. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell 2007;18:84-93. (Pubitemid 46066713)
24. Al Moussawi K, Ghigo E, Kalinke U, Alexopoulou L, Mege JL, Desnues B. Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei. PLoS Pathog 2010;6:e1000722.
25. Chawla-Sarkar M, Lindner DJ, Liu YF, Williams BR, Sen GC, Silverman RH et al. Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 2003;8:237-249. (Pubitemid 36749609)
26. Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997;326:1-16. (Pubitemid 27386911)
27. Zhang Y, Center DM, Wu DM, Cruikshank WW, Yuan J, Andrews DW et al. Processing and activation of pro-interleukin-16 by caspase-3. J Biol Chem 1998;273:1144-1149. (Pubitemid 28049215)
28. Besson A, Dowdy SF, Roberts JM. CDK inhibitors: cell cycle regulators and beyond. Dev Cell 2008;14:159-169. (Pubitemid 351189186)
29. Asada M, Yamada T, Ichijo H, Delia D, Miyazono K, Fukumuro K et al. Apoptosis inhibitory activity of cytoplasmic p21 (Cip1/WAF1) in monocytic differentiation. EMBO J 1999;18:1223-1234. (Pubitemid 29110307)
30. Ahmad N, Adhami VM, Afaq F, Feyes DK, Mukhtar H. Resveratrol causes WAF-1/p21-mediated G (1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin Cancer Res 2001;7:1466-1473. (Pubitemid 32708704)
31. Agrawal S, Agarwal ML, Chatterjee-Kishore M, Stark GR, Chisolm GM. Stat1-dependent, p53-independent expression of p21 (waf1) modulates oxysterol-induced apoptosis. Mol Cell Biol 2002;22:1981-1992. (Pubitemid 34224607)
32. Katayama T, Nakanishi K, Nishihara H, Kamiyama N, Nakagawa T, Kamiyama T et al. Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. Int J Oncol 2007;31:613-620.
33. Trakala M, Arias CF, Garcia MI, Moreno-Ortiz MC, Tsilingiri K, Fernandez PJ et al. Regulation of macrophage activation and septic shock susceptibility via p21 (WAF1/CIP1). Eur J Immunol 2009;39:810-819.
34. Scatizzi JC, Mavers M, Hutcheson J, Young B, Shi B, Pope RM et al. The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages. Eur J Immunol 2009;39:820-825.
35. Savill J, Dransfield I, Gregory C, Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev 2002;2:965-975. (Pubitemid 37323217)
36. Benoit M, Ghigo E, Capo C, Raoult D, Mege JL. The uptake of apoptotic cells drives Coxiella burnetii replication and macrophage polarization: a model for Q fever endocarditis. PLoS Pathog 2008;4:e1000066.
37. Boulos A, Rolain JM, Raoult D. Antibiotic susceptibility of Tropheryma whipplei in MRC5 cells. Antimicrob Agents Chemother 2004;48:747-752. (Pubitemid 38280319)
38. Wang L, Lu L. Pathway-specific effect of caffeine on protection against UV irradiationinduced apoptosis in corneal epithelial cells. Invest Ophthalmol Vis Sci 2007;48:652-660. (Pubitemid 351260697)
39. Luhrmann A, Roy CR. Coxiella burnetii inhibits activation of host cell apoptosis through a mechanism that involves preventing cytochrome c release from mitochondria. Infect Immun 2007;75:5282-5289. (Pubitemid 350033615)
40. Shapiro HM. Membrane potential estimation by flow cytometry. Methods 2000;21:271-279. (Pubitemid 32896751)