Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpaindependent proteolysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 22, 2001, Pages 12784-12789

  Kim, Yun J ^a   Yi, Yong ^a   Sapp, Ellen ^a   Wang, Yumei ^a   Cuiffo, Ben ^a   Kegel, Kimberly B ^a   Qin, Zheng Hong ^a   Aronin, Neil ^b   DiFiglia, Marian ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; CALPAIN; CASPASE 3; HUNTINGTIN; POLYGLUTAMINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL AGGREGATION; CELL DEATH; CELL MEMBRANE; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE ASSOCIATION; ENZYME REGULATION; HUNTINGTON CHOREA; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ADULT; ANIMALS; BRAIN; CALPAIN; CASPASE 3; CASPASES; CELL MEMBRANE; HUMANS; HUNTINGTON DISEASE; MICE; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS;

ANIMALIA;

EID: 0035940412     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.221451398     Document Type: Article

References (30)