Inhibition of prostaglandin E2 EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms

Journal of Neuroimmunology

Volumn 238, Issue 1-2, 2011, Pages 34-43

  Ikeda Matsuo, Yuri ^a   Tanji, Hayato ^a   Narumiya, Shuh ^b   Sasaki, Yasuharu ^a  

^a KITASATO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

Apoptosis; EP3 receptor; Focal cerebral ischemia; Inflammation; Neutrophil; Prostaglandin E2

Indexed keywords

CASPASE 3; ONO AE3 240; ONO AF3 240; PROSTAGLANDIN E RECEPTOR 3; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN EDEMA; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; GENE DELETION; GENE EXPRESSION; MEAN ARTERIAL PRESSURE; MICROGLIA; MOUSE; NERVE CELL; NEUROLOGIC DISEASE; NEUROPROTECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RECTUM TEMPERATURE; STROKE; TREATMENT RESPONSE;

ANILIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BENZOIC ACIDS; BLOOD PRESSURE; BLOOD-BRAIN BARRIER; BODY TEMPERATURE; BRAIN INFARCTION; CALCIUM-BINDING PROTEINS; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; IMMUNOGLOBULIN G; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MICROGLIA; NERVOUS SYSTEM DISEASES; NEURONS; NEUTROPHILS; RECEPTORS, PROSTAGLANDIN E, EP3 SUBTYPE; TIME FACTORS;

EID: 80052826881     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.06.014     Document Type: Article

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