TNF-α respecifies human mesenchymal stem cells to a neural fate and promotes migration toward experimental glioma

Cell Death and Differentiation

Volumn 18, Issue 5, 2011, Pages 853-863

  Egea, V ^a   Von Baumgarten, L ^a   Schichor, C ^a   Berninger, B ^a   Popp, T ^a   Neth, P ^a   Goldbrunner, R ^a   Kienast, Y ^a   Winkler, F ^a   Jochum, M ^a   Ries, C ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

CXCR4 SDF 1 axis; ERK1 2 MAPK; glioma mouse model; in vivo MPLSM; mesenchymal stem cells; TNF a

Indexed keywords

ALPHA CATENIN; ALPHA INTEGRIN; BETA CATENIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; BONE MORPHOGENETIC PROTEIN RECEPTOR 1B; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CXCR4; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA (CYTOSINE 5)METHYLTRANSFERASE 2; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FRIZZLED HOMOLOG 3; FRIZZLED HOMOLOG 4; FRIZZLED PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; KERATINOCYTE GROWTH FACTOR; LEUKEMIA INHIBITORY FACTOR; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NERVE CELL ADHESION MOLECULE; NESTIN; STROMAL CELL DERIVED FACTOR 1ALPHA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL CULTURE; CELL DIFFERENTIATION; CELL FATE; CELL INFILTRATION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL SPECIFICITY; CELL STRUCTURE; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; MALE; MESENCHYMAL STEM CELL; MOUSE; NERVE CELL GROWTH; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SRY GENE; UPREGULATION;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BRAIN NEOPLASMS; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; CELL SHAPE; CELLS, CULTURED; GENE EXPRESSION REGULATION; GLIOMA; HUMANS; LEUKEMIA INHIBITORY FACTOR; MALE; MESENCHYMAL STEM CELLS; MICE; MICE, NUDE; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PHENOTYPE; RECEPTORS, CXCR4; SOXB1 TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79954417539     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.154     Document Type: Article

References (40)

1. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-147. (Pubitemid 29282067)
2. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418: 41-49. (Pubitemid 34742565)
3. Sadan O, Melamed E, Offen D. Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases. Expert Opin Biol Ther 2009; 9: 1487-1497.
4. Bang OY, Lee JS, Lee PH, Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005; 57: 874-882. (Pubitemid 40798626)
5. Bexell D, Scheding S, Bengzon J. Toward brain tumor gene therapy using multipotent mesenchymal stromal cell vectors. Mol Ther 2010; 18: 1067-1075.
6. Muller FJ, Snyder EY, Loring JF. Gene therapy: can neural stem cells deliver? Nat Rev Neurosci 2006; 7: 75-84. (Pubitemid 41828933)
7. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001; 104: 487-501. (Pubitemid 32201945)
8. Greig NH, Mattson MP, Perry T, Chan SL, Giordano T, Sambamurti K et al. New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists. Ann NY Acad Sci 2004; 1035: 290-315. (Pubitemid 40362340)
9. Hallenbeck JM. The many faces of tumor necrosis factor in stroke. Nat Med 2002; 8: 1363-1368. (Pubitemid 36019420)
10. Turrin NP, Rivest S. Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity. J Neurosci 2006; 26: 143-151. (Pubitemid 43089527)
11. Iosif RE, Ekdahl CT, Ahlenius H, Pronk CJ, Bonde S, Kokaia Z et al. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci 2006; 26: 9703-9712. (Pubitemid 44427709)
12. Iosif RE, Ahlenius H, Ekdahl CT, Darsalia V, Thored P, Jovinge S et al. Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1. J Cereb Blood Flow Metab 2008; 28: 1574-1587.
13. Bernardino L, Agasse F, Silva B, Ferreira R, Grade S, Malva JO. Tumor necrosis factoralpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures. Stem Cells 2008; 26: 2361-2371.
14. Peng H, Whitney N, Wu Y, Tian C, Dou H, Zhou Y et al. HIV-1-infected and/or immuneactivated macrophage-secreted TNF-alpha affects human fetal cortical neural progenitor cell proliferation and differentiation. Glia 2008; 56: 903-916.
15. Cuschieri J, Maier RV. Mitogen-activated protein kinase (MAPK). Crit Care Med 2005; 33: S417-S419. (Pubitemid 41785976)
16. Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006; 354: 610-621. (Pubitemid 43209108)
17. Rempel SA, Dudas S, Ge S, Gutierrez JA. Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 2000; 6: 102-111. (Pubitemid 30064982)
18. Chen J, Li Y, Wang L, Lu M, Zhang X, Chopp M. Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci 2001; 189: 49-57. (Pubitemid 32776649)
19. Ji JF, He BP, Dheen ST, Tay SS. Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. Stem Cells 2004; 22: 415-427. (Pubitemid 38736625)
20. Ries C, Egea V, Karow M, Kolb H, Jochum M, Neth P. MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines. Blood 2007; 109: 4055-4063. (Pubitemid 46641761)
21. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 2003; 92: 827-839. (Pubitemid 36542523)
22. Schichor C, Birnbaum T, Etminan N, Schnell O, Grau S, Miebach S et al. Vascular endothelial growth factor A contributes to glioma-induced migration of human marrow stromal cells (hMSC). Exp Neurol 2006; 199: 301-310. (Pubitemid 44202456)
23. Winkler F, Kienast Y, Fuhrmann M, von Baumgarten L, Burgold S, Mitteregger G et al. Imaging glioma cell invasion in vivo reveals mechanisms of dissemination and peritumoral angiogenesis. Glia 2009; 57: 1306-1315.
24. Kienast Y, von Baumgarten L, Fuhrmann M, Klinkert WE, Goldbrunner R, Herms J et al. Real-time imaging reveals the single steps of brain metastasis formation. Nat Med 2010; 16: 116-122.
25. Laywell ED, Steindler DA, Silver DJ. Astrocytic stem cells in the adult brain. Neurosurg Clin N Am 2007; 18: 21-30, viii. (Pubitemid 46161191)
26. Tropel P, Platet N, Platel JC, Noel D, Albrieux M, Benabid AL et al. Functional neuronal differentiation of bone marrow-derived mesenchymal stem cells. Stem Cells 2006; 24: 2868-2876. (Pubitemid 46053023)
27. Wiese C, Rolletschek A, Kania G, Blyszczuk P, Tarasov KV, Tarasova Y et al. Nestin expression-a property of multi-lineage progenitor cells? Cell Mol Life Sci 2004; 61: 2510-2522. (Pubitemid 39586514)
28. Hermann A, Liebau S, Gastl R, Fickert S, Habisch HJ, Fiedler J et al. Comparative analysis of neuroectodermal differentiation capacity of human bone marrow stromal cells using various conversion protocols. J Neurosci Res 2006; 83: 1502-1514. (Pubitemid 43844995)
29. Pevny LH, Nicolis SK. Sox2 roles in neural stem cells. Int J Biochem Cell Biol 2010; 42: 421-424.
30. Nakashima K, Yanagisawa M, Arakawa H, Taga T. Astrocyte differentiation mediated by LIF in cooperation with BMP2. FEBS Lett 1999; 457: 43-46. (Pubitemid 29388176)
31. Yang H, Xia Y, Lu SQ, Soong TW, Feng ZW. Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ ERK, and transcription factor AP-1. J Biol Chem 2008; 283: 5287-5295.
32. Levy YS, Bahat-Stroomza M, Barzilay R, Burshtein A, Bulvik S, Barhum Y et al. Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson's disease. Cytotherapy 2008; 10: 340-352. (Pubitemid 351983158)
33. Buffo A, Rolando C, Ceruti S. Astrocytes in the damaged brain: molecular and cellular insights into their reactive response and healing potential. Biochem Pharmacol 2010; 79: 77-89.
34. Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto M, Teng YD et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci USA 2004; 101: 18117-18122. (Pubitemid 40054083)
35. Ni HT, Hu S, Sheng WS, Olson JM, Cheeran MC, Chan AS et al. High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells. Brain Res Dev Brain Res 2004; 152: 159-169. (Pubitemid 39194831)
36. Ponte AL, Marais E, Gallay N, Langonne A, Delorme B, Herault O et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells 2007; 25: 1737-1745. (Pubitemid 47121852)
37. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-996. (Pubitemid 40349501)
38. Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 2005; 65: 3307-3318. (Pubitemid 40524615)
39. Sasportas LS, Kasmieh R, Wakimoto H, Hingtgen S, van de Water JA, Mohapatra G et al. Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci USA 2009; 106: 4822-4827.
40. Ho IA, Chan KY, Ng WH, Guo CM, Hui KM, Cheang P et al. Matrix metalloproteinase 1 is necessary for the migration of human bone marrow-derived mesenchymal stem cells toward human glioma. Stem Cells 2009; 27: 1366-1375.