Targeting microglia-mediated neurotoxicity: The potential of NOX2 inhibitors

Cellular and Molecular Life Sciences

Volumn 69, Issue 14, 2012, Pages 2409-2427

  Surace, Michael J ^a   Block, Michelle L ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Microglia; NADPH oxidase; Neuroprotection; NOX2 inhibition; Parkinson's disease; Redox; ROS

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ACETYLSALICYLIC ACID; ALPHA SYNUCLEIN; APOCYNIN; ATORVASTATIN; BACTERIUM LIPOPOLYSACCHARIDE; DIPHENYLIODONIUM SALT; ENZYME INHIBITOR; GP91 DS TAT PEPTIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUPROFEN; IRON CHELATING AGENT; MEMANTINE; NATURAL PRODUCT; NONSTEROID ANTIINFLAMMATORY AGENT; OXIDOPAMINE; OXIDOREDUCTASE INHIBITOR; PARACETAMOL; PARAQUAT; PHOSPHOTRANSFERASE; PROTEIN P22; PROTEIN P47; PROTEIN P67; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; ROTENONE; SIMVASTATIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; BRAIN ISCHEMIA; CELL ACTIVATION; COMPLEX FORMATION; DEGENERATIVE DISEASE; DISEASE MODEL; DRUG EFFECT; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; EVIDENCE BASED MEDICINE; GENE DELETION; GENE EXPRESSION REGULATION; HUMAN; IRON CHELATION; MICROGLIA; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NERVE CELL PLASTICITY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; TREATMENT PLANNING; UPREGULATION;

ENZYME INHIBITORS; HUMANS; MEMBRANE GLYCOPROTEINS; MICROGLIA; NADPH OXIDASE; NEURODEGENERATIVE DISEASES; REACTIVE OXYGEN SPECIES;

EID: 84864334644     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1015-4     Document Type: Review

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