Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude

Acta Neuropathologica

Volumn 101, Issue 3, 2001, Pages 249-255

  Mittelbronn, M ^a   Dietz, K ^a   Schluesener, H J ^a   Meyermann, R ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Human brain; Immunohistochemistry; Microglia; Protein expression

Indexed keywords

BRAIN ANTIGEN; CALGRANULIN; CD4 ANTIGEN; CD45 ANTIGEN; CD68 ANTIGEN; CELL ANTIGEN; CHEMOTACTIC FACTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY;

ADULT; AGED; ANTIBODY LABELING; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; BRAIN CELL; BRAIN TISSUE; CELL DENSITY; CELL LABELING; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GRAY MATTER; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICROGLIA; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; WHITE MATTER;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BRAIN; CALCIUM-BINDING PROTEINS; CALGRANULIN A; CALGRANULIN B; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-16; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICROGLIA; MIDDLE AGED; REFERENCE VALUES; S100 PROTEINS;

EID: 0035105538     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010000284     Document Type: Article

References (48)

1. Expression of major histocompatibility complex and HIV antigens within the brains of AIDS patients
2. Alterations in glia and axons in the brains of Binswanger's disease patients
3. Expression of MRP14, 27E10, interferon-alpha and leukocyte common antigen by reactive microglia in postmortem human brain tissue
4. The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis
5. The role of macrophage subpopulations in autoimmune disease of the central nervous system
6. Perineuronal satellite cells in the motor cortex of ageing brains
7. Role of macrophages in the pathogenesis of human immunodeficiency virus (HIV) infection
8. Macrophages and microglia in HIV-related CNS neuropathology
9. Expression of microglial markers in the human CNS after closed head injury
10. Characterization of microglia and macrophages in the central nervous system of rats: Definition of the differential expression of molecules using standard and novel monoclonal antibodies in normal CNS and in four reaction
11. Ultrastructural location of major histocompatibility complex (MHC) class II positive perivascular cells in histologically normal human brain
12. Identification of neuroglia by light and electronmicroscopy
13. Microglia are the major cell type expressing MHC class II in human white matter
14. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
15. Cultured microglial cells have a distinct pattern of membrane channels different from peritoneal macrophages
16. Microglia: A sensor for pathological events in the CNS
17. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
18. A specific histochemical marker (lectin Ricinus communis agglutinin-1) for normal human microglia and application to routine histopathology
19. Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors
20. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
21. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
22. Identification of microglia by light and electronmicroscopy
23. The expression of cytokines and their receptors in normal and mildly reactive human brain
24. Reactive microglia in Creutzfeldt-Jakob disease
25. A light and electron microscopic study of HLA-DR positive cells in the human cerebral cortex and subcortical white matter
26. The inflammatory response in the CNS
27. Modulation of CD4 antigen on macrophages and microglia in rat brain
28. Macrophages and microglia in the nervous system
29. Altered antigen expression of microglia in the aged rodent CNS
30. Differential expression of MHC class II antigen in the contused rat spinal cord
31. Expression of the S-100 proteins MRP-8 and -14 in ischemic brain lesions
32. Allograft inflammatory factor-1 is upregulated in microglial cells in human cerebral infarctions
33. Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanism and cues to physiological function
34. Leukocyte chemotactic factor, a natural ligand to CD4, is expressed by lymphocytes and microglial cells of the MS plaque
35. Widespread expression of MRP8 and MRP14 in human cerebral malaria by microglial cells
36. Allograft-inflammatory factor-1 in rat experimental autoimmune encephalomyelitis, neuritis and uveitis: Expression by activated macrophages and microglial cells
37. Dynamics of microglial activation in the spinal cord after cerebral infarction are revealed by expression of MHC class II antigen
38. Identification of glial cell proliferation in early multiple sclerosis lesions
39. Microglial expression of MHC class II increases in normal aging of nonhuman primates
40. Blood monocytes and spleen macrophages differentiate into microglia-like cells on monolayers of astrocytes: Morphology
41. Reactive microgliosis
42. Upregulation of a new microglial gene, mrf-1, in response to programmed neuronal cell death and degeneration
43. Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells
44. HLA class II molecules (HLA-DR, -DP, -DQ) on cells in the human CNS studied in situ and in vitro
45. Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG
46. Activation of microglia in HIV-1 infected brains is not dependent on the presence of HIV-1 antigens
47. Biology of adult human microglia in culture: Comparisons with peripheral blood monocytes and astrocytes