Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation

Neuropharmacology

Volumn 60, Issue 2-3, 2011, Pages 373-380

  Liu, Yuxin ^a,d   Lo, Yi Ching ^a,b   Qian, Li ^a   Crews, Fulton Tim ^c   Wilson, Belinda ^a   Chen, Hui Ling ^a,e   Wu, Hung Ming ^a,e   Chen, Shih Heng ^a,e   Wei, Ke ^a   Lu, Ru Band ^e   Ali, Syed ^f   Hong, Jau Shyong ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d HEBEI UNIVERSITY   (China)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^f Neurochemistry Laboratory NCTR Jefferson   (United States)

Author keywords

Calcium channel blocker; Oxidative stress and neuroinflammation

Indexed keywords

CALCIUM CHANNEL; LIPOPOLYSACCHARIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE DISMUTASE; VERAPAMIL;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME ACTIVITY; FEMALE; GENETIC TRANSFECTION; LIGAND BINDING; MALE; MICROGLIA; MOUSE; NERVE CELL CULTURE; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; DOPAMINE; FEMALE; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; PREGNANCY; RATS; RATS, INBRED F344; VERAPAMIL;

EID: 78650844904     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.10.002     Document Type: Article

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