Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: In vitro and in vivo studies

GLIA

Volumn 32, Issue 1, 2000, Pages 51-59

  Possel, Heiko ^a,b   Noack, Heiko ^a   Putzke, Jörg ^a   Wolf, Gerald ^a   Sies, Helmut ^b  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Astrocytes; INOS; Microglia; NF B

Indexed keywords

CYTOKINE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL; ARTICLE; ASTROCYTE; BIOSYNTHESIS; BRAIN CORTEX; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MICROGLIA; PHYSIOLOGY; RAT; RAT STRAIN; UPREGULATION;

ANIMAL; ANIMALS, NEWBORN; ASTROCYTES; CELL CULTURE; CEREBRAL CORTEX; CYTOKINES; LIPOPOLYSACCHARIDES; MICROGLIA; NITRIC OXIDE; NITRIC-OXIDE SYNTHASE; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; UP-REGULATION;

EID: 0033771987     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-1136(200010)32:1<51::AID-GLIA50>3.0.CO;2-4     Document Type: Article

References (33)

1. Beta-Amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism
2. Characteristics of nitric oxide synthase type I of rat cerebellar astrocytes
3. Cloning and sequencing of the proximal promoter of the rat iNOS gene: Activation of NFkappaB is not sufficient for transcription of the iNOS gene in rat mesangial cells
4. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
5. Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS
6. Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism
7. Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures
8. Expression of inducible nitric oxide synthase during rat brain inflammation: Regulation by 1,25-dihydroxyvitamin D3
9. Interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-γ injection
10. Nitric-oxide synthase assays
11. A novel CD8 molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production
12. Hepatic ischemia/reperfusion in rats induces iNOS gene transcription by activation of NF-kappaB
13. + macrophages/microglia
14. Neurotoxicity of glia activated by gram-positive bacterial products depends on nitric oxide production
15. In vivo induction of inducible nitric oxide synthase by microinjection with interferon-γ and lipopolysaccharide in rat hippocampus
16. Rat brain microglia and peritoneal macrophages show similar responses to respiratory burst stimulants
17. Inducible nitric oxide synthase in human diseases
18. Brain iNOS: Current understanding and clinical implications
19. Interferon-γ plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus
20. High extracellular potassium modulates nitric oxide synthase expression in human astrocytes
21. Production of nitric oxide by glial cells: Regulation and potential roles in the CNS
22. Synthesis of nitric oxide in CNS glial cells
23. Differential expression of superoxide dismutase isoforms in neuronal and glial compartments in the course of excitotoxically mediated neurodegeneration: Relation to oxidative and nitrergic stress
24. Endothelin enhances lipopolysaccharide-induced expression of inducible nitric oxide synthase in rat glial cells
25. Molecular mechanisms regulating iNOS expression in various cell types
26. Primary cultures of astrocytes from mammalian brain as a tool in neurochemical research
27. Activated astrocytes induce nitric oxide synthase-2 in cerebral endothelium via tumor necrosis factor alpha
28. Progressive activation of adult microglial cells in vitro
29. Production, regulation and role of nitric oxide in glial cells
30. Control of nitric oxide production by transforming growth factor-beta1: Mechanistic insights and potential relevance to human disease
31. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta
32. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
33. Astrocytes modulate nitric oxide production by microglial cells through secretion of serine and glycine