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Volumn 21, Issue 14, 2002, Pages 2191-2200
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Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene
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Author keywords
ARE; Cysteine; Detoxifying genes; NQO1; Nrf2; Redox regulation
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Indexed keywords
ANTIOXIDANT;
HYDROQUINONE DERIVATIVE;
LEUCINE ZIPPER PROTEIN;
N ETHYLMALEIMIDE;
OXIDOREDUCTASE;
REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;
TRANSCRIPTION FACTOR NRF2;
UNCLASSIFIED DRUG;
AMINO ACID SUBSTITUTION;
ANTIOXIDANT ACTIVITY;
ARTICLE;
BINDING AFFINITY;
CONTROLLED STUDY;
CYTOSOL;
DNA BINDING;
DNA RESPONSIVE ELEMENT;
GENE EXPRESSION REGULATION;
GENE INDUCTION;
GENETIC CONSERVATION;
HEPATOBLASTOMA;
HUMAN;
HUMAN CELL;
NUCLEAR LOCALIZATION SIGNAL;
PRIORITY JOURNAL;
PROTEIN DNA BINDING;
PROTEIN DOMAIN;
SITE DIRECTED MUTAGENESIS;
AMINO ACID SEQUENCE;
ANIMALS;
ANTIOXIDANTS;
CYSTEINE;
DNA-BINDING PROTEINS;
ELECTROPHORETIC MOBILITY SHIFT ASSAY;
ETHYLMALEIMIDE;
GENE EXPRESSION REGULATION;
HUMANS;
MAFG TRANSCRIPTION FACTOR;
MICE;
MOLECULAR SEQUENCE DATA;
MUTAGENESIS, SITE-DIRECTED;
NADH, NADPH OXIDOREDUCTASES;
NF-E2-RELATED FACTOR 2;
REPRESSOR PROTEINS;
RESPONSE ELEMENTS;
SEQUENCE HOMOLOGY, AMINO ACID;
SERINE;
STRUCTURE-ACTIVITY RELATIONSHIP;
TRANS-ACTIVATORS;
TUMOR CELLS, CULTURED;
ANIMALIA;
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EID: 0037192626
PISSN: 09509232
EISSN: None
Source Type: Journal
DOI: 10.1038/sj.onc.1205288 Document Type: Article |
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Times cited : (93)
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References (40)
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