Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production

Journal of Neurochemistry

Volumn 80, Issue 1, 2002, Pages 73-80

  Bal Price, Anna ^a   Matthias, Anita ^a   Brown, Guy C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Inflammation; Microglia; Neurodegeneration; Nitric oxide; Peroxynitrite; Superoxide

Indexed keywords

ARGININE; CYTOCHROME C; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PEROXYNITRITE; PHORBOL 13 ACETATE 12 MYRISTATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL RESPIRATION; COCULTURE; ENZYME ACTIVATION; GRANULE CELL; INFLAMMATION; MICROGLIA; NERVE CELL DEGENERATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

ANIMALS; CELLS, CULTURED; EXTRACELLULAR SPACE; MICROGLIA; NADPH OXIDASE; NEURONS; NITRIC OXIDE; OXYGEN CONSUMPTION; PEROXYNITROUS ACID; RATS; RATS, WISTAR; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA;

EID: 0036273352     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-3042.2001.00675.x     Document Type: Article

References (29)

1. 2 receptor mRNA expression by striatal astroeytes in culture: In situ hybridization and polymerase chain reaction studies
2. Inflammatory neurodegeneration mediated by nitric oxide from activated glia inhibiting respiration, causing glutamate release and excitotoxicity
3. Cytooxicity of microglia
4. Nitric oxide, superoxide, and peroxynitrite; the good, the bad, and the ugly
5. Oxidative chemistry of peroxynitrite
6. Nitric oxide and mitochondrial respiration
7. Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome oxidase
8. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
9. Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration
10. Cerebellar granule cells
11. Cytokine-stimulated astrocytex damage human neurons via a NO mechanism
12. Production of superoxide anions by a CNS macrophage, the microglia
13. Molecular profile of reactive astrocytes: Implications for their role in neurologic disease
14. Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS
15. Microglia: A sensor for pathological events in the CNS
16. Peroxynitrite- and nitriteinduced oxidation of dopamine: Implications for nitric oxide in dopaminergic cell loss
17. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
18. Expression of NOS-2 in glia associated with CNS pathology
19. Superoxide dismutase and hydrogen peroxide cause rapid nitric oxide breakdown, peroxyintrite production and subsequent cell death
20. Production of nitric oxide by glial cells: Regulation and potential roles in the CNS
21. Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: In vitro and in vivo studies
22. Measurement and characterization of superoxide generation in microglia cells: Evidence for an NADPH oxidasedependent pathway
23. Determination of nitrite and nitrate by Griess reaction
24. Induction of nitric oxide synthase in glial cells
25. Effects of phorbol myristate (PMA) on functions of macrophages and microglia in vitro
26. Chromogranin A triggers a phenotypic transformation and the generation of nitric oxide in brain microglial cells
27. Amyloid β-peptide induces nitric oxide production in rat hippocampus: Association with cholinergic dysfunction and amelioration by inducible nitric oxide synthase inhibitors
28. Extensive peroxynitrite activity during progressive stages of central nervous system inflammation
29. The possible role of peroxynitrite in Alzhcimer's disease