Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: Involvement of angiotensin AT1 receptor expression and Rac1 GTPase

Molecular Pharmacology

Volumn 59, Issue 3, 2001, Pages 646-654

  Wassmann, Sven ^a   Laufs, Ulrich ^a   Bäumer, Anselm T ^b   Müller, Kirsten ^a   Konkol, Christian ^a   Sauer, Heinrich ^b   Böhm, Michael ^a   Nickenig, Georg ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ATORVASTATIN; CHOLESTEROL; CHOLESTEROL DERIVATIVE; FREE RADICAL; GERANYLGERANYLTRANSFERASE; GERANYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; PROTEIN FARNESYLTRANSFERASE; RAC1 PROTEIN; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CLOSTRIDIUM SORDELLII; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENETIC TRANSCRIPTION; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; RECEPTOR DENSITY; THORACIC AORTA; TIME; VASCULAR SMOOTH MUSCLE;

EID: 0035122832     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.3.646     Document Type: Article

References (40)

1. Bacterial toxins that target rho proteins
2. Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study
3. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
4. NADPH oxidase: An update
5. Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells
6. HMG-CoA reductase inhibition by atervastatin reduces neointimal inflammation in a rabbit model of atherosclerosis
7. Nitric oxide, free radicals and cell signalling in cardiovascular disease
8. Effect of simvastatin therapy on cell membrane cholesterol content and membrane function as assessed by polymorphonuclear cell NADPH oxidase activity
9. Influences of lovastatin administration on the respiratory bursts of leucocytes and the phosphorylation potential of mitochondria in guinea pigs
10. Mechanisms of NADPH oxidase activation in human neutrophils: p67phox is required for the translocation of rac1 but not rac2 from cytosol to the membranes
11. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
12. Current and future therapeutic approaches to hyperlipidemia
13. Regulation of the mevalonate pathway
14. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
15. Molecular biology of the renin-angiotensin system
16. Redox control of vascular smooth muscle proliferation
17. 3-Hydroxy-3-methylglutaryl coenzyme A reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
18. Endothelial function and oxidant stress
19. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells
20. Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
21. Upregulation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors
22. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by rho GTPase
23. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down- regulation of p27(Kip1)
24. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension
25. Cholesterol reduction in cardiovascular disease
26. Differential effect of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells
27. Estrogen modulates AT1 receptor gene expression in vitro and in vivo
28. Down-regulation by growth factors of vascular smooth muscle angiotensin receptor gene expression
29. Enhanced AT1 receptor mRNA degradation and induction of polyribosomal mRNA binding proteins by angiotensin II in vascular smooth muscle cells
30. Insulin induces up-regulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms
31. Up-regulation of vascular angiotensin II receptor gene expression by low density lipoprotein in vascular smooth muscle cells
32. Simvastatin, a HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month
33. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone
34. Rac1 disrupts p67phox/p40phox binding. A novel role for rac in NADPH oxidase activation
35. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia: West of Scotland Coronary Prevention Study Group
36. Cell transformation by the superoxide-generating oxidase mox1
37. Angiotensin II receptors and angiotensin II receptor antagonists
38. Statins do more than just lower cholesterol
39. Mechanism of hydrogen peroxide-induced contraction of rat aorta
40. Overview of results of randomized clinical trials in heart disease. II. Unstable angina, heart failure, primary prevention with aspirin, and risk factor modification