Alsin and SOD1G93A proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity

Journal of Biological Chemistry

Volumn 286, Issue 46, 2011, Pages 40151-40162

  Li, Qiang ^a   Spencer, Netanya Y ^a   Pantazis, Nicholas J ^a   Engelhardt, John F ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELL DEATH; CHEMICAL ACTIVATION; MAMMALS; OXYGEN; PROTEINS; REACTIVE OXYGEN SPECIES;

AMYOTROPHIC LATERAL SCLEROSIS; ENDOMEMBRANE COMPARTMENTS; GENE PRODUCTS; GENETIC MUTATIONS; MOTOR NEURONS; NEUROTOXICITY; OVER-EXPRESSION; PROINFLAMMATORY;

NEURONS;

ADENINE; ALSIN; COPPER ZINC SUPEROXIDE DISMUTASE; GUANINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; REGULATOR PROTEIN; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COMPARTMENTALIZATION; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOSOME; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC DISORDER; GLIA CELL; MOTONEURON; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WILD TYPE;

MUS;

EID: 81155154300     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.279711     Document Type: Article

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