Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity

Journal of Immunology

Volumn 179, Issue 2, 2007, Pages 1198-1209

  Qian, Li ^a,b   Kai, Soo Tan ^a,d   Wei, Sung Jen ^c   Wu, Hung Ming ^b,e   Xu, Zongli ^c   Wilson, Belinda ^b   Lu, Ru Bin ^e   Hong, Jau Shyong ^b   Flood, Patrick M ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; LIPOPOLYSACCHARIDE; MORPHINE; OPIATE RECEPTOR; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; HERBICIDE; MITOGEN ACTIVATED PROTEIN KINASE; NARCOTIC AGENT; NEUROPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL MEMBRANE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENANTIOMER; ENZYME ACTIVITY; FEMALE; GLIA CELL; KNOCKOUT MOUSE; MEDIATOR; MESENCEPHALON; MICROGLIA; MOUSE; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; COCULTURE; CONFOCAL MICROSCOPY; ENZYMOLOGY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE MUTANT; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEREOISOMERISM; WESTERN BLOTTING;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; COCULTURE TECHNIQUES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; HERBICIDES; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; MICROGLIA; MICROSCOPY, CONFOCAL; MORPHINE; NADPH OXIDASE; NARCOTICS; NEURONS; NEUROPROTECTIVE AGENTS; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, OPIOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEREOISOMERISM;

EID: 34548806001     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.2.1198     Document Type: Article

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