Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

Journal of Neuroinflammation

Volumn 8, Issue , 2011, Pages

  Zhang, Dan ^a,b   Hu, Xiaoming ^a,c   Qian, Li ^a,d   Chen, Shih Heng ^a,e   Zhou, Hui ^a   Wilson, Belinda ^a   Miller, David S ^a   Hong, Jau Shyong ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; MACROPHAGE ANTIGEN 1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN P47; REACTIVE OXYGEN METABOLITE; SCAVENGER RECEPTOR; SUPEROXIDE; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; AMYLOID BETA PROTEIN; CD11B ANTIGEN; DOPAMINE; NEUTROPHIL CYTOSOLIC FACTOR 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MALE; MESENCEPHALON; MICROGLIA; MOUSE; NERVE CELL CULTURE; NERVE CELL STIMULATION; NEUROTOXICITY; NONHUMAN; PROTEIN DEPLETION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; GENETICS; METABOLISM; MOUSE MUTANT; NERVE CELL; PHYSIOLOGY;

AMYLOID BETA-PEPTIDES; ANIMALS; CELLS, CULTURED; DOPAMINE; ENZYME ACTIVATION; GAMMA-AMINOBUTYRIC ACID; MACROPHAGE-1 ANTIGEN; MALE; MESENCEPHALON; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NADPH OXIDASE; NEURONS; PHOSPHATIDYLINOSITOL 3-KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 78651308665     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-8-3     Document Type: Article

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