The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease

Neuron

Volumn 44, Issue 2, 2004, Pages 227-238

  Hutter Paier, Birgit ^a   Huttunen, Henri J ^b   Puglielli, Luigi ^b   Eckman, Christopher B ^d   Kim, Doo Yeon ^b   Hofmeister, Alexander ^a   Moir, Robert D ^b   Domnitz, Sarah B ^b,c   Frosch, Matthew P ^b,c   Windisch, Manfred ^a   Kovacs, Dora M ^b  

^a JSW Life Sciences GmbH   (Austria)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ESTER; CP 113818; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; FEMALE; LEARNING; MALE; MUTATION; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ADRENAL GLANDS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BLOTTING, WESTERN; BRAIN; CHOLESTEROL ESTERS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; HUMANS; LEARNING; MALE; MICE; MICE, TRANSGENIC; PYRIDINES; SENILE PLAQUES; SEX FACTORS; STEROL O-ACYLTRANSFERASE;

EID: 5144227934     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2004.08.043     Document Type: Article

References (45)

1. Aguzzi A., Haass C. Games played by rogue proteins in prion disorders and Alzheimer's disease. Science. 302:2003;814-818
2. Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T., Prada C.M., Kim G., Seekins S., Yager D., et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron. 17:1996;1005-1013
3. Brou C., Logeat F., Gupta N., Bessia C., LeBail O., Doedens J.R., Cumano A., Roux P., Black R.A., Israel A. A novel proteolytic cleavage involved in Notch signaling. the role of the disintegrin-metalloprotease TACE Mol. Cell. 5:2000;207-216
4. Burns M., Duff K. Cholesterol in Alzheimer's disease and tauopathy. Ann. N Y Acad. Sci. 977:2002;367-375
5. Bush A.I., Pettingell W.H., Multhaup G., d Paradis M., Vonsattel J.P., Gusella J.F., Beyreuther K., Masters C.L., Tanzi R.E. Rapid induction of Alzheimer Aβ amyloid formation by zinc. Science. 265:1994;1464-1467
6. Callahan M.J., Lipinski W.J., Bian F., Durham R.A., Pack A., Walker L.C. Augmented senile plaque load in aged female β-amyloid precursor protein-transgenic mice. Am. J. Pathol. 158:2001;1173-1177
7. Champagne D., Pearson D., Dea D., Rochford J., Poirier J. The cholesterol-lowering drug Probucol increases apolipoprotein e production in the hippocampus of aged rats. implications for Alzheimer's disease Neuroscience. 121:2003;99-110
8. Chang C.C., Sakashita N., Ornvold K., Lee O., Chang E.T., Dong R., Lin S., Lee C.Y., Strom S.C., Kashyap R., et al. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. J. Biol. Chem. 275:2000;28083-28092
9. Chang T.Y., Chang C.C., Lu X., Lin S. Catalysis of ACAT may be completed within the plane of the membrane. A working hypothesis. J. Lipid Res. 42:2001;1933-1938
10. Citron M. Alzheimer's disease. treatments in discovery and development Nat. Neurosci. Suppl. 5:2002;1055-1057
11. Citron M. β-secretase inhibition for the treatment of Alzheimer's disease - promise and challenge. Trends Pharmacol. Sci. 25:2004;92-97
12. Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat. Med. 3:1997;67-72
13. De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active γ-Secretase complex. Neuron. 38:2003;9-12
14. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., et al. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature. 398:1999;518-522
15. Duff K., Eckman C., Zehr C., Yu X., Prada C.M., Perez-tur J., Hutton M., Buee L., Harigaya Y., Yager D., et al. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713
16. Fassbender K., Simons M., Bergmann C., Stroick M., Lutjohann D., Keller P., Runz H., Kuhl S., Bertsch T., von Bergmann K., et al. Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo. Proc. Natl. Acad. Sci. USA. 98:2001;5856-5861
17. Glenner G.G., Wong C.W. Alzheimer's disease. initial report of the purification and characterization of a novel cerebrovascular amyloid protein Biochem. Biophys. Res. Commun. 120:1984;885-890
18. Gu Y., Misonou H., Sato T., Dohmae N., Takio K., Ihara Y. Distinct intramembrane cleavage of the β-amyloid precursor protein family resembling γ-secretase-like cleavage of Notch. J. Biol. Chem. 276:2001;35235-35238
19. Hartmann T. Cholesterol, Aβ and Alzheimer's disease. Trends Neurosci. 24:2001;S45-S48
20. Holcomb L., Gordon M.N., McGowan E., Yu X., Benkovic S., Jantzen P., Wright K., Saad I., Mueller R., Morgan D., et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4:1998;97-100
21. Jarrett J.T., Berger E.P., Lansbury P.T. Jr. The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation. implications for the pathogenesis of Alzheimer's disease Biochemistry. 32:1993;4693-4697
22. Johnson-Wood K., Lee M., Motter R., Hu K., Gordon G., Barbour R., Khan K., Gordon M., Tan H., Games D., et al. Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. USA. 94:1997;1550-1555
23. Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Masters C.L., Grzeschik K.H., Multhaup G., Beyreuther K., Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature. 325:1987;733-736
24. Kawarabayashi T., Younkin L.H., Saido T.C., Shoji M., Ashe K.H., Younkin S.G. Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci. 21:2001;372-381
25. Kim D.Y., Ingano L.A., Kovacs D.M. Nectin-1α, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/γ-secretase-like cleavage. J. Biol. Chem. 277:2002;49976-49981
26. Lee J.Y., Cole T.B., Palmiter R.D., Suh S.W., Koh J.Y. Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Proc. Natl. Acad. Sci. USA. 99:2002;7705-7710
27. Ling Y., Morgan K., Kalsheker N. Amyloid precursor protein (APP) and the biology of proteolytic processing. relevance to Alzheimer's disease Int. J. Biochem. Cell Biol. 35:2003;1505-1535
28. Marambaud P., Wen P.H., Dutt A., Shioi J., Takashima A., Siman R., Robakis N.K. A CBP binding transcriptional repressor produced by the PS1/ε-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell. 114:2003;635-645
29. Marzetta C.A., Savoy Y.E., Freeman A.M., Long C.A., Pettini J.L., Hagar R.E., Inskeep P.B., Davis K., Stucchi A.F., Nicolosi R.J., et al. Pharmacological properties of a novel ACAT inhibitor (CP-113,818) in cholesterol-fed rats, hamsters, rabbits, and monkeys. J. Lipid Res. 35:1994;1829-1838
30. Park I.H., Hwang E.M., Hong H.S., Boo J.H., Oh S.S., Lee J., Jung M.W., Bang O.Y., Kim S.U., Mook-Jung I. Lovastatin enhances Aβ production and senile plaque deposition in female Tg2576 mice. Neurobiol. Aging. 24:2003;637-643
31. Petanceska S.S., DeRosa S., Olm V., Diaz N., Sharma A., Thomas-Bryant T., Duff K., Pappolla M., Refolo L.M. Statin therapy for Alzheimer's disease. will it work? J. Mol. Neurosci. 19:2002;155-161
32. Puglielli L., Konopka G., Pack-Chung E., Ingano L.A., Berezovska O., Hyman B.T., Chang T.Y., Tanzi R.E., Kovacs D.M. Acyl-coenzyme A. cholesterol acyltransferase modulates the generation of the amyloid β-peptide Nat. Cell Biol. 3:2001;905-912
33. Puglielli L., Tanzi R.E., Kovacs D.M. Alzheimer's disease. the cholesterol connection Nat. Neurosci. 6:2003;345-351
34. Refolo L.M., Pappolla M.A., LaFrancois J., Malester B., Schmidt S.D., Thomas-Bryant T., Tint G.S., Wang R., Mercken M., Petanceska S.S., Duff K.E. A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 8:2001;890-899
35. Rockenstein E., Mallory M., Mante M., Sisk A., Masliah E. Early formation of mature amyloid-β protein deposits in a mutant APP transgenic model depends on levels of Aβ(1-42). J. Neurosci. Res. 66:2001;573-582
36. Saido T.C. Alzheimer's disease as proteolytic disorders. anabolism and catabolism of β-amyloid Neurobiol. Aging. 19:1998;S69-S75
37. Selkoe D.J. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature. 399:1999;A23-A31
38. Shah P.K. Emerging non-statin LDL-lowering therapies for dyslipidemia and atherosclerosis. Rev. Cardiovasc. Med. 4:2003;136-141
39. Sinha S., Anderson J.P., Barbour R., Basi G.S., Caccavello R., Davis D., Doan M., Dovey H.F., Frigon N., Hong J., et al. Purification and cloning of amyloid precursor protein β-secretase from human brain. Nature. 402:1999;537-540
40. Suzuki N., Cheung T.T., Cai X.D., Odaka A., Otvos L. Jr., Eckman C., Golde T.E., Younkin S.G. An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (β APP717) mutants. Science. 264:1994;1336-1340
41. Tanzi R.E., Gusella J.F., Watkins P.C., Bruns G.A., St George-Hyslop P., Van Keuren M.L., Patterson D., Pagan S., Kurnit D.M., Neve R.L. Amyloid β protein gene. cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus Science. 235:1987;880-884
42. Vassar R. BACE1. the β-secretase enzyme in alzheimer's disease J. Mol. Neurosci. 23:2004;105-114
43. Wang J., Tanila H., Puolivali J., Kadish I., van Groen T. Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice. Neurobiol. Dis. 14:2003;318-327
44. Wolozin B. Cholesterol and the biology of Alzheimer's disease. Neuron. 41:2004;7-10
45. Xia W., Wolfe M.S. Intramembrane proteolysis by presenilin and presenilin-like proteases. J. Cell Sci. 116:2003;2839-2844