Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells

NeuroToxicology

Volumn 28, Issue 6, 2007, Pages 1079-1091

  Domico, Lisa M ^a   Cooper, Keith R ^a   Bernard, Laura P ^b   Zeevalk, Gail D ^b  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Fungicide; Manganese; NADPH oxidase; Oxidative stress; Parkinson's disease

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; 4 AMINOBUTYRIC ACID; ALLOPURINOL; AMINOTRIAZOLE; APOCYNIN; ASCORBIC ACID; CARBAMATE PESTICIDE; CATALASE; CD11B ANTIGEN; DIPHENYLIODONIUM SALT; DOPAMINE; FLUORESCEIN DERIVATIVE; HYDROGEN PEROXIDE; MANCOZEB; MANEB; MANGANESE; MINOCYCLINE; OXIDOREDUCTASE; OXIDOREDUCTASE INHIBITOR; REACTIVE OXYGEN METABOLITE; SIGNALING LYMPHOCYTE ACTIVATION MOLECULE ASSOCIATED PROTEIN; SUPEROXIDE DISMUTASE; XANTHINE; XANTHINE OXIDASE; ZINC;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL POPULATION; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; MESENCEPHALON; MICROGLIA; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT;

ACETOPHENONES; ALLOPURINOL; AMITROLE; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CATALASE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FUNGICIDES, INDUSTRIAL; HYDROGEN PEROXIDE; MANEB; MESENCEPHALON; MICROGLIA; MINOCYCLINE; MOLECULAR STRUCTURE; NADPH OXIDASE; NEURONS; ONIUM COMPOUNDS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; SUPEROXIDE DISMUTASE; TIME FACTORS; XANTHINE OXIDASE; ZINEB;

EID: 35648932406     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2007.04.008     Document Type: Article

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