-
1
-
-
33747376928
-
DNA repair pathways in clinical practice: Lessons from pediatric cancer susceptibility syndromes
-
DOI 10.1200/JCO.2005.05.4171
-
R.D. Kennedy, and A.D. D'Andrea DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes J Clin Oncol 24 2006 3799 3808 (Pubitemid 46622318)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.23
, pp. 3799-3808
-
-
Kennedy, R.D.1
D'Andrea, A.D.2
-
2
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
DOI 10.1038/nature03097
-
M.B. Kastan, and J. Bartek Cell-cycle checkpoints and cancer Nature 432 2004 316 323 (Pubitemid 39551659)
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
3
-
-
61449182121
-
Principles of cancer therapy: Oncogene and non-oncogene addiction
-
J. Luo, N.L. Solimini, and S.J. Elledge Principles of cancer therapy: oncogene and non-oncogene addiction Cell 136 2009 823 837
-
(2009)
Cell
, vol.136
, pp. 823-837
-
-
Luo, J.1
Solimini, N.L.2
Elledge, S.J.3
-
4
-
-
0034614637
-
The hallmarks of cancer
-
D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70 (Pubitemid 30046295)
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
5
-
-
0036561908
-
Modelling the molecular circuitry of cancer
-
W.C. Hahn, and R.A. Weinberg Modelling the molecular circuitry of cancer Nat Rev Cancer 2 2002 331 341 (Pubitemid 37328946)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.5
, pp. 331-341
-
-
Hahn, W.C.1
Weinberg, R.A.2
-
6
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
S. Jones, X. Zhang, D.W. Parsons, J.C. Lin, R.J. Leary, and P. Angenendt Core signaling pathways in human pancreatic cancers revealed by global genomic analyses Science 321 2008 1801 1806
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
-
7
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
DOI 10.1038/sj.onc.1210422, PII 1210422
-
P.J. Roberts, and C.J. Der Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer Oncogene 26 2007 3291 3310 (Pubitemid 46763022)
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3291-3310
-
-
Roberts, P.J.1
Der, C.J.2
-
9
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
B.J. Druker, S. Tamura, E. Buchdunger, S. Ohno, G.M. Segal, and S. Fanning Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells Nat Med 2 1996 561 566
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
-
10
-
-
0038311995
-
Ras family signaling: Therapeutic targeting
-
A.D. Cox, and C.J. Der Ras family signaling: therapeutic targeting Cancer Biol Ther 1 2002 599 606
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 599-606
-
-
Cox, A.D.1
Der, C.J.2
-
11
-
-
69249219178
-
Targeting the mevalonate pathway for improved anticancer therapy
-
G. Fritz Targeting the mevalonate pathway for improved anticancer therapy Curr Cancer Drug Targets 9 2009 626 638
-
(2009)
Curr Cancer Drug Targets
, vol.9
, pp. 626-638
-
-
Fritz, G.1
-
12
-
-
0026480293
-
Cancer risks from germline p53 mutations
-
T. Frebourg, and S.H. Friend Cancer risks from germline p53 mutations J Clin Invest 90 1992 1637 1641
-
(1992)
J Clin Invest
, vol.90
, pp. 1637-1641
-
-
Frebourg, T.1
Friend, S.H.2
-
13
-
-
0030933152
-
The genetic defect in ataxia-telangiectasia
-
DOI 10.1146/annurev.immunol.15.1.177
-
M.F. Lavin, and Y. Shiloh The genetic defect in ataxia-telangiectasia Annu Rev Immunol 15 1997 177 202 (Pubitemid 27169279)
-
(1997)
Annual Review of Immunology
, vol.15
, pp. 177-202
-
-
Lavin, M.F.1
Shiloh, Y.2
-
14
-
-
0942268166
-
DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
-
DOI 10.1016/j.biochi.2003.09.010
-
A.R. Lehmann DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy Biochimie 85 2003 1101 1111 (Pubitemid 38142364)
-
(2003)
Biochimie
, vol.85
, Issue.11
, pp. 1101-1111
-
-
Lehmann, A.R.1
-
15
-
-
0345073699
-
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
-
DOI 10.1038/ng1129
-
M. O'Driscoll, V.L. Ruiz-Perez, C.G. Woods, P.A. Jeggo, and J.A. Goodship A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome Nat Genet 33 2003 497 501 (Pubitemid 36390012)
-
(2003)
Nature Genetics
, vol.33
, Issue.4
, pp. 497-501
-
-
O'Driscoll, M.1
Ruiz-Perez, V.L.2
Woods, C.G.3
Jeggo, P.A.4
Goodship, J.A.5
-
16
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
DOI 10.1038/nrc1011
-
Y. Shiloh ATM and related protein kinases: safeguarding genome integrity Nat Rev Cancer 3 2003 155 168 (Pubitemid 37328868)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.3
, pp. 155-168
-
-
Shiloh, Y.1
-
17
-
-
3242889151
-
Ataxia-telangiectasia-like disorder (ATLD) - Its clinical presentation and molecular basis
-
DOI 10.1016/j.dnarep.2004.04.009, PII S1568786404001405
-
A.M. Taylor, A. Groom, and P.J. Byrd Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis DNA Repair (Amst) 3 2004 1219 1225 (Pubitemid 38997965)
-
(2004)
DNA Repair
, vol.3
, Issue.8-9
, pp. 1219-1225
-
-
Taylor, A.M.R.1
Groom, A.2
Byrd, P.J.3
-
18
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
DOI 10.1038/nature03482
-
J. Bartkova, Z. Horejsi, K. Koed, A. Kramer, F. Tort, and K. Zieger DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis Nature 434 2005 864 870 (Pubitemid 40558993)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
Kramer, A.4
Tort, F.5
Zleger, K.6
Guldberg, P.7
Sehested, M.8
Nesland, J.M.9
Lukas, C.10
Orntoft, T.11
Lukas, J.12
Bartek, J.13
-
19
-
-
33749039966
-
The CHEK2 gene and inherited breast cancer susceptibility
-
DOI 10.1038/sj.onc.1209877, PII 1209877
-
H. Nevanlinna, and J. Bartek The CHEK2 gene and inherited breast cancer susceptibility Oncogene 25 2006 5912 5919 (Pubitemid 44453447)
-
(2006)
Oncogene
, vol.25
, Issue.43
, pp. 5912-5919
-
-
Nevanlinna, H.1
Bartek, J.2
-
20
-
-
36448996703
-
Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
-
DOI 10.1038/nrc2054, PII NRC2054
-
J.D. Fackenthal, and O.I. Olopade Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations Nat Rev Cancer 7 2007 937 948 (Pubitemid 350165853)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.12
, pp. 937-948
-
-
Fackenthal, J.D.1
Olopade, O.I.2
-
21
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
B.B. Zhou, and S.J. Elledge The DNA damage response: putting checkpoints in perspective Nature 408 2000 433 439
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
-
22
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
DOI 10.1016/S1535-6108(03)00110-7, PII S1535610803001107
-
J. Bartek, and J. Lukas Chk1 and Chk2 kinases in checkpoint control and cancer Cancer Cell 3 2003 421 429 (Pubitemid 38340288)
-
(2003)
Cancer Cell
, vol.3
, Issue.5
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
23
-
-
36749022214
-
The DNA Damage Response: Ten Years After
-
DOI 10.1016/j.molcel.2007.11.015, PII S1097276507007836
-
J.W. Harper, and S.J. Elledge The DNA damage response: ten years after Mol Cell 28 2007 739 745 (Pubitemid 350217064)
-
(2007)
Molecular Cell
, vol.28
, Issue.5
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
24
-
-
63749131243
-
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
-
H.C. Reinhardt, and M.B. Yaffe Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2 Curr Opin Cell Biol 21 2009 245 255
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 245-255
-
-
Reinhardt, H.C.1
Yaffe, M.B.2
-
25
-
-
11344286593
-
2 /M transition and S phase progression in response to UV irradiation
-
DOI 10.1016/j.molcel.2004.11.021, PII S1097276504007129
-
I.A. Manke, A. Nguyen, D. Lim, M.Q. Stewart, A.E. Elia, and M.B. Yaffe MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation Mol Cell 17 2005 37 48 (Pubitemid 40075363)
-
(2005)
Molecular Cell
, vol.17
, Issue.1
, pp. 37-48
-
-
Manke, I.A.1
Nguyen, A.2
Lim, D.3
Stewart, M.Q.4
Elia, A.E.H.5
Yaffe, M.B.6
-
26
-
-
33846821915
-
P53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage
-
DOI 10.1016/j.ccr.2006.11.024, PII S1535610806003825
-
H.C. Reinhardt, A.S. Aslanian, J.A. Lees, and M.B. Yaffe p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage Cancer Cell 11 2007 175 189 (Pubitemid 46209849)
-
(2007)
Cancer Cell
, vol.11
, Issue.2
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
27
-
-
77957361354
-
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization
-
H.C. Reinhardt, P. Hasskamp, I. Schmedding, S. Morandell, M.A. van Vugt, and X. Wang DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization Mol Cell 40 2010 34 49
-
(2010)
Mol Cell
, vol.40
, pp. 34-49
-
-
Reinhardt, H.C.1
Hasskamp, P.2
Schmedding, I.3
Morandell, S.4
Van Vugt, M.A.5
Wang, X.6
-
28
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
DOI 10.1038/sj.onc.1208615
-
S.L. Harris, and A.J. Levine The p53 pathway: positive and negative feedback loops Oncogene 24 2005 2899 2908 (Pubitemid 40638098)
-
(2005)
Oncogene
, vol.24
, Issue.17
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
30
-
-
1542353401
-
Control of apoptosis by p53
-
DOI 10.1038/sj.onc.1207116, Apoptosis - Part 2
-
J.S. Fridman, and S.W. Lowe Control of apoptosis by p53 Oncogene 22 2003 9030 9040 (Pubitemid 38121703)
-
(2003)
Oncogene
, vol.22
, Issue.56 REV. ISS. 8
, pp. 9030-9040
-
-
Fridman, J.S.1
Lowe, S.W.2
-
31
-
-
0036674617
-
Live or let die: The cell's response to p53
-
DOI 10.1038/nrc864
-
K.H. Vousden, and X. Lu Live or let die: the cell's response to p53 Nat Rev Cancer 2 2002 594 604 (Pubitemid 37328926)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.8
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
32
-
-
0043066731
-
Regulating mammalian checkpoints through Cdc25 inactivation
-
DOI 10.1038/sj.embor.embor887
-
M. Donzelli, and G.F. Draetta Regulating mammalian checkpoints through Cdc25 inactivation EMBO Rep 4 2003 671 677 (Pubitemid 36974751)
-
(2003)
EMBO Reports
, vol.4
, Issue.7
, pp. 671-677
-
-
Donzelli, M.1
Draetta, G.F.2
-
33
-
-
0347361537
-
β-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
-
DOI 10.1101/gad.1157503
-
J. Jin, T. Shirogane, L. Xu, G. Nalepa, J. Qin, and S.J. Elledge SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase Genes Dev 17 2003 3062 3074 (Pubitemid 38040770)
-
(2003)
Genes and Development
, vol.17
, Issue.24
, pp. 3062-3074
-
-
Jin, J.1
Shirogane, T.2
Xu, L.3
Nalepa, G.4
Qin, J.5
Elledge, S.J.6
Harper, J.W.7
-
34
-
-
0012966157
-
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
-
DOI 10.1016/S1535-6108(03)00048-5
-
C.S. Sorensen, R.G. Syljuasen, J. Falck, T. Schroeder, L. Ronnstrand, and K.K. Khanna Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A Cancer Cell 3 2003 247 258 (Pubitemid 37443880)
-
(2003)
Cancer Cell
, vol.3
, Issue.3
, pp. 247-258
-
-
Sorensen, C.S.1
Syljuasen, R.G.2
Falck, J.3
Schroeder, T.4
Ronnstrand, L.5
Khanna, K.K.6
Zhou, B.-B.7
Bartek, J.8
Lukas, J.9
-
35
-
-
0032746942
-
DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding
-
Y. Zeng, and H. Piwnica-Worms DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding Mol Cell Biol 19 1999 7410 7419 (Pubitemid 29493404)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.11
, pp. 7410-7419
-
-
Zeng, Y.1
Piwnica-Worms, H.2
-
36
-
-
80455160346
-
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis
-
A.K. Gardino, and M.B. Yaffe 14-3-3 proteins as signaling integration points for cell cycle control and apoptosis Semin Cell Dev Biol 22 2011 688 695
-
(2011)
Semin Cell Dev Biol
, vol.22
, pp. 688-695
-
-
Gardino, A.K.1
Yaffe, M.B.2
-
37
-
-
70349912096
-
Exploiting synthetic lethal interactions for targeted cancer therapy
-
H.C. Reinhardt, H. Jiang, M.T. Hemann, and M.B. Yaffe Exploiting synthetic lethal interactions for targeted cancer therapy Cell Cycle 8 2009 3112 3119
-
(2009)
Cell Cycle
, vol.8
, pp. 3112-3119
-
-
Reinhardt, H.C.1
Jiang, H.2
Hemann, M.T.3
Yaffe, M.B.4
-
38
-
-
84872625067
-
Genetics of Natural Populations. Xiii. Recombination and Variability in Populations of Drosophila Pseudoobscura
-
T. Dobzhansky Genetics of Natural Populations. Xiii. Recombination and Variability in Populations of Drosophila Pseudoobscura Genetics 31 1946 269 290
-
(1946)
Genetics
, vol.31
, pp. 269-290
-
-
Dobzhansky, T.1
-
39
-
-
0035830860
-
Principles for the buffering of genetic variation
-
J.L. Hartman, B. Garvik, and L. Hartwell Principles for the buffering of genetic variation Science 291 2001 1001 1004
-
(2001)
Science
, vol.291
, pp. 1001-1004
-
-
Hartman, J.L.1
Garvik, B.2
Hartwell, L.3
-
40
-
-
25444497278
-
The concept of synthetic lethality in the context of anticancer therapy
-
DOI 10.1038/nrc1691, PII N1691
-
W.G. Kaelin Jr. The concept of synthetic lethality in the context of anticancer therapy Nat Rev Cancer 5 2005 689 698 (Pubitemid 41486362)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.9
, pp. 689-698
-
-
Kaelin Jr., W.G.1
-
41
-
-
0030667434
-
Integrating genetic approaches into the discovery of anticancer drugs
-
DOI 10.1126/science.278.5340.1064
-
L.H. Hartwell, P. Szankasi, C.J. Roberts, A.W. Murray, and S.H. Friend Integrating genetic approaches into the discovery of anticancer drugs Science 278 1997 1064 1068 (Pubitemid 27517876)
-
(1997)
Science
, vol.278
, Issue.5340
, pp. 1064-1068
-
-
Hartwell, L.H.1
Szankasi, P.2
Roberts, C.J.3
Murray, A.W.4
Friend, S.H.5
-
42
-
-
55949101858
-
Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen
-
A. Bommi-Reddy, I. Almeciga, J. Sawyer, C. Geisen, W. Li, and E. Harlow Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen Proc Natl Acad Sci U S A 105 2008 16484 16489
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16484-16489
-
-
Bommi-Reddy, A.1
Almeciga, I.2
Sawyer, J.3
Geisen, C.4
Li, W.5
Harlow, E.6
-
43
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
DOI 10.1038/nature03443
-
H.E. Bryant, N. Schultz, H.D. Thomas, K.M. Parker, D. Flower, and E. Lopez Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase Nature 434 2005 913 917 (Pubitemid 40559005)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
Kyle, S.7
Meuth, M.8
Curtin, N.J.9
Helleday, T.10
-
44
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
DOI 10.1038/nature03445
-
H. Farmer, N. McCabe, C.J. Lord, A.N. Tutt, D.A. Johnson, and T.B. Richardson Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 434 2005 917 921 (Pubitemid 40559006)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 917-921
-
-
Farmer, H.1
McCabe, H.2
Lord, C.J.3
Tutt, A.H.J.4
Johnson, D.A.5
Richardson, T.B.6
Santarosa, M.7
Dillon, K.J.8
Hickson, I.9
Knights, C.10
Martin, N.M.B.11
Jackson, S.P.12
Smith, G.C.M.13
Ashworth, A.14
-
45
-
-
0035902108
-
Genome maintenance mechanisms for preventing cancer
-
DOI 10.1038/35077232
-
J.H. Hoeijmakers Genome maintenance mechanisms for preventing cancer Nature 411 2001 366 374 (Pubitemid 32467046)
-
(2001)
Nature
, vol.411
, Issue.6835
, pp. 366-374
-
-
Hoeijmakers, J.H.J.1
-
47
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
P.C. Fong, D.S. Boss, T.A. Yap, A. Tutt, P. Wu, and M. Mergui-Roelvink Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers N Engl J Med 361 2009 123 134
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
Mergui-Roelvink, M.6
-
48
-
-
77955039099
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
-
M.W. Audeh, J. Carmichael, R.T. Penson, M. Friedlander, B. Powell, and K.M. Bell-McGuinn Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial Lancet 376 2010 245 251
-
(2010)
Lancet
, vol.376
, pp. 245-251
-
-
Audeh, M.W.1
Carmichael, J.2
Penson, R.T.3
Friedlander, M.4
Powell, B.5
Bell-Mcguinn, K.M.6
-
49
-
-
77954032829
-
Poly(ADP)-ribose polymerase inhibition: Frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval
-
P.C. Fong, T.A. Yap, D.S. Boss, C.P. Carden, M. Mergui-Roelvink, and C. Gourley Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval J Clin Oncol 28 2010 2512 2519
-
(2010)
J Clin Oncol
, vol.28
, pp. 2512-2519
-
-
Fong, P.C.1
Yap, T.A.2
Boss, D.S.3
Carden, C.P.4
Mergui-Roelvink, M.5
Gourley, C.6
-
50
-
-
77955019276
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
-
A. Tutt, M. Robson, J.E. Garber, S.M. Domchek, M.W. Audeh, and J.N. Weitzel Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial Lancet 376 2010 235 244
-
(2010)
Lancet
, vol.376
, pp. 235-244
-
-
Tutt, A.1
Robson, M.2
Garber, J.E.3
Domchek, S.M.4
Audeh, M.W.5
Weitzel, J.N.6
-
51
-
-
71049139405
-
Poly(ADP-ribose) polymerase inhibitors in cancer treatment: A clinical perspective
-
S.K. Sandhu, T.A. Yap, and J.S. de Bono Poly(ADP-ribose) polymerase inhibitors in cancer treatment: a clinical perspective Eur J Cancer 46 2010 9 20
-
(2010)
Eur J Cancer
, vol.46
, pp. 9-20
-
-
Sandhu, S.K.1
Yap, T.A.2
De Bono, J.S.3
-
52
-
-
67650476607
-
Synthetic lethality - A new direction in cancer-drug development
-
J.D. Iglehart, and D.P. Silver Synthetic lethality - a new direction in cancer-drug development N Engl J Med 361 2009 189 191
-
(2009)
N Engl J Med
, vol.361
, pp. 189-191
-
-
Iglehart, J.D.1
Silver, D.P.2
-
53
-
-
49249119415
-
A synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
-
A. Ashworth A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair J Clin Oncol 26 2008 3785 3790
-
(2008)
J Clin Oncol
, vol.26
, pp. 3785-3790
-
-
Ashworth, A.1
-
54
-
-
84885935321
-
-
ClinicalTrials.gov, A service of the U.S. National Institute of Health; (n.d.)
-
ClinicalTrials.gov, A service of the U.S. National Institute of Health; (n.d.); retrieved from www.clinicaltrials.gov
-
-
-
-
55
-
-
0028922462
-
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
-
Z.Q. Wang, B. Auer, L. Stingl, H. Berghammer, D. Haidacher, and M. Schweiger Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease Genes Dev 9 1995 509 520
-
(1995)
Genes Dev
, vol.9
, pp. 509-520
-
-
Wang, Z.Q.1
Auer, B.2
Stingl, L.3
Berghammer, H.4
Haidacher, D.5
Schweiger, M.6
-
56
-
-
34249948702
-
Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice
-
DOI 10.1038/sj.onc.1210156, PII 1210156
-
W.M. Tong, Y.G. Yang, W.H. Cao, D. Galendo, L. Frappart, and Y. Shen Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice Oncogene 26 2007 3857 3867 (Pubitemid 46878132)
-
(2007)
Oncogene
, vol.26
, Issue.26
, pp. 3857-3867
-
-
Tong, W.M.1
Yang, Y.G.2
Cao, W.H.3
Galendo, D.4
Frappart, L.5
Shen, Y.6
Wang, Z.Q.7
-
57
-
-
39849097680
-
Resistance to therapy caused by intragenic deletion in BRCA2
-
DOI 10.1038/nature06548, PII NATURE06548
-
S.L. Edwards, R. Brough, C.J. Lord, R. Natrajan, R. Vatcheva, and D.A. Levine Resistance to therapy caused by intragenic deletion in BRCA2 Nature 451 2008 1111 1115 (Pubitemid 351317441)
-
(2008)
Nature
, vol.451
, Issue.7182
, pp. 1111-1115
-
-
Edwards, S.L.1
Brough, R.2
Lord, C.J.3
Natrajan, R.4
Vatcheva, R.5
Levine, D.A.6
Boyd, J.7
Reis-Filho, J.S.8
Ashworth, A.9
-
58
-
-
39849106300
-
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
-
DOI 10.1038/nature06633, PII NATURE06633
-
W. Sakai, E.M. Swisher, B.Y. Karlan, M.K. Agarwal, J. Higgins, and C. Friedman Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers Nature 451 2008 1116 1120 (Pubitemid 351317449)
-
(2008)
Nature
, vol.451
, Issue.7182
, pp. 1116-1120
-
-
Sakai, W.1
Swisher, E.M.2
Karlan, B.Y.3
Agarwal, M.K.4
Higgins, J.5
Friedman, C.6
Villegas, E.7
Jacquemont, C.8
Farrugia, D.J.9
Couch, F.J.10
Urban, N.11
Taniguchi, T.12
-
59
-
-
34250010317
-
Chk1 regulates the density of active replication origins during the vertebrate S phase
-
DOI 10.1038/sj.emboj.7601714, PII 7601714
-
A. Maya-Mendoza, E. Petermann, D.A. Gillespie, K.W. Caldecott, and D.A. Jackson Chk1 regulates the density of active replication origins during the vertebrate S phase EMBO J 26 2007 2719 2731 (Pubitemid 46884282)
-
(2007)
EMBO Journal
, vol.26
, Issue.11
, pp. 2719-2731
-
-
Maya-Mendoza, A.1
Petermann, E.2
Gillespie, D.A.F.3
Caldecott, K.W.4
Jackson, D.A.5
-
60
-
-
47749141560
-
ATR: An essential regulator of genome integrity
-
DOI 10.1038/nrm2450, PII NRM2450
-
K.A. Cimprich, and D. Cortez ATR: an essential regulator of genome integrity Nat Rev Mol Cell Biol 9 2008 616 627 (Pubitemid 352032926)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.8
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
61
-
-
34250865564
-
CDC25 phosphatases in cancer cells: Key players? Good targets?
-
DOI 10.1038/nrc2169, PII NRC2169
-
R. Boutros, V. Lobjois, and B. Ducommun CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer 7 2007 495 507 (Pubitemid 46985396)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.7
, pp. 495-507
-
-
Boutros, R.1
Lobjois, V.2
Ducommun, B.3
-
63
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
E.J. Brown, and D. Baltimore ATR disruption leads to chromosomal fragmentation and early embryonic lethality Genes Dev 14 2000 397 402 (Pubitemid 30131885)
-
(2000)
Genes and Development
, vol.14
, Issue.4
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
64
-
-
17644432403
-
2 /M DNA damage checkpoint
-
Q. Liu, S. Guntuku, X.S. Cui, S. Matsuoka, D. Cortez, and K. Tamai Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint Genes Dev 14 2000 1448 1459 (Pubitemid 30421838)
-
(2000)
Genes and Development
, vol.14
, Issue.12
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.-S.3
Matsuoka, S.4
Cortez, D.5
Tamai, K.6
Luo, G.7
Carattini-Rivera, S.8
DeMayo, F.9
Bradley, A.10
Donehower, L.A.11
Elledge, S.J.12
-
65
-
-
0034659341
-
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
-
H. Takai, K. Tominaga, N. Motoyama, Y.A. Minamishima, H. Nagahama, and T. Tsukiyama Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice Genes Dev 14 2000 1439 1447 (Pubitemid 30421837)
-
(2000)
Genes and Development
, vol.14
, Issue.12
, pp. 1439-1447
-
-
Takai, H.1
Tominaga, K.2
Motoyama, N.3
Minamishima, Y.A.4
Nagahama, H.5
Tsukiyama, T.6
Ikeda, K.7
Nakayama, K.8
Nakanishi, M.9
Nakayama, K.-I.10
-
66
-
-
0025598852
-
Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C
-
I. Takahashi, E. Kobayashi, H. Nakano, C. Murakata, H. Saitoh, and K. Suzuki Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C J Pharmacol Exp Ther 255 1990 1218 1221
-
(1990)
J Pharmacol Exp Ther
, vol.255
, pp. 1218-1221
-
-
Takahashi, I.1
Kobayashi, E.2
Nakano, H.3
Murakata, C.4
Saitoh, H.5
Suzuki, K.6
-
67
-
-
0034053130
-
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
-
DOI 10.1074/jbc.275.8.5600
-
P.R. Graves, L. Yu, J.K. Schwarz, J. Gales, E.A. Sausville, and P.M. O'Connor The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01 J Biol Chem 275 2000 5600 5605 (Pubitemid 30115197)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.8
, pp. 5600-5605
-
-
Graves, P.R.1
Yu, L.2
Schwarz, J.K.3
Gales, J.4
Sausville, E.A.5
O'Connor, P.M.6
Piwnica-Worms, H.7
-
68
-
-
0034655281
-
The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
-
E.C. Busby, D.F. Leistritz, R.T. Abraham, L.M. Karnitz, and J.N. Sarkaria The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1 Cancer Res 60 2000 2108 2112 (Pubitemid 30225168)
-
(2000)
Cancer Research
, vol.60
, Issue.8
, pp. 2108-2112
-
-
Busby, E.C.1
Leistritz, D.F.2
Abraham, R.T.3
Karnitz, L.M.4
Sarkaria, J.N.5
-
69
-
-
0037034928
-
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)
-
DOI 10.1038/sj/onc/1205225
-
S. Sato, N. Fujita, and T. Tsuruo Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine) Oncogene 21 2002 1727 1738 (Pubitemid 34259036)
-
(2002)
Oncogene
, vol.21
, Issue.11
, pp. 1727-1738
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
70
-
-
0029992520
-
2 -checkpoint inhibitor
-
R.T. Bunch, and A. Eastman Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor Clin Cancer Res 2 1996 791 797 (Pubitemid 26168931)
-
(1996)
Clinical Cancer Research
, vol.2
, Issue.5
, pp. 791-797
-
-
Bunch, R.T.1
Eastman, A.2
-
71
-
-
39749185974
-
2 arrest
-
DOI 10.1158/1535-7163.MCT-07-2066
-
A.A. Levesque, A.A. Fanous, A. Poh, and A. Eastman Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest Mol Cancer Ther 7 2008 252 262 (Pubitemid 351302519)
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, Issue.2
, pp. 252-262
-
-
Levesque, A.A.1
Fanous, A.A.2
Poh, A.3
Eastman, A.4
-
72
-
-
0029895439
-
2 checkpoint function in cancer cells with disrupted p53
-
DOI 10.1093/jnci/88.14.956
-
Q. Wang, S. Fan, A. Eastman, P.J. Worland, E.A. Sausville, and P.M. O'Connor UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53 J Natl Cancer Inst 88 1996 956 965 (Pubitemid 26239383)
-
(1996)
Journal of the National Cancer Institute
, vol.88
, Issue.14
, pp. 956-965
-
-
Wang, Q.1
Fan, S.2
Eastman, A.3
Worland, P.J.4
Sausville, E.A.5
O'Connor, P.M.6
-
73
-
-
79959604565
-
A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies
-
P.M. Fracasso, K.J. Williams, R.C. Chen, J. Picus, C.X. Ma, and M.J. Ellis A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies Cancer Chemother Pharmacol 67 2011 1225 1237
-
(2011)
Cancer Chemother Pharmacol
, vol.67
, pp. 1225-1237
-
-
Fracasso, P.M.1
Williams, K.J.2
Chen, R.C.3
Picus, J.4
Ma, C.X.5
Ellis, M.J.6
-
74
-
-
79651470785
-
Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
-
C.X. Ma, J.W. Janetka, and H. Piwnica-Worms Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics Trends Mol Med 17 2011 88 96
-
(2011)
Trends Mol Med
, vol.17
, pp. 88-96
-
-
Ma, C.X.1
Janetka, J.W.2
Piwnica-Worms, H.3
-
75
-
-
79957880430
-
ATR mediates cisplatin resistance in a p53 genotype-specific manner
-
N. Sangster-Guity, B.H. Conrad, N. Papadopoulos, and F. Bunz ATR mediates cisplatin resistance in a p53 genotype-specific manner Oncogene 30 2011 2526 2533
-
(2011)
Oncogene
, vol.30
, pp. 2526-2533
-
-
Sangster-Guity, N.1
Conrad, B.H.2
Papadopoulos, N.3
Bunz, F.4
-
76
-
-
34247332735
-
Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation
-
DOI 10.1038/sj.onc.1210049, PII 1210049
-
P.J. Hurley, D. Wilsker, and F. Bunz Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation Oncogene 26 2007 2535 2542 (Pubitemid 46632006)
-
(2007)
Oncogene
, vol.26
, Issue.18
, pp. 2535-2542
-
-
Hurley, P.J.1
Wilsker, D.2
Bunz, F.3
-
77
-
-
11044234004
-
Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway
-
DOI 10.1093/hmg/ddh335
-
G.K. Alderton, H. Joenje, R. Varon, A.D. Borglum, P.A. Jeggo, and M. O'Driscoll Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway Hum Mol Genet 13 2004 3127 3138 (Pubitemid 40045265)
-
(2004)
Human Molecular Genetics
, vol.13
, Issue.24
, pp. 3127-3138
-
-
Alderton, G.K.1
Joenje, H.2
Varon, R.3
Borglum, A.D.4
Jeggo, P.A.5
O'Driscoll, M.6
-
78
-
-
34248158210
-
Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival
-
DOI 10.1158/1535-7163.MCT-06-0679
-
D. Wilsker, and F. Bunz Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival Mol Cancer Ther 6 2007 1406 1413 (Pubitemid 46712004)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.4
, pp. 1406-1413
-
-
Wilsker, D.1
Bunz, F.2
-
79
-
-
69249240178
-
The combined status of ATM and p53 link tumor development with therapeutic response
-
H. Jiang, H.C. Reinhardt, J. Bartkova, J. Tommiska, C. Blomqvist, and H. Nevanlinna The combined status of ATM and p53 link tumor development with therapeutic response Genes Dev 23 2009 1895 1909
-
(2009)
Genes Dev
, vol.23
, pp. 1895-1909
-
-
Jiang, H.1
Reinhardt, H.C.2
Bartkova, J.3
Tommiska, J.4
Blomqvist, C.5
Nevanlinna, H.6
-
80
-
-
79958865837
-
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
-
L.I. Toledo, M. Murga, R. Zur, R. Soria, A. Rodriguez, and S. Martinez A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations Nat Struct Mol Biol 18 2011 721 727
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 721-727
-
-
Toledo, L.I.1
Murga, M.2
Zur, R.3
Soria, R.4
Rodriguez, A.5
Martinez, S.6
-
81
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
S.M. Maira, F. Stauffer, J. Brueggen, P. Furet, C. Schnell, and C. Fritsch Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity Mol Cancer Ther 7 2008 1851 1863
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1851-1863
-
-
Maira, S.M.1
Stauffer, F.2
Brueggen, J.3
Furet, P.4
Schnell, C.5
Fritsch, C.6
-
82
-
-
79953773734
-
Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents
-
J.D. Charrier, S.J. Durrant, J.M. Golec, D.P. Kay, R.M. Knegtel, and S. MacCormick Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents J Med Chem 54 2011 2320 2330
-
(2011)
J Med Chem
, vol.54
, pp. 2320-2330
-
-
Charrier, J.D.1
Durrant, S.J.2
Golec, J.M.3
Kay, D.P.4
Knegtel, R.M.5
MacCormick, S.6
-
83
-
-
79959376888
-
Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
-
P.M. Reaper, M.R. Griffiths, J.M. Long, J.D. Charrier, S. Maccormick, and P.A. Charlton Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR Nat Chem Biol 7 2011 428 430
-
(2011)
Nat Chem Biol
, vol.7
, pp. 428-430
-
-
Reaper, P.M.1
Griffiths, M.R.2
Long, J.M.3
Charrier, J.D.4
MacCormick, S.5
Charlton, P.A.6
-
84
-
-
78649929369
-
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner
-
O. Gilad, B.Y. Nabet, R.L. Ragland, D.W. Schoppy, K.D. Smith, and A.C. Durham Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner Cancer Res 70 2010 9693 9702
-
(2010)
Cancer Res
, vol.70
, pp. 9693-9702
-
-
Gilad, O.1
Nabet, B.Y.2
Ragland, R.L.3
Schoppy, D.W.4
Smith, K.D.5
Durham, A.C.6
-
85
-
-
3142552523
-
Chk1 is haploinsufficient for multiple functions critical to tumor suppression
-
DOI 10.1016/j.ccr.2004.06.015, PII S1535610804001758
-
M.H. Lam, Q. Liu, S.J. Elledge, and J.M. Rosen Chk1 is haploinsufficient for multiple functions critical to tumor suppression Cancer Cell 6 2004 45 59 (Pubitemid 38903161)
-
(2004)
Cancer Cell
, vol.6
, Issue.1
, pp. 45-59
-
-
Lam, M.H.1
Liu, Q.2
Elledge, S.J.3
Rosen, J.M.4
-
86
-
-
0035503171
-
Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability
-
A. Menoyo, H. Alazzouzi, E. Espin, M. Armengol, H. Yamamoto, and S. Schwartz Jr. Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability Cancer Res 61 2001 7727 7730 (Pubitemid 33049356)
-
(2001)
Cancer Research
, vol.61
, Issue.21
, pp. 7727-7730
-
-
Menoyo, A.1
Alazzouzi, H.2
Espin, E.3
Armengol, M.4
Yamamoto, H.5
Schwartz Jr., S.6
-
87
-
-
0037099597
-
Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability
-
V. Vassileva, A. Millar, L. Briollais, W. Chapman, and B. Bapat Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability Cancer Res 62 2002 4095 4099 (Pubitemid 34791080)
-
(2002)
Cancer Research
, vol.62
, Issue.14
, pp. 4095-4099
-
-
Vassileva, V.1
Millar, A.2
Briollais, L.3
Chapman, W.4
Bapat, B.5
-
88
-
-
35348970340
-
Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase I DNA damage response axis in colon cancers
-
DOI 10.1002/gcc.20486
-
K.A. Lewis, J. Bakkum-Gamez, R. Loewen, A.J. French, S.N. Thibodeau, and W.A. Cliby Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers Genes Chromosomes Cancer 46 2007 1061 1068 (Pubitemid 47614540)
-
(2007)
Genes Chromosomes and Cancer
, vol.46
, Issue.12
, pp. 1061-1068
-
-
Lewis, K.A.1
Bakkum-Gamez, J.2
Loewen, R.3
French, A.J.4
Thibodeau, S.N.5
Cliby, W.A.6
-
89
-
-
0038011619
-
Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites
-
DOI 10.1093/annonc/mdg240
-
A. Fedier, M. Schlamminger, V.A. Schwarz, U. Haller, S.B. Howell, and D. Fink Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites Ann Oncol 14 2003 938 945 (Pubitemid 36827211)
-
(2003)
Annals of Oncology
, vol.14
, Issue.6
, pp. 938-945
-
-
Fedier, A.1
Schlamminger, M.2
Schwarz, V.A.3
Haller, U.4
Howell, S.B.5
Fink, D.6
-
90
-
-
0034141562
-
The controlling role of ATM in homologous recombinational repair of DNA damage
-
C. Morrison, E. Sonoda, N. Takao, A. Shinohara, K. Yamamoto, and S. Takeda The controlling role of ATM in homologous recombinational repair of DNA damage EMBO J 19 2000 463 471 (Pubitemid 30072616)
-
(2000)
EMBO Journal
, vol.19
, Issue.3
, pp. 463-471
-
-
Morrison, C.1
Sonoda, E.2
Takao, N.3
Shinohara, A.4
Yamamoto, K.-I.5
Takeda, S.6
-
91
-
-
1642556817
-
A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity
-
DOI 10.1158/0008-5472.CAN-03-2384
-
M. Kuhne, E. Riballo, N. Rief, K. Rothkamm, P.A. Jeggo, and M. Lobrich A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity Cancer Res 64 2004 500 508 (Pubitemid 38120888)
-
(2004)
Cancer Research
, vol.64
, Issue.2
, pp. 500-508
-
-
Kuhne, M.1
Riballo, E.2
Rief, N.3
Rothkamm, K.4
Jeggo, P.A.5
Lobrich, M.6
-
92
-
-
0030807476
-
Identification of defective illegitimate recombinational repair of oxidatively-induced DNA double-strand breaks in ataxia-telangiectasia cells
-
DOI 10.1016/S0921-8777(97)00021-9, PII S0921877797000219
-
M.E. Dar, T.A. Winters, and T.J. Jorgensen Identification of defective illegitimate recombinational repair of oxidatively-induced DNA double-strand breaks in ataxia-telangiectasia cells Mutat Res 384 1997 169 179 (Pubitemid 27394242)
-
(1997)
Mutation Research - DNA Repair
, vol.384
, Issue.3
, pp. 169-179
-
-
Dar, M.E.1
Winters, T.A.2
Jorgensen, T.J.3
-
93
-
-
33747097562
-
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
-
DOI 10.1038/nature04866, PII NATURE04866
-
A.L. Bredemeyer, G.G. Sharma, C.Y. Huang, B.A. Helmink, L.M. Walker, and K.C. Khor ATM stabilizes DNA double-strand-break complexes during V(D)J recombination Nature 442 2006 466 470 (Pubitemid 44264797)
-
(2006)
Nature
, vol.442
, Issue.7101
, pp. 466-470
-
-
Bredemeyer, A.L.1
Sharma, G.G.2
Huang, C.-Y.3
Helmink, B.A.4
Walker, L.M.5
Khor, K.C.6
Nuskey, B.7
Sullivan, K.E.8
Pandita, T.K.9
Bassing, C.H.10
Sleckman, B.P.11
-
94
-
-
9744220428
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to γ-H2AX foci
-
DOI 10.1016/j.molcel.2004.10.029, PII S1097276504006549
-
E. Riballo, M. Kuhne, N. Rief, A. Doherty, G.C. Smith, and M.J. Recio A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci Mol Cell 16 2004 715 724 (Pubitemid 39586530)
-
(2004)
Molecular Cell
, vol.16
, Issue.5
, pp. 715-724
-
-
Riballo, E.1
Kuhne, M.2
Rief, N.3
Doherty, A.4
Smith, G.C.M.5
Recio, M.-J.6
Reis, C.7
Dahm, K.8
Fricke, A.9
Krempler, A.10
Parker, A.R.11
Jackson, S.P.12
Gennery, A.13
Jeggo, P.A.14
Lobrich, M.15
-
96
-
-
0037124373
-
Synapsis of DNA ends by DNA-dependent protein kinase
-
DOI 10.1093/emboj/cdf299
-
L.G. DeFazio, R.M. Stansel, J.D. Griffith, and G. Chu Synapsis of DNA ends by DNA-dependent protein kinase EMBO J 21 2002 3192 3200 (Pubitemid 34670402)
-
(2002)
EMBO Journal
, vol.21
, Issue.12
, pp. 3192-3200
-
-
DeFazio, L.G.1
Stansel, R.M.2
Griffith, J.D.3
Chu, G.4
-
97
-
-
0942268167
-
Repair of DNA double strand breaks by non-homologous end joining
-
DOI 10.1016/j.biochi.2003.10.011
-
S.P. Lees-Miller, and K. Meek Repair of DNA double strand breaks by non-homologous end joining Biochimie 85 2003 1161 1173 (Pubitemid 38142369)
-
(2003)
Biochimie
, vol.85
, Issue.11
, pp. 1161-1173
-
-
Lees-Miller, S.P.1
Meek, K.2
-
98
-
-
33646714595
-
Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair
-
DOI 10.1016/j.molcel.2006.04.013, PII S1097276506002619
-
L. Spagnolo, A. Rivera-Calzada, L.H. Pearl, and O. Llorca Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair Mol Cell 22 2006 511 519 (Pubitemid 43740469)
-
(2006)
Molecular Cell
, vol.22
, Issue.4
, pp. 511-519
-
-
Spagnolo, L.1
Rivera-Calzada, A.2
Pearl, L.H.3
Llorca, O.4
-
100
-
-
0035125901
-
cs during murine embryogenesis
-
DOI 10.1016/S0960-9822(01)00048-3
-
K.E. Gurley, and C.J. Kemp Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis Curr Biol 11 2001 191 194 (Pubitemid 32152105)
-
(2001)
Current Biology
, vol.11
, Issue.3
, pp. 191-194
-
-
Gurley, K.E.1
Kemp, C.J.2
-
101
-
-
68949161769
-
P38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint
-
V. Lafarga, A. Cuadrado, I. Lopez de Silanes, R. Bengoechea, O. Fernandez-Capetillo, and A.R. Nebreda p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint Mol Cell Biol 29 2009 4341 4351
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4341-4351
-
-
Lafarga, V.1
Cuadrado, A.2
Lopez De Silanes, I.3
Bengoechea, R.4
Fernandez-Capetillo, O.5
Nebreda, A.R.6
-
102
-
-
0035799557
-
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
-
DOI 10.1038/35075107
-
D.V. Bulavin, Y. Higashimoto, I.J. Popoff, W.A. Gaarde, V. Basrur, and O. Potapova Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase Nature 411 2001 102 107 (Pubitemid 32428198)
-
(2001)
Nature
, vol.411
, Issue.6833
, pp. 102-107
-
-
Bulavin, D.V.1
Higashimoto, Y.2
Popoff, I.J.3
Gaarde, W.A.4
Basrur, V.5
Potapova, O.6
Appella, E.7
Fornace, A.J.8
-
103
-
-
34247269029
-
TAO kinases mediate activation of p38 in response to DNA damage
-
DOI 10.1038/sj.emboj.7601668, PII 7601668
-
M. Raman, S. Earnest, K. Zhang, Y. Zhao, and M.H. Cobb TAO kinases mediate activation of p38 in response to DNA damage EMBO J 26 2007 2005 2014 (Pubitemid 46625802)
-
(2007)
EMBO Journal
, vol.26
, Issue.8
, pp. 2005-2014
-
-
Raman, M.1
Earnest, S.2
Zhang, K.3
Zhao, Y.4
Cobb, M.H.5
-
104
-
-
0242663968
-
2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents
-
DOI 10.1128/MCB.23.22.8306-8315.2003
-
Y. Hirose, M. Katayama, D. Stokoe, D.A. Haas-Kogan, M.S. Berger, and R.O. Pieper The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents Mol Cell Biol 23 2003 8306 8315 (Pubitemid 37377519)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.22
, pp. 8306-8315
-
-
Hirose, Y.1
Katayama, M.2
Stokoe, D.3
Haas-Kogan, D.A.4
Berger, M.S.5
Pieper, R.O.6
-
105
-
-
2442689169
-
2 arrest following exposure to temozolomide
-
Y. Hirose, M. Katayama, M.S. Berger, and R.O. Pieper Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide J Neurosurg 100 2004 1060 1065 (Pubitemid 38661619)
-
(2004)
Journal of Neurosurgery
, vol.100
, Issue.6
, pp. 1060-1065
-
-
Hirose, Y.1
Katayama, M.2
Berger, M.S.3
Pieper, R.O.4
-
106
-
-
49349092475
-
Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia
-
J.L. Perfettini, R. Nardacci, M. Bourouba, F. Subra, L. Gros, and C. Seror Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia PLoS One 3 2008 e2458
-
(2008)
PLoS One
, vol.3
, pp. 2458
-
-
Perfettini, J.L.1
Nardacci, R.2
Bourouba, M.3
Subra, F.4
Gros, L.5
Seror, C.6
-
107
-
-
0035066383
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
-
J.M. Kyriakis, and J. Avruch Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation Physiol Rev 81 2001 807 869 (Pubitemid 32267078)
-
(2001)
Physiological Reviews
, vol.81
, Issue.2
, pp. 807-869
-
-
Kyriakis, J.M.1
Avruch, J.2
-
108
-
-
0026616796
-
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase
-
L.L. Parker, and H. Piwnica-Worms Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase Science 257 1992 1955 1957
-
(1992)
Science
, vol.257
, pp. 1955-1957
-
-
Parker, L.L.1
Piwnica-Worms, H.2
-
109
-
-
0026587204
-
The wee1 protein kinase is required for radiation-induced mitotic delay
-
R. Rowley, J. Hudson, and P.G. Young The wee1 protein kinase is required for radiation-induced mitotic delay Nature 356 1992 353 355
-
(1992)
Nature
, vol.356
, pp. 353-355
-
-
Rowley, R.1
Hudson, J.2
Young, P.G.3
-
110
-
-
0027244234
-
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase
-
R. Heald, M. McLoughlin, and F. McKeon Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase Cell 74 1993 463 474 (Pubitemid 23244612)
-
(1993)
Cell
, vol.74
, Issue.3
, pp. 463-474
-
-
Heald, R.1
McLoughlin, M.2
McKeon, F.3
-
111
-
-
0035158899
-
Positive regulation of Wee1 by Chk1 and 14-3-3 proteins
-
J. Lee, A. Kumagai, and W.G. Dunphy Positive regulation of Wee1 by Chk1 and 14-3-3 proteins Mol Biol Cell 12 2001 551 563 (Pubitemid 33052011)
-
(2001)
Molecular Biology of the Cell
, vol.12
, Issue.3
, pp. 551-563
-
-
Lee, J.1
Kumagai, A.2
Dunphy, W.G.3
-
112
-
-
33744905789
-
Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development
-
Y. Tominaga, C. Li, R.H. Wang, and C.X. Deng Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development Int J Biol Sci 2 2006 161 170 (Pubitemid 43846008)
-
(2006)
International Journal of Biological Sciences
, vol.2
, Issue.4
, pp. 161-170
-
-
Tominaga, Y.1
Li, C.2
Wang, R.-H.3
Deng, C.-X.4
-
113
-
-
16544392882
-
2 checkpoint and induces apoptosis
-
Y. Wang, S.J. Decker, and J. Sebolt-Leopold Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis Cancer Biol Ther 3 2004 305 313 (Pubitemid 41350885)
-
(2004)
Cancer Biology and Therapy
, vol.3
, Issue.3
, pp. 305-313
-
-
Wang, Y.1
Decker, S.J.2
Sebolt-Leopold, J.3
-
114
-
-
77956517283
-
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma
-
S.E. Mir, P.C. De Witt Hamer, P.M. Krawczyk, L. Balaj, A. Claes, and J.M. Niers In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma Cancer Cell 18 2010 244 257
-
(2010)
Cancer Cell
, vol.18
, pp. 244-257
-
-
Mir, S.E.1
De Witt Hamer, P.C.2
Krawczyk, P.M.3
Balaj, L.4
Claes, A.5
Niers, J.M.6
-
115
-
-
0031471249
-
In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor
-
R.L. Panek, G.H. Lu, S.R. Klutchko, B.L. Batley, T.K. Dahring, and J.M. Hamby In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor J Pharmacol Exp Ther 283 1997 1433 1444 (Pubitemid 28016519)
-
(1997)
Journal of Pharmacology and Experimental Therapeutics
, vol.283
, Issue.3
, pp. 1433-1444
-
-
Panek, R.L.1
Lu, G.H.2
Klutchko, S.R.3
Batley, B.L.4
Dahring, T.K.5
Hamby, J.M.6
Hallak, H.7
Doherty, A.M.8
Keiser, J.A.9
-
116
-
-
0035890610
-
2 checkpoint abrogator
-
Y. Wang, J. Li, R.N. Booher, A. Kraker, T. Lawrence, and W.R. Leopold Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator Cancer Res 61 2001 8211 8217 (Pubitemid 33091614)
-
(2001)
Cancer Research
, vol.61
, Issue.22
, pp. 8211-8217
-
-
Wang, Y.1
Li, J.2
Booher, R.N.3
Kraker, A.4
Lawrence, T.5
Leopold, W.R.6
Sun, Y.7
-
117
-
-
79955402190
-
WEE1 inhibition sensitizes osteosarcoma to radiotherapy
-
J. PosthumaDeBoer, T. Wurdinger, H.C. Graat, V.W. van Beusechem, M.N. Helder, and B.J. van Royen WEE1 inhibition sensitizes osteosarcoma to radiotherapy BMC Cancer 11 2011 156
-
(2011)
BMC Cancer
, vol.11
, pp. 156
-
-
Posthumadeboer, J.1
Wurdinger, T.2
Graat, H.C.3
Van Beusechem, V.W.4
Helder, M.N.5
Van Royen, B.J.6
-
118
-
-
79960339454
-
WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe
-
P.C. De Witt Hamer, S.E. Mir, D. Noske, C.J. Van Noorden, and T. Wurdinger WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe Clin Cancer Res 17 2011 4200 4207
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4200-4207
-
-
De Witt Hamer, P.C.1
Mir, S.E.2
Noske, D.3
Van Noorden, C.J.4
Wurdinger, T.5
-
119
-
-
67649710471
-
Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor
-
S. Mizuarai, K. Yamanaka, H. Itadani, T. Arai, T. Nishibata, and H. Hirai Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor Mol Cancer 8 2009 34
-
(2009)
Mol Cancer
, vol.8
, pp. 34
-
-
Mizuarai, S.1
Yamanaka, K.2
Itadani, H.3
Arai, T.4
Nishibata, T.5
Hirai, H.6
-
120
-
-
70949083026
-
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
-
H. Hirai, Y. Iwasawa, M. Okada, T. Arai, T. Nishibata, and M. Kobayashi Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents Mol Cancer Ther 8 2009 2992 3000
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2992-3000
-
-
Hirai, H.1
Iwasawa, Y.2
Okada, M.3
Arai, T.4
Nishibata, T.5
Kobayashi, M.6
-
121
-
-
77953711939
-
MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil
-
H. Hirai, T. Arai, M. Okada, T. Nishibata, M. Kobayashi, and N. Sakai MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil Cancer Biol Ther 9 2010 514 522
-
(2010)
Cancer Biol Ther
, vol.9
, pp. 514-522
-
-
Hirai, H.1
Arai, T.2
Okada, M.3
Nishibata, T.4
Kobayashi, M.5
Sakai, N.6
-
122
-
-
79955492036
-
MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts
-
N.V. Rajeshkumar, E. De Oliveira, N. Ottenhof, J. Watters, D. Brooks, and T. Demuth MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts Clin Cancer Res 17 2011 2799 2806
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2799-2806
-
-
Rajeshkumar, N.V.1
De Oliveira, E.2
Ottenhof, N.3
Watters, J.4
Brooks, D.5
Demuth, T.6
-
123
-
-
78649237831
-
Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents
-
S. Leijen, J.H. Beijnen, and J.H. Schellens Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents Curr Clin Pharmacol 5 2010 186 191
-
(2010)
Curr Clin Pharmacol
, vol.5
, pp. 186-191
-
-
Leijen, S.1
Beijnen, J.H.2
Schellens, J.H.3
-
124
-
-
0031463309
-
Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP
-
DOI 10.1093/emboj/16.24.7444
-
P. Vichi, F. Coin, J.P. Renaud, W. Vermeulen, J.H. Hoeijmakers, and D. Moras Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP EMBO J 16 1997 7444 7456 (Pubitemid 28010504)
-
(1997)
EMBO Journal
, vol.16
, Issue.24
, pp. 7444-7456
-
-
Vichi, P.1
Coin, F.2
Renaud, J.-P.3
Vermeulen, W.4
Hoeijmakers, J.H.J.5
Moras, D.6
Egly, J.-M.7
-
125
-
-
0034641753
-
UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II
-
D.A. Rockx, R. Mason, A. van Hoffen, M.C. Barton, E. Citterio, and D.B. Bregman UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II Proc Natl Acad Sci U S A 97 2000 10503 10508
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10503-10508
-
-
Rockx, D.A.1
Mason, R.2
Van Hoffen, A.3
Barton, M.C.4
Citterio, E.5
Bregman, D.B.6
-
126
-
-
4444236147
-
Portrait of transcriptional responses to ultraviolet and ionizing radiation in human cells
-
DOI 10.1093/nar/gkh783
-
K.E. Rieger, and G. Chu Portrait of transcriptional responses to ultraviolet and ionizing radiation in human cells Nucleic Acids Res 32 2004 4786 4803 (Pubitemid 39429683)
-
(2004)
Nucleic Acids Research
, vol.32
, Issue.16
, pp. 4786-4803
-
-
Rieger, K.E.1
Chu, G.2
-
127
-
-
0035162698
-
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR Homolog Mec1p
-
A.P. Gasch, M. Huang, S. Metzner, D. Botstein, S.J. Elledge, and P.O. Brown Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p Mol Biol Cell 12 2001 2987 3003 (Pubitemid 33062956)
-
(2001)
Molecular Biology of the Cell
, vol.12
, Issue.10
, pp. 2987-3003
-
-
Gasch, A.P.1
Huang, M.2
Metzner, S.3
Botstein, D.4
Elledge, S.J.5
Brown, P.O.6
-
128
-
-
0036677451
-
Global analysis of stress-regulated mRNA turnover by using cDNA arrays
-
J. Fan, X. Yang, W. Wang, W.H. Wood 3rd, K.G. Becker, and M. Gorospe Global analysis of stress-regulated mRNA turnover by using cDNA arrays Proc Natl Acad Sci U S A 99 2002 10611 10616
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 10611-10616
-
-
Fan, J.1
Yang, X.2
Wang, W.3
Wood III, W.H.4
Becker, K.G.5
Gorospe, M.6
-
129
-
-
40149096226
-
Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: Implications for cellular senescence
-
DOI 10.1515/BC.2008.022
-
K. Abdelmohsen, Y. Kuwano, H.H. Kim, and M. Gorospe Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence Biol Chem 389 2008 243 255 (Pubitemid 351329020)
-
(2008)
Biological Chemistry
, vol.389
, Issue.3
, pp. 243-255
-
-
Abdelmohsen, K.1
Kuwano, Y.2
Kim, H.H.3
Gorospe, M.4
-
130
-
-
34249316905
-
RNA-binding proteins: Modular design for efficient function
-
DOI 10.1038/nrm2178, PII NRM2178
-
B.M. Lunde, C. Moore, and G. Varani RNA-binding proteins: modular design for efficient function Nat Rev Mol Cell Biol 8 2007 479 490 (Pubitemid 46809150)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.6
, pp. 479-490
-
-
Lunde, B.M.1
Moore, C.2
Varani, G.3
-
131
-
-
0038153919
-
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
-
DOI 10.1073/pnas.1432104100
-
K. Mazan-Mamczarz, S. Galban, I. Lopez de Silanes, J.L. Martindale, U. Atasoy, and J.D. Keene RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation Proc Natl Acad Sci U S A 100 2003 8354 8359 (Pubitemid 36842549)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.14
, pp. 8354-8359
-
-
Mazan-Mamczarz, K.1
Galban, S.2
De Silanes, I.L.3
Martindale, J.L.4
Atasoy, U.5
Keene, J.D.6
Gorospe, M.7
-
132
-
-
0033959125
-
HuR regulates p21 mRNA stabilization by UV light
-
DOI 10.1128/MCB.20.3.760-769.2000
-
W. Wang, H. Furneaux, H. Cheng, M.C. Caldwell, D. Hutter, and Y. Liu HuR regulates p21 mRNA stabilization by UV light Mol Cell Biol 20 2000 760 769 (Pubitemid 30044212)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.3
, pp. 760-769
-
-
Wang, W.1
Furneaux, H.2
Cheng, H.3
Caldwell, M.C.4
Hutter, D.5
Liu, Y.6
Holbrook, N.7
Gorospe, M.8
-
133
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
DOI 10.1126/science.1140321
-
S. Matsuoka, B.A. Ballif, A. Smogorzewska, E.R. McDonald 3rd, K.E. Hurov, and J. Luo ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage Science 316 2007 1160 1166 (Pubitemid 46877472)
-
(2007)
Science
, vol.316
, Issue.5828
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald III, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
Shiloh, Y.11
Gygi, S.P.12
Elledge, S.J.13
-
134
-
-
67651119997
-
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability
-
R.D. Paulsen, D.V. Soni, R. Wollman, A.T. Hahn, M.C. Yee, and A. Guan A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability Mol Cell 35 2009 228 239
-
(2009)
Mol Cell
, vol.35
, pp. 228-239
-
-
Paulsen, R.D.1
Soni, D.V.2
Wollman, R.3
Hahn, A.T.4
Yee, M.C.5
Guan, A.6
-
135
-
-
77956283656
-
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability
-
K.E. Hurov, C. Cotta-Ramusino, and S.J. Elledge A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability Genes Dev 24 2010 1939 1950
-
(2010)
Genes Dev
, vol.24
, pp. 1939-1950
-
-
Hurov, K.E.1
Cotta-Ramusino, C.2
Elledge, S.J.3
-
136
-
-
0037115421
-
Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53
-
J. Hildesheim, D.V. Bulavin, M.R. Anver, W.G. Alvord, M.C. Hollander, and L. Vardanian Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53 Cancer Res 62 2002 7305 7315 (Pubitemid 36025254)
-
(2002)
Cancer Research
, vol.62
, Issue.24
, pp. 7305-7315
-
-
Hildesheim, J.1
Bulavin, D.V.2
Anver, M.R.3
Alvord, W.G.4
Hollander, M.C.5
Vardanian, L.6
Fornace Jr., A.J.7
-
137
-
-
0033616501
-
2 /M cell cycle checkpoint
-
DOI 10.1073/pnas.96.7.3706
-
X.W. Wang, Q. Zhan, J.D. Coursen, M.A. Khan, H.U. Kontny, and L. Yu GADD45 induction of a G2/M cell cycle checkpoint Proc Natl Acad Sci U S A 96 1999 3706 3711 (Pubitemid 29168974)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.7
, pp. 3706-3711
-
-
Wang, X.W.1
Zhan, Q.2
Coursen, J.D.3
Khan, M.A.4
Kontny, H.U.5
Yu, L.6
Hollander, M.C.7
O'Connor, P.M.8
Fornace Jr., A.J.9
Harris, C.C.10
-
138
-
-
0027988165
-
Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes
-
J. Jackman, I. Alamo Jr., and A.J. Fornace Jr. Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes Cancer Res 54 1994 5656 5662 (Pubitemid 24346263)
-
(1994)
Cancer Research
, vol.54
, Issue.21
, pp. 5656-5662
-
-
Jackman, J.1
Alamo Jr., I.2
Fornace Jr., A.J.3
-
139
-
-
33645962172
-
Posttranscriptional derepression of GADD45alpha by genotoxic stress
-
A. Lal, K. Abdelmohsen, R. Pullmann, T. Kawai, S. Galban, and X. Yang Posttranscriptional derepression of GADD45alpha by genotoxic stress Mol Cell 22 2006 117 128
-
(2006)
Mol Cell
, vol.22
, pp. 117-128
-
-
Lal, A.1
Abdelmohsen, K.2
Pullmann, R.3
Kawai, T.4
Galban, S.5
Yang, X.6
-
140
-
-
0037011121
-
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs
-
DOI 10.1093/emboj/cdf639
-
S. Rousseau, N. Morrice, M. Peggie, D.G. Campbell, M. Gaestel, and P. Cohen Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs EMBO J 21 2002 6505 6514 (Pubitemid 35448428)
-
(2002)
EMBO Journal
, vol.21
, Issue.23
, pp. 6505-6514
-
-
Rousseau, S.1
Morrice, N.2
Peggie, M.3
Campbell, D.G.4
Gaestel, M.5
Cohen, P.6
-
141
-
-
78650817044
-
Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?
-
H.C. Reinhardt, I.G. Cannell, S. Morandell, and M.B. Yaffe Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response? Cell Cycle 10 2011 23 27
-
(2011)
Cell Cycle
, vol.10
, pp. 23-27
-
-
Reinhardt, H.C.1
Cannell, I.G.2
Morandell, S.3
Yaffe, M.B.4
-
142
-
-
70349443284
-
When mutants gain new powers: News from the mutant p53 field
-
R. Brosh, and V. Rotter When mutants gain new powers: news from the mutant p53 field Nat Rev Cancer 9 2009 701 713
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 701-713
-
-
Brosh, R.1
Rotter, V.2
-
143
-
-
3342893272
-
Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion
-
DOI 10.1038/sj.onc.1207752
-
F. Guo, and Y. Zheng Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion Oncogene 23 2004 5577 5585 (Pubitemid 39093035)
-
(2004)
Oncogene
, vol.23
, Issue.33
, pp. 5577-5585
-
-
Guo, F.1
Zheng, Y.2
-
144
-
-
33745700179
-
Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells
-
S. Mizuarai, K. Yamanaka, and H. Kotani Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells Cancer Res 66 2006 6319 6326
-
(2006)
Cancer Res
, vol.66
, pp. 6319-6326
-
-
Mizuarai, S.1
Yamanaka, K.2
Kotani, H.3
-
145
-
-
66149091940
-
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
-
J. Luo, M.J. Emanuele, D. Li, C.J. Creighton, M.R. Schlabach, and T.F. Westbrook A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene Cell 137 2009 835 848
-
(2009)
Cell
, vol.137
, pp. 835-848
-
-
Luo, J.1
Emanuele, M.J.2
Li, D.3
Creighton, C.J.4
Schlabach, M.R.5
Westbrook, T.F.6
-
146
-
-
65849111219
-
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
-
C. Scholl, S. Frohling, I.F. Dunn, A.C. Schinzel, D.A. Barbie, and S.Y. Kim Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells Cell 137 2009 821 834
-
(2009)
Cell
, vol.137
, pp. 821-834
-
-
Scholl, C.1
Frohling, S.2
Dunn, I.F.3
Schinzel, A.C.4
Barbie, D.A.5
Kim, S.Y.6
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