The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

Cancer Research

Volumn 60, Issue 8, 2000, Pages 2108-2112

  Busby, Ericka C ^a   Leistritz, Dru F ^a   Abraham, Robert T ^b   Karnitz, Larry M ^a   Sarkaria, Jann N ^a  

^a MAYO CLINIC   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE G2 PHASE; DEPHOSPHORYLATION; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; GAMMA IRRADIATION; GENOTOXICITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOSENSITIZATION;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; DNA DAMAGE; G2 PHASE; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RADIATION-SENSITIZING AGENTS; SIGNAL TRANSDUCTION; STAUROSPORINE;

EID: 0034655281     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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