Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development

International Journal of Biological Sciences

Volumn 2, Issue 4, 2006, Pages 161-170

  Tominaga, Yohei ^a   Li, Cuiling ^a   Wang, Rui Hong ^a   Deng, Chu Xia ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Apoptosis; Cdk1; Chk2; G2 M; Genetic instability

Indexed keywords

4 HYDROXYTAMOXIFEN; CHECKPOINT KINASE 2; CRE RECOMBINASE; HISTONE H2AX; PROTEIN KINASE; PROTEIN WEE1; TAMOXIFEN; UNCLASSIFIED DRUG;

ANEUPLOIDY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; FEMALE; GAMMA RADIATION; GENE DELETION; GENE TARGETING; GENOTYPE; GROWTH RETARDATION; LOXP SITE; MALE; MITOSIS; MOUSE; NONHUMAN; PREIMPLANTATION EMBRYO;

MAMMALIA; MURINAE;

EID: 33744905789     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.2.161     Document Type: Article

References (28)

1. Kellogg DR. Wee1-dependent mechanisms required for coordination of cell growth and cell division. J Cell Sci 2003; 116: 4883-90.
2. Stumpff J, Duncan T, Homola E, et al. Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis. Curr Biol 2004; 14: 2143-8.
3. Harvey SL, and Kellogg DR. Conservation of mechanisms controlling entry into mitosis: budding yeast wee1 delays entry into mitosis and is required for cell size control. Curr Biol 2003; 13: 264-75.
4. Elledge SJ. Cell cycle checkpoints: preventing an identity crisis. Science 1996; 274: 1664-72.
5. Kastan MB, and Bartek J. Cell-cycle checkpoints and cancer. Nature 2004; 432: 316-23.
6. Kops GJ, Weaver BA, and Cleveland DW. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 2005; 5: 773-85.
7. Deng CX. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response, and cancer evolution. Nucleic Acids Res 2006; 34: 1416-26.
8. Dunphy WG, and Kumagai A. The cdc25 protein contains an intrinsic phosphatase activity. Cell 1991; 67: 189-96.
9. Strausfeld U, Labbe JC, Fesquet D, et al. Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature 1991; 351: 242-5.
10. Harvey SL, Charlet A, Haas W, et al. Cdk1-dependent regulation of the mitotic inhibitor Wee1. Cell 2005; 122: 407-20.
11. Deng CX, and Xu X. Generation and analysis of Brca1 conditional knockout mice. Methods Mol Biol 2004; 280: 185-200.
12. Hayashi S, and McMahon AP. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 2002; 244: 305-18.
13. Xu X, Weaver Z, Linke SP, et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell 1999; 3: 389-95.
14. Chen P, Gatei M, O'Connell MJ, et al. Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells. Oncogene 1999; 18: 249-56.
15. Falck J, Mailand N, Syljuasen RG, et al. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 2001; 410: 842-7.
16. Paull TT, Rogakou EP, Yamazaki V, et al. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 2000; 10: 886-95.
17. Yarden RI, Pardo-Reoyo S, Sgagias M, et al. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet 2002; 30: 285-9.
18. Yan Y, Spieker RS, Kim M, et al. BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation. Oncogene 2005; 24: 3285-96.
19. Liu Q, Guntuku S, Cui XS, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000; 14: 1448-59.
20. Takai H, Tominaga K, Motoyama N, et al. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev 2000; 14: 1439-47.
21. Matsuo T, Yamaguchi S, Mitsui S, et al. Control mechanism of the circadian clock for timing of cell division in vivo. Science 2003; 302: 255-9.
22. Xu X, Wagner KU, Larson D, et al. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet 1999; 22: 37-43.
23. Sauer B. Inducible gene targeting in mice using the Cre/lox system. Methods 1998; 14: 381-92.
24. Nagy A. Cre recombinase: the universal reagent for genome tailoring. Genesis 2000; 26: 99-109.
25. Yang X, Li C, Xu X, et al. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A 1998; 95: 3667-72.
26. Deng C, Wynshaw-Boris A, Zhou F, et al. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 1996; 84: 911-21.
27. Lakso M, Pichel JG, Gorman JR, et al. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 1996; 93: 5860-5.
28. Wang RH, Yu H, and Deng CX. A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. Proc Natl Acad Sci U S A 2004; 101: 17108-13.