Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

Molecular Biology of the Cell

Volumn 12, Issue 3, 2001, Pages 551-563

  Lee, J ^a   Kumagai, A ^a   Dunphy, W G ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CELL PROTEIN; CHECKPOINT KINASE 1; CYCLIN B; CYCLIN DEPENDENT KINASE 2; DNA; PROTEIN 14 3 3; PROTEIN WEE1; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA REPLICATION; INTERPHASE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; XENOPUS;

XENOPUS;

EID: 0035158899     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.3.551     Document Type: Article

References (52)

1. Regulation of Schizosaccharomyces pombe Wee1 tyrosine kinase
2. Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint
3. A human homologue of the checkpoint kinase Cds1 directly inhibit Cdc25 phosphatase
4. Replication checkpoint enforced by kinases Cds1 and Chk1
5. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
6. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
7. 14-3-3σ is required to prevent mitotic catastrophe after DNA damage
8. Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis
9. Cdc2 regulatory factors
10. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site
11. The cdc25 protein contains an intrinsic phosphatase activity
12. Cell cycle checkpoint: Preventing an identity crisis
13. wee1 mitotic inhibitor is a tyrosine/serine kinase
14. Cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
15. Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends
16. 14-3-3ζ protein binds to the carboxyl half of mouse Wee1 kinase
17. Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity
18. Regulation of the cdc25 protein during the cell cycle in Xenopus extracts
19. Control of the Cdc2/Cyclin B complex in Xenopus extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors
20. Regulation of Xenopus Cdc25 protein
21. Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25
22. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
23. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
24. 14-3-3 Proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts
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31. Cell cycle regulation of a Xenopus Wee1-like kinase
32. Myt1: A membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15
33. Analysis of the early embryonic cell cycles of Xenopus; regulation of cell cycle length by Xe-wee1 and Mos
34. Cell cycle extracts
35. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
36. The G2-phase DNA-damage checkpoint
37. 2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation
38. Regulating the onset of mitosis
39. + dependent manner
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41. 2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
42. Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis
43. 2 DNA damage checkpoint targets both Wee1 and Cdc25
44. The wee1 protein kinase is required for radiation-induced mitotic delay
45. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
46. 14-3-3 Proteins are required for maintenance of Raf-1 phosphorylation and kinase activity
47. 2-M cell population
48. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle
49. The structural basis for 14-3-3: Phosphopeptide binding specificity
50. 2 arrest in the Xenopus oocyte: A role for 14-3-3-mediated inhibition of Cdc25 nuclear import
51. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1
52. DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding